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ClinicalTrials.gov public records Last synced Nov 15, 2026, 6:51 AM EST

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Showing 289–312 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Alcohol Drinking, Marijuana
Interventions: Text Messaging and Brief Negotiation Interview; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 13 Years to 18 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Alcohol Use Disorder, Alcoholic Hepatitis
Interventions: Integrated AUD Treatment; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2027
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Substance Abuse, Risk Behaviors
Interventions: Parenting Mindfully Program, Parent Education Program; Behavioral · Other
Lead sponsor: George Mason University; Other
Eligibility: 12 Years to 16 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2019
U.S. locations: 1
States / cities: Fairfax, Virginia

Conditions: Opioid Dependence, Opioid Use Disorder
Interventions: Naloxone Education Intervention; Other
Lead sponsor: Edward Hospital; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2020
U.S. locations: 1
States / cities: Naperville, Illinois

Conditions: Substance-Related Disorders
Interventions: BRIGHT, STAR/TAU+; Behavioral · Other
Lead sponsor: Boston University Charles River Campus; Other
Eligibility: 18 Years and older · Female only
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Adolescent Substance Abuse, Attention Deficit Hyperactivity Disorder
Interventions: Medication integration protocol; Behavioral
Lead sponsor: The National Center on Addiction and Substance Abuse at Columbia University; Other
Eligibility: 13 Years to 17 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: New York, New York

Conditions: Substance Use, Conduct Disorders in Adolescence, Depression, Anxiety
Interventions: FCU-Online, web/ mobile only, FCU-Online, web/ mobile + coach; Behavioral
Lead sponsor: University of Oregon; Other
Eligibility: Not listed
Enrollment: 322 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Colorectal Disorders, Anorectal Disorder, Patient Satisfaction, Pain, Postoperative, Opioid Use, Opioid Abuse, Opioid Dependence
Interventions: ReCOVER Enhanced Recovery Protocol; Procedure
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: New York, New York

Conditions: Substance Use Disorders
Interventions: CBT for Loneliness, CBT for Substance Use Disorder; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Canandaigua, New York

Conditions: Substance Use Disorder
Interventions: Varenicline, Placebo; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Cigarette Smoking, Tobacco Smoking, Tobacco Use Disorder
Interventions: Sustained Care, Standard Care; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 1,359 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 3
States / cities: Boston, Massachusetts • Salem, Massachusetts • Pittsburgh, Pennsylvania

Conditions: Smoking Cessation, Tobacco Dependence
Interventions: Stop Smoking for Good Intervention in Spanish (SS-SP), Usual care (UC); Behavioral
Lead sponsor: H. Lee Moffitt Cancer Center and Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 42 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2021
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe, Criminal Behavior
Interventions: BNI Chatbot, OUD Education & Treatment Resources; Behavioral
Lead sponsor: Center for Progressive Recovery, LLC; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 4 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Smoking Status
Interventions: Control, Media Literacy; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 13 Years to 18 Years
Enrollment: 1,211 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2009
U.S. locations: 3
States / cities: McKeesport, Pennsylvania • Pittsburgh, Pennsylvania

Conditions: Drug Dependence, Substance Use Disorders
Interventions: Recovery Line; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Alcohol; Use, Problem, Stress, Binge Eating, Depression
Interventions: behavioral activation; Behavioral
Lead sponsor: University of Kansas; Other
Eligibility: 17 Years and older
Enrollment: 572 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: Lawrence, Kansas

Conditions: Opioid-use Disorder
Interventions: Psychoeducational Control, Affect Regulation, Affect Labelling; Behavioral
Lead sponsor: Mclean Hospital; Other
Eligibility: 18 Years and older
Enrollment: 119 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Alcohol Use, Cannabis Use, Nicotine Use, Illicit Drug Use, Prescription Opioid Misuse
Interventions: MATAspire Web-app; Behavioral
Lead sponsor: California State University, Northridge; Other
Eligibility: 18 Years and older
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Northridge, California

Conditions: Opioid-use Disorder, Opioid-related Disorders
Interventions: Not applicable - no defined intervention; Other
Lead sponsor: Indivior Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 534 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 35
States / cities: Haleyville, Alabama • Hamilton, Alabama • Little Rock, Arkansas + 30 more

Conditions: Depression, Substance Use
Interventions: Group Cognitive Behavioral Therapy, Group CBT for Depression; Behavioral
Lead sponsor: RAND; Other
Eligibility: 18 Years and older
Enrollment: 299 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2010
U.S. locations: 1
States / cities: Gardena, California

Conditions: Nicotine Dependence
Interventions: Atomoxetine, Placebo; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 55 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Tobacco Use Disorder
Interventions: Cigarette flavor restricted and e-cigarette flavor restricted, Cigarette flavor restricted and e-cigarette flavor unrestricted, Cigarette flavor unrestricted and e-cigarette flavor restricted, Cigarette flavor unrestricted and e-cigarette flavor unrestricted; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Enrollment: 302 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Hepatitis C, Liver Diseases, Drug Abuse, Alcoholism
Interventions: Pegylated Interferon and Ribavirin, Psychosocial, On-site (MMT Clinic) HCV evaluation and treatment, Off-site HCV evaluation and treatment; Drug · Behavioral
Lead sponsor: State University of New York - Upstate Medical University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 111 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2007
U.S. locations: 2
States / cities: Syracuse, New York

Conditions: Nicotine Addiction
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 50 Years
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2011
U.S. locations: 1
States / cities: Baltimore, Maryland

Search by objective public record fields.

Brief Interventions With Text Messaging to Reduce Adolescent Alcohol and Marijuana Use

Alcohol Treatment Outcomes Following Early vs. Standard Liver Transplant for SAH

Parenting Mindfully Study

Increasing Patient Knowledge of the Signs of Opioid Overdose and Naloxone in a Suburban Treatment Program

Growing Together: Women in Opioid Treatment and Their Infants

Family-Based Protocol for Medication Integration in Treatment of Comorbid ASU/ADHD in Routine Care

Prevention of Substance Use in At-Risk Students: A Family-Centered Web Program

A Multimodal Enhanced Recovery Program in Anorectal Surgery

Substance Use and Loneliness

Varenicline Treatment for Cannabis Use Disorder

Comparative Effectiveness of Post-Discharge Strategies for Hospitalized Smokers

Smoking-cessation: A Spanish-Language Clinical Trial

A Brief Negotiation Interview Chatbot to Improve Buprenorphine Engagement Among Justice-Involved Individuals

Media Literacy to Prevent Adolescent Smoking

Automated Recovery Line for Medication Assisted Treatment

A Behavioral Activation Intervention Administered in a College Freshman Orientation Course

Stress Response in Opioid Use Disorder

MATAspire: Mental Health Awareness Tailored App for Substance Prevention and Integrated Resilience Education

An Observational Study of Environmental and SocioEconomic Factors in Opioid Recovery

Building Recovery By Improving Goals, Habits, and Thoughts

Atomoxetine's Effects On Nicotine Response And Stress Response In Smokers

Cigarette and E-cigarette Flavors Manipulations in the Experimental Tobacco Marketplace

Improving Hepatitis C Treatment in Injection Drug Users

Quantitation of Human Cerebral Nicotinie Receptors With 2[18F]FA-85380 and PET Healthy Non-smokers and Ex-Smokers and in Heavy and Light Situational Smokers