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ClinicalTrials.gov public records Last synced Nov 15, 2026, 7:09 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 361–384 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Tobacco Dependence
Interventions: Pediatric Practice-Based Smoking Intervention; Behavioral
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 13 Years to 17 Years
Enrollment: 2,711 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1999 – 2004
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Substance Abuse, Criminal Behavior, Mental Disorder
Interventions: mobile and technology assisted aftercare, Treatment as usual; Behavioral · Other
Lead sponsor: Florida State University; Other
Eligibility: 18 Years and older
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Tallahassee, Florida

Conditions: Substance Use Disorder (SUD), Sexual and Reproductive Health, Sexual Risk Behavior
Interventions: WORTH Paths Digital Intervention, WORTH Paths Wellness Group; Behavioral
Lead sponsor: Fairleigh Dickinson University; Other
Eligibility: 18 Years to 44 Years · Female only
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Teaneck, New Jersey

Conditions: Tobacco Use Disorder
Interventions: Psilocybin, Niacin; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years and older
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 3
States / cities: Birmingham, Alabama • Baltimore, Maryland • New York, New York

Conditions: Marijuana Use, Opioid Use
Interventions: Marijuana, Opioid; Drug
Lead sponsor: Shanna Babalonis, PhD; Other
Eligibility: 18 Years to 50 Years
Enrollment: 8 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Human Immunodeficiency Virus, Sexually Transmitted Infections, Anxiety, Depression, Substance Use Disorders
Interventions: Project PRIDE; Behavioral
Lead sponsor: University of Houston; Other
Eligibility: 18 Years to 25 Years
Enrollment: 17 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Tobacco Use Disorder, Opioid-use Disorder
Interventions: Long-Term Varenicline, Short-Term Varenicline, Directly Observed Therapy, Self Administered Therapy; Drug · Behavioral
Lead sponsor: Albert Einstein College of Medicine; Other
Eligibility: 18 Years and older
Enrollment: 243 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2024
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Alcohol Drinking, Alcohol Abuse, Alcohol Use Disorder
Interventions: Intensive Day Monitoring; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 54 participants
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Alcoholism, Alcohol Drinking, Drinking Behavior, Alcohol-Related Disorders, Substance-Related Disorders, Mental Disorder, Anxiety, Depression
Interventions: Amplification of Positivity Training, Cognitive-behavioral Therapy; Behavioral
Lead sponsor: Charles Taylor; Other
Eligibility: 18 Years to 55 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 2
States / cities: La Jolla, California • Tulsa, Oklahoma

Conditions: Substance Use, Conduct Disorder, Depression, Anxiety
Interventions: Ecological Family Intervention and Treatment (EcoFIT); Other
Lead sponsor: University of Oregon; Other
Eligibility: 2 Years to 3 Years
Enrollment: 731 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2015
U.S. locations: 3
States / cities: Eugene, Oregon • Pittsburgh, Pennsylvania • Charlottesville, Virginia

Conditions: Potential Treatment for Alcohol Dependence-Alcohol Interaction
Interventions: PT150, Beverage; Drug · Other
Lead sponsor: Pop Test Oncology LLC; Industry
Eligibility: 21 Years to 64 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Nicotine Dependence
Interventions: Community level intervention; Behavioral
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 55 Years · Female only
Enrollment: 352 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2020
U.S. locations: 1
States / cities: Bethel, Alaska

Conditions: Tobacco Dependence, HIV Infections
Interventions: Standard Care Intervention (SCI), Culturally Tailored Intervention (CTI); Behavioral
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2011
U.S. locations: 8
States / cities: Lowell, Massachusetts • New Bedford, Massachusetts • Roxbury, Massachusetts + 3 more

Conditions: Sex Behavior
Interventions: Asdzaan Be'eena Program; Behavioral
Lead sponsor: Johns Hopkins Bloomberg School of Public Health; Other
Eligibility: 10 Years to 14 Years · Female only
Enrollment: 408 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 2
States / cities: Chinle, Arizona • Tuba City, Arizona

Conditions: Substance Use Disorders, Behavioral Health, Addiction Psychological, Addiction Disorders, Meditation, Mindfulness Based Stress Reduction, Prevention
Interventions: Mindfulness and Meditation-Based Relapse Prevention Program; Behavioral
Lead sponsor: Bout Me Healing; Industry
Eligibility: 18 Years and older
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Boca Raton, Florida

Conditions: Nicotine Addiction, Cigarette Smoking
Interventions: Smoking research cigarettes with e-cigarette, Nicotine discrimination thresholds; Drug
Lead sponsor: Rose Research Center, LLC; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 2
States / cities: Charlotte, North Carolina • Raleigh, North Carolina

Conditions: Addictive Behavior, Alcohol Use Disorder, Alcohol Abuse, Drug Abuse, Drug Use Disorders
Interventions: Treatment - Workit Health Online Program, Control - Resource List; Behavioral
Lead sponsor: Workit Health; Industry
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Linkage to Care, Homelessness, Substance Use Disorder, Mental Health
Interventions: Peer-support plus usual care from the Health Care for Reentry Veterans program, Usual care from the Health Care for Reentry Veterans program; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: Not listed
Enrollment: 79 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 2
States / cities: West Haven, Connecticut • Bedford, Massachusetts

Conditions: Nicotine Dependence
Interventions: Baclofen, placebo; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 60 Years
Enrollment: 44 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Tobacco Dependence
Interventions: Standard brief advice, Quitline intervention; Behavioral
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2011
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Nicotine Dependence
Interventions: Transcranial Magnetic Stimulation (Neuronetics), Sham Transcranial Magnetic Stimulation; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 50 Years
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Tobacco Use, Tobacco Smoking, Tobacco Dependence, Tobacco Use Disorder, Tobacco Use Cessation
Interventions: 300 mg Cannabidiol, 600 mg Cannabidiol, Placebo; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Tobacco Use Cessation, Smoking Cessation, Smoking, Tobacco Use Disorder
Interventions: Brief Intervention with NRT Initiation; Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 780 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Sex, Substance Use, HIV
Interventions: HIV prevention intervention randomized control trial; Behavioral
Lead sponsor: Hunter College of City University of New York; Other
Eligibility: 18 Years to 29 Years · Male only
Enrollment: 317 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2011
U.S. locations: 1
States / cities: New York, New York

Search by objective public record fields.

Provider and Peer Delivered Youth Smoking Intervention

Feasibility of Mobile and Technology Assisted Aftercare Services for Crisis Stabilization Units

WORTH Paths Intervention

5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder

Reinforcing Effects of Marijuana and Opioids

Project PRIDE (Promoting Resilience In Discriminatory Environments)

A Trial of Directly Observed and Long-term Varenicline

Novel Real-world Methods in Social Drinkers and AUD

Amplification of Positivity for Alcohol Use Disorder Co-Occurring With Anxiety or Depression

Early Family-Centered Prevention of Drug Use Risk (Aka Early Steps)

Effects of Ethanol on the Pharmacokinetics of PT-150 (Formerly ORG34517) (PT150 PK Study)

Community Intervention to Reduce Tobacco Use in Pregnant Women

Reducing Ethnic Health Disparities: Motivating HIV+ Latinos to Quit Smoking

Evaluation of Asdzáán Be'eená Teen Pregnancy and Substance Use Prevention Program for Native American Youth and Their Caregiver

Mindfulness and Meditation-Based Relapse Prevention for Substance Use Disorders

Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use

90-Day Online Substance Use Program

Improving Linkage to Health and Other Services for Veterans Leaving Incarceration

Baclofen Effects in Cigarette Smokers

Quitline Use in Surgical Patients

Transcranial Magnetic Stimulation Effects on Nicotine Craving

Oral Cannabidiol for Tobacco Cessation

Treating Low-Income Smokers in the Hospital Emergency Department

Risk Reduction Intervention for Vulnerable Young Adult Males