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ClinicalTrials.gov public records Last synced Nov 15, 2026, 7:17 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 385–408 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Vaping, Nicotine Dependence
Interventions: Varenicline, Placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 25 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Substance Use, Adolescent Behavior
Interventions: Parenting Wisely+, Treatment as Usual; Behavioral
Lead sponsor: Brown University; Other
Eligibility: 12 Years to 17 Years
Enrollment: 122 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 2
States / cities: Rockford, Illinois • Cranston, Rhode Island

Conditions: Nicotine Addiction, Smoking Cessation
Interventions: Retrieval-Extinction, Non-Retrieval Extinction; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 77 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Opioid Dependence, Opioid Use, Pain, Joint
Interventions: Lucid Lane Therapy Program, Surgical Preparedness Course; Behavioral
Lead sponsor: Lucid Lane, Inc; Industry
Eligibility: 21 Years to 90 Years
Enrollment: 103 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Risky Sexual Behavior
Interventions: Strong African American Families-Teen Program, FUEL; Behavioral
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 14 Years to 17 Years
Enrollment: 502 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2012
U.S. locations: 1
States / cities: Athens, Georgia

Conditions: Attention Deficit Disorder With Hyperactivity, Conduct Disorder, Substance Abuse
Interventions: Adderall; Drug
Lead sponsor: Jeffrey Newcorn; Other
Eligibility: 7 Years to 12 Years
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: New York, New York

Conditions: Alcohol Dependence, Alcohol Interaction
Interventions: PT150, Beverage; Drug · Other
Lead sponsor: Pop Test Oncology LLC; Industry
Eligibility: 21 Years to 64 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Alcohol Drinking, Alcohol Use Disorder, Alcohol Intoxication, Alcohol; Harmful Use, Alcoholism, Binge Drinking
Interventions: Alcohol, Placebo; Drug · Other
Lead sponsor: Carnegie Mellon University; Other
Eligibility: 21 Years to 29 Years
Enrollment: 782 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2025
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Smoking, Tobacco Use, Nicotine Dependence
Interventions: Brief Advice (BA), Motivational Interviewing (MI), Health Education (HE); Behavioral
Lead sponsor: University of Missouri, Kansas City; Other
Eligibility: 18 Years and older
Enrollment: 255 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Kansas City, Missouri

Conditions: Alcohol Use Disorder, Couples, Behavior, Addictive
Interventions: PartnerCHESS, A-CHESS; Behavioral
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 68 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Fall River, Massachusetts

Conditions: Behavioral Health
Interventions: Bodhi AIM (intervention group), HIB (control group); Behavioral
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 13 Years to 20 Years
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Substance Use Disorders, Opiate Dependence, Opiate Withdrawal Syndrome, Opioid-use Disorder, Alcohol Withdrawal, Alcohol Abuse, Alcohol Use Disorder, Cocaine Abuse, Cocaine Use Disorder, Cocaine Withdrawal, Benzodiazepine Abuse, Benzodiazepine Dependence, Substance Abuse, Heroin Overdoses, Heroin Withdrawal, Heroin Abuse
Interventions: Six Step Model of Self-Forgiveness, Treatment as Usual (TAU); Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: McKeesport, Pennsylvania

Conditions: Alcohol; Use, Problem
Interventions: Seed DS-01 Daily Synbiotic; Dietary Supplement
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 64 Years
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Nicotine Addiction, Serious Mental Illness
Interventions: Learn to Quit App, Nicotine patch, Nicotine lozenge, Technical Coaching, NCI QuitGuide App; Device · Drug · Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 63 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Thromboangiitis Obliterans (Buerger's Disease)
Interventions: ATI-1013 (0.2 g), ATI-1013 (0.8 g), ATI-1013 (3.2 g), Placebo; Biological · Other
Lead sponsor: Antidote Therapeutics, Inc; Industry
Eligibility: 23 Years to 59 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Overland Park, Kansas

Conditions: Cigarette Smoker, Tobacco Use Disorder
Interventions: Behavioral Intervention, Laboratory Biomarker Analysis, Nicotine Patch, Questionnaire Administration, Smoking Cessation Intervention; Behavioral · Other · Drug
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 85 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2027
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Smoking Cessation; Tobacco Dependence, E-Cig Use, Nicotine Dependence, Other Tobacco Product
Interventions: BREATHE Free Curriculum; Behavioral
Lead sponsor: Augusta University; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Augusta, Georgia

Conditions: PTSD, Depression, Opioid Use Disorder
Interventions: Modeling to Learn (MTL), Usual quality improvement (QI); Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 720 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Alcohol Abuse, Nicotine Dependence Tobacco Product
Interventions: E-cig use; Behavioral
Lead sponsor: Indiana University; Other
Eligibility: 21 Years and older
Enrollment: 35 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Alcohol Use Disorder
Interventions: Sunobinop, Placebo to match sunobinop; Drug
Lead sponsor: Knoa Pharma LLC; Industry
Eligibility: 18 Years and older
Enrollment: 209 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 4
States / cities: Brooklyn, New York • Columbus, Ohio • Baytown, Texas + 1 more

Conditions: Tobacco Use Disorder
Interventions: Varying the nicotine content of cigarettes, Varying the nicotine content of e-cigarettes; Other
Lead sponsor: University of Vermont; Other
Eligibility: 21 Years and older
Enrollment: 308 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 2
States / cities: Providence, Rhode Island • Burlington, Vermont

Conditions: Alcohol Use Disorder
Interventions: Exenatide, Sham injection; Drug · Other
Lead sponsor: Boston Medical Center; Other
Eligibility: 21 Years to 55 Years
Enrollment: 8 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Cardiovascular Risk Factor, Nicotine Dependence
Interventions: Electronic Cigarette; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years and older
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 2
States / cities: San Francisco, California

Conditions: Lung Cancer Screening, Tobacco Use Disorder, Smoking Cessation
Interventions: Smoking cessation multilevel Intervention; Behavioral
Lead sponsor: Louisiana State University Health Sciences Center in New Orleans; Other
Eligibility: 50 Years to 80 Years
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 2
States / cities: New Orleans, Louisiana

Search by objective public record fields.

Varenicline For Nicotine Vaping Cessation In Non Smoker Vaper Adolescents

Adolescents With Substance Use Disorders Transitioníng From Residential Treatment to the Community

Extinction Updating in Reconsolidation

Impact of a Behavioral Tele-health Program on the Quality of Recovery for Patients Undergoing Total Joint Replacement Surgery

Preventing Substance Use and Risky Behavior Among Rural African American Youth

Brain Indices of Stimulant Treatment in Drug-Naive Youth at Risk for Substance Use Disorder

Clinical Trial to Evaluate the Safety of PT150 (Formerly ORG34517) When it is Taken Concurrently With Alcohol

Behavioral Alcohol Responses (BAR) Study

Testing Counseling Styles to Motivate Smokers to Quit

Building and Pilot Testing a Couples-based Smartphone Systems to Address Alcohol Use Disorder

Testing the Effectiveness and Implementation of a Meditation App for Youth in the Legal System

The Effect of Self-Forgiveness on Self-Stigma in Addiction.

Probiotics, Immune Function, and the Brain in Alcohol Consumers

Feasibility Trial of a Tailored Smoking Cessation App for People With Serious Mental Illness

A First in Human Single Ascending Dose (SAD) Study of ATI-1013 in Healthy Smokers

Behavioral Activation Therapy and Nicotine Replacement Therapy in Increasing Smoking Cessation

BREATHE Free Curriculum

Participatory System Dynamics vs Usual Quality Improvement: Staff Use of Simulation as an Effective, Scalable and Affordable Way to Improve Timely Mental Health Care?

Reactions to E-cigs and Alcohol

Study of Sunobinop on Alcohol Consumption in Alcohol Use Disorder

Nicotine Regulation for Dual Users of E-cigarettes and Cigarettes

The Effects of Exenatide, a GLP-1 Agonist, on Alcohol Self-Administration in Heavy Drinkers

Short-Term Cardiovascular Effects of E-Cigarettes: Influence of Device Power

Multilevel Intervention for LDCT Lung Cancer Screening and Smoking Cessation Among African Americans