Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 15, 2026, 7:37 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 457–480 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Tobacco Use Disorder
Interventions: Combined intervention; Other
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 70 Years
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Cannabis, Cannabis Use, Marijuana, Marijuana Usage, Alcohol Drinking
Interventions: Marijuana, Alcohol, placebo alcohol, Inactive marijuana; Drug
Lead sponsor: Shanna Babalonis, PhD; Other
Eligibility: 21 Years to 50 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Binge Alcohol Consumption, Suicidal Ideation
Interventions: EA-Avatar, Suicide safety planning app; Behavioral
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years to 29 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 2
States / cities: Marlborough, Massachusetts • Worcester, Massachusetts

Conditions: Opioid Use, Alcohol Drinking, Marijuana Use
Interventions: TACUNA plus Wellness Circle, Opioid Education Workshop; Behavioral
Lead sponsor: RAND; Other
Eligibility: 18 Years to 25 Years
Enrollment: 541 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2025
U.S. locations: 3
States / cities: Los Angeles, California • Santa Monica, California

Conditions: Smoking Cessation, Marijuana Use
Interventions: Behavioral: Quitline treatment as usual, QL Marijuana Check-Up intervention (QL-MJCU); Behavioral
Lead sponsor: Consumer Wellness Solutions; Industry
Eligibility: 21 Years and older
Enrollment: 107 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Smoking, Smoking Cessation, Smoking, Tobacco, Opioid Use, Opioid Abuse
Interventions: Nicotine patch; Drug
Lead sponsor: University of Houston; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Smoking Cessation
Interventions: Nicotine Patches, Telephone Counseling, Brief Hospital Counseling; Drug · Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 1,270 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 6
States / cities: Chula Vista, California • Davis, California • La Jolla, California + 1 more

Conditions: Opiate Antagonist Overdose, Opioid-Related Disorders
Interventions: Naloxone Auto-Injector; Behavioral
Lead sponsor: University of New Mexico; Other
Eligibility: 18 Years and older
Enrollment: 395 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Albuquerque, New Mexico

Conditions: Tobacco Use Disorder
Interventions: Memantine; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 21 Years to 45 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: New York, New York

Conditions: Substance Use Behavior, Cannabis Intoxication, Alcohol Intoxication
Interventions: Alcohol beverage, Cannabis (smoked flower), Simultaneous Alcohol and Cannabis, Alcohol Consumption of Others, Alcohol/Cannabis Consumption of Others, No-Alcohol/Cannabis Control; Drug · Other
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 21 Years to 30 Years
Enrollment: 312 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2027 – 2031
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Addiction, Addiction Disorders
Interventions: SKY Breathing Program; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Sanborn, New York

Conditions: Cigarette Smoking, Nicotine Dependence
Interventions: Choose to Change, Enhanced usual care; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 190 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Opioid Abuse and Addiction
Interventions: MBC4OUD; Other
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 100 Years
Enrollment: 75 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Alcohol Abuse, Alcohol Dependence, Drug Abuse, Drug Dependence
Interventions: Integrated Twelve-Step Facilitation, Cognitive Behavioral Therapy; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 14 Years to 21 Years
Enrollment: 59 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Substance Use Disorder (SUD)
Interventions: Engagement Strategy 1, Engagement Strategy 2, Engagement Strategy 3, Engagement Strategy 4, Placebo; Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: San Diego, California

Conditions: Opioid Use Disorder, Pregnancy Related
Interventions: Empowering Pregnant Women and People Receiving Medications for Opioid Use Disorder; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Insomnia, Nicotine Dependence
Interventions: Eszopiclone, Bupropion; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 4 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2008
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Cannabis Use, THC, Marijuana Use, Cognitive Impairment, THC Vaping
Interventions: 15% THC Potency Reduction, 35% THC Potency Reduction; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 25 Years
Enrollment: 110 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Bipolar Disorder
Interventions: Bupropion, Placebo; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 65 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2006
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Substance Abuse, Depression, Anxiety Disorder
Interventions: Mindfulness Based Relapse Prevention (MBRP), Twelve-Step Facilitation Intervention (TSF); Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 75 Years
Enrollment: 204 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 2
States / cities: Tuscaloosa, Alabama • Charleston, South Carolina

Conditions: Nicotine Dependence
Interventions: zonisamide, placebo; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 74 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Parenting, Opioid-use Disorder, Father-Child Relations, Fathers
Interventions: Fathering In Recovery; Behavioral
Lead sponsor: Oregon Research Behavioral Intervention Strategies, Inc.; Industry
Eligibility: 18 Years and older · Male only
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Smoking Cessation
Interventions: Message Prime; Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Attention Deficit Disorder With Hyperactivity, Substance-Related Disorders
Interventions: Atomoxetine hydrochloride, Placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 15 Years to 30 Years
Enrollment: 108 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2006
U.S. locations: 1
States / cities: Boston, Massachusetts

Search by objective public record fields.

Combination Pharmacotherapy for Smoking Cessation Among Methadone Patients

Marijuana Effects on Simulated Driving Performance

Preliminary Trial of an Avatar Guided Digital Intervention for Emerging Adults

TACUNA (Traditions and Connections for Urban Native Americans)

Project CheckUP: A Brief Behavioral Intervention for Quitline Callers Who Use Marijuana (MJ) and Tobacco

Opioids and Smoking Cessation

Smoking Cessation in Hospitalized Smokers

Naloxone Auto-injector as a Universal Precaution for Patients With Opioid Use Disorder

Effect of Memantine Versus Bupropion on Smoking Relapse in Nicotine-Dependent Individuals - 3

Substance Use and Media Preferences

Effects of Breathwork and Meditation on Addiction Recovery

Reducing Tobacco Use Disparities Among Low-Income Adults

Innovatively Increasing PCP Prescribing of Buprenorphine: Measurement Based Care and Integrated Electronic Solution

Development and Testing of Adolescent Twelve-Step Facilitation

Engaging Family Members During Early SUD Treatment: A Hybrid Trial

Open Trial of Technology-Enhanced Behavioral Intervention for Buprenorphine Retention in Pregnant and Postpartum People

Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban

Cannabis THC Potency, Metabolism, and Cognitive Impairment in Young Adults

A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Affective Disorder

Mindfulness-Based Recovery in Veterans

Zonisamide Augmentation of Varenicline Treatment for Smoking Cessation

Fathering In Recovery

Message Priming and Enrollment in, and Response to, a Smoking Cessation Program: A Pilot Study

Effectiveness of ATMX in Treating Adolescents With ADHD and SUD