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ClinicalTrials.gov public records Last synced Nov 15, 2026, 7:42 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 481–504 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Opioid Abuse
Interventions: Overdose Notification; Behavioral
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years and older
Enrollment: 61 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Depression, Anxiety, Eating Disorders, Drug Use Disorders
Interventions: standardized diagnostic assessment, self-report questionnaires, behavioral tasks, physiological measurements, structural and functional magnetic resonance imaging and EEG, biomarker and microbiome assessments, blood to derive induced pluripotent stem cells, genetic and epigenetic assessments; Behavioral · Other
Lead sponsor: Laureate Institute for Brain Research, Inc.; Other
Eligibility: 18 Years to 55 Years
Enrollment: 1,271 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Conditions: Smoking Cessation, Smoking Behaviors, Smoking Reduction, Smoking, Cigarette, Smoking, Nicotine Dependence
Interventions: Clickotine®; Device
Lead sponsor: Click Therapeutics, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 78 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Major Depressive Disorder, Alcohol Use Disorder
Interventions: citalopram; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 65 Years
Enrollment: 674 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: New York, New York

Conditions: Smoking Cessation, Smoking, Nicotine Dependence
Interventions: Incentives for abstinence and treatment engagement, Attendance incentive; Behavioral
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older · Female only
Enrollment: 3,100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Behavior, Health
Interventions: Elongating Time HOrizons for Reentry (ETHoR), Standardized Episodic Thinking (SET); Behavioral
Lead sponsor: Henry Ford Health System; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Alcohol Use Disorder
Interventions: GET73, Placebo; Drug · Other
Lead sponsor: Laboratorio Farmaceutico Ct S.r.l.; Industry
Eligibility: 21 Years to 40 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Tobacco Use Disorder
Interventions: active repetitive transcranial magnetic stimulation, sham repetitive transcranial magnetic stimulation, cognitive behavioral therapy for smoking cessation, nicotine replacement therapy; Device · Behavioral · Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 75 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Drug Addiction, Smoking Cessation
Interventions: Nicotine transdermal system, Nicotine containing cigarette, Placebo cigarette; Drug · Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years to 50 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Alcohol Drinking, Alcohol Use Disorder
Interventions: Practice facilitation implementation intervention; Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 42 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 2
States / cities: Ann Arbor, Michigan • Pittsburgh, Pennsylvania

Conditions: Smoking Cessation, Tobacco Use Disorder
Interventions: Nicotine Replacement Therapies, Nicotine patch, Folic Acid; Drug · Dietary Supplement
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 13 Years to 18 Years
Enrollment: 128 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2002 – 2004
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Opioid Use Disorder, Chronic Pain
Interventions: Integrating the Management of Pain and Addiction via Collaborative Treatment (IMPACT), Enhanced Treatment as Usual (ETAU); Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2030
U.S. locations: 4
States / cities: West Haven, Connecticut • Bedford, Massachusetts • Boston, Massachusetts + 1 more

Conditions: Smoking, Tobacco Use Disorder
Interventions: QuitAdvisorMD Software Algorithm, Standard Smoking Cessation Counseling; Other · Behavioral
Lead sponsor: Silverchair Science & Communications, LLC; Industry
Eligibility: Not listed
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: Insomnia, Alcohol Use, Marijuana Use
Interventions: Brief Behavioral Therapy for Insomnia (BBTI), Brief Alcohol Screening and Intervention for College Students (BASICS), Attention Control; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years to 29 Years
Enrollment: 800 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Alcohol Drinking, Tobacco Use, Drug Use
Interventions: Native PATHS; Behavioral
Lead sponsor: University of Rhode Island; Other
Eligibility: 10 Years to 14 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Kingston, Rhode Island

Conditions: Substance Abuse, HIV Infections
Interventions: mirtazapine, placebo; Drug
Lead sponsor: San Francisco Department of Public Health; Government
Eligibility: 18 Years to 60 Years · Male only
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Smoking Cessation
Interventions: Nicotine Patch, Telephone Counseling, Placebo, Self-Help Materials; Drug · Behavioral · Other
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 4,200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: San Diego, California

Conditions: Tobacco Use, Cigarette Smoking
Interventions: Sham rTMS, Active rTMS 10 Hz DLPFC; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 22 Years to 70 Years
Enrollment: 64 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Attention Deficit Hyperactivity Disorder, Nicotine Dependence, Cannabis Use Disorder
Interventions: Bupropion, Placebo; Drug · Other
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 13 Years to 19 Years
Enrollment: 105 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Substance Use, Substance Abuse, Suicide, Adolescent
Interventions: WisePath for Teens, Peer Support Services (PSS), Control; Other · Behavioral · Device
Lead sponsor: Evidence-Based Practice Institute, Seattle, WA; Industry
Eligibility: 13 Years and older
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 2
States / cities: Baltimore, Maryland • Seattle, Washington

Conditions: Tobacco Use Disorder
Interventions: active tDCS, sham tDCS; Device
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 64 Years
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Substance Use Disorders, Mental Health Impairment, Health Behavior, Adherence, Patient
Interventions: In-Person Case Management at Homeless Recovery Program, Unlimited Smartphone, Smartphone Based Case Management (SPCM) app; Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years and older
Enrollment: 403 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 2
States / cities: Oklahoma City, Oklahoma • Dallas, Texas

Conditions: Substance Use, Self Esteem, Youth Drinking, Prevention, Suicide
Interventions: Native Spirit After-School Program; Behavioral
Lead sponsor: Arizona State University; Other
Eligibility: 12 Years to 17 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 2
States / cities: Scottsdale, Arizona • Tucson, Arizona

Conditions: Alcohol Use Disorder
Interventions: Semaglutide, Placebo; Drug
Lead sponsor: Oklahoma State University Center for Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Search by objective public record fields.

AESOPS Trial 2 (AESOPS-2): Availability of Opioid Harm

Latent Structure of Multi-level Assessments and Predictors of Outcomes in Psychiatric Disorders

Clinical Learning Study for a Mobile Smoking Cessation Program

STAR*D Alcohol: Treatment of Depression Concurrent With Alcohol Abuse

Striving to Quit: First Breath

Peer-Delivered Episodic Future Thinking for Returning Citizens

Effect of GET73 on MRS Measures of Central Glutamate and GABA in Individuals With Alcohol Use Disorder

Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD

Examining the Effect of the Nicotine Patch in Male and Female Smokers - 3

Improving Care for Unhealthy Alcohol Use in Primary Care

Effectiveness of Various Smoking Cessation Therapies in Reducing Smoking in Adolescents - 1

Digital Treatment for Chronic Pain and Addiction in Veterans With Opioid Use Disorder Receiving Buprenorphine

QuitAdvisorMD: A Point-of-care Tool for Brief Smoking Cessation Interventions

Brief Interventions to Reduce Comorbid Alcohol and Cannabis Misuse and Sleep Impairment in Young Adults (Rest-Up RCT)

Developing a Positive Approach to Substance Use Prevention in North American Indian Adolescents

Mirtazapine to Reduce Methamphetamine Use Among MSM With High-risk HIV Behaviors

Telephone Counseling and the Distribution of Nicotine Patches to Smokers

RTMS Targets Neural Circuits for Smoking Cessation

Bupropion for ADHD in Adolescents With Substance Use Disorder

Mobile Technology to Reduce Teen Substance Misuse

Effect of a Non-Invasive Brain Stimulation Technique on Smoking Cessation Behaviors

Homeless Care Management App

Native Spirit: Significant Aim 3: Intervention

Semaglutide Therapy for Alcohol Reduction - Tulsa