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ClinicalTrials.gov public records Last synced Nov 15, 2026, 7:49 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 505–528 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Nicotine Dependence
Interventions: Reduced Nicotine Non-Menthol (RNC), Reduced Nicotine Menthol (RNC-Men), Conventional Nicotine Non-Menthol (CN); Other
Lead sponsor: UConn Health; Other
Eligibility: 18 Years to 45 Years · Male only
Enrollment: 118 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 2
States / cities: Farmington, Connecticut • Hartford, Connecticut

Conditions: Intimate Partner Violence, Alcohol Use
Interventions: Standard Batterer Intervention, Brief Alcohol Intervention; Behavioral
Lead sponsor: The University of Tennessee, Knoxville; Other
Eligibility: Male only
Enrollment: 253 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2012
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Marijuana Usage, Alcohol Drinking
Interventions: One day with a dose of placebo cannabis paired with alcohol, One day with a dose of active THC cannabis paired with alcohol; Drug
Lead sponsor: Hartford Hospital; Other
Eligibility: 21 Years to 40 Years
Enrollment: 13 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Hartford, Connecticut

Conditions: Alcohol Drinking, Smoking, Marijuana Smoking
Interventions: Project ALERT; Behavioral
Lead sponsor: Pacific Institute for Research and Evaluation; Other
Eligibility: Not listed
Enrollment: 8,338 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Risky Health Behavior, Drinking, Alcohol, Alcohol Use Disorder, Drinking, Binge, Drinking Excessive
Interventions: Practice Facilitation; Other
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years and older
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 7
States / cities: Asheville, North Carolina • Charlotte, North Carolina • Greensboro, North Carolina + 4 more

Conditions: Tobacco Dependence
Interventions: Hatha Yoga (HY), Cardiovascular Exercise (CE), Smoking Cessation Counseling; Behavioral
Lead sponsor: H. Lee Moffitt Cancer Center and Research Institute; Other
Eligibility: 18 Years to 55 Years
Enrollment: 79 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2017
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Tobacco Use, Drug Use, Adolescent Behavior, Alcohol Use, Sexual Risk Behavior
Interventions: S4E, Attention-Matched Control Group; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 13 Years to 21 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 2
States / cities: Ann Arbor, Michigan • Ypsilanti, Michigan

Conditions: Tobacco Dependence
Interventions: varenicline, placebo; Drug
Lead sponsor: H. Lee Moffitt Cancer Center and Research Institute; Other
Eligibility: 18 Years to 60 Years
Enrollment: 163 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Cardiovascular Risk Factor, Nicotine Dependence
Interventions: Electronic Cigarette; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 70 Years
Enrollment: 14 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 2
States / cities: San Francisco, California

Conditions: Alcohol Use Disorder, Smoking
Interventions: Oxytocin nasal spray, Placebo; Drug
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Cannabis, Marijuana Use
Interventions: Constituents, Cognitive Functioning, Cardiovascular Health, Motor Vehicle Crashes, Dependence, Psychosis and Schizophrenia, Mental Health, Reproductive Health, Respiratory Health, Edibles, Cannabis Hyperemesis Syndrome, Control; Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years and older
Enrollment: 1,750 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Tobacco Use Disorder
Interventions: Cognitive Behavioral Therapy for Smoking Cessation, Nicotine Replacement Therapy, Bupropion, Varenicline, Mobile Contingency Management, Clinic-Based Smoking Cessation Counseling; Behavioral · Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2030
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Young Adults, Past-3-month Non-medical Use of Prescription Opioids, Without Substance Use Disorders, Social Media Users
Interventions: Theory-based and peer-led intervention on Instagram; Behavioral
Lead sponsor: University of South Carolina; Other
Eligibility: 18 Years to 25 Years
Enrollment: 70 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Columbia, South Carolina

Conditions: Pain, Depression, Substance Use
Interventions: Treating Opioid Patients' Pain and Sadness (TOPPS), Health Education; Behavioral
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years to 75 Years
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Alcohol Abuse, Alcohol Consumption, Drinking Behavior
Interventions: Motivational and Normative Feedback, Self-Awareness; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years to 24 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Nicotine Dependence
Interventions: mSMART; Device
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Opioid Use Disorder, Mental Health Disorder
Interventions: Medication for Opioid Use Disorder, MISSION Critical Time Intervention, MISSION Peer Support, MISSION Dual Recovery Therapy; Other · Behavioral
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years and older
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 5
States / cities: Holyoke, Massachusetts • Orange, Massachusetts • Springfield, Massachusetts + 1 more

Conditions: Suicide, Attempted, Drug Use, Alcohol; Use, Problem
Interventions: Brief intervention to prevent suicide attempt, Enhanced treatment as usual; Behavioral
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years and older
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Drug Addiction, Nicotine Dependence
Interventions: Nicotrol; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 55 Years
Enrollment: 43 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Alcohol-Related Disorders, Substance-Related Disorders, Mental Health, Reproductive Health, Sexual Health, Sexually Transmitted Diseases, Contraception, Maternal Health, Pregnancy, Women's Health
Interventions: Screening, Brief Intervention, and Referral to Treatment (SBIRT); Behavioral
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 4
States / cities: Boston, Massachusetts • Marlborough, Massachusetts • Springfield, Massachusetts + 1 more

Conditions: Smokeless Tobacco, Nicotine Dependence
Interventions: Tailored behavioral intervention, Behavioral activation for elevated depressive symptoms, Post-cessation weight gain management, Alcohol use risk reduction, Nicotine replacement therapy - transdermal nicotine patch, Nicotine replacement therapy - nicotine lozenge, Nicotine replacement therapy - nicotine gum, Bupropion sustained release, Varenicline, Combination nicotine replacement therapy, Combination nicotine replacement therapy + bupropion, Tobacco quit line, Educational materials; Behavioral · Drug
Lead sponsor: Mark Vander Weg; Federal
Eligibility: 18 Years to 99 Years
Enrollment: 123 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Smoking, Alcohol Abuse, Drug Abuse
Interventions: Self-administered computerized assessment for tobacco, substance abuse, and alcohol use., Self-Administered Computerized Assessment and Counseling for Tobacco, Alcohol, and Substance Abuse; Behavioral
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years and older
Enrollment: 758 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2015
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Substance Use, Sexual Risk Behaviors
Interventions: Risk Reduction Therapy for Adolescents, Usual services; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 12 Years to 17 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Alcohol Drinking, Alcohol Use Disorder, Alcohol Abstinence
Interventions: kudzu extract, puerarin, Placebo control; Dietary Supplement
Lead sponsor: Mclean Hospital; Other
Eligibility: 21 Years to 60 Years
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Belmont, Massachusetts

Search by objective public record fields.

Manipulating Tobacco Constituents in Male Menthol Smokers

Brief Intervention to Reduce Drinking Among Batterers

Neuroscience of Alcohol and Marijuana Impaired Driving

An Effectiveness Trial of Project ALERT

STUN (STop UNhealthy) Alcohol Use Now! Implementing Evidence-Based Services for Unhealthy Alcohol Use in Primary Care

Effects of Yoga and Cardiovascular Exercise on Smoking Motivation

Preventing Cigarette Use Among Urban Youth Via an M-Health Primary Care Preventive Intervention

Varenicline Effects on Cue Reactivity and Smoking Reward/Reinforcement

Short-Term Cardiovascular Effects of E-Cigarettes: Influence of E-Liquid pH

Alcohol and Cigarette Craving During Oxytocin Treatment

Developing and Strengthening Cannabis Warnings: Warning Message Testing

Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness

Theory-based Social Media Intervention for Non-medical Use of Prescription Opioids in Young Adults

Treating Chronic Pain in Buprenorphine Patients in Primary Care Settings

Pilot Study of a Text Message Platform to Reduce Risky Drinking in Young Adults

Stage Ib Trial of mSMART for Smoking Cessation Medication Adherence

Supporting Treatment Access and Recovery in COD

Brief New Treatment for Suicide Attempts

Assessing Top Down and Bottom Up Attention Mechanisms in Smokers Using Nicotine Nasal Spray

Improving Alcohol and Substance Use Care Access, Outcome, Equity During the Reproductive Years

Treating Smokeless Tobacco Use in Rural Veterans

Dynamic Assessment and Referral System - Evaluation

Targeting HIV Risk Behaviors in Juvenile Drug Court-Involved Youth

Alkontrol-herbal Effects on Alcohol Drinking