Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 15, 2026, 8:01 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 529–552 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Alcoholism
Interventions: Individualized Assess & Treatment (IATP), Packaged Cognitive-Behavioral (PCBT), Case Management (CaseM); Behavioral
Lead sponsor: UConn Health; Other
Eligibility: 18 Years and older
Enrollment: 173 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Post Traumatic Stress Disorder, Alcohol Use Disorder
Interventions: Zonisamide, Placebo Comparator; Drug
Lead sponsor: Pharmacotherapies for Alcohol and Substance Use Disorders Alliance; Other
Eligibility: 18 Years to 55 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Substance-related Disorders, Depression, High-risk Sex
Interventions: iSBIRT, iSBIRT/TE; Behavioral
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 12 Years to 21 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Smoking, Cigarette, Nicotine Dependence
Interventions: Nicotine (electronic cigarette), Nicotine (nicotine pouch); Other
Lead sponsor: Brown University; Other
Eligibility: 21 Years and older
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Alcohol Use, Marijuana Use, Sexual Behavior
Interventions: OnTrack, Treatment as Usual, Brief Motivational Interviewing; Behavioral
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 21 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: New York, New York

Conditions: Substance Use (Drugs, Alcohol)
Interventions: Integrated Intervention for Dual Problems and Early Action; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 70 Years
Enrollment: 360 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Somerville, Massachusetts

Conditions: THC, Cannabis, Cannabis Smoking, Cannabis Use, Unspecified, Cigarette Smoking, Tobacco Use, Nicotine Dependence, Nicotine Withdrawal, Cardiovascular Risk Factor
Interventions: Smoked Cannabis, Vaped Cannabis, Tobacco Cigarette; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years and older
Enrollment: 14 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 2
States / cities: San Francisco, California

Conditions: Nicotine Dependence, Nicotine Dependence, Cigarettes, Tobacco Use, Tobacco Smoking
Interventions: Virginia Tobacco flavored JUUL 5% ENDS, Cool Mint flavored JUUL 5% ENDS, Mango flavored JUUL 5% ENDS, Creme Brulee flavored JUUL 5% ENDS, VUSE Solo e-cigarette, Nicorette White Ice Mint 4mg nicotine polacrilex gum, Usual Brand combustible cigarette; Other
Lead sponsor: Juul Labs, Inc.; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 67 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Overland Park, Kansas

Conditions: Alcohol Use Disorder
Interventions: Contingency Management; Behavioral
Lead sponsor: Washington State University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 2
States / cities: Spokane, Washington

Conditions: Smoking, Nicotine, Tobacco, Addiction, Substance Use Disorders, Insomnia, Sleep
Interventions: Daridorexant 50 mg, Placebo; Drug · Other
Lead sponsor: Legacy Health System; Other
Eligibility: 18 Years to 55 Years
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Nicotine Dependence
Interventions: Nicotine patch - transdermal, placebo; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years to 60 Years
Enrollment: 127 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2018
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Addiction, Opioid-use Disorder
Interventions: reSET; Device
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Harrisburg, Pennsylvania

Conditions: Tobacco Dependence
Interventions: Placebo (sugar pill), Topiramate, Nicotine patch; Drug
Lead sponsor: UConn Health; Other
Eligibility: 18 Years to 65 Years
Enrollment: 57 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2013
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Driving Behavior, Driving Under the Influence
Interventions: Placebo (Lactose) Capsule, 0.75 mg Alprazolam Capsule, Cannabis (6.18% THC / <0.025% CBD), Cannabis (0%/ THC / 0% CBD); Drug
Lead sponsor: Timothy L. Brown; Other
Eligibility: 19 Years to 45 Years
Enrollment: 13 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Alcoholism
Interventions: Transcranial Magnetic Stimulation (rTMS), Sham (SS); Device
Lead sponsor: Nassima Ait-Daoud Tiouririne; Other
Eligibility: 22 Years and older
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: E-cigarette Use, Vaping, Nicotine Dependence
Interventions: Varenicline 1mg BID, Placebo; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 326 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 2
States / cities: New Haven, Connecticut • Charleston, South Carolina

Conditions: Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD)
Interventions: Placebo, Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 40µg, Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 80µg, Ethanol Infusion, PTSD Reactivity Condition, Alcohol Cue Reactivity; Drug · Procedure · Behavioral
Lead sponsor: Pharmacotherapies for Alcohol and Substance Use Disorders Alliance; Other
Eligibility: 21 Years to 65 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: HIV, AIDS, Nicotine Dependence
Interventions: Bupropion, Brief Counseling, High-magnitude prize contingency management, Monitored support to quit smoking, No additional treatment, Prize contingency management for abstinence, Low intensity prize contingency management; Drug · Behavioral
Lead sponsor: Wayne State University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 165 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2021
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Alcohol Drinking, Alcohol-Related Disorders, Pandemic, Psychological Stress
Interventions: Not listed
Lead sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA); NIH
Eligibility: 18 Years to 100 Years
Enrollment: 1,500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2026
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Nicotine Dependence
Interventions: ATTOC Intervention, UC Intervention; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 99 Years
Enrollment: 832 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking Cessation, Tobacco Use Disorder
Interventions: nicotine transdermal system; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 55 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: Ends 2005
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: HIV, Sexually Transmitted Infections, Substance Use
Interventions: MI + CBST Intervention; Behavioral
Lead sponsor: Hunter College of City University of New York; Other
Eligibility: 18 Years and older · Female only
Enrollment: 143 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: New York, New York

Conditions: Anxiety Disorders, Anxiety, Tobacco Dependence, Smoking, Cigarette, Smoking, Tobacco
Interventions: Personalized Feedback Intervention, Smoking Information Control; Behavioral
Lead sponsor: University of Houston; Other
Eligibility: 18 Years to 65 Years
Enrollment: 95 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Nicotine Use Disorder, Nicotine Dependence, Smoking, Tobacco Use Disorder
Interventions: Baclofen, Placebo; Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: Providence, Rhode Island

Search by objective public record fields.

Individualized Assessment and Treatment for Alcoholism II

Zonisamide Outpatient Study

Primary Care iSBIRT to Reduce Serious Teen Health Risks

Using ANDS to Reduce Harm for Low SES Cigarette Smokers

Development and Testing of a Smartphone Application to Reduce Substance Use and Sexual Risk Among Homeless Young Adults

International Latino Research Partnership

THC Crossover Study

United States Pre-Market Tobacco Application Pharmacokinetics

Automated Reinforcement Management Systems, Phase II

Impact of Daridorexant on Sleep, Daytime Alertness, and Smoking

Nicotine Dependence, Withdrawal and Replacement Therapy Assessed by PET Imaging

Comprehensive CBT (Cognitive Behavioral Therapy) Via reSET App

Topiramate Alone and in Combination With the Nicotine Patch for Smoking Cessation: A Pilot Study

Validation of the Drug Impaired Driving Scenario (DIDS) on the CRCDS-miniSim

Transcranial Magnetic Stimulation (TMS) Treatment for Alcohol Use Disorder

A Trial of Varenicline for E-cigarette Cessation

Effect of Sublingual Formulation of Dexmedetomidine HCl (BXCL501) - Alcohol Interaction Study

Smoking Cessation for People Living With HIV/AIDS

COVID-19 Pandemic Impact on Alcohol (PIA) - A Natural History Study

Testing an Organizational Change Model to Address Smoking in Mental Healthcare

Effectiveness of the Nicotine Patch in Suppressing Nicotine Withdrawal Symptoms in Women Versus Men - 1

Multicomponent Intervention to Reduce Sexual Risk and Substance Use

Personalized Feedback for Smokers With Elevated Anxiety Sensitivity

Baclofen Effects on Smoking Urge and Withdrawal