Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 15, 2026, 8:15 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 553–576 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Alcoholism, Stress Disorders, Post-Traumatic
Interventions: Experiential acceptance, Cognitive restructuring, No-intervention control: Nutrition information; Behavioral · Other
Lead sponsor: Seattle Institute for Biomedical and Clinical Research; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Substance Abuse, Substance Addiction, Substance Use Disorder (SUD), Substance Use (Drugs, Alcohol), Human Immunodeficiency Virus (HIV)
Interventions: The TLC Program; Behavioral
Lead sponsor: Illinois Institute of Technology; Other
Eligibility: 18 Years and older
Enrollment: 124 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Nicotine Dependence, Nicotine Withdrawal
Interventions: Progesterone, Placebo; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 50 Years
Enrollment: 81 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2021
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Opioid Use Disorder (OUD)
Interventions: Communities That HEAL, Wait-list control; Other
Lead sponsor: RTI International; Other
Eligibility: Not listed
Enrollment: 67 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 4
States / cities: Lexington, Kentucky • Boston, Massachusetts • New York, New York + 1 more

Conditions: Smoking, Nicotine Dependence, Addiction, Smoking, Cigarette
Interventions: Real cTBS, Sham cTBS; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Cocaine Use Disorder
Interventions: Prize-Based Contingency Management, Treatment As Usual Outpatient Substance Use Treatment; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 75 Years
Enrollment: 63 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Alcohol Dependence, Alcohol Use Disorder
Interventions: XR-NTX+CM (Extended-Release Naltrexone plus Care Management); Drug
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 80 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: New York, New York

Conditions: Opioid Use Disorder
Interventions: KIOS App, KIOS App education, Treatment as usual; Device · Behavioral
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 18 Years and older
Enrollment: 116 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Tobacco Use Disorder, Smoking Cessation
Interventions: Nicotine Polacrilex Gum (2 mg), Cognitive Behavioral Group Therapy (CBGT); Drug · Behavioral
Lead sponsor: University of Hawaii; Other
Eligibility: 18 Years to 80 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Honolulu, Hawaii

Conditions: HIV/AIDS and Infections, Drug Abuse, Adolescent Behavior, Drug Usage
Interventions: S4E, Usual Care; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 14 Years to 21 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Ypsilanti, Michigan

Conditions: Nicotine Dependence
Interventions: Nicotine patch, ENDS, Placebo patch, Placebo ENDS; Drug · Other
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Violence, Substance Use, Criminal Behavior
Interventions: IntERact; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 16 Years to 24 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Flint, Michigan

Conditions: Cannabis Use, Alcohol Use, Inflammation
Interventions: Not listed
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 21 Years to 60 Years
Enrollment: 77 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Substance Use Disorders
Interventions: Intervention to Promote Healthy Behaviors; Behavioral
Lead sponsor: University of Texas at Austin; Other
Eligibility: 18 Years to 24 Years
Enrollment: 602 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Nicotine Dependence, E-cigarette Use
Interventions: Nicotine Level 1 (0mg/ml), Nicotine Level 2 (36mg/ml), Nicotine Level 3 (59mg/ml); Other
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 44 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Ketogenic Diet, Alcohol Drinking, Alcohol Use Disorder, Magnetic Resonance Imaging, Alcohol Intoxication
Interventions: Ketogenic diet; Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 21 Years to 50 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Alcohol Dependence, Bipolar Disorder
Interventions: Acamprosate; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Alcohol Use Disorder, Alcohol Dependence, Insomnia
Interventions: Sleep Healthy Using the Internet (SHUTi); Behavioral
Lead sponsor: National Institutes of Health Clinical Center (CC); NIH
Eligibility: 18 Years to 65 Years
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Tobacco Dependence
Interventions: Reduced Nicotine Content Cigarettes, Usual Nicotine Content Cigarettes; Drug
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 245 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 2
States / cities: Boston, Massachusetts • Hershey, Pennsylvania

Conditions: Nicotine Dependence
Interventions: Tolcapone, Placebo; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 55 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Cocaine Dependence, Cocaine Abuse, Cocaine Addiction, Drug Abuse, Substance Abuse
Interventions: quetiapine fumarate, Matched Placebo, Cognitive-behavioral Therapy; Drug · Behavioral
Lead sponsor: Seattle Institute for Biomedical and Clinical Research; Other
Eligibility: 18 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Tacoma, Washington

Conditions: Cigarette Smoking
Interventions: Research ENDS S-TA-U001, Nicorette Inhalator; Drug
Lead sponsor: NJOY, Inc.; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 34 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Burbank, California

Conditions: Risk Behavior, HIV/AIDS, Medication Adherence, Substance Abuse
Interventions: CHRP-BB; Other
Lead sponsor: University of Connecticut; Other
Eligibility: 18 Years and older
Enrollment: 237 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2023
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Nicotine Addiction
Interventions: Nicotine polacrilex, Placebo, satiety, abstinence; Drug · Other
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 54 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Durham, North Carolina

Search by objective public record fields.

Reducing Alcohol Use & Post-traumatic Stress Disorder (PTSD) With Cognitive Restructuring & Experiential Acceptance

The Trans-Led Care Study

Progesterone and Brain Imaging Study

HEALing Communities Study

Nicotine TMS EFT Smoking Pilot Study

Neurocognitive Factors in Substance Use Treatment Response: The Ways of Rewarding Abstinence Project

Extended-release Naltrexone and Care Management for Alcohol Dependent Frequent Emergency Department Users

KIOS Mobile App Evaluation

Quit-Smoking Study for Native Hawaiians

Preventing HIV/STI in Urban Adolescents Via an mHealth Primary Care Intervention

Electronic Nicotine Delivery Systems as a Smoking Cessation Treatment

Project IntERact Study

Alcohol and Cannabis Co-Use and the Gut-Brain Axis

An Intervention to Promote Healthy Behaviors in Homeless Youth

Sex Differences in E-Cigarette Perception

Effects of Ketogenic Diet on Alcohol Intoxication

Open Label Trial of Acamprosate in Bipolar Alcoholics

RCT of Web-Based Behavioral Sleep Intervention for Individuals With Alcohol Use Disorder

Reduced Nicotine Cigarettes in Smokers With Mood and Anxiety Disorders

Pilot Study of Tolcapone in Smokers

Quetiapine for the Reduction of Cocaine Use

Nicotine Pharmacokinetics From Research Electronic Nicotine Delivery System S-TA-U001 in Smokers and E-Cigarette Users

Testing an Integrated Bio-Behavioral Primary HIV Prevention Intervention Among High-Risk People Who Use Drugs

Acute and Chronic Nicotine Modulation of Reinforcement Learning