Search | Clinical Trials Finder

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 15, 2026, 8:25 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 577–600 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Smoking Cessation, Nicotine Dependence, Tobacco Use, Cigarette Smoking
Interventions: Social media-based education, counseling, and support, Nicotine replacement therapies (NRT), Gamification; Behavioral · Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 121 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Violence, Substance Use, Criminal Behavior, Violence in Adolescence
Interventions: Remote Therapy Intervention (RTI), Artificial Intelligence Remote Therapy Intervention; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 14 Years to 24 Years
Enrollment: 584 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2026
U.S. locations: 4
States / cities: Atlanta, Georgia • Detroit, Michigan • Flint, Michigan + 1 more

Conditions: Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders, Substance-Related Disorders
Interventions: NRP104; Drug
Lead sponsor: New River Pharmaceuticals; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Tobacco Use Disorder, Head and Neck Neoplasms, Thoracic Neoplasms, Radiation
Interventions: Comprehensive smoking cessation intervention, Enhanced usual care; Other · Behavioral
Lead sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Other
Eligibility: 18 Years to 105 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Cannabis Use, Tobacco Use, Electronic Cigarette Use
Interventions: THC High Dose, THC Low Dose, THC 0mg, E-Cigarette Full Nicotine, E-Cigarette Placebo Nicotine; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Emotional Dysregulation, Therapeutic Alliance, Depression Disorder, Anxiety Disorders, Stress Disorders, Substance Use Disorders, Mental Health Disorders
Interventions: Multi-sensory emotional regulation intervention (Heal); Behavioral
Lead sponsor: SoundHeal; Industry
Eligibility: 12 Years to 18 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: San Luis Obispo, California

Conditions: Cancer, Tobacco Use, Smoking, Nicotine Dependence
Interventions: Tobacco Use Treatment Service and Varenicline Management; Other
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: Not listed
Enrollment: 685 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 2
States / cities: Philadelphia, Pennsylvania

Conditions: Opioid Use Disorder
Interventions: Treatment as usual (TAU), CHaRRM-CN; Other
Lead sponsor: Washington State University; Other
Eligibility: 18 Years and older
Enrollment: 136 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 2
States / cities: Tahlequah, Oklahoma • Seattle, Washington

Conditions: Smoking Cessation, Smoking, Nicotine Dependence
Interventions: CIS - telephone cessation quitline counseling, Lozenge - nicotine mini-lozenges, Emails - Brief smoking prevention messages, Full website - standard smokefree.gov website content, Lite website - lite version of smokefree.gov, Full mailed booklet - NCI's detailed 36-page quit guide, brief mailed booklet - smaller version of NCI's booklet; Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 1,034 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Tobacco-Use Disorder, Schizophrenia, Psychotic Disorders
Interventions: bupropion SR, Cognitive Behavioral Group Therapy, nicotine replacement therapy; Drug · Behavioral
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 65 Years
Enrollment: 51 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1998 – 2004
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Depression, Substance-Related Disorders
Interventions: Motivational Interviewing, Control (brochure); Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 307 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Union City, California

Conditions: Post Traumatic Stress Disorder (PTSD), Addiction, Alcohol Abuse
Interventions: N-Acetylcysteine (NAC) Treatment, Cognitive Behavioral Therapy (CBT), Inactive Placebo Oral Capsule, Functional magnetic resonance imaging (fMRI), Proton magnetic resonance spectroscopy (MRS) Imaging; Drug · Behavioral · Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 70 Years
Enrollment: 182 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2022
U.S. locations: 2
States / cities: Charleston, South Carolina

Conditions: Cigarette Smoking, Nicotine Dependence
Interventions: varenicline (Chantix), bupropion (Zyban), nicotine patches; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 2
States / cities: Durham, North Carolina • Raleigh, North Carolina

Conditions: Burnout, Secondary Trauma, Compassion Fatigue, Opioid Use Disorder, Stimulant Use Disorder, Substance Use Disorder
Interventions: PATH (Peer Advanced Training for total Health); Behavioral
Lead sponsor: Chestnut Health Systems; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Cardiovascular Risk Factor, Nicotine Dependence
Interventions: Low Nicotine E-Liquid, Medium or High Nicotine E-Liquid; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 70 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 2
States / cities: San Francisco, California

Conditions: Alcohol; Harmful Use, Binge Drinking, Risk Behavior, HIV Infection
Interventions: Computerized brief alcohol intervention + IVR booster calls, Computerized brief alcohol intervention, Attention Control; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 90 Years · Female only
Enrollment: 439 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Opiate Substitution Treatment
Interventions: Standard Medical Management (SMM); Behavioral
Lead sponsor: Kaiser Permanente; Other
Eligibility: 18 Years and older
Enrollment: 239 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Smoking Cessation
Interventions: Behavioral and Enhanced Perinatal Intervention for Cessation (B-EPIC), Treatment As Usual; Behavioral
Lead sponsor: Kristin Ashford; Other
Eligibility: 18 Years to 49 Years · Female only
Enrollment: 78 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 2
States / cities: Lexington, Kentucky

Conditions: Smoking, Smoking, Cigarette, E-Cig Use, Nicotine Dependence
Interventions: very low nicotine content cigarettes, normal nicotine content cigarettes, Study e-cigarette; Other
Lead sponsor: Duke University; Other
Eligibility: 21 Years and older
Enrollment: 7 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Accidental Overdose of Opiate
Interventions: Take home rapid drug test; Behavioral
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 35 Years
Enrollment: 93 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Adolescent Development
Interventions: Yoga during physical education; Behavioral
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 11 Years to 14 Years
Enrollment: 211 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Suicide, Alcohol Use Disorder
Interventions: Crisis Line Facilitation (CLF), Enhanced Usual Care (EUC); Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 21 Years and older
Enrollment: 530 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2025
U.S. locations: 2
States / cities: Detroit, Michigan • Waterford, Michigan

Conditions: Opioid Use, Opioid Use Disorder, Risk Reduction, Hiv, Hepatitis C
Interventions: Suboxone, Truvada, Mavyret; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 2
States / cities: Durham, North Carolina • Greensboro, North Carolina

Conditions: Marijuana Use, Marijuana Dependence, Tobacco Use, Alcohol Use, Unspecified
Interventions: Domain-Specific Episodic Future Thinking; Behavioral
Lead sponsor: Michael Sofis; Industry
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022
U.S. locations: 1
States / cities: Sudbury, Massachusetts

Search by objective public record fields.

Engaging Sexual and Gender Minority Cigarette Smokers Into Social Media-based Treatment

Using Re-inforcement Learning to Automatically Adapt a Remote Therapy Intervention (RTI) for Reducing Adolescent Violence Involvement

Study to Evaluate the Likeability, Safety, and Abuse Potential of NRP 104 in Adults With Histories of Stimulant Abuse

A Comprehensive Smoking Cessation Intervention Duration Radiation for Upper Aerodigestive Cancers

Effect of Cannabis on E-Cigarette Use Behavior

Effectiveness of the SoundHeal Multi-Sensory Integrative Therapy Among Justice-Involved Youth

Improving Tobacco Treatment Rates for Cancer Patients Who Smoke

Counseling for Harm Reduction and Retention in Medication-assisted Treatment - Cherokee Nation

Evaluation of National Cancer Institute (NCI) Smoking Intervention Resources

Safety and Effectiveness of Sustained Release Bupropion in Treating Individuals With Schizophrenia Who Smoke

Motivational Interviewing to Reduce Substance Use Among Depression Patients

Clinical Trial for Alcohol Use Disorder and Post Traumatic Stress Disorder (PTSD)

Tailored Smoking Cessation Treatment for LIVE FOR LIFE® Participants

PATH to Reducing Burnout Among Peers Who Deliver Overdose Prevention Services (R33 Phase Clinical Trial)

Vaping High vs. Low Nicotine E-Liquid

Computerized Brief Alcohol Intervention (BI) for Binge Drinking HIV At-Risk and Infected Women

Buprenorphine and Substance Abuse Services for Prescription Opioid Dependence

Behavioral and Enhanced Perinatal Intervention for Cessation (B-EPIC): Reducing Tobacco Use Among Opioid Addicted Women

Impact of New Standards for Tobacco Products Among Dual E-Cigarette/Combusted Cigarette Users - Project 2

Rapid Self-Testing to Prevent Fentanyl Overdose Among Young People Who Use Drugs

Evaluation of Yoga for Substance Use Risk Factors in a School Setting

Facilitating Use of the National Suicide Prevention Lifeline in Alcohol Patients (Reach Out)

Providing PrEP, Hepatitis C Treatment, and MOUD Through Telemedicine at Greensboro SSP

Examining Effects of Domain Specific Episodic Future Thinking on Cannabis Use