Search | Clinical Trials Finder

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 15, 2026, 8:31 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 601–624 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Nicotine Dependence
Interventions: N-acetylcysteine, Placebo; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Tobacco Use Cessation, Tobacco Use Disorder
Interventions: stage-tailored intervention; Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 224 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2011
U.S. locations: 2
States / cities: San Francisco, California

Conditions: Alcohol Use Disorder
Interventions: Alcohol; Drug
Lead sponsor: Jessica Weafer; Other
Eligibility: 21 Years to 26 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Cocaine Use Disorder, Opioid Use Disorder, Stimulant Use Disorder
Interventions: n-acetylcysteine, Hydromorphone, Placebo n-acetylcystine, Placebo hydromorphone; Drug
Lead sponsor: William Stoops; Other
Eligibility: 18 Years to 55 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 2
States / cities: Lexington, Kentucky

Conditions: Alcohol Withdrawal, Substance Use Disorders
Interventions: Patient navigation, Motivational interviewing (MI); Behavioral
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years and older
Enrollment: 206 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Fairbanks, Alaska

Conditions: Smoking Cessation, Tobacco Use Disorder
Interventions: EMB-01; Drug
Lead sponsor: Rose Research Center, LLC; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021
U.S. locations: 1
States / cities: Raleigh, North Carolina

Conditions: Nicotine Dependence
Interventions: Ad Libitum Use followed by Instructed Use of the Inspire Device, Instructed Use followed by Ad Libitum Use of the Inspire Device, Smart-T Smoking Cessation App with the Inspire Device Condition, Smart-T Smoking Cessation App Without the Inspire Device Condition, Nicotine replacement therapy (NRT), Inspire Device; Device · Drug
Lead sponsor: University of Houston; Other
Eligibility: 18 Years and older
Enrollment: 132 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Tobacco Use Disorder, Alcohol Use Disorder, Drug Use Disorder, Smoking, Alcohol Drinking, Drug Abuse
Interventions: Family-Skills Training; Behavioral
Lead sponsor: University of Minnesota; Other
Eligibility: Not listed
Enrollment: 800 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Addiction, Depression/Anxiety, Trauma, Psychological, Self-harm
Interventions: First Face for Mental Heatlh; Behavioral
Lead sponsor: Cambridge Health Alliance; Other
Eligibility: Not listed
Enrollment: 92 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Spokane Valley, Washington

Conditions: Substance-Related Disorders, Opioid Medication Assisted Treatment, Opioid Use Disorder, Opioid Use, Opioid Addiction, Treatment Adherence, Retention in Care
Interventions: Peer-Delivered Behavioral Activation ("Peer Activate"); Behavioral
Lead sponsor: University of Maryland, College Park; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 2
States / cities: Baltimore, Maryland • College Park, Maryland

Conditions: Opioid Use Disorder, Poor Quality Sleep
Interventions: mHealth application and sleep health education, Simplified mHealth application and sleep health education; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Alcohol Use Disorder
Interventions: Intranasal oxytocin, Intranasal placebo; Drug
Lead sponsor: Indiana University; Other
Eligibility: 21 Years to 60 Years
Enrollment: 6 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Substance Abuse, Intravenous, HIV, Heroin Dependence, Opioid Dependence, Cocaine Dependence, Amphetamine Dependence
Interventions: Change the Cycle; Behavioral
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years and older
Enrollment: 979 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 2
States / cities: Los Angeles, California • San Francisco, California

Conditions: Substance Abuse, Mental Health, Educational Problems
Interventions: Bridges 4-week Program; Behavioral
Lead sponsor: Arizona State University; Other
Eligibility: 10 Years to 15 Years
Enrollment: 664 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Tempe, Arizona

Conditions: Nicotine Dependence
Interventions: Varenicline, Bupropion, Nicotine patches, Nicotine Inhaler; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 702 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 4
States / cities: Charlotte, North Carolina • Durham, North Carolina • Raleigh, North Carolina + 1 more

Conditions: Smoking Cessation, Nicotine Addiction
Interventions: Not listed
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Alcohol Use, Marijuana Use
Interventions: MICUNAY, Community Wellness Gathering; Behavioral · Other
Lead sponsor: RAND; Other
Eligibility: 14 Years to 18 Years
Enrollment: 185 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2018
U.S. locations: 2
States / cities: Los Angeles, California • Oakland, California

Conditions: Nicotine Dependence, Electronic Cigarette Use
Interventions: Electronic Cigarette, Nicotine Lozenge; Drug
Lead sponsor: Butler Hospital; Other
Eligibility: 21 Years to 65 Years
Enrollment: 183 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Nicotine Dependence, Schizophrenia
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 55 Years
Enrollment: 62 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Catonsville, Maryland

Conditions: Opioid-use Disorder, Depression, Anxiety, Craving
Interventions: unilateral transcranial photobiomodulation, near infrared mode, Sham treatment; Device
Lead sponsor: MindLight, LLC; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Newton Highlands, Massachusetts

Conditions: Nicotine Dependence
Interventions: Not listed
Lead sponsor: Southern Illinois University Carbondale; Other
Eligibility: 18 Years to 25 Years
Enrollment: 115 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2021
U.S. locations: 1
States / cities: Carbondale, Illinois

Conditions: Nicotine Dependence
Interventions: varenicline, transdermal nicotine patch; Drug · Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 140 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2013
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: HIV/AIDS, Nicotine Dependence
Interventions: Varenicline, Nicotine patch, Standard treatment, Standard treatment + Managed Problem Solving (MAPS) adherence intervention; Drug · Behavioral
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 18 Years and older
Enrollment: 340 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 2
States / cities: Chicago, Illinois • Philadelphia, Pennsylvania

Conditions: Alcohol Use Disorder, Substance Use Disorders, Alcohol Use Complicating Pregnancy, Unspecified Trimester, Drug Use Disorders, Drug Use Complicating Pregnancy, Unspecified Trimester
Interventions: Parent-Child Assistance Program - One-Year Version; Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Enid, Oklahoma • Oklahoma City, Oklahoma

Search by objective public record fields.

N-Acetylcysteine and Smoking Reduction

Treating Tobacco Dependence in Inpatient Psychiatry - 1

Neural and Hormonal Influences on Sex Differences in Risk for AUD

Behavioral Effects of Drugs (Inpatient): 43 (Opioids, Cocaine, n-Acetylcysteine)

NCARE, Transition to Recovery

Efficacy and Safety of Combination EMB-001 as a Potential Smoking Cessation Treatment

Smart Olfaction App to Reduce Relapse

Family-Skills Training to Prevent Tobacco and Other Substance Use in Latino Youth

Healing Lodge First Face Training Evaluation Study

Peer Activate: Trial of Peer-Delivered Behavioral Activation for Methadone Adherence

Development of an mHealth Behavioral Sleep Medicine Intervention for Use During Medication Assisted Treatment for MOUD

Does Oxytocin Alter Tolerance to or Motivation for Alcohol

Change the Cycle: An RCT to Prevent Injection Initiation

Optimizing a Drug Abuse Prevention Program for Dissemination

Concurrent Bupropion / Varenicline for Smoking Cessation

Nicotine Receptor Levels and Smoking Cessation

Motivational Interviewing and Culture for Urban Native American Youth (MICUNAY)

Methadone-Maintained Smokers Switching to E-Cigarettes

Effects of Nicotine on Areas of Impaired and Preserved Functioning in Schizophrenia

Transcranial Photobiomodulation for the Treatment of Opioid Cravings

EEG & Behavioral Predictors of Changes in Smoking Trajectories in Young Light Smokers

Menstrual Cycle Effects on Smoking Cessation and Cue Reactivity

Optimizing Tobacco Use Treatment for PLWHA

Evaluating a One-Year Version of the Parent-Child Assistance Program