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ClinicalTrials.gov public records Last synced Nov 15, 2026, 9:01 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 673–696 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Stress Disorders, Post-Traumatic, Substance-Related Disorders
Interventions: Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure, Relapse Prevention Treatment, Active Monitoring Control Group; Behavioral
Lead sponsor: The City College of New York; Other
Eligibility: 18 Years to 65 Years
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2014
U.S. locations: 1
States / cities: New York, New York

Conditions: Nicotine Dependence, Cigarettes
Interventions: Web + text smoking cessation intervention; Behavioral
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years to 30 Years
Enrollment: 437 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Nicotine Dependence
Interventions: Nicotine gum and lozenge, Taboka, Camel Snus; Drug · Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 70 Years
Enrollment: 130 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Nicotine Dependence
Interventions: Transdermal nicotine patch; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 525 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2014
U.S. locations: 2
States / cities: Chicago, Illinois • Philadelphia, Pennsylvania

Conditions: Post Traumatic Stress Disorder, Cannabis Use, Suicide, Veterans, Marijuana
Interventions: Tetrahydrocannabinol, Cannabidiol, Placebo; Drug
Lead sponsor: Wayne State University; Other
Eligibility: 19 Years to 69 Years
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Nicotine Dependence, Psychotic Disorders
Interventions: Contingency Management, Reward; Behavioral
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years and older
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2012
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Alcohol Use Disorder, Heavy Drinking
Interventions: SHUTi Intervention, Web-Based Insomnia Education Program; Behavioral
Lead sponsor: Jessica Weafer; Other
Eligibility: 18 Years to 50 Years
Enrollment: 113 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Tobacco Use, Smoking Cessation, Nicotine Dependence
Interventions: Ketamine Hydrochloride, Motivational enhancement therapy; Drug · Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years to 65 Years
Enrollment: 7 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Substance Use, Adolescent Behavior
Interventions: Parent SMART, Treatment as Usual; Behavioral
Lead sponsor: Brown University; Other
Eligibility: 12 Years to 18 Years
Enrollment: 220 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 3
States / cities: Rockford, Illinois • Sioux City, Iowa • Plymouth, Minnesota

Conditions: Nicotine Dependence
Interventions: Behavioral Counseling, Self-help control; Behavioral
Lead sponsor: Temple University; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2011
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Mental Health Issue, Alcohol Use Disorder, Depression, Anxiety, Insomnia, Post Traumatic Stress Disorder
Interventions: Cognitive Behavioral Therapy for Treatment Seeking (CBT-TS); Behavioral
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years and older
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Cigarette Smoking, Nicotine Dependence, Smoking Cessation
Interventions: High Nicotine Dose, Low Nicotine Dose; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Stigma, Social, Substance Use
Interventions: RESTART; Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Portsmouth, Ohio

Conditions: Tobacco Dependence
Interventions: Tobacco/Physical Activity Intervention, Diet plus BP/CHOL Intervention; Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 19 Years and older
Enrollment: 299 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2020
U.S. locations: 2
States / cities: Nome, Alaska • Stanford, California

Conditions: Substance Abuse
Interventions: Personalized feedback report, Personalized feedback report plus education; Behavioral
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: 18 Years to 105 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: Copd, Smoking Cessation, Nicotine Dependence, Tobacco Use, Cigarette Smoking
Interventions: Unified Protocol adapted for smoking cessation; Behavioral
Lead sponsor: Rush University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Nicotine Dependence
Interventions: Psilocybin-assisted treatment, Nicotine Replacement Therapy (NRT); Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 82 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2023
U.S. locations: 2
States / cities: Baltimore, Maryland

Conditions: Cigarette Smoking, Marijuana Abuse
Interventions: bupropion, transdermal nicotine patch, Nicotine polacrilex, nicotine lozenge, counseling for marijuana and smoking cessation, mobile contingency management; Drug · Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Opioid Use Disorder
Interventions: Naltrexone, Placebo, Buprenorphine; Drug
Lead sponsor: Alkermes, Inc.; Industry
Eligibility: 18 Years to 60 Years
Enrollment: 101 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 9
States / cities: Lauderhill, Florida • Oakland Park, Florida • Winfield, Illinois + 6 more

Conditions: Substance Use, Pregnancy Related, Mental Health
Interventions: Virtual Mindfullness-Based Intervention; Behavioral
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years and older · Female only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Caregiver Burnout
Interventions: Support as usual, Problem solving therapy, ICU diary; Behavioral
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 70 Years
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Smoking Cessation
Interventions: Removal of Financial Barriers, Financial Incentives, Mobile Health Application; Behavioral
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 18 Years and older
Enrollment: 3,228 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 5
States / cities: Oakland, California • Detroit, Michigan • Danville, Pennsylvania + 2 more

Conditions: Nicotine Dependence
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 60 Years
Enrollment: 159 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 2013
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Substance Use, Criminal Recidivism
Interventions: HOPE, Probation as Usual; Behavioral
Lead sponsor: RTI International; Other
Eligibility: 18 Years to 90 Years
Enrollment: 1,504 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2015
U.S. locations: 4
States / cities: Benton, Arkansas • Salem, Massachusetts • Oregon City, Oregon + 1 more

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Concurrent Treatment for Substance Dependent Individuals With Post-Traumatic Stress Disorder (PTSD)

Improving Smoking Cessation in Socioeconomically-Disadvantaged Young Adults

Health Effects of SLT, Cigarette Smoking, and New Tobacco Products

An Effectiveness Trial of Maintenance Therapy for Nicotine Dependence

Warrior CARE: Cannabis Behavioral Health

Contingency Management for Smoking Cessation Among Veterans With Psychotic Disorders

Online Insomnia Intervention to Reduce Alcohol Use

Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder

Parent SMART (Substance Misuse in Adolescents in Residential Treatment)

Counseling to Reduce Children's SHS Exposure: A Trial With Maternal Smokers

Acceptability and Feasibility of Cognitive Behavioral Therapy for Treatment-Seeking (CBT-TS) With Deaf Individuals

Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches

Feasibility and Acceptability of a Stigma Text Message Intervention for People Who Use Drugs

Healing and Empowering Alaskan Lives Towards Healthy-Hearts Study

Impact of Personalized Feedback Alone on Substance Use Behaviors

Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start Study

Psilocybin-facilitated Smoking Cessation Treatment: A Pilot Study

Mobile Contingency Management for Marijuana and Tobacco Cessation

Evaluating Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Transitioning From Buprenorphine Maintenance Prior to First Dose of VIVITROL

Brief Virtual Mindfulness-based Group Intervention With Social Support for Perinatal Individuals

Building Resilience In Caregivers of Trauma Survivors

Comparing Smoking Cessation Interventions Among Underserved Patients Referred for Lung Cancer Screening

Multimodal Neuroimaging Genetic Biomarkers of Nicotine AddictionSeverity

HOPE Demonstration Field Experiment Multisite Evaluation