Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 15, 2026, 9:24 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 745–768 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Smoking Cessation, Smoking, Cigarette, Nicotine Dependence
Interventions: sirolimus, Placebo; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Substance Use, Mental Health Issue
Interventions: ePACE Personalized Intervention, eFACE Fixed Intervention; Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 12 Years and older
Enrollment: 132 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Albuquerque, New Mexico

Conditions: Diet Modification, Substance Use Disorders, Diabetes Mellitus Risk, Cardiovascular Risk Factor, Lifestyle Risk Reduction, Parenting
Interventions: Nutrition/substance use prevention, Substance use prevention only, Academic success program; Behavioral
Lead sponsor: Arizona State University; Other
Eligibility: 12 Years and older
Enrollment: 844 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Diabetes Mellitus, Type 2, Substance-related Disorders
Interventions: Referral to Treatment, Brief Intervention; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 134 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Cannabis Use, Alcohol Use, Unspecified, Substance Use, Substance Use Disorders
Interventions: modified Approach-Avoidance Task (mAAT), which aims to modify automatic approach bias, modified Approach-Avoidance Task (mAAT) that does not aim to modify automatic approach bias.; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 13 Years to 17 Years
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Opioid-use Disorder
Interventions: Disclosing Recovery: A Decision Aid and Toolkit, Mindfulness; Behavioral
Lead sponsor: University of Delaware; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Wilmington, Delaware

Conditions: Alcohol Use Disorder (AUD), Alcohol Related Liver Disease
Interventions: Endurance Exercise; Behavioral
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Nicotine Addiction
Interventions: Galantamine ER; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 60 Years
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Alcohol Use Disorder, Post Traumatic Stress Disorder
Interventions: Seeking Safety + Signs of Safety toolkit; Behavioral
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years and older
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Alcohol Use Disorder
Interventions: XR-NTX, Placebo, HRC; Drug · Other · Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 21 Years to 65 Years
Enrollment: 308 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2019
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Substance Use Disorders, Stigma, Social
Interventions: Unit-based "Person First" Anti-stigma Awareness Rounds, Individual Text-based Messaging; Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 170 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD)
Interventions: Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 40µg, Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 80µg; Drug
Lead sponsor: Pharmacotherapies for Alcohol and Substance Use Disorders Alliance; Other
Eligibility: 21 Years to 65 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Nicotine Dependence
Interventions: Transdermal Nicotine; Drug
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 116 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: HIV Infections, Substance Use, Trauma, Medication Adherence
Interventions: Acceptance and Commitment Therapy (ACT), Body weight circuit training, Empathetic social support, Control - list of resources; Behavioral · Other
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older · Female only
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: San Diego, California

Conditions: Opioid Use
Interventions: Study provides naloxone to participants who wish to have it. Not required to accept naloxone and no control.; Other
Lead sponsor: National Development and Research Institutes, Inc.; Other
Eligibility: 18 Years and older
Enrollment: 600 participants
Timeline: 2019 – 2023
U.S. locations: 2
States / cities: New York, New York

Conditions: Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders, Substance-Related Disorders
Interventions: NRP104; Drug
Lead sponsor: New River Pharmaceuticals; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Antisocial Behavior, Psychopathology, Substance Use, HIV Infections
Interventions: Nurse Home Visiting; Behavioral
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 17 Years to 65 Years
Enrollment: 1,880 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2015
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Smoking Cessation, Smoking, Cigarette, Nicotine Dependence
Interventions: AXS-05, Bupropion SR; Drug
Lead sponsor: James Davis; Other
Eligibility: 18 Years and older
Enrollment: 58 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Substance Use Disorders, Attention Deficit Hyperactivity Disorder
Interventions: Atomoxetine; Drug
Lead sponsor: University of Pittsburgh; Other
Eligibility: 13 Years to 18 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Opioid Use Disorder, Substance Use Disorders, Stigma, Social
Interventions: Photo of a person injecting drugs, Photo of EMS responding to an overdose (White), Photo of EMS responding to an overdose (Black), Photo of a person receiving treatment (Jail), Photo of a person receiving treatment (Community), Photo of a person in recovery (White), Photo of a person in recovery (Black), Photo of a family member of an overdose decedent; Behavioral
Lead sponsor: Johns Hopkins Bloomberg School of Public Health; Other
Eligibility: 18 Years and older
Enrollment: 3,570 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Risk for an Alcohol-Exposed Pregnancy, Hazardous Alcohol Use, Risk for Unintended Pregnancy
Interventions: Brief Motivational Counseling; Behavioral
Lead sponsor: Centers for Disease Control and Prevention; Federal
Eligibility: 18 Years to 44 Years · Female only
Enrollment: 1,200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2004
U.S. locations: 11
States / cities: Fort Lauderdale, Florida • Dayton, Texas • Houston, Texas + 1 more

Conditions: Posttraumatic Stress Disorders, Combat Disorders, Alcohol Dependence, Drug Dependence
Interventions: Concurrent Treatment with Prolonged Exposure (COPE); Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 81 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Harm Reduction, Opioid-use Disorder, Naloxone
Interventions: Nasal Spray Naloxone, Intramuscular Naloxone, Improvised Nasal Atomizer; Device
Lead sponsor: State University of New York - Upstate Medical University; Other
Eligibility: 18 Years and older
Enrollment: 208 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 1
States / cities: Syracuse, New York

Conditions: Borderline Personality Disorder in Adolescence
Interventions: DBT-A; Behavioral
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 13 Years to 20 Years
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Piscataway, New Jersey

Search by objective public record fields.

Enhancing Self Regulation Among Smokers

Adolescent Screening and Personalized Intervention Resource for Enhancement of Behavioral Health and Substance Use

The Impact of a Parenting Intervention on Latino Youth Health Behaviors

Screening, Brief Intervention, and Referral to Treatment in Primary Care

CARS: Cannabis and Alcohol Reduction Study

Disclosure Intervention for People in Recovery From Opioid Use Disorder

Exercise Training Decreases Alcohol Consumption and Tissue Injury by an FGF21-dependent Mechanism

Effect of Galantamine on Smoking Abstinence

Piloting "Signs of Safety": A Deaf-Accessible Therapy Toolkit for Alcohol Use Disorder and Trauma

Harm Reduction With Pharmacotherapy (HaRP)

Nursing Attitudes Towards SUD

Effect of Sublingual Formulation of Dexmedetomidine Hydrochloride (HCl) (BXCL501) - Outpatient Study

Coping Skills Treatment for Smoking Cessation

Women Focused Encounters for Resilience Independence Strength and Eudaimonia

Overdose Risk Management and Naloxone

Safety, Tolerability and Abuse Liability Study of Intravenous NRP104 in Adults With Stimulant Abuse Histories

Age-17 Follow-up of Home Visiting Intervention

AXS-05 Phase II Trial on Smoking Behavior

Atomoxetine to Treat Adolescents With Coexisting Alcohol and Other Substance Use Disorder and ADHD

The Effects of Mass Media Photographs on Drug-Related Stigma

Project CHOICES Efficacy Study

Integrated Treatment of OEF/OIF Veterans With PTSD & Substance Use Disorders

A Usability Assessment of Naloxone Administration by Untrained Community Members

Dialectical Behavior Therapy for Adolescents at Rutgers University