Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 15, 2026, 9:31 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 769–792 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Nicotine Use Disorder
Interventions: Transcranial Magnetic Stimulation; Device
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 18 Years to 55 Years
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Newark, New Jersey

Conditions: Anxiety, Loneliness, Depression, Alcohol Use Disorder, Utilization, Health Care
Interventions: Shared Medical Visit; Behavioral
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 23 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Tobacco Use, Smoking, Tobacco Dependence, Tobacco Use Disorder, Tobacco Use Cessation, Tobacco Smoking, Smoking Cessation, Smoking, Cigarette, Smoking, Tobacco
Interventions: POP-6:, TSP-6:; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 25 Years
Enrollment: 173 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Smoking, Tobacco Dependence, Alcohol Dependence
Interventions: Varenicline, placebo; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 33 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2014
U.S. locations: 2
States / cities: Rochester, Minnesota • La Crosse, Wisconsin

Conditions: Tobacco Use Cessation, Tobacco Use Disorder, Nicotine Dependence, Smokeless Tobacco Use
Interventions: QuitAid (pharmacist-delivered MTM), Nicotine Replacement Therapy (NRT); Behavioral · Drug
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: ADHD, Cannabis Use Disorder
Interventions: Delayed-release, extended-release methylphenidate, Placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 16 Years to 26 Years
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Smoking Cessation, Tobacco Use, Tobacco Dependence, Tobacco Use Disorder, Tobacco Smoking, Cigarette Smoking, Nicotine Dependence, Nicotine Use Disorder, Smoking, Smoking, Cigarette
Interventions: Contingency management; Behavioral
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 55 Years
Enrollment: 11 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: New York, New York

Conditions: Alcohol Use Disorder
Interventions: Placebo, Glucagon-Like Peptide-1 Agonist (GLP-1), Naltrexone (oral tablets); Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Havre de Grace, Maryland

Conditions: Cigarette Smoking, Nicotine Dependence
Interventions: Coaching calls, Nicotine replacement therapy, Financial Incentives; Behavioral · Drug
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years and older
Enrollment: 165 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Nicotine Dependence, Tobacco Use
Interventions: Nicotine replacement therapy - Transdermal nicotine patch, Nicotine replacement therapy - Nicotine gum, Nicotine replacement therapy - Nicotine lozenge, Bupropion, Varenicline, Combination pharmacotherapy - Transdermal nicotine patch + nicotine gum, Combination pharmacotherapy - Transdermal nicotine patch + nicotine lozenge, Combination pharmacotherapy - Transdermal nicotine patch + bupropion, Tobacco quitline referral, Tailored behavioral intervention, Alcohol use risk reduction, Behavioral activation for depressive symptoms, Behavioral management of postcessation weight gain; Drug · Behavioral
Lead sponsor: Mark Vander Weg; Other
Eligibility: 18 Years to 99 Years
Enrollment: 411 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2018
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Pregnancy Related, Tobacco Use Disorder
Interventions: Bupropion SR, Smoking Cessation Counseling, Placebo; Drug · Behavioral
Lead sponsor: The University of Texas Medical Branch, Galveston; Other
Eligibility: 18 Years and older · Female only
Enrollment: 65 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: Galveston, Texas

Conditions: Opioid Use Disorder, Behavioral Symptoms, Psychiatric or Mood Diseases or Conditions
Interventions: Remote Motivational Enhancement (RME) Intervention Arm, Information Only; Behavioral · Other
Lead sponsor: Cambridge Health Alliance; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Cambridge, Massachusetts

Conditions: Cannabis Use, Adolescent
Interventions: Treatment as usual, Teen Empowerment through Computerized Health (TECH) app; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 14 Years to 18 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 4
States / cities: Chicago, Illinois • Providence, Rhode Island

Conditions: Nicotine Addiction, Drug Addiction, Drug Dependence, Substance Use Disorder, Tobacco Dependence
Interventions: Mobile Smoking Cessation Solution; Device
Lead sponsor: Click Therapeutics, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 416 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: New York, New York

Conditions: Substance Use, Smoking Reduction
Interventions: Mindfulness Intervention, Control Intervention; Behavioral
Lead sponsor: Wayne State University; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Adverse Childhood Experiences, Family Functioning
Interventions: Garnering Resilience in Traumatized youth and families (GRIT), Digital Citizenship Curriculum (DCC); Behavioral
Lead sponsor: University of California, Irvine; Other
Eligibility: 11 Years to 14 Years
Enrollment: 210 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Irvine, California

Conditions: Tobacco Dependence
Interventions: Flavor; Other
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 21 Years to 60 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Nicotine Addiction
Interventions: ABT-089, Placebo; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Adolescent Drinking, Adolescent Problem Behavior
Interventions: Qlarity app users; Behavioral
Lead sponsor: Oregon Research Behavioral Intervention Strategies, Inc.; Industry
Eligibility: 13 Years to 18 Years
Enrollment: 257 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Springfield, Oregon

Conditions: Tobacco Use Disorder, Smoking
Interventions: Ariva Silver Wintergreen, Placebo Wintergreen; Other
Lead sponsor: Star Scientific, Inc; Industry
Eligibility: 23 Years to 72 Years
Enrollment: 43 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009
U.S. locations: 1
States / cities: Martinsburg, West Virginia

Conditions: Opioid Use
Interventions: opioid-containing analgesic, two over-the-counter analgesics; Drug
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 18 Years and older
Enrollment: 1,815 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 5
States / cities: Chicago, Illinois • Baltimore, Maryland • Ann Arbor, Michigan + 2 more

Conditions: Cocaine Addiction
Interventions: Propranolol, 40 mg, Propranolol, 80 mg, Placebo; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 181 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2018
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Smoking, Nicotine Dependence
Interventions: Naltrexone, Varenicline; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Delayed Sleep Phase Syndrome
Interventions: Increase morning bright light, Decrease evening blue light, Sleep Scheduling, Monitor sleep, mood, and substance use; Other · Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 13 Years to 15 Years
Enrollment: 115 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

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Identify the Optimal TMS Pulse Protocol to Modulate Reward Activity

Loneliness and Health Outcomes in the High Need Population

An Extended Facebook Intervention for Young Sexual and Gender Minority Smokers

Varenicline Treatment for Active Alcoholic Smokers

Feasibility of a Medical-Legal Partnership Model to Connect Coal Miners QuitAid

Delayed-Release, Extended-Release Methylphenidate (Jornay PM) for Adolescents and Young Adults With Attention-Deficit/Hyperactivity Disorder and Cannabis Use Disorder

Electroretinogram: a New Human Biomarker for Smoking Cessation Treatment

Combination Therapy for Alcohol Use Disorder

Incentives for Oklahoma Tobacco Helpline Engagement in Persistent Poverty Counties

Dissemination of a Tailored Tobacco Quitline for Rural Veteran Smokers

Bupropion for Smoking Cessation During Pregnancy

Effects of RME on Engagement in Buprenorphine Treatment

TECH App Marijuana Use Intervention for Court-Involved Adolescents

Clinical Trial of Smoking Cessation Mobile Phone Program

Feasibility and Efficacy of a Brief Mindfulness-Based Intervention SMOKING INTERVENTION VIA THE INTERNET

The THRIVE Study: Teaching Healthy Regulation in Individuals & Vulnerable Environments

Testing the Effect of ENDS Flavors on Neurotransmission

Effects of ABT-089 on Smoking Abstinence Symptoms and Reward

Mindfulness Mobile App to Reduce Adolescent Substance Use

A Pilot Study to Evaluate the Efficacy of Ariva® Silver Wintergreen, a Smoking Aversive Lozenge

Opioid Analgesic Reduction Study

Enhancing Disrupted Reconsolidation: Impact on Cocaine Craving

Naltrexone and Varenicline: Weight Gain and Tolerability in Cigarette Smokers

Experimental Manipulation of Sleep and Circadian Rhythms and the Role Played on Reward Function in Teens