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ClinicalTrials.gov public records Last synced Nov 15, 2026, 9:39 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 793–816 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Sex, Unsafe, Drug Use
Interventions: Communication skills training video, substance use module, Couples HIV Testing and Counseling; Behavioral
Lead sponsor: Hunter College of City University of New York; Other
Eligibility: 18 Years to 60 Years · Male only
Enrollment: 140 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: New York, New York

Conditions: Nicotine Dependence
Interventions: Cognitive Behavioral Therapy for smoking cessation, Cognitive Behavioral Therapy for smoking cessation and anxiety sensitivity reduction.; Behavioral
Lead sponsor: Florida State University; Other
Eligibility: 18 Years to 45 Years
Enrollment: 378 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Tallahassee, Florida

Conditions: Substance-Related Disorders
Interventions: Behavior Therapy; Behavioral
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 99 Years · Female only
Enrollment: 409 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2005
U.S. locations: 7
States / cities: Jacksonville, Florida • Miami, Florida • Brooklyn, New York + 3 more

Conditions: Heavy Drinking, Driving Under the Influence, Riding With Driver Under the Influence
Interventions: Computer-facilitated Screening and Brief Intervention; Behavioral
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 14 Years to 17 Years
Enrollment: 169 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 3
States / cities: Itasca, Illinois • Boston, Massachusetts • Philadelphia, Pennsylvania

Conditions: Bipolar Disorder, Tobacco Use Disorder
Interventions: Future Self-BD, Daily Check-Ins; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Health Behavior, Wellness, Psychological, Substance Use
Interventions: Cue reactivity paradigm; Other
Lead sponsor: Brown University; Other
Eligibility: 13 Years to 16 Years
Enrollment: 224 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: HIV Medication Adherence, Methamphetamine Use, Sexual Risk, Poly-substance Use, HIV Infections
Interventions: Motivational Interviewing + Cognitive Behavioral Skills Training, Education Attention Control; Behavioral
Lead sponsor: Hunter College of City University of New York; Other
Eligibility: 18 Years and older · Male only
Enrollment: 210 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2012
U.S. locations: 1
States / cities: New York, New York

Conditions: Tobacco Use Disorder
Interventions: Tobacco Use Disorder, Standard Web-based intervention; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 792 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2002 – 2009
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Veterans With Opioid Use Disorder
Interventions: Treatment As Usual Vocational Rehabilitation (TAU-VR), Individual Placement and Support (IPS); Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 19 Years and older
Enrollment: 123 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2027
U.S. locations: 2
States / cities: Birmingham, Alabama • Tuscaloosa, Alabama

Conditions: Overdose
Interventions: MI-CHANCE (TS + FTIR + MI), TS + FTIR + Flu and Hepatitis A Education; Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 588 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: San Diego, California

Conditions: Nicotine Addiction
Interventions: Not listed
Lead sponsor: Rochester Institute of Technology; Other
Eligibility: 21 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Stimulant Use (Diagnosis)
Interventions: Science to Service Laboratory; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 76 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 9
States / cities: Chicago, Illinois • Rockford, Illinois • Pawtucket, Rhode Island + 1 more

Conditions: Nicotine Dependence
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 55 Years
Enrollment: 17 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Catonsville, Maryland

Conditions: Smoking
Interventions: Methylphenidate, Placebo; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Substance Dependence
Interventions: GSK598809, Nicotine Replacement Transdermal Patch, Placebo; Drug
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008
U.S. locations: 10
States / cities: DeLand, Florida • Pembroke Pines, Florida • Stockbridge, Georgia + 7 more

Conditions: Smoking
Interventions: Proactive outreach to counseling, Reactive outreach to counseling, Intensive counseling, Self-help; Procedure
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: Not listed
Enrollment: 3,120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2009
U.S. locations: 3
States / cities: Palo Alto, California • Sepulveda, California • New York, New York

Conditions: Prevention, Family Function, Substance Use, Sexual Behavior
Interventions: Familias Unidas; Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 12 Years and older
Enrollment: 746 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Tobacco Use Disorder/Cigarette Smoking, HIV
Interventions: nicotine patch, nicotine gum, nicotine lozenge, varenicline, bupropion, Multi-target Contingency Management, Teamlet booster; Drug · Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 794 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2031
U.S. locations: 5
States / cities: Bridgeport, Connecticut • New Haven, Connecticut • Jersey City, New Jersey + 2 more

Conditions: Nicotine Dependence, Schizophrenia
Interventions: NRT, Bupropion SR 150mg bid, Relapse Prevention-Oriented Cognitive Behavioral Therapy; Drug · Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Alcohol Use Disorder (AUD), Withdrawal From Addictive Substance; Detoxification, Craving
Interventions: Cannabidiol (CBD), Placebo; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 105 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Tobacco Cessation, Tobacco Dependence, Food Security
Interventions: Smoking cessation counseling and food delivery, Smoking cessation counseling, Food delivery; Behavioral
Lead sponsor: University of Arkansas; Other
Eligibility: 21 Years to 75 Years
Enrollment: 540 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Little Rock, Arkansas

Conditions: Opioid Use, Stimulant Use
Interventions: harm reduction intervention; Behavioral
Lead sponsor: Brittany Miller-Roenigk; Other
Eligibility: 18 Years to 65 Years
Enrollment: 63 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 3
States / cities: Louisville, Kentucky • Cincinnati, Ohio

Conditions: Tobacco Use, Nicotine Dependence, Other Tobacco Product, Tobacco Smoking
Interventions: JUUL 5%, Virginia Tobacco, ENDS product; Other
Lead sponsor: Juul Labs, Inc.; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 2
States / cities: Charlotte, North Carolina • Raleigh, North Carolina

Conditions: Pain
Interventions: Psychoeducation for substance abuse, CBT for pain in Substance abuse; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 510 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2017
U.S. locations: 1
States / cities: Waterford, Michigan

Search by objective public record fields.

Addressing Substance Use Through CVCT

Smoking Treatment and Anxiety Management Program

Women's Treatment for Trauma and Substance Use Disorders - 1

Adolescent Substance Use Prevention Intervention Research Study in Pediatric Primary Care

A Future Thinking Intervention for Comorbid Tobacco Use Disorder and Bipolar Disorder

Teen Health Choices & Wellness

Intervention Targeting Medication Adherence and Methamphetamine Use in HIV Positive Men (ACE)

LGBT Internet Based Smoking Treatment - 1

Together in Recovery With Veterans Through Employment

Motivational Interviewing to Increase Uptake of Drug Checking and Safe Drug Use Behaviors to Reduce Overdose

Developing Evidence to Inform Regulatory Policy on Nicotine Content in E-Liquids

Implementing Contingency Management for Stimulant Use in Specialty Addiction Treatment Organizations

Assessment of Craving in Nicotine-Dependent Patients With Schizophrenia Using Virtual Reality

Testing Methylphenidate for Smoking Abstinence

Relapse Prevention Study in Newly Abstinent Smokers

TeleQuit Smoking Cessation Program

Familias Unidas: Preventing Substance Abuse in Hispanic Youth

Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation Trial

Extended Duration Nicotine Replacement Therapy and Bupropion in Smokers With Schizophrenia

Cannabidiol as an Adjunct Treatment for Alcohol Withdrawal and Craving

FRESH Delivers: An Innovative Approach to Reducing Tobacco Use Among Rural Smokers

THRIVE: Culturally AdapTed Harm Reduction Intervention

A Study to Characterize Puff Topography With Use of JUUL 5% Electronic Nicotine Delivery Systems (ENDS) in Adult Smokers

Psychosocial Pain Management During Addictions Treatment to Improve Outcomes