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ClinicalTrials.gov public records Last synced Nov 15, 2026, 9:57 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 841–864 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Smoking, Nicotine Dependence
Interventions: No intervention: observation only; Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 99 Years
Enrollment: 422 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2019
U.S. locations: 2
States / cities: Madison, Wisconsin • Milwaukee, Wisconsin

Conditions: Nicotine Dependence, Cigarette Smoking, Alcohol Consumption, Heavy Drinking
Interventions: Varenicline; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Substance-Related Disorders, Depressive Disorder, Anxiety Disorder
Interventions: Outpatient MST/OPTION-A, Usual Services; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 12 Years to 17 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2010
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Tobacco Use Cessation, Tobacco Use Disorder
Interventions: Tobacco Use Cessation; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 13 Years to 25 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 3
States / cities: San Bruno, California • San Francisco, California • San Mateo, California

Conditions: Tobacco Use Disorder, Tobacco Dependence, Smoking
Interventions: Anatabloc(TM), CigRx(R); Dietary Supplement
Lead sponsor: Rock Creek Pharmaceuticals, Inc.; Industry
Eligibility: 23 Years to 72 Years
Enrollment: 109 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011
U.S. locations: 1
States / cities: Martinsburg, West Virginia

Conditions: Smoking, Tobacco Use Disorder
Interventions: brief pre-delivery smoking cessation counseling, additional pre-delivery smoking cessation counseling, post- delivery smoking cessation counseling, incentives; Behavioral
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 185 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Driving Under the Influence, Marijuana Intoxication, Alcohol Intoxication
Interventions: Cannabis (THC) (Inhaled) Placebo, Cannabis (High% THC) (Inhaled), Cannabis (Very High% THC) (Inhaled), Alcohol (oral); Drug
Lead sponsor: Advanced Brain Monitoring, Inc.; Industry
Eligibility: 18 Years to 50 Years
Enrollment: 124 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Smoking, Smoking Cessation, Nicotine Dependence
Interventions: Counseling before quit attempt, Minimal In-person counseling during quit attempt, Intensive in-person counseling during the quit attempt, Minimal phone counseling during the quit attempt, Intensive phone counseling during the quit attempt, Long Term Nicotine Patch+ Nicotine Gum During Quit Attempt, Short Term Nicotine Patch + Nicotine Gum during the quit attempt, Pre-Quit Nicotine Gum, Pre-Quit Nicotine Patch, Pre-Quit Nicotine Patch + Pre-Quit Nicotine Gum; Behavioral · Drug
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 99 Years
Enrollment: 637 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Alcohol Use Disorder
Interventions: [18F]NOS; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 4 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Social Stigma, Substance Use Disorders, HIV Infections, Physician-Patient Relations
Interventions: Substance use stigma training; Behavioral
Lead sponsor: Wayne State University; Other
Eligibility: 18 Years and older
Enrollment: 51 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: HIV, Substance Use Disorder (SUD)
Interventions: Wellness, Intervention Strategies and HIV Care (WISH), Movie Night Club - Attention and Time Matched Control; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older · Female only
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Oakland, California • San Francisco, California

Conditions: HIV Infection, Alcohol Consumption, Falls, Accidental, Falls
Interventions: Fall Prevention Intervention; Behavioral
Lead sponsor: Boston University; Other
Eligibility: 18 Years and older
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Cigarette Smoking, Nicotine Dependence, Nicotine Withdrawal
Interventions: Smoking Abstinence, Ad Lib Smoking; Other
Lead sponsor: University of Oklahoma; Other
Eligibility: 21 Years to 55 Years
Enrollment: 58 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Conditions: Opioid Use Disorder
Interventions: Mom Power; Behavioral
Lead sponsor: Stony Brook University; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 2
States / cities: Ann Arbor, Michigan • Stony Brook, New York

Conditions: Mental Health, Mental Health Services, Substance Use, Continuity of Patient Care, Recidivism
Interventions: TASC Service Linkages - Discharge Area Only, SRC Overnight Stay, TASC Services Linkages - SRC Onsite, APN Appointment; Behavioral
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years and older · Male only
Enrollment: 15,195 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2025
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Tobacco Use Disorder
Interventions: Either normal nicotine content cigarettes (15.8mg/g) or reduced nicotine content cigarettes (0.4mg/g), E-Cigarettes; Other
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 326 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Providence, Rhode Island • Burlington, Vermont

Conditions: Tobacco Dependence
Interventions: EDIS, Care as usual; Other
Lead sponsor: The Miriam Hospital; Other
Eligibility: 18 Years and older
Enrollment: 444 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2017
U.S. locations: 2
States / cities: Worcester, Massachusetts • Providence, Rhode Island

Conditions: Arthritis, Asthma, Chronic Obstructive Lung Disease, Diabetes, Heart Failure, Hypertension, Anxiety, Chronic Pain, Depression, Fibromyalgia, Insomnia, Irritable Bowel Syndrome, Problem Drinking, Substance Use Disorder
Interventions: Integration; Other
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years and older
Enrollment: 4,025 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Smoking Cessation, Acceptability of Health Care, Nicotine Dependence, Cigarettes
Interventions: Abstinent Contingent (AC) Re-Connect; Behavioral
Lead sponsor: Rowan University; Other
Eligibility: 18 Years and older
Enrollment: 9 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Glassboro, New Jersey

Conditions: Alcohol Withdrawal, Alcohol Abstinence, Alcohol Use Disorder
Interventions: Sodium Acetate, Placebo; Drug
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 21 Years and older
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Tobacco Use Disorder
Interventions: Tobacco free snuff; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 70 Years
Enrollment: 138 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2002 – 2005
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Tobacco Use Disorder, Nicotine Addiction
Interventions: Cognitive Training, Control training; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 213 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Tobacco Use Disorder
Interventions: Bupropion SR, placebo; Drug · Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older · Female only
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2006
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Substance Abuse, Juvenile Delinquency, Sexual Behavior, Criminal Behavior, Violence, Depression, Anxiety, Suicide, Sexually Transmitted Infection, Educational Attainment
Interventions: Communities That Care; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 10 Years and older
Enrollment: 52,323 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2025
U.S. locations: 1
States / cities: Seattle, Washington

Search by objective public record fields.

E-Cigarettes: Dynamic Patterns of Use and Health Effects

New Approaches to Smoking Cessation in Heavy Drinkers

Outpatient Adolescent Treatment for Comorbid Substance Use and Internalizing Disorders

Treating Tobacco Dependence in Adolescents With Co-occurring Psychiatric Disorders

Study to Evaluate the Safety and Efficacy of Dietary Supplement Anatabloc in Reducing Daily Smokers' Urge to Smoke

Disseminating and Implementing a Smoking Cessation Program for Pregnant and Postpartum Women

Cannabis Impairment Detection Application (CIDA)

Identifying Optimal Smoking Cessation Intervention Components (Cessation)

Imaging Inflammation With Alcohol Use Disorder: an [18F]NOS Study

Planning a Multi-Level Intervention to Reduce Substance Use Stigma in HIV Prevention and Care

Wellness, Intervention Strategies and HIV Care

Boston ARCH 4F Intervention to Reduce Fall Risk in People With HIV and Alcohol Use

Nicotine Withdrawal and Reward Processing

Postpartum Intervention for Mothers With Opioid Use Disorders

Supportive Release Center Study

Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders

System Based Tracking and Treatment for Emergency Patients Who Smoke: STTEPS

Integrating Behavioral Health and Primary Care for Comorbid Behavioral and Medical Problems

Re-Connect Application for Smoking Cessation

Intravenous Acetate as an Adjunctive Treatment for Alcohol Withdrawal in Hospitalized Patients

Effectiveness of Using Tobacco Free Snuff in Reducing Negative Effects of Smokeless Tobacco Use

Cognitive Training for Nicotine Dependence

Pilot Study of Bupropion for Smoking Cessation in Postpartum Non-breastfeeding Women

The Community Youth Development Study: A Test of Communities That Care