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ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:06 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 913–936 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Alcohol Use Disorder (AUD)
Interventions: assessment only; Other
Lead sponsor: University of New Mexico; Other
Eligibility: 18 Years and older
Enrollment: 192 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Albuquerque, New Mexico

Conditions: Nicotine Dependence
Interventions: Varenicline, Initial Individual counseling, Check-ins with medical staff, Extended Individual Counseling - Health Model, Extended Individual Counseling - Relapse Prevention Model; Drug · Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 216 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2016
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Alcohol-Related Disorders, Anxiety Disorders
Interventions: Venlafaxine, CBT, Progressive muscle relaxation therapy (PMR), Placebo medication; Drug · Behavioral · Other
Lead sponsor: Boston Medical Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 162 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2009
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Hepatitis C, Depression, PTSD, Substance Use Disorder, Fibrosis
Interventions: Brief mental health interventions and case management; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 75 Years
Enrollment: 83 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: San Diego, California

Conditions: Opioid Use Disorder, Substance Use Disorders, Stigma, Social
Interventions: Words Matter - Visual Campaign, Words Matter - Visual Campaign & Narrative Vignette (Messenger: Person with Opioid Use Disorder) Experimental: Words Matter - Visual Campaign & Narrative Vignette (Messenger: Clinician), Words Matter - Visual Campaign & Narrative Vignette (Messenger: Clinician), Words Matter - Visual Campaign & Narrative Vignette (Messenger: Health System Administrator), Medication Treatment for Opioid Use Disorder Works - Visual Campaign, Medication Treatment for Opioid Use Disorder Works - Visual Campaign & Narrative Vignette (Messenger: Person with Opioid Use Disorder), Medication Treatment for Opioid Use Disorder Works - Visual Campaign & Narrative Vignette (Messenger: Clinician), Medication Treatment for Opioid Use Disorder Works - Visual Campaign & Narrative Vignette (Messenger: Health System Administrator); Behavioral
Lead sponsor: Johns Hopkins Bloomberg School of Public Health; Other
Eligibility: 18 Years and older
Enrollment: 1,842 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Opioid-use Disorder
Interventions: OXD01 digital therapy, Standard of Care; Device · Other
Lead sponsor: Orexo AB; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 437 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 21
States / cities: Birmingham, Alabama • Oceanside, California • San Diego, California + 17 more

Conditions: Substance Use Disorder (SUD), Opioid Use Disorder (OUD)
Interventions: Deep Brain Stimulation; Device
Lead sponsor: University of California, San Francisco; Other
Eligibility: 22 Years to 75 Years
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2031
U.S. locations: 1
States / cities: San Francisco, California

Conditions: HIV, Contingency Management, Justice Involved Populations, Status Neutral Interventions, Mental Health, Substance Use
Interventions: Health Navigation, Health Navigation, Employment Navigation plus Contingency Management Intervention; Behavioral
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years and older
Enrollment: 350 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Opioid Use Disorder
Interventions: Disclosing Recovery: A Decision Aid and Toolkit; Behavioral
Lead sponsor: University of Delaware; Other
Eligibility: 18 Years and older
Enrollment: 480 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Wilmington, Delaware

Conditions: Opioid-use Disorder
Interventions: Psychosocial treatment; Behavioral
Lead sponsor: Public Health Management Corporation; Other
Eligibility: 18 Years and older
Enrollment: 440 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Tobacco Use Disorder
Interventions: Nicotrol; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 40 Years to 79 Years · Female only
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1993 – 2000
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Opioid Withdrawal
Interventions: Dexmedetomidine, Placebo; Drug
Lead sponsor: BioXcel Therapeutics Inc; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 225 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 3
States / cities: Miami Lakes, Florida • Marlton, New Jersey • New York, New York

Conditions: Opioid-use Disorder, Pain
Interventions: Exercise, Psychotherapy for Pain (I-STOP); Behavioral
Lead sponsor: Case Western Reserve University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 63 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 2
States / cities: Denver, Colorado • Cleveland, Ohio

Conditions: Alcohol Use Disorder
Interventions: Alcohol, Placebos, Duloxetine (60 MG), Methylphenidate, Duloxetine (30 MG); Drug
Lead sponsor: Craig Rush; Other
Eligibility: 21 Years to 55 Years
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Substance Use, Mindfulness, Psychological Well-being
Interventions: Mindfulness-Oriented Recovery Enhancement; Behavioral
Lead sponsor: University of Utah; Other
Eligibility: 15 Years to 21 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Opioid Use Disorders
Interventions: uMAT-R mobile app with coaching component; Device
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years to 80 Years · Female only
Enrollment: 125 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Smoking Cessation, Depression, Anxiety, Nicotine Dependence, Gender Minority Stress
Interventions: PRIDE QUIT, Enhanced Treatment As Usual (ETAU); Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 3
States / cities: Boston, Massachusetts

Conditions: Alcoholic Intoxication
Interventions: Alcohol intoxication, Objectification; Behavioral
Lead sponsor: University of Nebraska Lincoln; Other
Eligibility: 21 Years to 30 Years
Enrollment: 359 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Lincoln, Nebraska

Conditions: Case Management, Managed Care Program
Interventions: Care Support Intervention; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 292 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Opioid Use Disorder, Cocaine Use Disorder
Interventions: Oxytocin, Placebo; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Tobacco Use Disorder
Interventions: Neutral or active cigarette cues; Behavioral
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 21 Years to 45 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2006
U.S. locations: 1
States / cities: New York, New York

Conditions: Substance-related Disorders, Alcohol-related Disorders
Interventions: Specialized Substance Abuse Supervision (SSAS); Behavioral
Lead sponsor: University of Nebraska; Other
Eligibility: 17 Years and older
Enrollment: 344 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Tobacco Dependence, Smoking
Interventions: Active bupropion + counseling, Active bupropion, No counseling, Placebo medication + counseling, Placebo medication, No counseling; Drug
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 463 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2001 – 2003
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Family Planning Services, Substance-Related Disorders, Opiate Substitution Treatment, Sexual Health
Interventions: Sexual Health Initiative for Navigation and Education (SHINE) Health Educator Intervention; Behavioral
Lead sponsor: Denver Health and Hospital Authority; Other
Eligibility: 18 Years to 44 Years
Enrollment: 199 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Denver, Colorado

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Comprehensive Process Model of AA-related Behavior Change

Maintaining Nonsmoking

Psychosocial and Medication Treatment for Anxiety in Alcoholism

Integrated Care for Patients With High Risk Substance Use and Psychiatric Disorder With Chronic Direct Acting Antiviral Treatment

Strategies to Reduce Addiction Stigma Among Health Professionals

OXD01 in Combination With Sublingual Buprenorphine/Naloxone for Treatment of Opioid Use Disorder

Individualized Adaptive Deep Brain Stimulation in Opioid Use Disorder

J-RISE: Relevant Implementation Strategies to Eliminate the Social and Structural Barriers to HIV Services Among Justice-involved Black Men Who Have Sex With Men and Other Key Populations

Disclosure Intervention for People in Treatment for Opioid Use Disorder

Therapy and Peer Support for Patients Taking Medication for Opioid Use Disorder

Tobacco Cessation in Postmenopausal Women (Part II) - 2

Dexmedetomidine in the Treatment of Symptoms Of Acute Opioid Withdrawal

Enhancing Exercise and Psychotherapy to Treat Pain and Addiction in Opioid Use Disorders ("EXPO" Pilot Trial)

Behavioral Effects of Drugs: Inpatient (36) (Alcohol, Duloxetine, and Methylphenidate)

Impact of Mindfulness Training on Adolescent Well-Being and Behavior

mHealth to Help Pregnant and Postpartum Women in Recovery for Opioid Use Disorder

Adapting and Pilot Testing a Skills-based Smoking Cessation Intervention to Address Developmental and Health-related Stress Among Adults Who Smoke

Alcohol Myopia, Objectification, and Sexual Assault

San Francisco Health Plan Care Support Trial

Cocaine Opioid Oxytocin Option - Limited

Effect of Smoking Exposure on Smoking Relapse Following Brief Abstinence - 2

Specialized Substance Abuse Supervision (SSAS) Versus Non-SSAS Recidivism Rates Among Nebraska Felony Drug Offenders

Bupropion SR Plus Counseling for Smoking Cessation

Increasing Linkage to Family Planning Care for Individuals With Substance Use Disorder