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ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:17 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 937–960 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Risk Behavior, Medication Adherence, HIV
Interventions: 3H+ (Holistic Health for HIV), HHRP+ (Holistic Health Recovery Program); Behavioral
Lead sponsor: University of Connecticut; Other
Eligibility: 18 Years and older
Enrollment: 106 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2018
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Bipolar Disorder, Substance Use Disorders
Interventions: Integrated Treatment Adherence Program for Veterans (ITAP-VA), Safety Assessment and Follow-up Evaluation (SAFE); Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 138 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Tobacco Use Disorder
Interventions: Zileuton, Celecoxib, laboratory biomarker analysis; Drug · Other
Lead sponsor: National Cancer Institute (NCI); NIH
Eligibility: 18 Years and older
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 2
States / cities: New York, New York • Houston, Texas

Conditions: Adolescent Drinking, Adolescent Substance Use, Risk Behavior, Health
Interventions: Indicated Prevention, Clinical Staff, Selective Prevention, Expanded Paraprofessional Workforce; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 14 Years to 19 Years
Enrollment: 21,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Substance Use Disorders, Substance Use, Substance Dependence
Interventions: Enhanced Usual Care (EUC), TeleTx intervention; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 75 Years
Enrollment: 277 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 2
States / cities: Ann Arbor, Michigan

Conditions: Substance-Related Disorders, Recidivism, Opioid-Related Disorders, Substance Use, Criminal Behavior
Interventions: Learning Health System; Other
Lead sponsor: Indiana University; Other
Eligibility: 11 Years and older
Enrollment: 7,316 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Alcohol Drinking, Alcohol Use Disorder
Interventions: Ketone Ester "(R)-3-hydroxybutyl (R)-3-hydroxybutyrate", Isocaloric dextrose placebo, Alcohol drinks; Dietary Supplement · Drug · Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 21 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Substance Use Risk, Structural Stressors
Interventions: Not listed
Lead sponsor: Columbia University; Other
Eligibility: 11 Years to 14 Years
Enrollment: 72 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Smoking, Nicotine Dependence
Interventions: Gain-Framed counseling & Gain-framed materials, Standard care counseling + standard materials; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 2,032 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Posttraumatic Stress Disorder, Alcohol Use Disorder
Interventions: Cognitive Processing Therapy + Relapse Prevention, Relapse Prevention; Behavioral
Lead sponsor: Texas A&M University; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 2
States / cities: Charleston, South Carolina • College Station, Texas

Conditions: Substance Use Disorders, Depression, Bipolar Disorder, Psychosis, Personality Disorders
Interventions: Natural Recovery-Horticulture, Natural Recovery-Art/Music; Behavioral
Lead sponsor: Hampton VA Medical Center; Federal
Eligibility: 18 Years to 85 Years
Enrollment: 643 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011
U.S. locations: 1
States / cities: Hampton, Virginia

Conditions: Insomnia
Interventions: In-person Cognitive Behavioral Therapy of Insomnia, Internet Cognitive Behavioral Therapy of Insomnia; Behavioral
Lead sponsor: Daniel J. Taylor, Ph.D.; Other
Eligibility: 18 Years and older
Enrollment: 185 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Fort Hood, Texas

Conditions: Relapse/Recurrence, Substance Use (Drugs, Alcohol), Burnout
Interventions: Mindfulness Based Relapse Prevention, Standard of Care; Behavioral
Lead sponsor: University of Texas at Austin; Other
Eligibility: 18 Years to 100 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Tobacco Dependence, Tobacco Use Cessation, Cancer
Interventions: Interactive Mobile Doctor (iMD); Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Alcohol Use Disorder, Alcohol Use, Unspecified, Heavy Drinker, Alcohol Use Disorder, Moderate, in Sustained Remission
Interventions: Deuterium Metabolic Imaging with deuterated acetate tracer; Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2030
U.S. locations: 2
States / cities: New Haven, Connecticut

Conditions: Posttraumatic Stress Disorder, Alcohol Use Disorders
Interventions: Brief Cognitive Therapy; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 57 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Nicotine Dependence
Interventions: Varenicline, Placebo, Smoking Cessation Counseling; Drug · Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 207 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2018
U.S. locations: 2
States / cities: Chicago, Illinois • Philadelphia, Pennsylvania

Conditions: Alcohol Use Disorder, Alcohol Abuse
Interventions: CBT by Phone to Promote Treatment, Reading the Subject a Pamphlet on Obtaining Alcohol Use Disorder Treatment; Behavioral · Other
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Alcohol Abuse, Alcohol Use Disorder, Alcohol Drinking, Relations, Interpersonal, Military Family
Interventions: CRAFT Web-Based Intervention, Phone-Based CRAFT, CRAFT Workbook, Gottman Self-Guided Resources; Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 744 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Cannabis Use Disorder, Cannabis Withdrawal
Interventions: Progesterone, Placebo; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Substance Use Disorders, Simulation Training, Pregnancy Related, Patient-centered Care, Bias, Implicit
Interventions: INSPIRE; Behavioral
Lead sponsor: University of Utah; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Tobacco Use, Substance Use Disorders
Interventions: Switching to E-Cigarette, Quitting using Medication, Counseling; Behavioral · Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 240 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 4
States / cities: Charleston, South Carolina • Conway, South Carolina • Greenville, South Carolina + 1 more

Conditions: Tobacco, Tobacco Abstinence, Smoking Cessation, Smoking Cessation; Tobacco Dependence, Human Immunodeficiency Virus (HIV), Tobacco Dependence Caused by Cigarettes, Cancer Prevention
Interventions: Learn to Quit-HIV (LTQ-H) App, QuitStart; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 314 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Alcohol Use Disorder
Interventions: Placebo, GLWL-01; Other · Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 70 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Baltimore, Maryland

Search by objective public record fields.

Secondary HIV Prevention and Adherence Among HIV-infected Drug Users

Post-Hospital Intervention for Veterans With Comorbid Bipolar and Substance Use Disorders

Zileuton With or Without Celecoxib As Chemopreventive Agents in Smokers

Optimizing and Advancing SBIRT in Schools

Harnessing Telemedicine to Improve Alcohol Use Disorder Outcomes in Primary Care Patients

Alliances to Disseminate Addiction Prevention and Treatment (ADAPT)

Ketone Ester Intervention in Alcohol Use Disorder

Structural Stressors, Reward Related Decision Making and Substance Use Risk

Message Framing for Telephone Quitline Callers

Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD

A Novel Person-Centered Treatment Component for Substance Use Treatment

Comparing Internet and In-Person Brief Cognitive Behavioral Therapy of Insomnia

Mindfulness-based Relapse Prevention for Peer Workers

Interactive Mobile Doctor (iMD) to Promote Tobacco Cessation Among Cancer Patients

Drinking, Acetate, and Stress

Brief Restructuring Intervention Following Trauma Exposure

Extended Varenicline Treatment for Smoking Among Cancer Patients

Talk Therapy by Phone to Promote Treatment for Alcohol Problems

A SMART Evaluation of an Adaptive Web-based AUD Treatment for Service Members and Their Partners

Progesterone for Cannabis Withdrawal

Interprofessional Simulation Program for Clinical Resilience and Empathy: Project INSPIRE

STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking

Quitting Matters Human Immunodeficiency Virus Hybrid Trial

Manipulating Ghrelin Signaling Via GOAT Inhibition in Alcohol Use Disorder