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ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:34 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 985–1008 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Alcohol Use Disorder, Addiction
Interventions: TaskFlow Transcranial Electrical Stimulation device, Executive Function Focused Cognitive Training; Device · Behavioral
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 65 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Tobacco Use, Alcohol Abuse, Prescription Drug Abuse, Substance Use
Interventions: Screening; Other
Lead sponsor: Baylor Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Child Abuse, Child Neglect, Risk Behavior, Delinquency, Mental Health Impairment, Substance Use, Educational Problems, Adolescent Development, Adolescent Behavior, Sexual Behavior, Child Maltreatment
Interventions: FHF-T; Behavioral
Lead sponsor: University of Denver; Other
Eligibility: 13 Years to 16 Years
Enrollment: 234 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2044
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Tobacco Use Disorder, Substance Use Disorders
Interventions: Smartphone Contingency Management Intervention; Behavioral
Lead sponsor: BrightView LLC; Industry
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Injection Site Infection, Substance Use Disorders
Interventions: SIRI Team, Treatment as Usual; Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 480 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 6
States / cities: Birmingham, Alabama • Miami, Florida • Tampa, Florida + 3 more

Conditions: Smoking Cessation, Nicotine Addiction, Drug Addiction, Drug Dependence, Tobacco Dependence, Tobacco Use Disorder, Substance Use Disorder, Tobacco Smoking
Interventions: CT-101-M, QuitGuide; Device
Lead sponsor: My Digital Study; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 158 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: New York, New York

Conditions: Substance Use Disorders, HIV/AIDS, Homosexuality, Male
Interventions: Project Matter; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older · Male only
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Cancer, Tobacco Dependence, Tobacco Use Cessation
Interventions: CareConnect, AutoReach, Biospecimen samples; Behavioral · Other · Procedure
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Opioid Use Disorder, Infectious Disease, Risk Reduction Behavior, Substance Use, Substance Abuse, Stimulant Use Disorder
Interventions: Patient Navigator, Mobile Health Unit; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 601 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 3
States / cities: New Haven, Connecticut • Dallas, Texas • Fort Worth, Texas

Conditions: Nicotine Dependence
Interventions: Mindfulness based smoking cessation, Behavioral Smoking Cessation intervention; Behavioral
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years to 99 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2018
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: Tobacco Use Disorder
Interventions: Bupropion, Bupropion + Naltrexone; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2010
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Sexually Transmitted Diseases, Unsafe Sex, Substance-Related Disorders
Interventions: PACT, TAU; Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 480 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: New York, New York

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Not listed
Lead sponsor: UConn Health; Other
Eligibility: 16 Years to 45 Years · Female only
Enrollment: 182 participants
Timeline: 2018 – 2023
U.S. locations: 6
States / cities: Denver, Colorado • Farmington, Connecticut • Hartford, Connecticut + 2 more

Conditions: Tobacco Use Disorder
Interventions: Nicotine Patch, VLNC Cigarette, VLNC Cigarette Plus Nicotine Patch; Drug · Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 235 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2012
U.S. locations: 2
States / cities: Duluth, Minnesota • Minneapolis, Minnesota

Conditions: Hospitalized Smokers, Chronic Diseases, Tobacco Use Disorder
Interventions: Smoking relapse prevention; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2005
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Major Depressive Disorder, Substance Use Disorders
Interventions: Peer Activate, Peer-delivered non-specific services; Behavioral
Lead sponsor: Wayne State University; Other
Eligibility: 18 Years and older
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Opioid Use Disorder
Interventions: 12 Week Manualized Cognitive-Behavioral Therapy Intervention; Behavioral
Lead sponsor: Philadelphia College of Osteopathic Medicine; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Cardiovascular Diseases, Hypertension, Hyperlipidemias, Dyslipidemias, Obesity, Diabetes Mellitus, Tobacco Use Disorder, Overweight
Interventions: CV Toolkit Components; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older · Female only
Enrollment: 6,009 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 4
States / cities: Sepulveda, California • West Los Angeles, California • West Haven, Connecticut + 1 more

Conditions: Opioid-use Disorder
Interventions: Mindfulness Oriented Recovery Enhancement Sessions; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Schizophrenia, Schizoaffective Disorder, Alcohol Dependence, Nicotine Dependence
Interventions: Varenicline, Placebo; Drug
Lead sponsor: State University of New York - Upstate Medical University; Other
Eligibility: 18 Years to 69 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Syracuse, New York

Conditions: Alcohol Drinking, Problem Drinking
Interventions: Alcohol Cue Reactivity Personalized Feedback Intervention; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years to 24 Years
Enrollment: 99 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Smoking Cessation, Smoking, Tobacco, Mental Illness, Tobacco Use Disorder
Interventions: Videogame-based physical activity, Sedentary videogame, Bupropion, Counseling; Behavioral · Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 108 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Electronic Cigarette Use, Smoking, Cigarette, Nicotine Dependence
Interventions: NJOY ACE e-cigarette; Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 50 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Family Members, Relatives, Substance-Related Disorders, Alcohol-Related Disorders, Coping Skills, Stress, Psychological, Stress Physiology
Interventions: 5-Step Method Intervention; Behavioral
Lead sponsor: Villanova University; Other
Eligibility: 18 Years and older
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Winchester, Virginia

Search by objective public record fields.

Tdcs And cogNitive traininG cOmbined for AUD (TANGO)

Tobacco, Alcohol, Prescription Drug, and Illicit Substance Use- Electronic Spanish Platform

Fostering Healthy Futures for Teens: An RCT

A Digital Smoking Cessation Intervention for Adults With Substance Use Disorder

Integrated Care and Treatment for Severe Infectious Diseases and Substance Use Disorders Among Hospitalized Patients

Innovative Digital Therapeutic for Smoking Cessation

Project Matter: Intervention to Improve HIV Self-care Among Men Who Have Sex With Men (MSM) With Substance Use Disorders

Tobacco Cessation Care for Cancer Patients by Automated Interactive Outreach

Addressing Risk Through Community Treatment for Infectious Disease and Opioid Use Disorder Now (ACTION) Among Justice-involved Populations

A Mindfulness Based Application for Smoking Cessation

Study of Bupropion Versus Bupropion + Naltrexone for Smoking Cessation

Protect and Connect: Couple HIV Prevention for Drug Involved Male Offenders

Electronic Cigarette Use During Pregnancy

Innovative Interventions for Smoking Cessation

Enhancing Tobacco Abstinence Following Hospitalization

Peer-Delivered Behavioral Activation in a CCBHC

Therapy for People With Opioid Use Disorder

Cardiovascular Risk Screening and Risk Reduction in Women Vets

Mindfulness Oriented Recovery Enhancement in Hospitalized People With Opioid Use Disorder

Varenicline Treatment in Alcohol and Nicotine Dependent Patients With Schizophrenia

Testing Brief Personalized Feedback Integrating EMA Alcohol Cue Information

PARQuit Smoking Cessation Intervention for Adults With Serious Mental Illness

Assessing E-Cigarettes for Tobacco Harm Reduction in the Context of Lung Cancer Screening

Feasibility of the 5-Step Method in the U.S.