Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:43 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1009–1032 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Binge Drinking, Suicidal Ideation
Interventions: EA-Avatar; Behavioral
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years to 29 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Marlborough, Massachusetts • Worcester, Massachusetts

Conditions: Marijuana Smoking
Interventions: Inactive Marijuana (0% THC), Active Marijuana (5.5% THC), Active Marijuana (6.2% THC), Naltrexone, Placebo naltrexone; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 21 Years to 45 Years
Enrollment: 23 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: New York, New York

Conditions: Opioid Use Disorder, Suicidal Ideation
Interventions: Ketamine, Saline Solution; Drug · Other
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Alcohol Use Disorder, Alcohol Abuse, Alcohol Drinking, Alcohol Dependence
Interventions: Cognitive Behavior Therapy, Mindfulness Based Relapse Prevention; Behavioral
Lead sponsor: University of New Mexico; Other
Eligibility: 22 Years to 85 Years
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2025
U.S. locations: 2
States / cities: Albuquerque, New Mexico

Conditions: Opioid Use Disorder
Interventions: Recovery Connect; Device
Lead sponsor: Bright Therapeutics; Industry
Eligibility: 18 Years and older
Enrollment: 1,524 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 9
States / cities: Anchorage, Alaska • Wasilla, Alaska • Billings, Montana + 6 more

Conditions: Alcohol Use, Tobacco Use, Substance Use, Sexual Health
Interventions: Journey of Transformation-Native Youth Health Leadership Program curriculum; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 13 Years to 16 Years
Enrollment: 33 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Opioid Use Disorder
Interventions: Treatment with Ketamine, Treatment with Very Low Dose Ketamine; Drug
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 65 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Sexually Transmitted Infection (STI) Prevention, Unintended Pregnancy Prevention, Sexual Risk Reduction, Alcohol and Other Substance Use Prevention, Intimate Partner Violence Prevention
Interventions: Preventing Helath Damaging Health Behaviors in Male and Female Army Recruits; Behavioral
Lead sponsor: United States Department of Defense; Federal
Eligibility: 18 Years and older
Enrollment: 933 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Columbia, South Carolina

Conditions: Housing Problems, Household Substance Abuse, Substance Use Disorders, Harm Reduction
Interventions: Technology-based Intervention; Behavioral
Lead sponsor: Oregon Research Behavioral Intervention Strategies, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Springfield, Oregon

Conditions: HIV, Substance Use Disorder (SUD)
Interventions: Substance use disorder screening, Social network intervention; Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older · Male only
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Domestic Violence, Substance Abuse
Interventions: Motivational Enhancement Therapy, Educational information; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older · Male only
Enrollment: 140 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Alcohol Use Disorder, Alcohol Dependence, Drug Dependence
Interventions: DynamiCare Motivation Support Program, Untreated or Routine Care Control Group; Combination Product · Other
Lead sponsor: DynamiCare Health; Industry
Eligibility: 18 Years and older
Enrollment: 236 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Tobacco Use Disorder
Interventions: Varenicline, Contingency Management, Counseling; Drug · Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 40 Years
Enrollment: 181 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 3
States / cities: Charleston, South Carolina • Florence, South Carolina • Pickens, South Carolina

Conditions: Nicotine Dependence
Interventions: Transcranial magnetic stimulation; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 60 Years
Enrollment: 42 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Opioid Use Disorder, Pregnancy
Interventions: Empowering Pregnant Women and People Receiving medications for opioid use disorder (EMPWR), Medication monitoring (control); Behavioral · Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 37 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Tobacco Use Disorder
Interventions: Cognitive Behavioral Therapy (CBT), Cue-based treatment intervention; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Tobacco-flavored EC, Sweet-Cooling EC, Sweet Non-cooling EC
Interventions: Brief individual counseling sessions; Behavioral
Lead sponsor: Prisma Health-Upstate; Other
Eligibility: 21 Years and older
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Greenville, South Carolina

Conditions: Patient Adherence, Chronic Hepatitis C, Alcohol-related Disorders
Interventions: VBMI; Behavioral
Lead sponsor: G.V. (Sonny) Montgomery VA Medical Center; Federal
Eligibility: 18 Years to 90 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Jackson, Mississippi

Conditions: Cigarette Smoking, Veterans
Interventions: Healthy Changes Nicotine Replacement Therapy (NRT), Cessation Treatment Nicotine Replacement Therapy (NRT), Cessation Treatment Counseling, Healthy Changes Counseling; Drug · Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 112 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2031
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Nicotine Dependence, Nicotine Vaping
Interventions: (S)-Nicotine, (R)- nicotine, Racemic nicotine; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 65 Years
Enrollment: 18 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Mental Health, Substance Use Disorders, Co-occurring Mental and Substance Use Disorders
Interventions: Full MISSION-CJ, Peer Linkage Support; Behavioral
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years and older
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 2
States / cities: Northampton, Massachusetts • West Boylston, Massachusetts

Conditions: Mental Health Disorders, Substance Use Disorders
Interventions: Full MISSION, Linkage Only Delivered by a Peer Specialist; Behavioral
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years and older
Enrollment: 208 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Delinquency, HIV Risk, Substance Use, Trauma Exposure
Interventions: Integrated intervention for parents and adolescent girls; Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 13 Years to 18 Years · Female only
Enrollment: 416 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2020
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Head and Neck Cancer, Alcohol Use, Unspecified
Interventions: Alcohol Cessation Text Messages, Usual Care; Behavioral
Lead sponsor: Northwell Health; Other
Eligibility: 18 Years and older
Enrollment: 126 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Manhasset, New York

Search by objective public record fields.

Open Pilot Trial Evaluating an Avatar-Guided Intervention for Emerging Adults With Alcohol Use Problems and Suicide Risk

Effects of Low-dose Naltrexone in Combination With a Range of Smoked Marijuana

Ketamine for OUD and Suicidal Ideation in the ED

Neurocognitive and Neurobehavioral Mechanisms of Change Following Psychological Treatment for Alcohol Use Disorder

A Stepped-Wedge Cluster Randomized Trial of a Digital App to Support Medication-Assisted Treatment in Individuals With Opioid Use Disorder

Journey of Transformation Curriculum for Native American Adolescents

Ketamine for Opioid Use Disorder

Preventing Health Damaging Behaviors in Male and Female Army Recruits

Innovating Technology Solutions for Residents in Support Housing Communities w SUD Through Community-Engaged Research

Combining Social Network Strategies and Routine Substance Use Screening

The Men's Domestic Abuse Check-Up Engages Adult Men Concerned About Their Abusive Behavior and Alcohol or Drug Use

Tech-Enabled CM for AUD at Scale

Cannabis and Tobacco Co-use Study

Repetitive Transcranial Magnetic Stimulation (rTMS) for Nicotine Addiction

Technology-Enhanced Therapy vs. Medication Monitoring for Buprenorphine Retention in Pregnant Persons

Project Q: Cue-based Treatment Intervention to Promote Cessation Among People Who Smoke Lightly or Non-daily

Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine

VBMI to Increase Treatment Completion With MK-MK-5172/MK-8742 Among Veterans With Active Substance Use Disorders Genotype 1 Chronic Hepatitis C

Evaluating an Innovative Tobacco Treatment Approach for Veterans in Substance Use Treatment

Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine

Supporting Treatment Access and Recovery in Re-entry (STAR-R)

Supporting Treatment Access and Recovery Through Linkage and Support

The ProGirls Study

Alcohol Cessation Among Head and Neck Cancer Survivors