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ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:52 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1033–1056 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Nicotine Dependence
Interventions: Sustained Care, Usual Care; Behavioral
Lead sponsor: University of Texas at Austin; Other
Eligibility: 18 Years and older
Enrollment: 422 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Cannabis Use, Tobacco, Biomarkers
Interventions: Cannabis (THC), Tobacco Cigarette; Drug
Lead sponsor: Hannah Harris; Other
Eligibility: 18 Years to 55 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Cigarette Smoking, Alcohol Use Disorders
Interventions: Varenicline, Prazosin, Placebo; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Tobacco Use Cessation, Alcohol-related Disorders
Interventions: behavioral counseling plus contingency management; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 151 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 2
States / cities: Newington, Connecticut • West Haven, Connecticut

Conditions: Opioid Use Disorder
Interventions: Psychosocial treatment; Behavioral
Lead sponsor: Philadelphia College of Osteopathic Medicine; Other
Eligibility: 18 Years and older
Enrollment: 340 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 5
States / cities: Atlantic City, New Jersey • Philadelphia, Pennsylvania

Conditions: Stress Disorders, Post-Traumatic, Opioid Use Disorder
Interventions: MDMA Assisted Therapy; Drug
Lead sponsor: University of New Mexico; Other
Eligibility: 18 Years and older · Female only
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Albuquerque, New Mexico

Conditions: Substance Use, Binge Drinking, Marijuana Use, Alcohol Drinking, Prescription Opioid Misuse, Illicit Drug Use
Interventions: iSTART Web-app; Behavioral
Lead sponsor: California State University, Northridge; Other
Eligibility: 18 Years to 30 Years
Enrollment: 1,100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Northridge, California

Conditions: Nicotine Dependence
Interventions: Varenicline Standard Protocol, Nicotine Patch Standard Protocol, Varenicline Adaptive Protocol, Nicotine Adaptive Protocol; Behavioral · Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 188 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Alcohol Use Disorder
Interventions: Placebo, Spironolactone; Other · Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 21 Years to 99 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Stress Disorders, Post-Traumatic, Depressive Symptoms, Hydrocortisone, Substance Use
Interventions: Modified Mindfulness-based Stress Reduction, Health Promotion Wellness Classes; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older · Female only
Enrollment: 156 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Escondido, California • Pomona, California

Conditions: Substance Abuse
Interventions: Enhanced Replicating Effective Programs (Enhanced REP), Standard implementation; Behavioral
Lead sponsor: Wayne State University; Other
Eligibility: 14 Years to 99 Years
Enrollment: 825 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Substance Use Disorders, Posttraumatic Stress Disorder
Interventions: Prolonged Exposure Therapy, Prolonged Exposure therapy + VR/ER; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Nicotine Dependence
Interventions: Nicotine; Other
Lead sponsor: Mclean Hospital; Other
Eligibility: 18 Years to 40 Years · Female only
Enrollment: 72 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2016
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: HEPATITIS C (HCV), Opioid Use Disorder, Substance Use Disorder (SUD), Drug Use Disorders, Healthcare Access, Harm Reduction
Interventions: Partner navigation intervention booster session; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Anxiety Disorders, Alcohol Use Disorder, Stress, Psychological
Interventions: active heat, Active c tactile fiber stimulation, sham heat, Sham c tactile fiber stimulation; Device · Drug
Lead sponsor: Soovu Labs Inc.; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Substance Use Disorders
Interventions: Standard Contingency Management (CM), Enhanced Contingency Management (CM+); Behavioral
Lead sponsor: Oregon Social Learning Center; Other
Eligibility: 12 Years to 18 Years
Enrollment: 129 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2024
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Opioid-Related Disorders
Interventions: Video-based DOT Application; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 78 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 2
States / cities: Boston, Massachusetts • Seattle, Washington

Conditions: Cannabis Use Disorder
Interventions: Lorcaserin, Placebo oral capsule; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 70 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: New York, New York

Conditions: Alcohol Use Disorder (AUD), Alcohol-Related Disorders
Interventions: Diclofenac 100mg, Diclofenac 75mg, Diclofenac 50mg, Placebo control; Drug
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 21 Years to 65 Years
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Catonsville, Maryland

Conditions: Nicotine Use Disorder, Smoking Cessation, Smoking Cessation Intervention
Interventions: Enhanced Courage to Quit; Behavioral
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years to 26 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Tobacco Smoking, Electronic Cigarette Use, Substance Use
Interventions: CC+ECIG Condition, CC Condition, Sham Condition; Other
Lead sponsor: University of Houston; Other
Eligibility: 18 Years and older
Enrollment: 107 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Marijuana Abuse
Interventions: Dronabinol 30mg/day, Dronabinol 60mg/day, Dronabinol 120mg/day, Placebo; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Drug Use, Substance Abuse, Mental Illness
Interventions: Integrated Harm Reduction Intervention (IHRI); Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 3
States / cities: New Haven, Connecticut • New York, New York • Orangeburg, New York

Conditions: Chronic Pain, Opioid Use Disorder, Opioid Misuse and Addiction
Interventions: Usual Care, Pain Self-Management; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 204 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 17
States / cities: Baltimore, Maryland • Allison Park, Pennsylvania • Blawnox, Pennsylvania + 9 more

Search by objective public record fields.

Smoking Cessation Following Psychiatric Hospitalization

Lung Health and Breath Biomarkers: Acute Effects of Inhaled Cannabis

Varenicline + Prazosin for Heavy Drinking Smokers

Concurrent Alcohol and Smoking Treatment: Effects on Alcohol Relapse Risk

Therapy and Peer Support for Patients Taking Medication for Opioid Use Disorder

MDMA for Co-occurring PTSD and OUD After Childbirth

iSTART: A Campus & Community Initiative for Services in Tec-health

Adaptive Pharmacotherapy for Smoking Cessation

Spironolactone in Alcohol Use Disorder (SAUD)

Mindfulness-based Intervention to Address PTSD in Trauma-exposed, Homeless Women

Preventing Substance Use Among Youth

Post-traumatic Stress Disorder (PTSD), Addiction, and Virtual Reality

Multiple Cigarette Induced Changes in Hormone Function, Mood States and Behavior

Pilot Study of an Adapted Partner Navigation Intervention Booster Session for Sustained Healthcare Engagement Among People Who Inject Drugs

Treating Stress and Anxiety in Individuals With Alcohol Use Disorder (AUD)

Enhancing Adolescent Substance Abuse Treatment

Trial of Adherence App for Buprenorphine Treatment (TAAB) Study

Lorcaserin for Cannabis Use Disorder

Diclofenac Dose Response Study

Implementation of Tobacco Cessation Programming at Community Behavioral Health Sites

Dual Use Approach Bias Training for Nicotine Addiction

The Effect of Prescription Medications in Marijuana Users

Harm Reduction Services

Pain Self-Management and Treatment Engagement for Patients Taking Opioids