Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 15, 2026, 2:16 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1105–1128 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Nicotine Dependence
Interventions: mSMART, Chantix; Device · Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Violence in Adolescence, Substance Use, Avoidance of Healthcare
Interventions: BrotherlyACT, BrotherlyACT Waitlist Control Group (WCG); Behavioral · Other
Lead sponsor: Rush University Medical Center; Other
Eligibility: 15 Years to 24 Years · Male only
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Opioid Use, Pain, Marijuana Use
Interventions: Cannabis, Prescription Opioid Taper Support (POTS); Drug · Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 75 Years
Enrollment: 87 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 3
States / cities: Portland, Maine • Boston, Massachusetts • Cambridge, Massachusetts

Conditions: HIV Infections
Interventions: CHECKIT!; Other
Lead sponsor: Johns Hopkins Bloomberg School of Public Health; Other
Eligibility: 18 Years and older
Enrollment: 493 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Opioid Use
Interventions: Behavioral Activation (BA); Behavioral
Lead sponsor: Henry Ford Health System; Other
Eligibility: 18 Years and older
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Nicotine Dependence
Interventions: Cognitive Behavioural Therapy, Contingency Management, Nicotine Transdermal Patch; Behavioral · Drug
Lead sponsor: Yale University; Other
Eligibility: 14 Years to 19 Years
Enrollment: 154 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2015
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Alcohol Use Disorder, Anxiety, Depression
Interventions: Cognitive Behavioral Therapy, Amplification of Positivity Therapy, Surveys and Interviews; Behavioral
Lead sponsor: Laureate Institute for Brain Research, Inc.; Other
Eligibility: 18 Years to 65 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Conditions: Tobacco Use Disorder
Interventions: Pharmacotherapies for Smoking Cessation; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 20 Years to 65 Years
Enrollment: 293 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1999 – 2006
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Marijuana Use, Pregnancy
Interventions: eSBIRT, Tailored texting; Behavioral
Lead sponsor: Wayne State University; Other
Eligibility: 18 Years to 40 Years · Female only
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Alcohol Use Disorder
Interventions: Individual clinician-provided CBT, CBT4CBT; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 99 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 2
States / cities: Bridgeport, Connecticut • New Haven, Connecticut

Conditions: Human Immunodeficiency Virus, Smoking Cessation, Smoking, Cigarette, Smoking, Anxiety, Depression, Nicotine Dependence
Interventions: QUIT, Time-Matched Control (TM); Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 79 Years
Enrollment: 131 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 3
States / cities: Boston, Massachusetts • Houston, Texas

Conditions: Tobacco Use Disorder, Nicotine Dependence, Cigarette Smoking
Interventions: Propranolol, Nicotine Patch, Placebo Propranolol, Placebo Patch; Drug
Lead sponsor: University of Oklahoma; Other
Eligibility: 21 Years to 60 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Conditions: Cannabis Use Disorder
Interventions: Cannabidiol oral solution, Placebo; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 25 Years
Enrollment: 148 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Nicotine Addiction
Interventions: Scheduled Gradual Reduction + Varenicline, Scheduled Gradual Reduction + Placebo Drug, Basic Advice + Varenicline, Basic Advice + Placebo Drug; Other
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years and older
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: New York, New York

Conditions: Nicotine Addiction, E-Cig Use, Cigarette Smoking, Sex Differences
Interventions: E-liquid Flavor 1, E-liquid Flavor 2, E-liquid Flavor 3; Other
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 44 Years
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Condomless Sex, Human Immunodeficiency Virus (HIV), Sexually Transmitted Infection (STI), Alcohol and Drug Use
Interventions: Face-to-Face Young Women's CoOp (YWC), mHealth Young Women's CoOp (YWC), HIV Counseling and Testing; Behavioral
Lead sponsor: RTI International; Other
Eligibility: 18 Years to 25 Years · Female only
Enrollment: 652 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2020
U.S. locations: 4
States / cities: Durham, North Carolina • Greensboro, North Carolina • High Point, North Carolina + 1 more

Conditions: HIV Infections, Substance Use
Interventions: Peer Activate-LAI, Standard of Care HIV treatment or prevention with LAI-PrEP/ART; Behavioral · Other
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 88 Years
Enrollment: 186 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 2
States / cities: Washington D.C., District of Columbia • Baltimore, Maryland

Conditions: Smoking, Sleep Disturbance, Nicotine Dependence
Interventions: Sleep restriction condition, Sleep extension condition; Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years and older
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Smoking, Smoking Cessation, Motivation, Nicotine Dependence
Interventions: Nicotine Patch, Nicotine Gum, Motivational Interviewing, Smoking Reduction, No Intervention, Nicotine Patch + Nicotine Gum; Drug · Behavioral · Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 99 Years
Enrollment: 517 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Depression, Dual Diagnosis, Substance Use
Interventions: Creatine monohydrate; Drug
Lead sponsor: Perry Renshaw; Other
Eligibility: 13 Years to 55 Years · Female only
Enrollment: 14 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Opioid-use Disorder, Cocaine Use Disorder, Opioid Use, Cocaine Use, Substance Use, Methamphetamine Abuse, Methamphetamine-dependence
Interventions: App-Based Contingency Management, Sham Control; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 206 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 2
States / cities: Oconomowoc, Wisconsin • Wauwatosa, Wisconsin

Conditions: Suicide, Alcohol Use Disorder
Interventions: Qungasvik (Tools for Life); Behavioral
Lead sponsor: University of Alaska Fairbanks; Other
Eligibility: 12 Years to 21 Years
Enrollment: 542 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2023
U.S. locations: 1
States / cities: Fairbanks, Alaska

Conditions: Opioid Use Disorder
Interventions: Values-based Behavioral Activation; Behavioral
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Smoking
Interventions: Placebo, AB-free kava; Drug
Lead sponsor: University of Florida; Other
Eligibility: 21 Years to 75 Years
Enrollment: 76 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Gainesville, Florida

Search by objective public record fields.

Stage Ib Trial of mSMART With Varenicline

BrotherlyACT: A Tech-Enhanced Violence and Substance Use Intervention for Black Boys and Young Men

Evaluation of Medical Cannabis and Prescription Opioid Taper Support for Reduction of Pain and Opioid Dose in Patients With Chronic Non-Cancer Pain

Substance Checking Outreach and Pre-Exposure Prophylaxis (PrEP) Engagement Study

FOREward Together: Training Peer Recovery Coaches to Promote Retention and Adherence to MOUD

Enhancing a High School Based Smoking Cessation Program

Amplification of Positivity for Alcohol Use

Bupropion as an Adjunct to the Nicotine Patch Plus CBT

Computer-delivered Screening & Brief Intervention for Marijuana Use in Pregnancy

Efficacy and Mechanisms of CBT4CBT for Alcohol Use Disorders

Effectiveness of an Integrated Treatment to Address Smoking Cessation and Anxiety/ Depression in People Living With HIV

Beta-Adrenergic Modulation of Drug Cue Reactivity

SCORE Emerging Adult Cannabis Use & Stress

A Smoking Intervention Study Using Scheduled Gradual Reduction With Varenicline to Help With Cessation

Sex Differences in E-cig Perception: Study 1

NC Young Women's CoOp

Peer Behavioral Activation Utilization to Improve Substance Use and HIV Outcomes in People Receiving Long Acting Injectable-PrEP/ART (PUSH)

Racial Differences in Circadian and Sleep Mechanisms for Nicotine Dependence, Craving, and Withdrawal

Identifying Treatments to Motivate Smokers to Quit

Open-Label Creatine Study for Female Meth Users

Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives

Qungasvik (Toolbox): Prevention of Alcohol/Suicide Risk in Alaska Native Youth

Behavioral Activation for Opioid Use Disorder

The Potential of Kava in Enabling Tobacco Cessation - Its Holistic Effects in Managing Stress and Insomnia Associated With Abstinence