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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:07 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1177–1200 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Smoking Cessation
Interventions: RITCh Treatment, Standard Treatment; Behavioral
Lead sponsor: The City College of New York; Other
Eligibility: 18 Years and older
Enrollment: 256 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: New York, New York

Conditions: Contraceptive Usage, Opioid Dependence
Interventions: Treatment as usual, WHO contraception protocol, Incentives; Behavioral
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years to 44 Years · Female only
Enrollment: 138 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Smoking Cessation
Interventions: nicotine patch, experimental use, nicotine patch, labeled use; Drug
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years and older
Enrollment: 701 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Cocaine Use Disorder
Interventions: CBT-RP; Behavioral
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 60 Years
Enrollment: 68 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Nicotine Dependence
Interventions: Varenicline; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 21 Years to 65 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Alcohol Use Disorder (AUD), Alcohol Consumption, Craving
Interventions: Probenecid Oral Tablet, Placebo Oral Tablet; Drug
Lead sponsor: Brown University; Other
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Substance-Related Disorders, Underage Drinking, Drug Use
Interventions: The SUPPER Project, Improving nutrition and physical activity among youth; Behavioral
Lead sponsor: Tufts University; Other
Eligibility: 9 Years to 14 Years
Enrollment: 402 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Tobacco Smoking, Nicotine Dependence
Interventions: Electronic Cigarette, Tobacco Cigarette; Other
Lead sponsor: Laureate Institute for Brain Research, Inc.; Other
Eligibility: 18 Years to 50 Years
Enrollment: 27 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Conditions: Nicotine Addiction, E-Cig Use, Quitting Smoking
Interventions: Nicotine replacement therapy patch, Nicotine replacement therapy lozenge, Quit electronic cigarettes, Continue electronic cigarettes; Drug · Behavioral
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years to 29 Years
Enrollment: 396 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Nicotine Dependence, Cigarettes
Interventions: Nicotine patch, Placebo patch, E-cigarettes, Non-nicotine e-cigarettes; Drug · Other
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 94 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Alcohol and Substance-Related Mental Disorders
Interventions: SBIRT, Treatment as usual; Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 15 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: New York, New York

Conditions: Smoking Cessation, Tobacco Use Disorder
Interventions: Internal tobacco coach, External tobacco coach; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 106 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Tobacco Use Disorder/Cigarette Smoking
Interventions: Multi-Theory Model (MTM)-Based Smoking Cessation Program; Behavioral
Lead sponsor: University of Nevada, Las Vegas; Other
Eligibility: 18 Years to 29 Years
Enrollment: 144 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Tobacco Use Disorder
Interventions: varenicline, Adaptation of Motivational Interviewing; Drug · Behavioral
Lead sponsor: VA Boston Healthcare System; Federal
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
U.S. locations: 1
States / cities: Brockton, Massachusetts

Conditions: Alcohol Use Disorder, Depression
Interventions: Internet Delivered Brief Intervention (IDBI); Behavioral
Lead sponsor: Cornell University; Other
Eligibility: 18 Years to 62 Years
Enrollment: 140 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Musculoskeletal Pain, Chronic Pain
Interventions: Cognitive Therapy (CT), Mindfulness Meditation (MM), Behavioral Activation (BA); Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 91 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Nicotine Dependence, Nicotine Addiction, Nicotine Use Disorder, Nicotine Vaping, Vaping
Interventions: Smartphone app, Text Message, Survey Administration; Behavioral · Other
Lead sponsor: Fred Hutchinson Cancer Center; Other
Eligibility: 18 Years to 30 Years
Enrollment: 61 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Tobacco Use, Tobacco Smoking, Tobacco Use Cessation, Tobacco Use Disorder, Second Hand Tobacco Smoke
Interventions: Smokefree Implementation Framework and Toolkit; Behavioral
Lead sponsor: Harvard School of Public Health (HSPH); Other
Eligibility: 18 Years and older
Enrollment: 480 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Smoking, Nicotine Addiction, Surgery
Interventions: ENDD (NJOY), NRT (NicoDerm CQ), telephone counseling, brief advice, brochure; Behavioral · Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Tobacco Use Disorder
Interventions: Nicotine polacrilex, Bupropion; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 50 Years and older
Enrollment: 403 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2001 – 2009
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Marijuana Use
Interventions: Brief Motivational Intervention (BMI), Substance-Free Activity Session (SFAS), Relaxation Session; Behavioral
Lead sponsor: University of Memphis; Other
Eligibility: 18 Years and older
Enrollment: 133 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Tobacco Abuse, Alcohol Abuse, Drug Abuse
Interventions: Computer Screening, Brief Intervention, Referral toTreatment; Behavioral
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 12 Years to 21 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Adolescent Problem Behavior, Truancy; Unsocialized, Marijuana Abuse, Truancy; Socialized, Substance Abuse, Alcohol Abuse
Interventions: Motivational + Family Check-up (MET+FCU), Psychoeducation; Behavioral · Other
Lead sponsor: Brown University; Other
Eligibility: 12 Years to 18 Years
Enrollment: 110 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 2
States / cities: Providence, Rhode Island

Conditions: Nicotine Dependence
Interventions: Nicotine Patch, Moclobemide; Drug
Lead sponsor: Jed E. Rose; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 76 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 3
States / cities: Charlotte, North Carolina • Durham, North Carolina • Winston-Salem, North Carolina

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RITCH: Reducing Disparities in Tobacco Cessation Outcomes

Improving Effective Contraceptive Use Among Opioid-maintained Women: Stage II

Treatment of Smoking Lapses and Relapses

Treatment Outcome in CBT for Cocaine Use

Measuring Smoking Behaviors While Using Varenicline

Probenecid Administration for Alcohol Craving and Consumption

Testing a Brief Substance Misuse Preventative Intervention for Parents/Guardians of 5th-7th Grade Students

Neurophysiological and Immunological Effects of the Transition From Combustible to Electronic Cigarettes

Quit Smoking Study for People Who Use E-Cigarettes

The Role of Nicotine Dose and Route of Delivery in Affecting Adoption of E-cigarettes and Reducing Exposure to Toxic Combustion Products

Effectiveness of an Evidence-based Stepped Care System for Alcohol and Other Drug Use Problems Among Congolese Refugees in Zambia

Comparative Effectiveness of Two Tobacco Cessation Interventions for Employees of Partners HealthCare, Inc.

Smoking Cessation Intervention for Young Adults Using MTM: A Randomized Controlled Trial

Treating Schizophrenic Smokers: Effects on Craving, Cues and Withdrawal

Project VALOR: Veteran Stress and Wellbeing

Living in Full Even With Pain Study

A Smartphone Application (ACT on Vaping) for Vaping Cessation in Young Adults

Enhancing Equity in Smoke-free Housing

The END Perioperative Smoking Pilot Study

Maintaining Nonsmoking: Older Smokers - 1

Improving Brief Marijuana Interventions With a Behavioral Economic Supplement

cSBIRT to Reduce Teen Tobacco, Alcohol and Drug Use

Substance Use Interventions for Truant Adolescents

Evaluation of Moclobemide, a Reversible MAO-A Inhibitor, as an Adjunct to Nicotine Replacement Therapy in Female Smokers