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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:18 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1201–1224 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Substance Use, Sexual Risk Behavior
Interventions: Group MI risk reduction program; Behavioral
Lead sponsor: RAND; Other
Eligibility: 18 Years to 24 Years
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 2
States / cities: Hollywood, California • Venice Beach, California

Conditions: Smoking Cessation, Harm Reduction, E-Cig Use, Cigarette Smoking, Tobacco Dependence, Tobacco Use Cessation
Interventions: JUUL; Other
Lead sponsor: Rose Research Center, LLC; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 2
States / cities: Charlotte, North Carolina • Raleigh, North Carolina

Conditions: Tobacco Use
Interventions: Staff training and academic detailing; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: Not listed
Enrollment: 1,365 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Tobacco Use Disorder, Tobacco Dependence
Interventions: Quitbuddy, Control, SDoH Augmentation, SDoH Control; Other
Lead sponsor: Bryan W. Heckman; Other
Eligibility: 21 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Tobacco Use Disorder, Tobacco Use Cessation, Nicotine Dependence
Interventions: Varenicline, Placebo; Drug
Lead sponsor: University of Vermont Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 220 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 2
States / cities: Omaha, Nebraska • Burlington, Vermont

Conditions: Opioid Use Disorder
Interventions: Bias Modification Biofeedback; Device
Lead sponsor: Neurotype Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Alcohol-Related Disorders, Alcohol Drinking, Alcoholism, Alcohol Abuse, Alcohol Use Disorders
Interventions: Motivation Enhancement Therapy, Modified Behavioral Self-Control Therapy, Naltrexone, Brief Advice, Referral to specialty substance use disorder treatment; Behavioral · Drug · Other
Lead sponsor: Northwell Health; Other
Eligibility: 18 Years to 75 Years
Enrollment: 27 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Great Neck, New York

Conditions: Healthy, Nicotine Addiction, Electronic Cigarette Use
Interventions: Lower nicotine e-liquid, Higher nicotine eliquid; Drug
Lead sponsor: Rochester Institute of Technology; Other
Eligibility: 21 Years and older
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Alcohol Abuse, Cannabis Abuse, Major Depressive Disorder, Substance-Related Disorders
Interventions: Integrated Cognitive Behavioral Therapy, Twelve Step Facilitation Therapy; Behavioral
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years to 70 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2004
U.S. locations: 1
States / cities: San Diego, California

Conditions: Smoking, Tobacco Use Disorder
Interventions: CigRx Lozenge, Tobacco Lozenge; Dietary Supplement · Other
Lead sponsor: Rock Creek Pharmaceuticals, Inc.; Industry
Eligibility: 23 Years to 72 Years
Enrollment: 109 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010
U.S. locations: 1
States / cities: Martinsburg, West Virginia

Conditions: Severe Mental Illness, Nicotine Dependence, Schizophrenia, Tobacco Use Disorder
Interventions: EDSS with CO feedback and health checklist, EDSS with health checklist feedback alon; Behavioral
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 124 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Tobacco Use, Opioid Use Disorder, Tobacco-Related Disorders
Interventions: E-cigarette, Control/Standard Advice; Other · Behavioral
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 50 Years and older
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Smoking Cessation, Nicotine Dependence
Interventions: Nicotine Replacement Treatment (NRT), varenicline, Behavioral counseling for smoking cessation; Drug · Behavioral
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 158 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Opioid-Related Disorders
Interventions: Youth Opioid Recovery Support service model; Behavioral
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 26 Years
Enrollment: 44 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: AOD Use, Abuse, and Dependence, Depression
Interventions: MET/CBT-12, CBT-D, D-TAU; Behavioral · Other
Lead sponsor: Duke University; Other
Eligibility: 13 Years to 263 Months
Enrollment: 103 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 2
States / cities: Farmington, Connecticut • Durham, North Carolina

Conditions: Schizophrenia, Substance Abuse, Cocaine Abuse, Tobacco Use Disorder
Interventions: Various Screening psychiatric and medical assessments; Behavioral
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 64 Years
Enrollment: 523 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2019
U.S. locations: 1
States / cities: Catonsville, Maryland

Conditions: E-cigarette Use, Substance Use
Interventions: ENDS Prevention Intervention (TBD); Behavioral
Lead sponsor: University of Hawaii; Other
Eligibility: 10 Years to 14 Years
Enrollment: 500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Honolulu, Hawaii

Conditions: PTSD - Post Traumatic Stress Disorder, PTSD and Alcohol Use Disorder, PTSD and Trauma-related Symptoms, Substance Use Disorder (SUD), Depression, Mental Health, Trauma, Trauma Exposure, Traumatic Stress Disorder, Traumatic Stress, Post Traumatic Stress Symptoms
Interventions: Group Cognitive Processing Therapy (CPT), Control Group Individual trauma focused self-help via workbook; Behavioral
Lead sponsor: University of Arkansas; Other
Eligibility: 18 Years and older
Enrollment: 640 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 6
States / cities: Little Rock, Arkansas • Osceola, Arkansas • Texarkana, Arkansas + 2 more

Conditions: Nicotine Dependence
Interventions: Naltrexone, Transdermal nicotine replacement, Behavioral counseling; Drug · Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 172 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2009
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Nicotine Dependence
Interventions: Exposure to smoking advertising with coupon, Exposure to smoking advertising without coupons, Exposure to non health related images; Behavioral
Lead sponsor: National Institute on Minority Health and Health Disparities (NIMHD); NIH
Eligibility: 18 Years to 29 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Depression, Tobacco Use Disorder
Interventions: Behavioral Activation Therapy, Discussion, Health Education, Questionnaire Administration, Tobacco Cessation Counseling; Behavioral · Procedure · Other
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Alcohol Use Disorder
Interventions: CIRCLE mHealth app; Behavioral
Lead sponsor: Southcentral Foundation; Other
Eligibility: 21 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Anchorage, Alaska

Conditions: Posttraumatic Stress Disorder (PTSD), Anxiety, Depression - Major Depressive Disorder
Interventions: Mindful Self Compassion, Treatment as Usual (TAU); Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older · Female only
Enrollment: 230 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Pomona, California

Conditions: Mental Health, Stress Disorders, Post-Traumatic, Substance-Related Disorders, Tobacco Use Disorder
Interventions: Integrated Care for Smoking Cessation in PTSD patients, Standard of Care; Behavioral
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years to 80 Years
Enrollment: 943 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2009
U.S. locations: 11
States / cities: Tuscaloosa, Alabama • San Diego, California • Washington D.C., District of Columbia + 8 more

Search by objective public record fields.

Substance Use and Sexual Risk Reduction Intervention for Homeless Youth

Assisting Smokers to Switch to a JUUL E-Cigarette by Devaluing Combustible Cigarettes

Comparing an Opt-out to an opt-in Approach for Smoking Cessation in VA Primary Care Clinics

Equitable Smoking Relapse Prevention

Efficacy of Varenicline in Ambivalent Smokers

Brain Training for Substance Use Disorders

Collaborative Care for Alcohol Use Disorders in the Patient-centered Medical Home

Compensatory Behavior of E-cig Users in Response to Reduced Nicotine E-liquids

Study Comparing Two Types of Psychotherapy for Treating Depression and Substance Abuse

A Pilot Study to Evaluate Safety and Efficacy of CigRx™ in Smokers

Electronic Decision Support Systems for Smokers With Severe Mental Illness

E-cigarette Switching Older Adults

Varenicline and Motivational Advice for Smokers With Substance Use Disorders

Youth Opioid Recovery Support: Improving Care Systems

Treatment for Teens With Alcohol Abuse and Depression

Screening Protocol for Research Participants

The Development and Evaluation of a Culturally Grounded ENDS Intervention for Rural Hawaiian Youth

Effectiveness, Implementation, and Cost of Cognitive Processing Therapy in Prisons

Targeted Interventions for Weight-Concerned Smokers

Understanding How Cigarette Direct Mail Marketing Influences Smoking Behaviors Among High and Low Socioeconomic Status Young Adult Smokers

A Behavioral Activation Prenatal and Postpartum Intervention for Depressed Pregnant Smokers

mHealth App for Changing Alcohol Use in Alaska Native American Indian People

Mindful Self-Compassion to Address PTSD and Substance Use in Unhoused Women

Integrating Clinical Practice Guidelines for Smoking Cessation Into Mental Health Care for Veterans With Posttraumatic Stress Disorder