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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:24 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1225–1248 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Tobacco Use Disorder, Alcohol Abuse, Lack of Physical Activity, Poor Diet
Interventions: CHERL; Behavioral
Lead sponsor: Great Lakes Research Into Practice Network; Network
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 3
States / cities: Flint, Michigan • Grand Rapids, Michigan • Marquette, Michigan

Conditions: Tobacco Dependence
Interventions: Nicotine Containing ECIG with tobacco flavor, Nicotine Containing ECIG with Strawberry Vanilla Flavor, Placebo ECIG with Tobacco Flavor, Placebo ECIG with Strawberry Vanilla Flavor; Other
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 21 Years to 60 Years
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Alcohol Use, Unspecified, Substance Use, Sex Behavior
Interventions: PrEP acronym (pre-exposure prophylaxis), Initial Web Survey, Interactive Voice Response (IVR) monitoring, Educational material on alcohol and sexual health behavior, Interactive Voice Response (IVR) assessment with personalized information, Personalized information based on web-based survey responses & standardized information; Drug · Behavioral
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 30 Years · Male only
Enrollment: 88 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Polysubstance Addiction, Opioid Medication Assisted Treatment, Treatment Adherence, Retention in Care, Substance-Related Disorders
Interventions: Peer-Delivered Behavioral Activation ("Peer Activate"); Behavioral
Lead sponsor: University of Maryland, College Park; Other
Eligibility: 18 Years and older
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 4
States / cities: Washington D.C., District of Columbia • Baltimore, Maryland • College Park, Maryland + 1 more

Conditions: Nicotine Dependence, E-Cig Use
Interventions: Nicotine patch, Phone Counseling, Digital Coaching; Drug · Behavioral
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years to 24 Years
Enrollment: 508 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Tobacco Use Disorder
Interventions: Behavior Therapy; Behavioral
Lead sponsor: University of Minnesota; Other
Eligibility: 40 Years to 79 Years · Female only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1997 – 2003
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Vaping, Vaping Cessation, Nicotine Dependence
Interventions: Social Media Intervention; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 13 Years and older
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Tobacco Use Disorder
Interventions: Flavored filtered cigars, Unflavored filtered cigars; Other
Lead sponsor: UConn Health; Other
Eligibility: 21 Years to 34 Years
Enrollment: 89 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Cocaine-Related Disorders, Opioid-Related Disorders, Heroin Dependence, Substance Abuse, Intravenous
Interventions: Abstinence & Work, Work Only; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 117 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2004
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Addiction, Cocaine, Methadone, Opiates
Interventions: Attentional retraining, Control condition; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Nicotine Dependence
Interventions: Varenicline, Bupropion, Nicotine patches, Placebo varenicline, Placebo bupropion, Placebo patch; Drug · Other
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 50 Years
Enrollment: 282 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 2
States / cities: Durham, North Carolina • Raleigh, North Carolina

Conditions: Veterans, Tobacco Use Disorder, Cigarette Smoking, Tobacco Dependence
Interventions: Motivation-Phase Varenicline, Motivation-Phase Nicotine Mini-Lozenge, Cessation-Phase Combination Nicotine Replacement Therapy (NRT), Cessation-Phase Varenicline, Motivation-Phase Counseling, Cessation-Phase Counseling; Drug · Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 21 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 4
States / cities: San Diego, California • Minneapolis, Minnesota • Durham, North Carolina + 1 more

Conditions: Alcohol Use, Marijuana Use, Sexually Transmitted Infections
Interventions: motivational intervention, health education; Behavioral
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years to 25 Years
Enrollment: 566 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: HIV Infections, Sexual Risk Behavior, Substance Use Risks
Interventions: Positive Choice; Behavioral
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years and older
Enrollment: 497 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2006
U.S. locations: 5
States / cities: Oakland, California • San Francisco, California • San Leandro, California

Conditions: Sexually Transmitted Diseases, HIV Infections, Implementation Science, Substance Use, MSM
Interventions: uTECH + YMHP, YMHP, uTECH; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older · Male only
Enrollment: 388 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Alcohol Drinking, Cigarette Smoking, Marijuana Smoking
Interventions: Project CHOICE; Behavioral
Lead sponsor: RAND; Other
Eligibility: 11 Years to 15 Years
Enrollment: 6,455 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2014
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Antisocial Behavior
Interventions: Multisystemic Therapy-Emerging Adults, Enhanced Treatment as Usual; Behavioral
Lead sponsor: Chestnut Health Systems; Other
Eligibility: 16 Years to 26 Years
Enrollment: 183 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2023
U.S. locations: 4
States / cities: Hamden, Connecticut • Hartford, Connecticut • New Haven, Connecticut + 1 more

Conditions: Nicotine Dependance, Serious Mental Illness, Smoking (Tobacco) Addiction, Tobacco Cessation, Community Health Workers, Cardiovascular (CV) Risk, Tobacco Use Disorder
Interventions: Integrated CHW Support intervention, Enhanced usual care (EUC); Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 75 Years
Enrollment: 937 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Tobacco Dependence, PTSD
Interventions: Behavioral Activation Therapy, Health and Smoking Education, Standard Smoking Cessation Therapy; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 124 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2019
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Opioid-use Disorder
Interventions: reSET-O app; Device
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 18 Years to 100 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Harrisburg, Pennsylvania

Conditions: Alcohol Dependence, Alcohol Drinking, Stress, Alcohol-Related Disorders
Interventions: Pioglitazone, Placebo; Drug
Lead sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA); NIH
Eligibility: 21 Years to 65 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Nicotine Dependence
Interventions: GW468816, Placebo Comparator: Placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 264 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 2
States / cities: Belmont, Massachusetts • Boston, Massachusetts

Conditions: Substance Use Disorders, Alcohol Use Disorder, Stimulant-Related Disorder
Interventions: Cognitive Behavioral Therapy, Standard CBT; Device · Behavioral
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years to 65 Years · Male only
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Tobacco Dependence
Interventions: Usual care, Lung age, Contingency Management, Lung age + Contingency Management; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Baltimore, Maryland

Search by objective public record fields.

CHERL, Connecting Primary Care Patients With Community Resources to Facilitate Behavior Change

Establishing the Effect of Flavor on the Addictive Potential of Electronic Cigarettes

ANCHORS Alcohol & Sexual Health Study: UH3 Project

Peer Recovery to Improve Polysubstance Use and Mobile Telemedicine Retention

Research and Innovation to Stop E-cigarette/Vaping in Young Adults

Tobacco Cessation in Postmenopausal Women (Part I) - 1

Social Media Support Groups for Adolescent Vaping Cessation

Impact of Cigar Flavor in Dual Users

The Therapeutic Workplace Initiation Study

Attention Training for Opioid-maintained Cocaine Users

Mechanistic Evaluations of Pre-Cessation Therapies for Smoking Cessation

Varenicline for Smoking Reduction in Veterans Not Ready To Quit

Emerging Adults Who Use Alcohol and Marijuana

Positive Choice: Prevention for Positive Health

UTECH: Machine Learning for HIV Prevention Among Substance Using GBMSM

Brief Voluntary Alcohol and Drug Intervention for Middle School Youth

Multisystemic Therapy-Emerging Adults (MST-EA) for Substance Abuse

Evaluation of Community Health Worker Support to Help People With Serious Mental Illness to Quit Smoking

Behavioral Activation for Smoking Cessation in PTSD

reSET-O RCT (Randomized Controlled Trial)

Role of Proinflammatory Signaling in Alcohol Craving

Effectiveness of GW468816, an NMDA Glycine Site Antagonist, for Prevention of Relapse to Smoking

A Randomized Controlled Trial of Digital CBT to Treat Addiction: Digital RITch®CBT vs. Standard CBT

A Study of Novel Smoking Cessation Interventions in Current and Former Injection Drug Users