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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:32 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1249–1272 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: CBD, Stress, Nicotine Dependence, Tobacco Smoking
Interventions: Epidiolex; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years to 70 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Mental Health, Depression, Post-Traumatic Stress Disorder, Anxiety, Substance Use Disorder
Interventions: VetEd Mobile Application; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 13 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Bedford, Massachusetts

Conditions: Opioid Use Disorder, Criminal Justice, Treatment Adherence and Compliance
Interventions: Not listed
Lead sponsor: Lifespan; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Cranston, Rhode Island

Conditions: Relationship, Family (Foster), Substance Use Prevention
Interventions: Connecting; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 11 Years to 15 Years
Enrollment: 220 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Vaping Teens, Vaping Behaviors, Vaping Cessation, Tobacco Use Disorder
Interventions: E-cigarette Cessation Manual; Behavioral
Lead sponsor: Florida International University; Other
Eligibility: 14 Years to 18 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Alcohol Use Disorder, Depression
Interventions: Lifestyle Physical Activity (LPA), Fitbit Only; Behavioral
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 176 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Tobacco Dependence
Interventions: Quitline Treatment as Usual (TAU), Remote Carbon Monoxide (CO) Monitoring, Incentivized Remote CO Monitoring; Combination Product
Lead sponsor: Consumer Wellness Solutions; Industry
Eligibility: 18 Years and older
Enrollment: 229 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Tobacco Use Disorder
Interventions: Bupropion SR, Placebo Oral Tablet; Drug
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 64 Years · Female only
Enrollment: 52 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2001 – 2005
U.S. locations: 1
States / cities: Catonsville, Maryland

Conditions: Opioid Use Disorder, Methamphetamine Abuse, Cocaine Use Disorder
Interventions: DynamiCare app (app-based contingency management), Sham control; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 2
States / cities: Chicago, Illinois • Milwaukee, Wisconsin

Conditions: Smoking Cessation, Tobacco Use Disorder
Interventions: Cytisinicline, Placebo Oral Capsule; Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 65 Years
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Tobacco Smoking, Smoking Behaviors
Interventions: Odorants; Other
Lead sponsor: Tim McClintock; Other
Eligibility: 18 Years to 60 Years
Enrollment: 27 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Alcohol Use Disorder, Cigarette Smoking
Interventions: Semaglutide, Sham/placebo; Drug
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 21 Years to 65 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Smoking Cessation, Tobacco Use Disorder, Smoking, HIV, AIDS, Pharmacy
Interventions: ENgaging pHarmacists to AdvANCE Tobacco Treatment Service delivery (ENHANCE-TTS); Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 172 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: HIV Infections, AIDS, Lung Cancer, Tobacco Addiction, Drug Addiction
Interventions: Not listed
Lead sponsor: National Cancer Institute (NCI); NIH
Eligibility: 17 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Stress Disorders, Post-Traumatic, Marijuana Abuse
Interventions: Personalized Feedback Session (PFS); Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 75 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2031
U.S. locations: 1
States / cities: San Diego, California

Conditions: Alcohol Drinking, Alcohol Intoxication, Alcohol Poison, Alcohol-Related Disorders, Alcohol Impairment, Alcohol Withdrawal, Alcohol Abstinence, Alcohol; Harmful Use, Sex Behavior, Sexual Aggression, Sexual Harassment, Relation, Interpersonal
Interventions: Smart Choices 4 Teens; Behavioral
Lead sponsor: Pacific Institute for Research and Evaluation; Other
Eligibility: 16 Years to 17 Years
Enrollment: 411 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Berkeley, California

Conditions: Nicotine Dependence
Interventions: Transdermal nicotine patch; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 234 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2012
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Alcohol Use Disorder, Alcohol Drinking, Alcohol Use Disorder (AUD)
Interventions: ASP8062, Placebo; Drug
Lead sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA); NIH
Eligibility: 21 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 3
States / cities: Los Angeles, California • Aurora, Colorado • Providence, Rhode Island

Conditions: Recovery Management Checkup (RMC), Outcome Monitoring
Interventions: Recovery Management Checkups, Outcome Monitoring; Behavioral · Other
Lead sponsor: Chestnut Health Systems; Other
Eligibility: 18 Years and older · Female only
Enrollment: 480 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2015
U.S. locations: 2
States / cities: Chicago, Illinois • Normal, Illinois

Conditions: Alcohol Drinking, Alcohol Abuse, Alcohol; Harmful Use
Interventions: Personalized Normative Feedback; Behavioral
Lead sponsor: Loyola Marymount University; Other
Eligibility: 21 Years to 55 Years · Female only
Enrollment: 500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: HIV Infections, Substance Use, Adherence, Medication, Adherence, Treatment
Interventions: Descovy or Truvada, ID-Cap System, Beiwe; Drug · Device
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older · Male only
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Opioid-use Disorder, Opioid Dependence, Treatment Adherence
Interventions: Contingency Management (CM), Brief Motivational Intervention + Substance Free Activities Session + Mindfulness-Based Adherence Promotion (BSM); Behavioral
Lead sponsor: Karen Derefinko, PhD; Other
Eligibility: 18 Years and older
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: HIV/AIDS, Diabetes Mellitus, Hypertension, Substance Use
Interventions: Patient Navigation; Behavioral
Lead sponsor: St. Luke's-Roosevelt Hospital Center; Other
Eligibility: 18 Years and older
Enrollment: 144 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 2
States / cities: New York, New York

Conditions: Parenting, Parent-Child Relations, Opioid Misuse, Opioid Use Disorder, Stress, Depression, Parenting Self-efficacy
Interventions: Family Check-Up; Behavioral
Lead sponsor: University of Oregon; Other
Eligibility: 18 Years and older
Enrollment: 356 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Portland, Oregon

Search by objective public record fields.

Effects of Cannabidiol on Stress and Nicotine Withdrawal

Designing a Mobile App to Support Academic Success for Student Veterans

Injectable Extended-Release Buprenorphine (XR-B) in a Correctional Setting: Qualitative Interviews

A Trial of Connecting to Promote Foster Teen Well-Being

Developing an E-Cigarette Cessation Intervention for Hispanic/Latina(o) Youth in Florida: The BReATHE Study

Testing a Lifestyle Physical Activity Intervention for Women With Depression in Alcohol Treatment

CO Monitoring for Tobacco Cessation in Quitlines

A Comparison of Bupropion SR and Placebo for Smoking Cessation

Contingency Management for Drug Use: Does Age Matter?

Examining the Effects of Cytisinicline on Neural Substrates of Cigarette Cue-reactivity

Human Perception of Odors and Odor Blockers

Semaglutide for Alcohol Use Disorder

Engaging Pharmacists to Advance Tobacco Treatment Service Delivery

HIV Infection and Tobacco Use Among Injection Drug Users in Baltimore, Maryland: A Pilot Study of Biomarkers

Applying Mixed Methods to Identify Links Between PTSD Symptoms, Cannabis Use, and Functional Behaviors With Personalized Feedback Intervention Development

Family Based Prevention of Alcohol and Risky Sex for Older Teens

Assessment of a Teachable Moment for Smoking Cessation

Human Laboratory Study of ASP8062 for Alcohol Use Disorder

Recovery Management Checkups for Women Offenders

A Gamified, Social Media Inspired Personalized Normative Feedback Alcohol Intervention for Sexual Minority Women

SmartSteps: A Context-Aware, PrEP Adherence Intervention for Individuals With Substance Use Disorder

SMART Effectiveness Trial

Study on the Impact of Patient Navigators on the Health Education and Quality of Life in Formerly Incarcerated Patients

Parenting Young Children Study