Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:45 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1273–1296 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Nicotine Addiction
Interventions: Cycloserine, Placebo; Drug
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years to 55 Years
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Alcohol Use Disorder (AUD), Alcohol Drinking
Interventions: Ketone Ester "(R)-3-hydroxybutyl (R)-3-hydroxybutyrate", FDG; Dietary Supplement · Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 21 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Cocaine Dependence
Interventions: Buprenorphine + Naltrexone, Placebo + Naltrexone; Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 65 Years
Enrollment: 302 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 11
States / cities: Los Angeles, California • San Francisco, California • Denver, Colorado + 8 more

Conditions: Tobacco Use Disorder, Tobacco Smoking
Interventions: [F18]-ASEM (3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-6-[18F]fluorodibenzo[b,d]thiophene 5,5-dioxide), Contingency Management; Drug · Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years to 50 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Opioid Dependence, Opioid Use Disorder (OUD)
Interventions: VK4-116, Placebo; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 60 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Overland Park, Kansas

Conditions: Tobacco Use Cessation, Tobacco Use Disorder
Interventions: Bupropion-SR, Placebo; Drug · Other
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 12 Years to 25 Years
Enrollment: 172 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2011
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Substance Use Disorders
Interventions: Contingency Management, Placebo; Behavioral · Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 332 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 2
States / cities: Minneapolis, Minnesota • Seattle, Washington

Conditions: Major Depressive Disorder, Nicotine Dependence, Depression
Interventions: Fluoxetine, Dextrose; Drug
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 206 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Autonomic Nervous System Imbalance, Heart Rate Variability (HRV), Opioid Use Disorder, Breathing Techniques, Opioid Craving, Recovery, Emotional Regulation, Positive and Negative Affect, Stress, Biofeedback
Interventions: Heart rate variability biofeedback; Behavioral
Lead sponsor: Arizona State University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: E Cigarette Use, Vaping, Smoking, Tobacco Smoking, Nicotine Use Disorder, Qt Interval, Variation in, HIV I Infection, Oxidative Stress, Inflammation
Interventions: TCIG, ECIG, sham control; Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 21 Years to 45 Years
Enrollment: 37 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Los Angeles, California

Conditions: Schizophrenia, Nicotine Dependence
Interventions: Smoking Cues, Neutral Cues; Behavioral
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 64 Years
Enrollment: 44 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Catonsville, Maryland

Conditions: Substance Abuse, Exercise
Interventions: contingency management; Behavioral
Lead sponsor: UConn Health; Other
Eligibility: 55 Years to 75 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Tobacco Use Disorder, Nicotine Dependence
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 55 Years
Enrollment: 61 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: PTSD, Depression, Chronic Pain, Alcohol Use Disorder, Traumatic Brain Injury
Interventions: Not listed
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 377 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 2
States / cities: Temple, Texas • Waco, Texas

Conditions: Alcohol Use Disorder, Intermittent Explosive Disorder
Interventions: Alcohol (Ethanol), Placebo; Drug
Lead sponsor: Ohio State University; Other
Eligibility: 21 Years to 55 Years
Enrollment: 144 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: E-cigarette Use/Vaping Prevention, Nicotine Dependence Prevention, Adolescent Mental Health
Interventions: Virtual Reality E-Cigarette Prevention Program; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 11 Years to 15 Years
Enrollment: 1,251 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Addiction, Opioid Use, Substance Use Disorders, Opioid Use Disorder
Interventions: Placebo, Auvelity; Drug
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Substance Use Disorders, Drug Abuse, Alcohol Abuse, Posttraumatic Stress Disorder, PTSD, Recidivism, Depression
Interventions: Cognitive Processing Therapy, Control Group; Behavioral
Lead sponsor: University of Arkansas; Other
Eligibility: 18 Years and older
Enrollment: 148 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2025
U.S. locations: 2
States / cities: Osceola, Arkansas • West Memphis, Arkansas

Conditions: HIV, Risk Behavior, Alcohol Abuse
Interventions: CLT- Concrete text messages, CLT- Abstract text messages, Control messages, No messages, GamePlan Online Program; Behavioral
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 30 Years · Male only
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Gambling, Tobacco Use Disorder
Interventions: N Acetyl Cysteine, Sugar Pill; Drug · Other
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years to 75 Years
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 2
States / cities: New Haven, Connecticut • Minneapolis, Minnesota

Conditions: Opioid-use Disorder, Anxiety, Depression, Stress Related Disorder
Interventions: M-ROCC; Behavioral
Lead sponsor: Cambridge Health Alliance; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Somerville, Massachusetts

Conditions: Smokeless Tobacco Use, Tobacco Dependence
Interventions: Not listed
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 359 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2013
U.S. locations: 3
States / cities: Minneapolis, Minnesota • Eugene, Oregon • Morgantown, West Virginia

Conditions: Pain, Pain, Acute, Pain, Chronic, Pain, Neuropathic, Opioid-use Disorder, Opioid Abuse and Addiction, Opioid Withdrawal
Interventions: Quality IQ Patient Simulations; Other
Lead sponsor: Qure Healthcare, LLC; Industry
Eligibility: Not listed
Enrollment: 220 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Smoking Cessation, Smoking, Nicotine Dependence
Interventions: Nicotine patch, Cessation Counseling, Mobile Games; Drug · Behavioral · Device
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Madison, Wisconsin

Search by objective public record fields.

Investigation of Cycloserine as a Smoking Cessation Treatment

Relationship Between Brain and Heart Glucose Metabolism in Alcohol Use Disorder

Cocaine Use Reduction With Buprenorphine

Brain Imaging in Tobacco Smokers During a Quit Attempt

VK4-116 Phase I Study With Food-Effect

Effectiveness of Bupropion for Treating Nicotine Dependence in Young People

The Effect of a Contingency Management Intervention on Substance Use

Sequential Use of Fluoxetine for Smokers With Elevated Depressive Symptoms

Evaluating the Feasibility, Acceptability, and Preliminary Outcomes of Heart Rate Variability Biofeedback for Individuals With Opioid Use Disorder.

Acute Effects of TCIG vs ECIG in PLWH

Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Smokers With and Without Schizophrenia

Substance Use and Fitness

A Multi-Modal Investigation of the Smoking Cessation Medication Varenicline: Dopaminergic Modulation of Reward Processing and Cognitive Control

Impact of Modifiable Psychosocial Factors on Veterans' Long-term Trajectories of Functioning and Quality of Life

Neural Correlates During Alcohol Intoxication

A Virtual Reality E-cigarette Prevention and Emotion Regulation Intervention for Adolescents

Phase Ib/2a Drug-drug Interaction Study of a Combination of 45mg Dextromethorphan With 105 mg Bupropion

Leveraging Implementation Science to Increase Access to Trauma Treatment for Incarcerated Drug Users

Project SPACE: Testing Daily Text Messages to Reduce Alcohol Use and HIV Risk Behavior

N-Acetyl Cysteine Plus Behavioral Therapy for Nicotine Dependent Pathological Gamblers

MINDFUL-OBOT: Effect of Mindfulness on Opioid Use and Anxiety During Primary Care Buprenorphine Treatment

Novel Determinants and Measures of Smokeless Tobacco Use: Study 1

Assessing Opioid Care Practices Using CPV Patient Simulation Modules

A Quit Smoking Study Using Smartphones