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ClinicalTrials.gov public records Last synced Nov 15, 2026, 6:02 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1321–1344 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Bipolar Disorder, Schizophrenia, Schizoaffective Disorder, Nicotine Dependence
Interventions: Varenicline; Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years to 70 Years
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Tobacco Use, Smoking, Tobacco Dependence, Tobacco Use Disorder, Tobacco Use Cessation, Tobacco Smoking, Smoking Cessation, Smoking, Cigarette, Smoking, Tobacco
Interventions: POP:, TSP:; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 25 Years
Enrollment: 165 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Tobacco Use Disorder
Interventions: Bupropion and NRT; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years and older
Enrollment: 407 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2002 – 2009
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Mental Health Disorder, Substance Use Disorder, Stigmatization, Implementation Science
Interventions: Modified Health Policy Project (HPP) HIV-Stigma and Discrimination Reduction Training Curriculum, You℞ Decision prescribing platform; Behavioral · Device
Lead sponsor: RTI International; Other
Eligibility: 18 Years and older
Enrollment: 333 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 2
States / cities: Decatur, Georgia • Duluth, Georgia

Conditions: Tobacco Dependence, Suicidal
Interventions: DBT-C, Treatment as usual; Behavioral
Lead sponsor: Veterans Medical Research Foundation; Other
Eligibility: 18 Years and older
Enrollment: 67 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: San Diego, California

Conditions: Posttraumatic Stress Symptom, Alcohol Drinking, Alcohol Problem
Interventions: Activity scheduling, Cognitive restructuring, Coaching calls, Non-core intervention components; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 464 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Substance Use Disorders, Risk Reduction
Interventions: Risk Reduction Group; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 87 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Substance Use Disorders, Alcohol Abuse, Alcoholism, Substance Dependence, Substance Abuse
Interventions: Contracting, Prompting and Reinforcement arm, Control arm; Behavioral
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years and older
Enrollment: 183 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2011
U.S. locations: 2
States / cities: Jackson, Mississippi • Salem, Virginia

Conditions: Tobacco Dependence
Interventions: Nicotine free cigarettes, Extra-low nicotine cigarettes, Nicotine Lozenge; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 70 Years
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2006
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: HIV Seropositivity, Substance Use, STI, Stigma, Social
Interventions: Stigma counseling for PrEP use; Behavioral
Lead sponsor: University of Connecticut; Other
Eligibility: 18 Years and older · Male only
Enrollment: 500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Post Traumatic Stress Disorders, Unsafe Sex, Substance Use Disorders
Interventions: Cognitive Processing Therapy-Cognitive; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older · Female only
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Toppenish, Washington

Conditions: Tobacco Dependence, Tobacco Smoking
Interventions: Smoke-free home resident intervention, Lay Health Worker coaching; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 544 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Tobacco Use Cessation, Tobacco Use Disorder
Interventions: Progesterone, Placebo; Drug · Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 35 Years · Female only
Enrollment: 46 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Tobacco Dependence
Interventions: repetitive transcranial magnetic stimulation (rTMS) 10 Hertz (Hz), repetitive transcranial magnetic stimulation (rTMS) 20Hz, SHAM repetitive transcranial magnetic stimulation (rTMS); Device
Lead sponsor: University of Arkansas; Other
Eligibility: 19 Years to 55 Years
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Little Rock, Arkansas

Conditions: Tobacco Dependence
Interventions: Very low nicotine content cigarettes, Normal nicotine content cigarettes; Drug
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 21 Years to 60 Years
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Adolescent Substance Use
Interventions: Guiding Good Choices; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 11 Years to 12 Years
Enrollment: 3,636 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2025
U.S. locations: 3
States / cities: Oakland, California • Aurora, Colorado • Detroit, Michigan

Conditions: Nicotine Dependence, Nicotine Use Disorder
Interventions: Bupropion SR, Contingency Management, Placebo; Drug · Behavioral · Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 12 Years to 21 Years
Enrollment: 134 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2009
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Nicotine Dependence, Cigarette Smoking, Insomnia
Interventions: Cognitive-Behavioral Counseling, Smoking Cessation Counseling; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Smoking
Interventions: Functional Magnetic Resonance Imaging (fMRI); Other
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 64 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 2008
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Behavior, Health
Interventions: Episodic Future Thinking (EFT), Episodic Recent Thinking (ERT); Behavioral
Lead sponsor: Henry Ford Health System; Other
Eligibility: Not listed
Enrollment: 72 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Flint, Michigan

Conditions: Substance Use Disorders, Violence
Interventions: IVPT; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 131 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Opioid-use Disorder, Overdose of Opiate, Patient Participation
Interventions: Patient Reported Outcomes Electronic Survey; Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 101 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Tobacco Use Disorder
Interventions: EMB-001; Drug
Lead sponsor: Embera NeuroTherapeutics, Inc.; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 2
States / cities: Miami Lakes, Florida • Raliegh, North Carolina

Conditions: Traumatic Brain Injury, Major Depressive Disorder, Bipolar Disorder, Schizophrenia, Attention Deficit Hyperactivity Disorder, Borderline Personality Disorder, Substance Use Disorders
Interventions: Transcranial Direct Current Stimulation; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 600 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

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Novel Pharmacotherapy Approaches in Smokers With Serious Mental Illness

A Facebook Intervention for Young Sexual and Gender Minority Smokers

Maintaining Abstinence in Chronic Cigarette Smokers - 1

The IMPROV Project: Improving Mental Health and Substance Use Treatment Provision (IMPROV) Among People Living With HIV (Human Immunodeficiency Virus) in Atlanta

DBT for Smoking Cessation in High Risk Veterans

Testing the Impact of Thrive App Versions on Alcohol Use and Posttraumatic Stress After Recent Sexual Assault

Community Supported Risk Reduction for Syringe Exchange Participants

Reinforcement of Abstinence and Continuing Care in Substance Abuse Treatment

Comparisons of Nicotine-free Cigarettes, Extra Low Nicotine Cigarettes vs. Medicinal Nicotine

Assessing the PrEP Care Cascade Among Black Men and Transwomen in the Southeastern US

Cognitive Processing Intervention for Trauma, HIV/STI Risks, and Substance Use Among Native Women

Smoke-free Home Study in Subsidized Housing

Progesterone & Postpartum Relapse to Smoking

Changing Thought and Action in Tobacco Dependence With Transcranial Magnetic Stimulation

Measuring Neuroadaptations in Response to Very Low Nicotine Content Cigarettes

Guiding Good Choices for Health

Combined Pharmaco/Behavior Therapy in Adolescent Smokers

Smoking Cessation for Smokers With Sleep Problems

Genetic Differences in Limbic Activation Associated With Nicotine Withdrawal

Future Thinking to Improve Parent-Child Relationships

Developing Violence Prevention Therapy for Substance Abusers

Patient Reported Outcomes for Opioid Use Disorder

Study of EMB-001 as a Potential Smoking Cessation Treatment

Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations