Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:20 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 145–168 of 1,374 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Substance Use Behavior Clear all

Conditions: Substance Use Disorders, Insomnia
Interventions: Brief Behavioral Therapy for Insomnia (BBTI); Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 83 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Tobacco Smoking, Nicotine Dependence
Interventions: Very Low Nicotine Content Cigarettes, Normal Nicotine Content Cigarettes; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 21 Years and older
Enrollment: 799 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2023
U.S. locations: 6
States / cities: San Francisco, California • Minneapolis, Minnesota • Durham, North Carolina + 3 more

Conditions: Tobacco Use Disorder, Homelessness
Interventions: Nicotine Patches, mobile contingency management (mCM), Smoking cessation counseling, Nicotine rescue method, Bupropion; Drug · Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 70 Years
Enrollment: 133 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking Cessation, Cigarette Smoking, Tobacco Use, Nicotine Dependence
Interventions: Mindful Smoking and Sensor-Band Intervention, Smoking Cessation Information; Behavioral
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Smokeless Tobacco Use
Interventions: Nicotine Lozenges, Placebo lozenge; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 270 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2009
U.S. locations: 2
States / cities: Rochester, Minnesota • Eugene, Oregon

Conditions: Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent), Prescription Drug Abuse and Dependency, Health Behavior, Benzodiazepine Abuse, Benzodiazepine Dependent
Interventions: Automated Reports on prescription patterns for their patients; Other
Lead sponsor: Duke University; Other
Eligibility: Not listed
Enrollment: 427 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: College Drinking, Underage Drinking, Alcohol Use Disorder
Interventions: Gamified Personalized Normative Feedback; Behavioral
Lead sponsor: Loyola Marymount University; Other
Eligibility: 18 Years to 20 Years
Enrollment: 1,143 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Use; Tobacco, Harmful, Alcohol Abuse, Drug Abuse
Interventions: iMET, iMET/TE; Behavioral
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 12 Years to 21 Years
Enrollment: 121 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Smoking Cessation, Tobacco Dependence
Interventions: Varenicline, Counseling and Support Materials, Laboratory Assessments; Drug · Other
Lead sponsor: H. Lee Moffitt Cancer Center and Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 86 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2019
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Posttraumatic Stress Disorder, Substance Dependence
Interventions: Treatment for Integrated Posttraumatic Stress and Substance Use (TIPSS), Cognitive-Behavioral Therapy for Substance Dependence; Behavioral
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Alcohol Use Disorder
Interventions: Brief Motivational Interviewing, Culturally adaptation brief motivational interviewing; Behavioral
Lead sponsor: University of Texas, El Paso; Other
Eligibility: 18 Years and older
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: El Paso, Texas

Conditions: HIV Infections, Substance Use Disorders, Addiction, Opioid Use, Drug Use, Intravenous Drug Usage
Interventions: Peer-educator-based network; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 360 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 2
States / cities: Baltimore, Maryland • Frederick, Maryland

Conditions: Tobacco Dependence
Interventions: Placebo, Nicotine; Drug
Lead sponsor: McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 257 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011
U.S. locations: 19
States / cities: Muscle Shoals, Alabama • Oceanside, California • Griffin, Georgia + 16 more

Conditions: Nicotine Dependence, Tobacco Toxicity, Cardiovascular Risk Factors
Interventions: Standardized Research E-Cigarette (SREC), Over the Counter E-Cigarette (EC), Biological Samples, Smoking-related Questionnaires; Other · Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 70 Years
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Tobacco Use Disorder, Nicotine Dependence
Interventions: text messaging for smoking cessation, Generic text messages; Behavioral
Lead sponsor: The Miriam Hospital; Other
Eligibility: 18 Years to 35 Years
Enrollment: 84 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Schizophrenia, Nicotine Dependence, Smoking, Tobacco
Interventions: Music session; Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 2 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: New York, New York

Conditions: Substance Use Disorders, Posttraumatic Stress Disorder, Opioid Use Disorder, Violence, Sexual, Violence, Gender-Based, Violence, Domestic
Interventions: Screening/Referral and Prevention; Behavioral
Lead sponsor: Clemson University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 2
States / cities: Greenville, South Carolina

Conditions: Psychosis, Substance Use, Substance Use Disorders, Family, Tobacco Use, Nicotine Use Disorder, Cigarette Smoking, Cannabis, Marijuana, Alcohol Use Disorder, Alcohol, Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Mental Disorder
Interventions: CRAFT-FT; Behavioral
Lead sponsor: Mclean Hospital; Other
Eligibility: 18 Years to 70 Years
Enrollment: 29 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Opioid-use Disorder, Amphetamine Use Disorders
Interventions: Neurocognitive Empowerment for Addiction Treatment (NEAT), Active Control; Behavioral
Lead sponsor: Laureate Institute for Brain Research, Inc.; Other
Eligibility: 18 Years to 65 Years
Enrollment: 104 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Conditions: Opioid-use Disorder
Interventions: Mindfulness-Based Relapse Prevention - Rolling Admission (MBRP-RA), Treatment-As-Usual; Behavioral
Lead sponsor: West Chester University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 105 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: West Chester, Pennsylvania

Conditions: Nicotine Addiction
Interventions: Nicotine pouch: Low dose, Nicotine pouch: High dose, Low pH, High pH; Other
Lead sponsor: Emory University; Other
Eligibility: 21 Years to 35 Years
Enrollment: 84 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Cigarette Smoking, Tobacco Smoking, Nicotine Dependence, Smoking Cessation
Interventions: Mindfulness Training, Smoking Cessation Therapy; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Cocaine Dependence, Methamphetamine Dependence, Nicotine Dependence
Interventions: Smoking-cessation treatment; Other
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years and older
Enrollment: 538 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 12
States / cities: Tucson, Arizona • Rancho Cucamonga, California • Tarzana, California + 9 more

Conditions: MDMA Discontinuation Syndrome
Interventions: 3,4-methylenedioxymethamphetamine or Placebo; Drug
Lead sponsor: California Pacific Medical Center Research Institute; Other
Eligibility: 18 Years to 50 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: San Francisco, California

Search by objective public record fields.

Feasibility of Brief Behavioral Therapy for Insomnia (BBTI) in SUD Recovery

Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace

Abstinence Reinforcement Therapy (ART) for Homeless Veteran Smokers

Quit With Sense: Using Mindful Smoking and Wearable Device for Smoking Cessation

Nicotine Lozenges for Treatment of Smokeless Tobacco Addiction

An Opioid Prescribing Nudge

Revolutionizing Normative Re-education

Dental and Medical Office iMET to Reduce Teen Tobacco, Alcohol, and Drug Use

Translating Extinction Research to Improve Pharmacotherapy for Tobacco Dependence

Trial of a Novel Cognitive-Behavioral Treatment for Posttraumatic Stress and Substance Dependence

Trial of a Culturally Informed Brief Intervention to Reduce Alcohol Related Health Disparities and Treatment Inequities Among Latinxs

Syringe Service Based Telemedicine and Social Network Driven HIV Prevention Service Implementation

Study to Determine if a New Nicotine Replacement Therapy Can Safely Help Smokers to Quit Smoking

Pharmacokinetics and Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC)

Examining a Text Message Intervention for Smoking Cessation

Music to Reduce Use of Smoking in Patients With Schizophrenia

Trauma Screening/Referral and Interpersonal Violence Prevention for Women with Substance Use Disorders

Families With Substance Use and Psychosis: A Pilot Study

Neurocognitive Empowerment for Addiction Treatment (NEAT) in Opioid Use Disorder and Amphetamine Use Disorder

Mindfulness-Based Relapse Prevention to Improve Medication Assisted Treatment Adherence and Drug-use Outcomes for Opioid Use Disorder

Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches

Mindfulness Training for Smoking Cessation

Smoking-Cessation and Stimulant Treatment (S-CAST)

Study of the Effects of MDMA/Ecstasy on Water Regulation, Sleep, and Cognition.