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ClinicalTrials.gov public records Last synced Oct 29, 2026, 5:11 AM EDT

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Showing 1–24 of 100 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Substance Use Disorder (SUD) Clear all
Completed Not applicable Interventional

CPT for Offenders With SUD

NCT01277939
View directory record Official record
Conditions
Computer-assisted, Evidence-based Psychosocial Intervention, for Substance Abuse Treatment
Interventions
Therapeutic Education System (TES), Standard Care
Behavioral
Lead sponsor
National Development and Research Institutes, Inc.
Other
Eligibility
18 Years and older
Enrollment
376 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
10
States / cities
Cañon City, Colorado • Denver, Colorado • Model, Colorado + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 2, 2013 · Synced Oct 29, 2026, 5:11 AM EDT
Completed Not applicable Interventional

Program for Alleviating and Reducing Trauma, Stress, and Substance Use

NCT06207409
View directory record Official record
Conditions
PTSD, Substance Use Disorders
Interventions
PARTS-SUD
Behavioral
Lead sponsor
Cambridge Health Alliance
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Malden, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 25, 2025 · Synced Oct 29, 2026, 5:11 AM EDT
Completed Not applicable Interventional

Reentry Assist (R-Assist)

NCT06980233
View directory record Official record
Conditions
Substance Use Disorder (SUD), Mental Health Disorder, Criminal Recidivism
Interventions
reentry assistance mobile health app
Behavioral
Lead sponsor
Meaningful Measurement, Inc
Industry
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 29, 2026, 5:11 AM EDT
Recruiting Not applicable Interventional

Effectiveness, Implementation, and Cost of Cognitive Processing Therapy in Prisons

NCT06923423
View directory record Official record
Conditions
PTSD - Post Traumatic Stress Disorder, PTSD and Alcohol Use Disorder, PTSD and Trauma-related Symptoms, Substance Use Disorder (SUD), Depression, Mental Health, Trauma, Trauma Exposure, Traumatic Stress Disorder, Traumatic Stress, Post Traumatic Stress Symptoms
Interventions
Group Cognitive Processing Therapy (CPT), Control Group Individual trauma focused self-help via workbook
Behavioral
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years and older
Enrollment
640 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
6
States / cities
Little Rock, Arkansas • Osceola, Arkansas • Texarkana, Arkansas + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Oct 29, 2026, 5:11 AM EDT
Completed No phase listed Observational

Mindfulness and Meditation-Based Relapse Prevention for Substance Use Disorders

NCT07417579
View directory record Official record
Conditions
Substance Use Disorders, Behavioral Health, Addiction Psychological, Addiction Disorders, Meditation, Mindfulness Based Stress Reduction, Prevention
Interventions
Mindfulness and Meditation-Based Relapse Prevention Program
Behavioral
Lead sponsor
Bout Me Healing
Industry
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Boca Raton, Florida
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Oct 29, 2026, 5:11 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pilot Test of a Mobile App That Helps Spanish-speakers Find Mental Health Services in the US.

NCT06619431
View directory record Official record
Conditions
Health Disparity, Minority and Vulnerable Populations
Interventions
Mobile Application
Device
Lead sponsor
Volver Health
Industry
Eligibility
18 Years to 75 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Oct 29, 2026, 5:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nursing Attitudes Towards SUD

NCT05218681
View directory record Official record
Conditions
Substance Use Disorders, Stigma, Social
Interventions
Unit-based "Person First" Anti-stigma Awareness Rounds, Individual Text-based Messaging
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 9, 2022 · Synced Oct 29, 2026, 5:11 AM EDT
Completed Not applicable Interventional

Feasibility and Acceptability of Switching to E-cigarettes Among Cigarette Smokers Engaged in SUD Treatment

NCT05918887
View directory record Official record
Conditions
Tobacco Dependence Caused by Cigarettes
Interventions
NJOY ACE commercial e-cigarette
Device
Lead sponsor
University of Nevada, Reno
Other
Eligibility
21 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Reno, Nevada
Source: ClinicalTrials.gov public record
Updated May 13, 2025 · Synced Oct 29, 2026, 5:11 AM EDT
Not yet recruiting Not applicable Interventional

Preventing Overdose and Promoting Recovery Through Court Navigation

NCT07700407
View directory record Official record
Conditions
Substance Use Disorder (SUD)
Interventions
CourtConnect, Information Only
Behavioral · Other
Lead sponsor
RTI International
Other
Eligibility
18 Years to 100 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
2
States / cities
South Bend, Indiana • Research Triangle Park, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Oct 29, 2026, 5:11 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Open-Label Psilocybin Study in Transdiagnostic Population

NCT06442423
View directory record Official record
Conditions
Transdiagnostic, Depression - Major Depressive Disorder, Anxiety, PTSD Symptoms, PTSD, Substance Use, Substance Use Disorder (SUD), OCD
Interventions
Psilocybin
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Oct 29, 2026, 5:11 AM EDT
Not yet recruiting Not applicable Interventional

Senyo Health App - Comorbid Alcohol Use Disorder Treatment in Individuals With Bipolar Disorder Using a Telehealth Collaborative Care Platform

NCT07556861
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Senyo Health App
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 31, 2026 · Synced Oct 29, 2026, 5:11 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Olfactory Function and Model-Based Behavior in People Living With HIV and SUD

NCT07637669
View directory record Official record
Conditions
HIV, Substance Use Disorder
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2031
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 28, 2026 · Synced Oct 29, 2026, 5:11 AM EDT
Recruiting Phase 2Phase 3 Interventional

The Many Roads to Trauma Recovery: A Clinical Trial Comparing Empirically Supported Treatments for Veterans With Co-Morbid Posttraumatic Stress and Substance Use Disorder Symptoms

NCT07756723
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD), Substance Use Disorder (SUD)
Interventions
Trauma Informed Heart Rate Variability Biofeedback, Present Centered Therapy
Behavioral
Lead sponsor
Coatesville VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Coatesville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 29, 2026, 5:11 AM EDT
Completed Phase 2 Interventional

Very Low-Nicotine Cigarettes in Smokers With SUD

NCT01989507
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine, behavioral counseling for smoking cessation
Drug · Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 75 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 28, 2021 · Synced Oct 29, 2026, 5:11 AM EDT
Recruiting Not applicable Interventional

Family Support Protocol for Adolescent Internalizing Disorders

NCT06413979
View directory record Official record
Conditions
Internalizing Disorders, Substance Use Disorders
Interventions
Family Support Protocol for Adolescent Internalizing Disorders (Fam-AID)
Behavioral
Lead sponsor
The National Center on Addiction and Substance Abuse at Columbia University
Other
Eligibility
13 Years to 21 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
4
States / cities
Jacksonville, Florida • Chicago, Illinois • Indianapolis, Indiana + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 17, 2026 · Synced Oct 29, 2026, 5:11 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

A Single Ascending Dose Trial of CVL-936 in Healthy Subjects

NCT04232878
View directory record Official record
Conditions
Substance Use Disorders (SUD)
Interventions
CVL-936, Matching Placebo
Drug
Lead sponsor
Cerevel Therapeutics, LLC
Industry
Eligibility
18 Years to 50 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Marlton, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 22, 2020 · Synced Oct 29, 2026, 5:11 AM EDT
Not yet recruiting Phase 3 Interventional

Recovery Management Checkup Scalability and Sustainability Hybrid Experiment

NCT07873944
View directory record Official record
Conditions
Substance Use Disorder (SUD), Opioid Use Disorders, Stimulant Overdose, Overdose Risk, Alcohol Use Disorder
Interventions
Recovery Management Checkups (RMC) delivered by community-based agencies (RMC adopters), Recovery Management Checkups (RMC) delivered by staff under the research team (RMC by research staff)
Behavioral
Lead sponsor
Chestnut Health Systems
Other
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 14, 2026 · Synced Oct 29, 2026, 5:11 AM EDT
Recruiting Not applicable Interventional

Individualized Adaptive Deep Brain Stimulation in Opioid Use Disorder

NCT07214467
View directory record Official record
Conditions
Substance Use Disorder (SUD), Opioid Use Disorder (OUD)
Interventions
Deep Brain Stimulation
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
22 Years to 75 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2031
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Oct 29, 2026, 5:11 AM EDT
Recruiting Not applicable Interventional

Pathways to Perinatal Mental Health Equity

NCT06790641
View directory record Official record
Conditions
Perinatal Anxiety, Perinatal Depression, Social Determinants of Health (SDOH), Peer Support, Obstetric Care, Substance Use Disorder (SUD), Perinatal Depression, Substance Use
Interventions
Program in Support of Moms (PRISM), PSI Peer Support
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years to 70 Years
Enrollment
1,270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Shrewsbury, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Oct 29, 2026, 5:11 AM EDT
Not yet recruiting Not applicable Interventional

Pilot Study of an Adapted Partner Navigation Intervention Booster Session for Sustained Healthcare Engagement Among People Who Inject Drugs

NCT07631559
View directory record Official record
Conditions
HEPATITIS C (HCV), Opioid Use Disorder, Substance Use Disorder (SUD), Drug Use Disorders, Healthcare Access, Harm Reduction
Interventions
Partner navigation intervention booster session
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 29, 2026, 5:11 AM EDT
Not yet recruiting Not applicable Interventional

Recovery Works - Facilitating Sustainable Recovery Through Workforce

NCT07216612
View directory record Official record
Conditions
Substance Use Disorder (SUD)
Interventions
Community Restitution Apprenticeship-Focused Training (CRAFT), Standard Employment Model
Other
Lead sponsor
West Virginia School of Osteopathic Medicine
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Lewisburg, West Virginia
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Oct 29, 2026, 5:11 AM EDT
Recruiting Not applicable Interventional

Implementation of TBI-RECOVER in Substance Use Treatment

NCT07215221
View directory record Official record
Conditions
Traumatic Brain Injury, Substance Use Disorder (SUD)
Interventions
TBI-RECOVER, Control
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Oct 29, 2026, 5:11 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Contingency Management Using Smartphone App in Patients With SUD

NCT04162132
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Smartphone app
Device
Lead sponsor
BrightView LLC
Industry
Eligibility
Not listed
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 20, 2019 · Synced Oct 29, 2026, 5:11 AM EDT
Recruiting Early Phase 1 Interventional

Evaluating Pain Control Strategies in Postpartum Patients on Opioid Use Disorder Medications.

NCT06617949
View directory record Official record
Conditions
Substance Use Disorder (SUD)
Interventions
Regional Anesthesia, Hydromorphone Patient Controlled Analgelsic, Epidural local anesthetic infusion
Drug · Procedure
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
2
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Oct 29, 2026, 5:11 AM EDT