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Showing 1–24 of 98 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Substance Use Disorder (SUD) Clear all
Active, not recruiting Not applicable Interventional

Wellness, Intervention Strategies and HIV Care

NCT07069374
View directory record Official record
Conditions
HIV, Substance Use Disorder (SUD)
Interventions
Wellness, Intervention Strategies and HIV Care (WISH), Movie Night Club - Attention and Time Matched Control
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Oakland, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Sep 14, 2026, 1:51 AM EDT
Completed Not applicable Interventional Results available

SUPER Study (Substance Use and PTSD Treatment Effectiveness Research Study)

NCT00265564
View directory record Official record
Conditions
Substance Use Disorders, Posttraumatic Stress Disorder
Interventions
Modified Seeking Safety integrated into std outpatient SUD care, Standard outpatient SUD care
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older · Male only
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 6, 2020 · Synced Sep 14, 2026, 1:51 AM EDT
Not yet recruiting Early Phase 1 Interventional Accepts healthy volunteers

Research Investigating Drug Effects-2 (RiDE-2)

NCT06758596
View directory record Official record
Conditions
Cannabis Use, Substance Use Disorder (SUD), Healthy
Interventions
Placebo Oral Capsule, THC
Drug
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 21 Years
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2031
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 18, 2025 · Synced Sep 14, 2026, 1:51 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pilot Test of a Mobile App That Helps Spanish-speakers Find Mental Health Services in the US.

NCT06619431
View directory record Official record
Conditions
Health Disparity, Minority and Vulnerable Populations
Interventions
Mobile Application
Device
Lead sponsor
Volver Health
Industry
Eligibility
18 Years to 75 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Sep 30, 2024 · Synced Sep 14, 2026, 1:51 AM EDT
Recruiting Not applicable Interventional

Reducing Parental Substance Use and Enhancing Family Resilience Among Rural Families Through Ohio START

NCT07278427
View directory record Official record
Conditions
Substance Use Disorder (SUD), Rural Health, Family Resilience, Child Maltreatment, Child Well-beiing, Substance Use Recovery
Interventions
Ohio START (Ohio Sobriety, Treatment, and Reducing Trauma)
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Sep 14, 2026, 1:51 AM EDT
Recruiting Early Phase 1 Interventional

Evaluating Pain Control Strategies in Postpartum Patients on Opioid Use Disorder Medications.

NCT06617949
View directory record Official record
Conditions
Substance Use Disorder (SUD)
Interventions
Regional Anesthesia, Hydromorphone Patient Controlled Analgelsic, Epidural local anesthetic infusion
Drug · Procedure
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
2
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Sep 14, 2026, 1:51 AM EDT
Recruiting Not applicable Interventional

Project COMET: Massed Prolonged Exposure for PTSD and SUD

NCT06968832
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD), Substance Use Disorders (SUD), Comorbidity, Trauma and Stressor Related Disorders
Interventions
Massed Prolonged Exposure Therapy (M-PE), Standard outpatient SUD care
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 26, 2025 · Synced Sep 14, 2026, 1:51 AM EDT
Active, not recruiting Not applicable Interventional

EXHIT ENTRE Implementation Trial of High Intensity Versus Low Intensity Strategy

NCT04921787
View directory record Official record
Conditions
Substance Use Disorders, Opioid Use Disorder, Severe, Opioid Use Disorder, Moderate
Interventions
Low Intensity, High Intensity
Other
Lead sponsor
Gavin Bart
Other
Eligibility
Not listed
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
4
States / cities
Boston, Massachusetts • Minneapolis, Minnesota • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Sep 14, 2026, 1:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Atomoxetine for Attention Deficit Hyperactivity Disorder in Adolescents With Substance Use Disorder

NCT00399763
View directory record Official record
Conditions
Attention Deficit Hyperactivity Disorder, Substance Abuse
Interventions
Atomoxetine, Placebo
Drug
Lead sponsor
Denver Health and Hospital Authority
Other
Eligibility
12 Years to 19 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 7, 2015 · Synced Sep 14, 2026, 1:51 AM EDT
Terminated Phase 2 Interventional

A Study to Investigate the Safety and Efficacy of TMP-301 Compared to Placebo in Adult Patients With Alcohol Use Disorder

NCT06648655
View directory record Official record
Conditions
Alcohol Use Disorder (AUD)
Interventions
TMP-301, Placebo
Drug
Lead sponsor
Tempero Bio, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
14
States / cities
Scottsdale, Arizona • New Haven, Connecticut • Hollywood, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Sep 14, 2026, 1:51 AM EDT
Not yet recruiting Phase 2 Interventional

Substance Use in Pregnancy - Optimizing Retention in Treatment by Maximizing Opportunities for Management

NCT07776457
View directory record Official record
Conditions
Pregnancy, Substance Use Disorder (SUD)
Interventions
Contingency Management, Social Drivers of Health Screening
Behavioral · Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older · Female only
Enrollment
245 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Sep 14, 2026, 1:51 AM EDT
Completed No phase listed Observational

Mindfulness and Meditation-Based Relapse Prevention for Substance Use Disorders

NCT07417579
View directory record Official record
Conditions
Substance Use Disorders, Behavioral Health, Addiction Psychological, Addiction Disorders, Meditation, Mindfulness Based Stress Reduction, Prevention
Interventions
Mindfulness and Meditation-Based Relapse Prevention Program
Behavioral
Lead sponsor
Bout Me Healing
Industry
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Boca Raton, Florida
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 14, 2026, 1:51 AM EDT
Completed Not applicable Interventional

Body-oriented Therapy for Women in SUD Treatment

NCT01960036
View directory record Official record
Conditions
Substance Use Disorder
Interventions
Mindful Awareness in Body-oriented Therapy, Womens Health Education
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
217 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 11, 2018 · Synced Sep 14, 2026, 1:51 AM EDT
Not yet recruiting Not applicable Interventional

Recovery Works - Facilitating Sustainable Recovery Through Workforce

NCT07216612
View directory record Official record
Conditions
Substance Use Disorder (SUD)
Interventions
Community Restitution Apprenticeship-Focused Training (CRAFT), Standard Employment Model
Other
Lead sponsor
West Virginia School of Osteopathic Medicine
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Lewisburg, West Virginia
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Sep 14, 2026, 1:51 AM EDT
Recruiting Not applicable Interventional

Individualized Adaptive Deep Brain Stimulation in Opioid Use Disorder

NCT07214467
View directory record Official record
Conditions
Substance Use Disorder (SUD), Opioid Use Disorder (OUD)
Interventions
Deep Brain Stimulation
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
22 Years to 75 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2031
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Sep 14, 2026, 1:51 AM EDT
Completed Phase 2 Interventional Results available

CAP: Doxazosin in the Treatment of Co-Occurring PTSD and Alcohol Use Disorders

NCT02500602
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Alcohol Use Disorders
Interventions
doxazosin, placebo
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 12, 2021 · Synced Sep 14, 2026, 1:51 AM EDT
Terminated Phase 2Phase 3 Interventional

Substance Use Disorder (SUD)-Associated Infections' Treatment With Dalbavancin ENabling OUtpatient Transition

NCT04847921
View directory record Official record
Conditions
Gram-Positive Bacterial Infections, Gram-Positive Bacteraemia, Substance Use Disorders, Intravenous Substance Abuse
Interventions
Dalbavancin
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 18, 2023 · Synced Sep 14, 2026, 1:51 AM EDT
Enrolling by invitation Not applicable Interventional

Incentives and Long-Acting Injectable Adherence After Involuntary Hospitalization

NCT07130500
View directory record Official record
Conditions
Schizophrenia Disorder, Schizoaffective Disorder, Bipolar Disorder (BD), Substance Use Disorder (SUD)
Interventions
Financial incentives for adherence to long-acting injectable medication, Standard of care with monthly surveys
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 65 Years
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
5
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Sep 14, 2026, 1:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Records for Alcohol Care Enhancement

NCT05492942
View directory record Official record
Conditions
Alcohol Use Disorder (AUD)
Interventions
Best Practice Advisory (BPA) and Population Health Management (PHM), Best Practice Advisory (BPA) and Clinical Care Management (CCM), Best Practice Advisory (BPA) and Population Health Management (PHM) and Clinical Care Management (CCM)
Behavioral
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
134 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Sep 14, 2026, 1:51 AM EDT
Recruiting Not applicable Interventional

Culturally Engaged REcovery: MOms Connected Through Native communitY

NCT06747442
View directory record Official record
Conditions
Substance Use Disorders (SUD), Pregnancy, Maternal Morbidity and Mortality, Cultural Adaptation
Interventions
Cradleboard Journey
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older · Female only
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Sep 14, 2026, 1:51 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Open-Label Psilocybin Study in Transdiagnostic Population

NCT06442423
View directory record Official record
Conditions
Transdiagnostic, Depression - Major Depressive Disorder, Anxiety, PTSD Symptoms, PTSD, Substance Use, Substance Use Disorder (SUD), OCD
Interventions
Psilocybin
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Sep 14, 2026, 1:51 AM EDT
Not yet recruiting Not applicable Interventional

Combining Social Network Strategies and Routine Substance Use Screening

NCT07414459
View directory record Official record
Conditions
HIV, Substance Use Disorder (SUD)
Interventions
Substance use disorder screening, Social network intervention
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Male only
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Sep 14, 2026, 1:51 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Adolescent Stress and Substance Intervention Subsequent to Trauma

NCT07197476
View directory record Official record
Conditions
PTSD, Substance Use Disorder (SUD), Acute Stress Disorder
Interventions
ASSIST Video Intervention
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
12 Years to 17 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Sep 14, 2026, 1:51 AM EDT
Completed Phase 2Phase 3 Interventional

EXHIT ENTRE Comparative Effectiveness Trial

NCT04345718
View directory record Official record
Conditions
Substance Use Disorder, Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe
Interventions
Extended Release Buprenorphine, Treatment as Usual
Drug
Lead sponsor
Gavin Bart
Other
Eligibility
18 Years and older
Enrollment
344 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
6
States / cities
New Haven, Connecticut • Baltimore, Maryland • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Sep 14, 2026, 1:51 AM EDT