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Showing 1–24 of 249 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Substance Use Prevention Clear all
Not yet recruiting Not applicable Interventional

Remote Intervention to Prevent Overdose

NCT07128485
View directory record Official record
Conditions
Accidental Overdose of Opiate
Interventions
Overdose prevention resources, Overdose prevention education
Other · Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Sep 6, 2026, 2:17 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Effects of Chantix on Relapse Prevention for Smoking Cessation

NCT00948649
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Placebo, Varenicline
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 16, 2010 · Synced Sep 6, 2026, 2:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Preventing HIV Among Native Americans Through the Treatment PTSD & Substance Use

NCT03112369
View directory record Official record
Conditions
HIV Prevention, PTSD and Substance Use Disorder
Interventions
Narrative Exposure Therapy (NET), Motivational Interviewing w/Skills Training (MIST)
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
16 Years and older
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 6, 2026, 2:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Community-Based, Client-Centered Prevention Homes to Address the Rural Opioid Epidemic- Aim 3

NCT04268173
View directory record Official record
Conditions
Drug Use Disorders, Hepatitis C, Harm Reduction, Opioid-use Disorder
Interventions
Community-Based, Client-Centered Prevention Home
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
343 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
6
States / cities
Appleton, Wisconsin • Eau Claire, Wisconsin • Green Bay, Wisconsin + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 31, 2024 · Synced Sep 6, 2026, 2:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Minds and Mentors Program (MiMP)- R61

NCT04233671
View directory record Official record
Conditions
Opioid-use Disorder, Medication Assisted Treatment, Substance Use Disorders
Interventions
Mindfulness based relapse prevention and peer mentoring
Behavioral
Lead sponsor
University of Alabama, Tuscaloosa
Other
Eligibility
19 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
2
States / cities
Birmingham, Alabama • Homewood, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 20, 2023 · Synced Sep 6, 2026, 2:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Southwest Hub for American Indian Youth Suicide Prevention Research

NCT03543865
View directory record Official record
Conditions
Suicide, Surveillance, Mental Health, Substance Use, Depressive Symptoms
Interventions
New Hope (NH), Elders Resilience (ER), Case Management (CM)
Behavioral · Other
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
16 Years to 29 Years
Enrollment
304 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Whiteriver, Arizona
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Sep 6, 2026, 2:17 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

A Trial of Connecting to Promote Foster Teen Well-Being

NCT03157895
View directory record Official record
Conditions
Relationship, Family (Foster), Substance Use Prevention
Interventions
Connecting
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
11 Years to 15 Years
Enrollment
220 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 30, 2019 · Synced Sep 6, 2026, 2:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Preventing HIV/STI in Urban Adolescents Via an mHealth Primary Care Intervention

NCT03368456
View directory record Official record
Conditions
HIV/AIDS and Infections, Drug Abuse, Adolescent Behavior, Drug Usage
Interventions
S4E, Usual Care
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
14 Years to 21 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Ypsilanti, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 30, 2022 · Synced Sep 6, 2026, 2:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Prevention of Substance Use in Youth in Ukraine

NCT02347644
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Brief Motivational Interview
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 25 Years
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 2, 2015 · Synced Sep 6, 2026, 2:17 AM EDT
Completed Not applicable Interventional

Providing PrEP, Hepatitis C Treatment, and MOUD Through Telemedicine at Greensboro SSP

NCT05108935
View directory record Official record
Conditions
Opioid Use, Opioid Use Disorder, Risk Reduction, Hiv, Hepatitis C
Interventions
Suboxone, Truvada, Mavyret
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
2
States / cities
Durham, North Carolina • Greensboro, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 26, 2023 · Synced Sep 6, 2026, 2:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

TACUNA (Traditions and Connections for Urban Native Americans)

NCT04617938
View directory record Official record
Conditions
Opioid Use, Alcohol Drinking, Marijuana Use
Interventions
TACUNA plus Wellness Circle, Opioid Education Workshop
Behavioral
Lead sponsor
RAND
Other
Eligibility
18 Years to 25 Years
Enrollment
541 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
3
States / cities
Los Angeles, California • Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Sep 6, 2026, 2:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Rapid Self-Testing to Prevent Fentanyl Overdose Among Young People Who Use Drugs

NCT03373825
View directory record Official record
Conditions
Accidental Overdose of Opiate
Interventions
Take home rapid drug test
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 35 Years
Enrollment
93 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 23, 2018 · Synced Sep 6, 2026, 2:17 AM EDT
Completed Not applicable Interventional

Pre-exposure Prophylaxis (PrEP) Rapid Access

NCT05528562
View directory record Official record
Conditions
Drug Use, Pre-exposure Prophylaxis (PrEP), Opioid Use Disorder
Interventions
PrEP Rapid Access, HIV self-testing, Dried blood spot testing
Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 15, 2024 · Synced Sep 6, 2026, 2:17 AM EDT
Enrolling by invitation Not applicable Interventional

Optimizing and Advancing SBIRT in Schools

NCT06206161
View directory record Official record
Conditions
Adolescent Drinking, Adolescent Substance Use, Risk Behavior, Health
Interventions
Indicated Prevention, Clinical Staff, Selective Prevention, Expanded Paraprofessional Workforce
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
14 Years to 19 Years
Enrollment
21,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Sep 6, 2026, 2:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Master Mind Program Evaluation Study

NCT03212066
View directory record Official record
Conditions
Substance Abuse, Mindfulness
Interventions
Master Mind
Behavioral
Lead sponsor
Innovation Research & Training
Other
Eligibility
8 Years to 12 Years
Enrollment
518 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 9, 2019 · Synced Sep 6, 2026, 2:17 AM EDT
Recruiting Not applicable Interventional

Mindfulness-based Relapse Prevention for Peer Workers

NCT07741825
View directory record Official record
Conditions
Relapse/Recurrence, Substance Use (Drugs, Alcohol), Burnout
Interventions
Mindfulness Based Relapse Prevention, Standard of Care
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 100 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Sep 6, 2026, 2:17 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Qungasvik (Toolbox): Prevention of Alcohol/Suicide Risk in Alaska Native Youth

NCT05400135
View directory record Official record
Conditions
Suicide, Alcohol Use Disorder
Interventions
Qungasvik (Tools for Life)
Behavioral
Lead sponsor
University of Alaska Fairbanks
Other
Eligibility
12 Years to 21 Years
Enrollment
542 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
1
States / cities
Fairbanks, Alaska
Source: ClinicalTrials.gov public record
Updated May 31, 2022 · Synced Sep 6, 2026, 2:17 AM EDT
Completed Phase 4 Interventional Results available

Extended-Release Naltrexone vs. Buprenorphine for Opioid Treatment

NCT02032433
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Extended-Release Naltrexone, Buprenorphine-Naloxone
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
570 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
8
States / cities
Tarzana, California • Jacksonville, Florida • Rockville, Maryland + 5 more
Source: ClinicalTrials.gov public record
Updated Aug 12, 2020 · Synced Sep 6, 2026, 2:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Prevention of Substance Use in At-Risk Students: A Family-Centered Web Program

NCT03060291
View directory record Official record
Conditions
Substance Use, Conduct Disorders in Adolescence, Depression, Anxiety
Interventions
FCU-Online, web/ mobile only, FCU-Online, web/ mobile + coach
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
Not listed
Enrollment
322 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 18, 2023 · Synced Sep 6, 2026, 2:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Automating Peer Learning to Reduce Alcohol Use and Related Deviant Behavior in Secondary School

NCT04478240
View directory record Official record
Conditions
Substance Use, Stress, Relation, Interpersonal, Bullying, Victimisation, Mental Health Issue, Sleep, Inadequate, Social Skills
Interventions
PeerLearning.net
Behavioral
Lead sponsor
Oregon Research Behavioral Intervention Strategies, Inc.
Industry
Eligibility
Not listed
Enrollment
924 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 2, 2023 · Synced Sep 6, 2026, 2:17 AM EDT
Recruiting Phase 4 Interventional

Long-acting Cabotegravir Injectable Pre-exposure Prophylaxis for People Who Inject Drugs

NCT07199335
View directory record Official record
Conditions
HIV, Substance Use Disorder (SUD), Injection Drug Use
Interventions
APRETUDE (cabotegravir)
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Sep 6, 2026, 2:17 AM EDT
Recruiting Not applicable Interventional

Pre-exposure Prophylaxis (PrEP) Uptake and Adherence Intervention for Women with Trauma-related Conditions

NCT06558825
View directory record Official record
Conditions
Substance Use
Interventions
Integrated Intervention to Promote PrEP Uptake, Standard Treatment Condition
Behavioral · Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 29, 2024 · Synced Sep 6, 2026, 2:17 AM EDT
Not listed Not applicable Interventional

Preventing OUD in Justice-Involved Youth

NCT04901312
View directory record Official record
Conditions
Substance Use Disorders, Recidivism
Interventions
Adolescent Community Reinforcement Approach, Assertive Continuing Care, Trauma Affect Regulation Guide for Education and Therapy, Motivational Interviewing, Opioid Education Workbook
Behavioral · Other
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
15 Years to 25 Years
Enrollment
215 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Olympia, Washington
Source: ClinicalTrials.gov public record
Updated Oct 26, 2022 · Synced Sep 6, 2026, 2:17 AM EDT
Completed Not applicable Interventional Results available

Boston ARCH 4F Intervention to Reduce Fall Risk in People With HIV and Alcohol Use

NCT04804579
View directory record Official record
Conditions
HIV Infection, Alcohol Consumption, Falls, Accidental, Falls
Interventions
Fall Prevention Intervention
Behavioral
Lead sponsor
Boston University
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 28, 2023 · Synced Sep 6, 2026, 2:17 AM EDT