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ClinicalTrials.gov public records Last synced Oct 20, 2026, 8:02 PM EDT

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Showing 73–96 of 194 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Substance Use Recovery Clear all
Recruiting Not applicable Interventional

Project STRONGER: Stepped Care for Opioid Use Disorder Treatment Engagement and Recovery

NCT07115030
View directory record Official record
Conditions
Opioid Use Disorder, Intimate Partner Violence (IPV), Post Traumatic Stress Disorder PTSD
Interventions
PCT+2HOPE
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older · Female only
Enrollment
532 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
3
States / cities
Bridgeport, Connecticut • Enfield, Connecticut • West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 20, 2026, 8:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Feasibility, Acceptability, Usability, and an Initial Estimate of Effect of a Novel Training Platform on Peer Recovery Supporter Skill, Adherence, and Knowledge Gain-Phase I

NCT07090590
View directory record Official record
Conditions
Substance-related Disorders, Alcohol and Other Substance Use Prevention, Alcohol and Other Drug Use Disorders
Interventions
Thrive Digital Peer Platform (TDPP)
Behavioral
Lead sponsor
Thrive Digital Health, LLC
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Solon, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 29, 2025 · Synced Oct 20, 2026, 8:02 PM EDT
Recruiting Not applicable Interventional

Building Retention and Initiation Through Delivery of Peer-Guided Evidence-Based Practices

NCT07541417
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Certified Peer Support Specialist Intervention
Behavioral
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
750 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Oct 20, 2026, 8:02 PM EDT
Active, not recruiting Not applicable Interventional

Substance Use Prevention for Youth With Parents in Recovery

NCT05397691
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Modified Family Talk, Control-like parameter estimation
Other
Lead sponsor
Brown University
Other
Eligibility
12 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Pawtucket, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Oct 20, 2026, 8:02 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Community Driven Substance Use Recovery for High Opioid Overdose Areas

NCT05260047
View directory record Official record
Conditions
Substance Use, Mental Health Issue, Opioid Use, Medication Assisted Treatment
Interventions
IMANI, Telehealth MAT, Traditional MAT plus Referral and Linkage
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
525 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
8
States / cities
Bridgeport, Connecticut • Hartford, Connecticut • New Britain, Connecticut + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 20, 2026, 8:02 PM EDT
Completed Not applicable Interventional

Competitive Revision for CLARO: Collaboration Leading to Addiction Treatment and Recovery From Other Stresses

NCT04634279
View directory record Official record
Conditions
Opioid-use Disorder, Addiction, Depression, Post Traumatic Stress Disorder, Suicidal Ideation
Interventions
Collaborative care Plus
Behavioral
Lead sponsor
RAND
Other
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
12
States / cities
Los Angeles, California • Santa Monica, California • Albuquerque, New Mexico + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 9, 2024 · Synced Oct 20, 2026, 8:02 PM EDT
Recruiting Not applicable Interventional

Renewed Recovery: a Pilot Test of a Web-Based Mindfulness-Based Relapse Prevention Continuing Care Intervention for Alcohol Use Disorder

NCT06987526
View directory record Official record
Conditions
Alcohol Use Disorder (AUD)
Interventions
Mindfulness-Based Relapse Prevention
Behavioral
Lead sponsor
University of Georgia
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Macon, Georgia • Winder, Georgia
Source: ClinicalTrials.gov public record
Updated May 30, 2025 · Synced Oct 20, 2026, 8:02 PM EDT
Recruiting Not applicable Interventional

TMS to Improve Recovery Outcomes Among Patients With Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD)

NCT07171359
View directory record Official record
Conditions
Alcohol Use Disorder, Opioid Use Disorder
Interventions
TMS Low-Dose, TMS High-Dose
Device
Lead sponsor
Washington State University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 20, 2026, 8:02 PM EDT
Completed Not applicable Interventional

Understanding and Testing Recovery Processes for PTSD and Alcohol Use Following Sexual Assault

NCT04124380
View directory record Official record
Conditions
Alcohol; Use, Problem, Posttraumatic Stress Disorder
Interventions
Imaginal Exposure, Alcohol Skills Training, Supportive Telehealth
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 20, 2026, 8:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Peer-Delivered Episodic Future Thinking for Returning Citizens

NCT06119503
View directory record Official record
Conditions
Behavior, Health
Interventions
Elongating Time HOrizons for Reentry (ETHoR), Standardized Episodic Thinking (SET)
Behavioral
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Oct 20, 2026, 8:02 PM EDT
Not listed Not applicable Interventional

Contingency Management for Recovery Oriented Activities at Recovery Houses

NCT05585203
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Contingency management, Usual Care
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 8, 2024 · Synced Oct 20, 2026, 8:02 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Testing the CrOss Systems Technical Assistance for Retaining Staff (COSTARS) Model for Improving Staff Retention Among Child Welfare Workers and Peer Supporters, and Implementation of Evidence Based Interventions.

NCT07439783
View directory record Official record
Conditions
Substance Use Disorder, Opioid Use Disorder, Child Maltreatment, Implementation, Peer Recovery Supporters
Interventions
COSTARS, Implementation As Usual
Other
Lead sponsor
Alicia Bunger
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 20, 2026, 8:02 PM EDT
Recruiting Not applicable Interventional

Disclosure Intervention for People in Treatment for Opioid Use Disorder

NCT06458985
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Disclosing Recovery: A Decision Aid and Toolkit
Behavioral
Lead sponsor
University of Delaware
Other
Eligibility
18 Years and older
Enrollment
480 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Wilmington, Delaware
Source: ClinicalTrials.gov public record
Updated Jul 18, 2025 · Synced Oct 20, 2026, 8:02 PM EDT
Completed Not applicable Interventional Results available

Start Treatment and Recovery for Opioid Use Disorder

NCT04505540
View directory record Official record
Conditions
Opioid-use Disorder, Mental Disorder, Opioid Medication Assisted Treatment
Interventions
Bridge Clinic
Other
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Dec 11, 2023 · Synced Oct 20, 2026, 8:02 PM EDT
Completed Not applicable Interventional

Collaboration Leading to Addiction Treatment and Recovery From Other Stresses

NCT04559893
View directory record Official record
Conditions
Opioid-use Disorder, Addiction, Depression, Post-traumatic Stress Disorder
Interventions
Collaborative Care
Behavioral
Lead sponsor
RAND
Other
Eligibility
18 Years and older
Enrollment
729 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
16
States / cities
Los Angeles, California • Santa Monica, California • Albuquerque, New Mexico + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 15, 2025 · Synced Oct 20, 2026, 8:02 PM EDT
Recruiting Phase 2 Interventional

Study of Tirzepatide for Recovery and Alcohol Use Management

NCT06727331
View directory record Official record
Conditions
Alcohol Use Disorder (AUD)
Interventions
Tirzepatide, Saline Placebo
Drug · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Boston, Massachusetts • Jamaica Plain, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 20, 2026, 8:02 PM EDT
Terminated Not applicable Interventional

A Multimodal Enhanced Recovery Program in Anorectal Surgery

NCT03992079
View directory record Official record
Conditions
Colorectal Disorders, Anorectal Disorder, Patient Satisfaction, Pain, Postoperative, Opioid Use, Opioid Abuse, Opioid Dependence
Interventions
ReCOVER Enhanced Recovery Protocol
Procedure
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 25, 2020 · Synced Oct 20, 2026, 8:02 PM EDT
Completed Not applicable Interventional Results available

FOREward Together: Training Peer Recovery Coaches to Promote Retention and Adherence to MOUD

NCT05098795
View directory record Official record
Conditions
Opioid Use
Interventions
Behavioral Activation (BA)
Behavioral
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 14, 2025 · Synced Oct 20, 2026, 8:02 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Coordinated Access for Addiction Recovery and Equity in VA Supportive Housing

NCT07141394
View directory record Official record
Conditions
Homelessness, Substance Use Disorder (SUD)
Interventions
Medication for Addiction Treatment (MAT), Cognitive Behavioral Therapy for Substance Use Disorders (CBT-SUD)
Drug · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
7,908 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
West Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 20, 2026, 8:02 PM EDT
Recruiting Phase 3 Interventional

Smartphones for Opiate Addiction Recovery

NCT05033028
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Smartphone app
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 85 Years
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
2
States / cities
Piscataway, New Jersey • New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Oct 20, 2026, 8:02 PM EDT
Completed Not applicable Interventional

Enhancing Prospective Thinking in Early Recovery (NERF)

NCT06283446
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
High-Intensity Cue, Low-Intensity Cue
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 60 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 28, 2026 · Synced Oct 20, 2026, 8:02 PM EDT
Completed Not applicable Interventional

Enhancing Prospective Thinking in Early Recovery (PARK)

NCT05908097
View directory record Official record
Conditions
Opioid Use, Opioid Use Disorder, Substance Use Disorders
Interventions
Virtual Reality Avatar Intervention, Virtual Reality Empty Park
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 60 Years
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
Indianapolis, Indiana • Coburg, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 20, 2026, 8:02 PM EDT
Not yet recruiting Phase 2 Interventional

Psilocybin Therapy for Methamphetamine Use Disorder and HIV

NCT07756736
View directory record Official record
Conditions
Methamphetamine Use Disorder, Human Immunodeficiency Virus (HIV)
Interventions
Psilocybin 5 mg, Psilocybin 25 mg, Motivational Support
Drug · Behavioral
Lead sponsor
Nicky Mehtani, MD, MPH
Other
Eligibility
25 Years to 64 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 20, 2026, 8:02 PM EDT
Completed No phase listed Observational Results available

Impact of Modifiable Psychosocial Factors on Veterans' Long-term Trajectories of Functioning and Quality of Life

NCT03615222
View directory record Official record
Conditions
PTSD, Depression, Chronic Pain, Alcohol Use Disorder, Traumatic Brain Injury
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
377 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
2
States / cities
Temple, Texas • Waco, Texas
Source: ClinicalTrials.gov public record
Updated Oct 24, 2024 · Synced Oct 20, 2026, 8:02 PM EDT