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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Substance-induced Cognitive Disorder Clear all
Completed Not applicable Interventional

Neurocognitive Empowerment for Addiction Treatment (NEAT) in Opioid Use Disorder and Amphetamine Use Disorder

NCT03922646
View directory record Official record
Conditions
Opioid-use Disorder, Amphetamine Use Disorders
Interventions
Neurocognitive Empowerment for Addiction Treatment (NEAT), Active Control
Behavioral
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Aug 27, 2023 · Synced Sep 26, 2026, 12:23 PM EDT
Completed Not applicable Interventional Results available

Efficacy and Mechanisms of CBT4CBT for Alcohol Use Disorders

NCT02742246
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Individual clinician-provided CBT, CBT4CBT
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
2
States / cities
Bridgeport, Connecticut • New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Sep 26, 2026, 12:23 PM EDT
Enrolling by invitation Not applicable Interventional

Developing and Testing Innovative Care Pathways for Screening and Treatment of OUD/PTSD in Jails

NCT07490717
View directory record Official record
Conditions
Post-traumatic Stress Disorder (PTSD), Post-traumatic Stress Symptoms, Opioid Use Disorder (OUD), Stimulant Use Disorder, Stimulant Use & Co-occuring Opioid Use Disorders, Co-occurring Mental and Substance Use Disorders, Medications for Opioid Use Disorder
Interventions
Cognitive Processing Therapy (CPT), Written Exposure Therapy (WET)
Other
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years and older
Enrollment
338 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
2
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Sep 26, 2026, 12:23 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

The Effect of Prescription Medications in Marijuana Users

NCT00893074
View directory record Official record
Conditions
Marijuana Abuse
Interventions
Dronabinol 30mg/day, Dronabinol 60mg/day, Dronabinol 120mg/day, Placebo
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 2, 2017 · Synced Sep 26, 2026, 12:23 PM EDT
Completed Phase 2 Interventional Results available

Gabapentin Treatment of Cannabis Dependence

NCT00974376
View directory record Official record
Conditions
Cannabis Dependence, Cannabis Withdrawal, Cognitive Deficits
Interventions
gabapentin 1200mg/day, Placebo, Manual-guided behavioral counseling
Drug · Behavioral
Lead sponsor
The Scripps Research Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2016
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jun 5, 2017 · Synced Sep 26, 2026, 12:23 PM EDT
Completed Phase 2 Interventional

Sertraline and Cognitive Therapy in Depressed Alcoholics

NCT00000458
View directory record Official record
Conditions
Alcoholism, Depression
Interventions
sertraline (Zoloft), cognitive behavior therapy
Drug · Behavioral
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2002
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Sep 26, 2026, 12:23 PM EDT
Completed Not applicable Interventional Results available

Acceptability and Feasibility of Cognitive Behavioral Therapy for Treatment-Seeking (CBT-TS) With Deaf Individuals

NCT05520190
View directory record Official record
Conditions
Mental Health Issue, Alcohol Use Disorder, Depression, Anxiety, Insomnia, Post Traumatic Stress Disorder
Interventions
Cognitive Behavioral Therapy for Treatment Seeking (CBT-TS)
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jan 9, 2025 · Synced Sep 26, 2026, 12:23 PM EDT
Terminated Phase 2 Interventional Results available

Efficacy of D-Cycloserine for Enhancing the Effects of CBT for Substance Use

NCT00430573
View directory record Official record
Conditions
Substance-Related Disorders
Interventions
D-cycloserine, Placebo
Drug
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years to 70 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 16, 2018 · Synced Sep 26, 2026, 12:23 PM EDT
Recruiting Not applicable Interventional

Preoperative Opioid Tapering Before Spine Surgery

NCT07221786
View directory record Official record
Conditions
Opioid Consumption, Postoperative, Pain After Surgery, Opioid Dependency
Interventions
Opioid tapering with CBT and education, Opioid tapering with education alone
Other
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Philadephia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Sep 26, 2026, 12:23 PM EDT
Completed Phase 2Phase 3 Interventional

The Combination of Donepezil and Cognitive Training for Treating Alcohol Use Disorder

NCT04318639
View directory record Official record
Conditions
Alcohol Use Disorder, Mild Cognitive Impairment
Interventions
Donepazil
Combination Product
Lead sponsor
VA Connecticut Healthcare System
Federal
Eligibility
21 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 23, 2020 · Synced Sep 26, 2026, 12:23 PM EDT
Completed Not applicable Interventional

Chronic Pain and Opioid Dependence Assessment and Treatment

NCT00727675
View directory record Official record
Conditions
Chronic Pain, Opioid Dependency
Interventions
Integrated Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2015
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 2, 2020 · Synced Sep 26, 2026, 12:23 PM EDT
Recruiting Not applicable Interventional

Enhancing Addiction Treatment Through Psychoeducation

NCT07178158
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Installing the Metacognium software app, Continue treatment as usual
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Sep 26, 2026, 12:23 PM EDT
Not yet recruiting Phase 1 Interventional Accepts healthy volunteers

Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance

NCT06351540
View directory record Official record
Conditions
Cannabis Use, Impaired Driving, Cognitive Impairment
Interventions
Cannabis
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 26, 2026, 12:23 PM EDT
Completed Not applicable Interventional Results available

Targeting Self-regulatory Deficits Through Cognitive Remediation Intervention

NCT03373240
View directory record Official record
Conditions
Drug Use Disorders
Interventions
TAU plus Cognitive Remediation Program, TAU plus Control Tasks
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 50 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 7, 2021 · Synced Sep 26, 2026, 12:23 PM EDT
Completed Phase 2 Interventional

Youth Drug Abuse Family and Cognitive-Behavioral Therapy

NCT00198874
View directory record Official record
Conditions
Drug Abuse
Interventions
Integrated Family and Cognitive-Behavioral Therapy, Education
Behavioral · Other
Lead sponsor
University of Florida
Other
Eligibility
13 Years to 21 Years
Enrollment
296 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 27, 2012 · Synced Sep 26, 2026, 12:23 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers Results available

The Effect of Food on the Oral Bioavailability of AEF0117 in Healthy Volunteers

NCT05451017
View directory record Official record
Conditions
Marijuana Abuse
Interventions
3ß-(4-methoxybenzyloxy)pregn-5-en-20-one in fed condition, 3ß-(4-methoxybenzyloxy)pregn-5-en-20-one in fasting condition
Drug
Lead sponsor
Aelis Farma
Industry
Eligibility
18 Years to 55 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Sep 26, 2026, 12:23 PM EDT
Not listed Phase 4 Interventional

Cognitive Correlates of Substance Abuse - 11

NCT00000346
View directory record Official record
Conditions
Amphetamine-Related Disorders
Interventions
counseling
Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
Not listed
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Sep 26, 2026, 12:23 PM EDT
Terminated Early Phase 1 Interventional Accepts healthy volunteers

N-acetylcysteine Effects on Tetrahydrocannabinol

NCT02335060
View directory record Official record
Conditions
Healthy
Interventions
Delta-9-THC, N-acetylcysteine, Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 55 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 30, 2022 · Synced Sep 26, 2026, 12:23 PM EDT
Completed Phase 1 Interventional

Outpatient Adolescent Treatment for Comorbid Substance Use and Internalizing Disorders

NCT00438685
View directory record Official record
Conditions
Substance-Related Disorders, Depressive Disorder, Anxiety Disorder
Interventions
Outpatient MST/OPTION-A, Usual Services
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
12 Years to 17 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 13, 2018 · Synced Sep 26, 2026, 12:23 PM EDT
Completed Not applicable Interventional Results available

Cognitive Retraining and Brain Stimulation for Alcohol Use

NCT02045108
View directory record Official record
Conditions
Binge Drinking
Interventions
Active Retraining, Sham TDCS, Active TDCS, Sham Retraining
Behavioral · Device
Lead sponsor
The Mind Research Network
Other
Eligibility
21 Years to 30 Years
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Mar 19, 2018 · Synced Sep 26, 2026, 12:23 PM EDT
Completed Not applicable Interventional

Cognitive Behavioral Smoking Cessation Intervention for Adults With Chronic Pain

NCT01091090
View directory record Official record
Conditions
Smoking Cessation
Interventions
Cognitive behavioral, Control
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 24, 2012 · Synced Sep 26, 2026, 12:23 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

PURSUIT: A Technologically Augmented School-based Program to Improve Child Coping and Prevent Substance Use.

NCT07266740
View directory record Official record
Conditions
Pediatric Pain, Anxiety, Mood, Stress, Feasibility Studies, Acceptability, Health Promotion, Online Mental Health Program
Interventions
PURSUIT
Behavioral
Lead sponsor
Michigan State University
Other
Eligibility
8 Years to 18 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Sep 26, 2026, 12:23 PM EDT
Completed Not applicable Interventional Results available

Computer Based Treatment for Cognitive Behavioral Therapy and Cooperative Pain Education and Self-Management

NCT05204576
View directory record Official record
Conditions
Opioid Use Disorder, Chronic Pain
Interventions
CBT4CBT COPES
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
3
States / cities
Bridgeport, Connecticut • Danbury, Connecticut • Waterbury, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 26, 2026, 12:23 PM EDT
Active, not recruiting Not applicable Interventional

Open Pilot Trial of Adapted Cognitive Processing Therapy for Comorbid PTSD and Opioid Use Disorder

NCT06872164
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD), Opioid Use Disorder
Interventions
Cognitive Processing Therapy
Behavioral
Lead sponsor
The City College of New York
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 26, 2026, 12:23 PM EDT