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Showing 1–20 of 20 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Substrate Oxidation Clear all
Recruiting No phase listed Observational

Relationship Between Aspirin Metabolism and Markers of Metabolic Dysfunction Among Pregnant Persons at Risk of Pre-eclampsia

NCT06802861
View directory record Official record
Conditions
Preeclampsia, Preeclampsia (PE), Preeclampsia (PE) Risk, Obesity and Obesity-related Medical Conditions, Pregnancy, Pregnancy Complications, Gestational Diabetes, Gestational Diabetes Mellitus in Pregnancy, Gestational Complications
Interventions
Not listed
Lead sponsor
University of Tennessee Graduate School of Medicine
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 9, 2025 · Synced Jul 22, 2026, 4:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Fat Burning After a Meal

NCT02211599
View directory record Official record
Conditions
Postprandial Effect of Carbohydrate Beverage Consumption
Interventions
15% protein, 30% protein, Sweetened beverage
Other
Lead sponsor
USDA Grand Forks Human Nutrition Research Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Grand Forks, North Dakota
Source: ClinicalTrials.gov public record
Updated Feb 1, 2022 · Synced Jul 22, 2026, 4:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

SubsTRate OxidatioN in Girls

NCT04483921
View directory record Official record
Conditions
Overweight Adolescents
Interventions
Acute exercise
Other
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
13 Years to 17 Years · Female only
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 1, 2024 · Synced Jul 22, 2026, 4:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Eating Beans on Metabolism

NCT06123208
View directory record Official record
Conditions
Overweight
Interventions
Whole cooked pinto bean, Pinto bean flour, Control
Other
Lead sponsor
USDA Grand Forks Human Nutrition Research Center
Federal
Eligibility
19 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Grand Forks, North Dakota
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Jul 22, 2026, 4:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Development of Novel Therapies for NIDDM

NCT01905722
View directory record Official record
Conditions
Metabolism
Interventions
3 Tesla, 7 Tesla
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 60 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 30, 2019 · Synced Jul 22, 2026, 4:51 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Energy Expenditure and Substrate Oxidation in a Whole Room Calorimeter

NCT04061369
View directory record Official record
Conditions
Overweight, Obesity, Body Weight
Interventions
Low fat meal, Moderate fat meal, High fat meal, High fat liquid meal
Other
Lead sponsor
USDA, Western Human Nutrition Research Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated May 14, 2023 · Synced Jul 22, 2026, 4:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Protective Effect of Exercise on Acute High-fat Overfeeding

NCT07633704
View directory record Official record
Conditions
Insulin Sensitivity/Resistance
Interventions
High Fat Overfeeding, High Fat Overfeeding + Exercise
Behavioral
Lead sponsor
George Washington University
Other
Eligibility
20 Years to 40 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Jul 22, 2026, 4:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Exercise-Induced Rates of Fat Oxidation with and Without Ingestion of a Caffeine-Based Energy Drink

NCT06308731
View directory record Official record
Conditions
Substrate Oxidation, Energy Expenditure, Reaction Time, Cognition, Exercise Performance
Interventions
Caffeine-Based Energy Drink, Placebo
Dietary Supplement · Other
Lead sponsor
Lindenwood University
Other
Eligibility
18 Years to 50 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Saint Charles, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 16, 2024 · Synced Jul 22, 2026, 4:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Caloric Content and Timing of Meal on Postprandial Substrate Oxidation and Pulse Wave Analysis

NCT07122765
View directory record Official record
Conditions
Feeding, Metabolism, Indirect Calorimetry, Blood Flow Velocity, Pulse Wave Analysis, Pulse Wave Velocity, Carbohydrate Metabolism, Fatty Acid Metabolism, Healthy Participants
Interventions
Mixed Meal Feeding Challenge
Other
Lead sponsor
George Washington University
Other
Eligibility
18 Years to 45 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Jul 22, 2026, 4:51 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Differences in Nutrient Use During Exercise Between Children of Varying Body Mass Indices and Fitness Levels

NCT04819308
View directory record Official record
Conditions
Obesity
Interventions
Not listed
Lead sponsor
Arkansas Children's Hospital Research Institute
Other
Eligibility
8 Years to 11 Years
Enrollment
95 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Feb 24, 2025 · Synced Jul 22, 2026, 4:51 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Effect of Hydration Status on Substrate Oxidation at Rest and During Light and Moderate Exercise

NCT07298863
View directory record Official record
Conditions
Hydration Status, Substrate Metabolism During Exercise
Interventions
Exercise Trial, Experimental Trial
Other
Lead sponsor
PepsiCo Global R&D
Industry
Eligibility
18 Years to 35 Years
Enrollment
74 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Valhalla, New York
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Jul 22, 2026, 4:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Astaxanthin Reduces Exercising Heart Rate.

NCT05282355
View directory record Official record
Conditions
Metabolic Flexibility
Interventions
Astaxanthin, Placebo
Dietary Supplement
Lead sponsor
University of North Alabama
Other
Eligibility
18 Years to 45 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Florence, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 15, 2022 · Synced Jul 22, 2026, 4:51 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Metabolic Adaptations to High-fat Diet

NCT06537401
View directory record Official record
Conditions
Adiposity, Insulin Sensitivity, Impaired Glucose Tolerance, Metabolic Disturbance
Interventions
Hypercaloric, High Fat Diet
Behavioral
Lead sponsor
George Washington University
Other
Eligibility
20 Years to 45 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 25, 2025 · Synced Jul 22, 2026, 4:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Black Pepper on Energy Expenditure and Substrate Utilization

NCT01729143
View directory record Official record
Conditions
Obesity
Interventions
24-hour energy expenditure and substrate utilization
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
50 Years to 65 Years · Female only
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 5, 2016 · Synced Jul 22, 2026, 4:51 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effects of Resistance Training on Substrate Metabolism During the Menstrual Cycle

NCT04024826
View directory record Official record
Conditions
Menstrual Cycle, Substrate Metabolism
Interventions
EFP, LFP, ELP, LLP
Behavioral
Lead sponsor
Southern Illinois University Edwardsville
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Edwardsville, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 3, 2021 · Synced Jul 22, 2026, 4:51 AM EDT
Recruiting No phase listed Observational

Cardiometabolic Disease and Substrate Metabolism

NCT07565727
View directory record Official record
Conditions
Preeclampsia, Gestational Diabetes Mellitus (GDM), Preeclampsia (PE), Preeclampsia (PE) Risk, Gestational Diabetes, Gestational Diabetes Mellitus in Pregnancy, Cardiometabolic Diseases, Insulin Resistance, Placental Dysfunction, Pregnancy, Pregnancy Complications, Gestational Complications
Interventions
Not listed
Lead sponsor
University of Tennessee Graduate School of Medicine
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Jul 22, 2026, 4:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Lactose, Fructose, Sucrose, Whey Protein, and Soy Protein on Substrate Absorption and Oxidation: a Pilot Study

NCT00942513
View directory record Official record
Conditions
Substrate Absorption, Substrate Oxidation, Glucose Regulation
Interventions
trt 1, trt 2, trt 3, trt 4, trt 5, trt 6, trt 7
Other
Lead sponsor
United States Department of Agriculture (USDA)
Federal
Eligibility
25 Years to 65 Years · Male only
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
U.S. locations
1
States / cities
Beltsville, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 8, 2011 · Synced Jul 22, 2026, 4:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Substrate Oxidation in Children in Response to High and Low Dairy Intake

NCT01664702
View directory record Official record
Conditions
Childhood Obesity
Interventions
Dairy Products, Dairy Servings
Dietary Supplement
Lead sponsor
University of Kansas
Other
Eligibility
10 Years to 13 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005
U.S. locations
1
States / cities
Lawrence, Kansas
Source: ClinicalTrials.gov public record
Updated Aug 13, 2012 · Synced Jul 22, 2026, 4:51 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Ketone Supplements and Substrate Oxidation and Physical Performance

NCT04737694
View directory record Official record
Conditions
Ketosis, Glucose Metabolism
Interventions
Ketone ester, Glucose
Dietary Supplement
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
18 Years to 39 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 13, 2021 · Synced Jul 22, 2026, 4:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sleep Restriction and Energy Expenditure

NCT01751581
View directory record Official record
Conditions
Obesity
Interventions
Short Sleep, Habitual sleep
Behavioral
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
21 Years to 45 Years · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 1, 2013 · Synced Jul 22, 2026, 4:51 AM EDT