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Showing 1–24 of 395 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Suicide and Self Harm Clear all
Completed Phase 4 Interventional Results available

Cyclical Neuroactive Steroid Changes, Arousal, and Proximal Suicide Risk: An Experimental Approach

NCT04112368
View directory record Official record
Conditions
Suicidal Ideation
Interventions
Estradiol Transdermal Patch 0.1 mg/24 hrs, Oral Micronized Progesterone 200mg, Inactive Clear Patch, Placebo capsule
Drug
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Jul 22, 2026, 2:18 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Digital Cognitive Behavior Therapy Program for Suicide Prevention

NCT03595254
View directory record Official record
Conditions
Suicidal Ideation, Depression, Anxiety
Interventions
Thrive
Behavioral
Lead sponsor
Montana State University
Other
Eligibility
18 Years and older
Enrollment
725 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated Sep 1, 2020 · Synced Jul 22, 2026, 2:18 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents

NCT05437588
View directory record Official record
Conditions
Major Depressive Disorder, Suicidal Ideas, Suicide, Attempted, MDD, Depression, Depression, Teen, Depression and Suicide, Depression in Adolescence, Suicide
Interventions
Genetic testing
Genetic
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
10 Years to 24 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
2
States / cities
Birmingham, Alabama • Huntsville, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Jul 22, 2026, 2:18 PM EDT
Recruiting Not applicable Interventional

Development and Testing of imHere4U: A Digital Suicide Prevention Intervention for Cyberbullied Adolescents

NCT06002191
View directory record Official record
Conditions
Psychological Distress, Suicidal Ideation
Interventions
Flourish, Questionnaires of Online Experiences
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years to 17 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Jul 22, 2026, 2:18 PM EDT
Not listed Not applicable Interventional

Suicide in Urban Natives: Detection and Networks to Combat Events

NCT03136094
View directory record Official record
Conditions
Suicide Prevention
Interventions
SBIRT+12, SBIRT+Usual Care
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 34 Years
Enrollment
698 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Jun 26, 2024 · Synced Jul 22, 2026, 2:18 PM EDT
Completed Not applicable Interventional

An ED-based RCT of Lethal Means Counseling for Parents of At-Risk Youth

NCT03143283
View directory record Official record
Conditions
Suicidal and Self-injurious Behavior
Interventions
Safety Study Lethal Means Counseling
Behavioral
Lead sponsor
Northeastern University
Other
Eligibility
10 Years to 17 Years
Enrollment
575 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
8
States / cities
Colorado Springs, Colorado • Fort Collins, Colorado • Loveland, Colorado + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 9, 2020 · Synced Jul 22, 2026, 2:18 PM EDT
Terminated Phase 2 Interventional Results available

Study of Efficacy and Safety of MIJ821 in Addition to Comprehensive Standard of Care on the Rapid Reduction of Symptoms of Major Depressive Disorder in Subjects Who Have Suicidal Ideation With Intent

NCT04722666
View directory record Official record
Conditions
Major Depressive Disorder With Suicidal Ideation With Intent
Interventions
MIJ821 Intravenous Injection, Placebo Intravenous Injection
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years to 65 Years
Enrollment
199 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
6
States / cities
Birmingham, Alabama • Farmington, Connecticut • Oakland Park, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Jul 22, 2026, 2:18 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Biomarkers as Predictors of Suicidal Risk in Adolescents

NCT03014518
View directory record Official record
Conditions
Suicide, Attempted, Suicidal Ideation, Suicidal Intention, Suicide
Interventions
Clinical assessments and blood samples; follow-up for 12 mos, Clinical assessments and blood samples; no 12mo follow-up
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
12 Years to 18 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 15, 2021 · Synced Jul 22, 2026, 2:18 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Teen Brain Training (TBT)

NCT06183580
View directory record Official record
Conditions
Suicide, Attempted, Suicide, Ideation, Depression
Interventions
neurofeedback training involving dACC, neurofeedback training involving amygdala
Other
Lead sponsor
University of Minnesota
Other
Eligibility
11 Years to 18 Years
Enrollment
157 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Jul 22, 2026, 2:18 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Improving Screening and Follow Up for Suicidal Ideation and Behaviors Among Latinx Youth in Primary Care

NCT06229223
View directory record Official record
Conditions
Suicidal Ideation
Interventions
PALOMA
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
10 Years to 100 Years
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 22, 2026, 2:18 PM EDT
Recruiting Not applicable Interventional

Flourish in Schools Pilot Study

NCT07506525
View directory record Official record
Conditions
Psychological Distress, Suicidal Ideation
Interventions
Flourish
Device
Lead sponsor
Candice Biernesser
Other
Eligibility
11 Years to 21 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Bay Village, Ohio • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Jul 22, 2026, 2:18 PM EDT
Recruiting Not applicable Interventional

Assessment of Emotion Regulation Strategies Used When Suicidal

NCT05722197
View directory record Official record
Conditions
Suicidal Ideation, Treatment Refusal, Emotion Regulation
Interventions
Crisis Response Planning and Lethal Means Safety Counseling
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
334 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Jul 22, 2026, 2:18 PM EDT
Completed Not applicable Interventional

Alcohol, Suicide and HIV Prevention for Teens in Mental Health Treatment

NCT02228044
View directory record Official record
Conditions
Suicide, Alcohol Abuse, Drug Abuse, HIV
Interventions
Prevention program
Behavioral
Lead sponsor
George Mason University
Other
Eligibility
13 Years to 18 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 27, 2014 · Synced Jul 22, 2026, 2:18 PM EDT
Completed Not applicable Interventional Results available

PracticeGround: Transforming Training and Delivery of Mental Health EBPs

NCT02314624
View directory record Official record
Conditions
Depression, Insomnia, Suicide
Interventions
Behavioral Activation for Depression, Cognitive Behavior Therapy for Insomnia, Collaborative Assessment and Management of Suicidality, Care-as-Usual Psychotherapy
Behavioral
Lead sponsor
Evidence-Based Practice Institute, Seattle, WA
Industry
Eligibility
18 Years and older
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 29, 2024 · Synced Jul 22, 2026, 2:18 PM EDT
Not listed Phase 3 Interventional

NRX-101 for Maintenance of Remission From Severe Bipolar Depression in Patients With Suicidal Ideation

NCT03396068
View directory record Official record
Conditions
Bipolar Depression, Suicidal Ideation
Interventions
NRX-101, Lurasidone HCl
Drug
Lead sponsor
NeuroRx, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
4
States / cities
Birmingham, Alabama • Hollywood, Florida • Fort Worth, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 18, 2024 · Synced Jul 22, 2026, 2:18 PM EDT
Completed Not applicable Interventional Results available

Combined TMS and Brief Cognitive Behavioral Therapy to Reduce Suicide

NCT03952468
View directory record Official record
Conditions
Suicide
Interventions
Transcranial Magnetic Stimulation, Brief Cognitive Behavioral Therapy
Device · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 75 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 8, 2025 · Synced Jul 22, 2026, 2:18 PM EDT
Recruiting Not applicable Interventional

Efficacy of the I-CARE Digital Health Intervention

NCT07150832
View directory record Official record
Conditions
Mental Health Disorder, Suicide Attempt, Suicidal Ideation, Emergency Psychiatric
Interventions
Improving Care, Accelerating Recovery & Education (ICARE)
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
12 Years to 17 Years
Enrollment
173 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
4
States / cities
New Haven, Connecticut • Hanover, New Hampshire • Lebanon, New Hampshire + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Jul 22, 2026, 2:18 PM EDT
Completed Not applicable Interventional Results available

Mobile Technology for Reducing and Preventing Adolescent Suicide

NCT04896593
View directory record Official record
Conditions
Suicide, Attempted, Suicidal Ideation
Interventions
Smartphone App
Behavioral
Lead sponsor
Hartford Hospital
Other
Eligibility
13 Years to 17 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 29, 2023 · Synced Jul 22, 2026, 2:18 PM EDT
Completed Not applicable Interventional

Treatment for Relationships and Safety Together

NCT04816149
View directory record Official record
Conditions
Suicide, Interpersonal Relations
Interventions
VA Standard Suicide Intervention, Treatment for Relationships and Safety Together (TR&ST)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Jul 22, 2026, 2:18 PM EDT
Recruiting Not applicable Interventional

The BEAR Program for Women With Trauma Who Have Suicidal Thoughts

NCT07346638
View directory record Official record
Conditions
Interpersonal Trauma, Depression, PTSD, Anxiety, Suicidal Ideations, Sexual Assault
Interventions
BEAR-SI
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 75 Years · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Jul 22, 2026, 2:18 PM EDT
Completed Not applicable Interventional

Adaptation and Evaluation of the KEEP Model

NCT05816421
View directory record Official record
Conditions
Depression, Anxiety, Post Traumatic Stress Disorder, Suicide and Self-harm, Externalizing Behavior
Interventions
KEEP, Non-Affinity KEEP
Behavioral
Lead sponsor
Oregon Social Learning Center
Other
Eligibility
4 Years to 21 Years
Enrollment
283 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 4, 2025 · Synced Jul 22, 2026, 2:18 PM EDT
Completed Not applicable Interventional Results available

Social Connections and Late Life Suicide

NCT02188485
View directory record Official record
Conditions
Depression, Suicidal Ideation
Interventions
ENGAGE
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
60 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 6, 2021 · Synced Jul 22, 2026, 2:18 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Suicide Prevention for Sexual and Gender Minority Youth (Randomized Controlled Trial)

NCT05669976
View directory record Official record
Conditions
Suicide
Interventions
Safety Planning Intervention with Navigation Services, Safety Planning Intervention
Behavioral
Lead sponsor
San Diego State University
Other
Eligibility
15 Years to 29 Years
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Jul 22, 2026, 2:18 PM EDT
Recruiting Not applicable Interventional

Project Safe Guard-Trauma

NCT06876740
View directory record Official record
Conditions
PTSD, Firearm Injury, Suicide Prevention, Firearm Safety
Interventions
Project Safe Guard - Trauma, Project Safe Guard
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 19, 2025 · Synced Jul 22, 2026, 2:18 PM EDT