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Showing 1–24 of 405 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Suicide and Self-harm Clear all
Completed Phase 3 Interventional

Risperidone and Suicidality in Major Depressive Disorder

NCT00167154
View directory record Official record
Conditions
Depression
Interventions
Risperidone and placebo comparator
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 9, 2021 · Synced Sep 22, 2026, 10:06 PM EDT
Not listed Phase 2Phase 3 Interventional

Emergency Ketamine Treatment of Suicidal Ideation

NCT02183272
View directory record Official record
Conditions
Depression, Suicidal Ideation, Suicidal Impulses
Interventions
Intranasal Ketamine, Intranasal Saline Placebo
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 4, 2016 · Synced Sep 22, 2026, 10:06 PM EDT
Recruiting Not applicable Interventional

Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality

NCT05925322
View directory record Official record
Conditions
Depression, Suicidal Ideation, Major Depressive Disorder, Depressive Disorder
Interventions
"Engage & Connect" Psychotherapy, Symptom Review and Psychoeducation (SRP)
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
50 Years to 80 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Not applicable Interventional

Randomized Controlled Trial of a Single-session Mechanism-focused Intervention for Suicidal Thoughts and Behaviors

NCT05816317
View directory record Official record
Conditions
Suicidal Ideation, Hopelessness, Wish to Live, Wish to Die
Interventions
Single-Session Mechanism-Focused Intervention (SSMFI), Distress Tolerance Skills Review
Behavioral
Lead sponsor
Shannon E. Sauer-Zavala
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 31, 2025 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Not applicable Interventional

Optimizing Suicide Prevention Strategies for Pediatric Primary Care

NCT06194331
View directory record Official record
Conditions
Suicidal Ideation, Suicidal and Self-injurious Behavior, Depression
Interventions
iCHART/cASAP, Treatment as usual
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years to 17 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Itasca, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 22, 2026, 10:06 PM EDT
Terminated Phase 2 Interventional

Ketamine for OUD and Suicidal Ideation in the ED

NCT06111339
View directory record Official record
Conditions
Opioid Use Disorder, Suicidal Ideation
Interventions
Ketamine, Saline Solution
Drug · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 7, 2025 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Not applicable Interventional Results available

Suicide Prevention for Patients With Chronic Pain

NCT04490265
View directory record Official record
Conditions
Suicide, Chronic Pain
Interventions
Problem-solving treatment, Supportive Psychotherapy
Behavioral
Lead sponsor
Veterans BioMedical Research Institute
Other
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
East Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Improving Firearm Storage in Alaska Native Villages

NCT00643812
View directory record Official record
Conditions
Suicide, Suicide, Attempted, Wounds and Injuries
Interventions
Installation of gun locker in household
Other
Lead sponsor
University of Washington
Other
Eligibility
21 Years and older
Enrollment
266 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 25, 2008 · Synced Sep 22, 2026, 10:06 PM EDT
Recruiting Not applicable Interventional

Caring Connections Youth Suicide Detection and Intervention Study

NCT06353711
View directory record Official record
Conditions
Suicide, Suicide Prevention, Suicide Ideation, Suicide Attempt
Interventions
Caring Connections, Treatment as Usual
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
13 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Sep 22, 2026, 10:06 PM EDT
Suspended Phase 4 Interventional

IM Ketamine vs Midazolam for Suicidal ER Patients

NCT04640636
View directory record Official record
Conditions
Depression, Unipolar, Depression, Bipolar, Suicidal Ideation
Interventions
Ketamine hydrochloride injection, Midazolam injection
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 25, 2026 · Synced Sep 22, 2026, 10:06 PM EDT
Recruiting Not applicable Interventional

Evaluating Treatments for Suicidal Veterans With PTSD

NCT05974631
View directory record Official record
Conditions
Self-directed Violence, Post-traumatic Stress Disorder (PTSD)
Interventions
Dialectical Behavior Therapy, Dialectical Behavior Therapy Prolonged Exposure protocol, Prolonged Exposure therapy, Suicide risk management
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
4
States / cities
Minneapolis, Minnesota • Durham, North Carolina • San Antonio, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Sep 22, 2026, 10:06 PM EDT
Recruiting Not applicable Interventional

Efficacy, Effectiveness, and Implementation of Jaspr Health in Emergency Department- Part A

NCT06223867
View directory record Official record
Conditions
Suicidal Ideation, Suicide Attempt, Self Harm
Interventions
Jaspr App + JAH, ETAU
Device · Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Enrollment
670 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Not applicable Interventional

Triple Chronotherapy in Adolescents

NCT03679962
View directory record Official record
Conditions
Depressive Disorder, Major, Bipolar Depression, Suicidal Ideation
Interventions
Triple Chronotherapy, Treatment as Usual
Behavioral
Lead sponsor
Billings Clinic
Other
Eligibility
12 Years to 17 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Billings, Montana
Source: ClinicalTrials.gov public record
Updated Aug 15, 2023 · Synced Sep 22, 2026, 10:06 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

An Exploration of the Relationship Between Chronic Pain and Suicide Attempt Among Veterans

NCT01502436
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Traumatic Brain Injury, Suicide Attempt
Interventions
Not listed
Lead sponsor
VA Eastern Colorado Health Care System
Federal
Eligibility
18 Years to 89 Years
Enrollment
230 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2014
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 27, 2023 · Synced Sep 22, 2026, 10:06 PM EDT
Recruiting Not applicable Interventional

The Effectiveness of Individualized Imagery Scripts on Sleep, Psychosis, and Suicidality Among Inpatients With Psychosis

NCT06194344
View directory record Official record
Conditions
Psychosis
Interventions
Individualized imagery, Control
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 15, 2025 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Not applicable Interventional Results available

Trauma Survivors Outcomes and Support Study IV

NCT01625416
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Depression, Suicide, Traumatic Brain Injury, Alcohol Use, Drug Use
Interventions
Stepped Care Management
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
14 Years and older
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 12, 2017 · Synced Sep 22, 2026, 10:06 PM EDT
Terminated Phase 2Phase 3 Interventional Results available

Lithium for Suicidal Behavior in Mood Disorders

NCT01928446
View directory record Official record
Conditions
Depressive Disorder, Bipolar Disorder, Suicide, Suicide, Attempted
Interventions
Lithium, Placebo
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
519 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
28
States / cities
Phoenix, Arizona • Tucson, Arizona • North Little Rock, Arkansas + 25 more
Source: ClinicalTrials.gov public record
Updated Apr 28, 2024 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Not applicable Interventional

Suicide Prevention Intervention for Schizophrenia-Spectrum Disorders

NCT04221269
View directory record Official record
Conditions
Schizophrenia, Suicide
Interventions
Enhanced Treatment as Usual, Coping Long-term with Active Suicide Program for Schizophrenia
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 10, 2023 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Not applicable Interventional Results available

PracticeGround: Transforming Training and Delivery of Mental Health EBPs

NCT02314624
View directory record Official record
Conditions
Depression, Insomnia, Suicide
Interventions
Behavioral Activation for Depression, Cognitive Behavior Therapy for Insomnia, Collaborative Assessment and Management of Suicidality, Care-as-Usual Psychotherapy
Behavioral
Lead sponsor
Evidence-Based Practice Institute, Seattle, WA
Industry
Eligibility
18 Years and older
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 29, 2024 · Synced Sep 22, 2026, 10:06 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Cranial Electric Stimulation to Modify Suicide Risk Factors in Psychiatric Inpatients.

NCT02846740
View directory record Official record
Conditions
Suicide, Depression, Anxiety, Insomnia, Agitation
Interventions
Alpha-Stim®., Montgomery-Åsberg Depression Rating Scale, Hamilton Anxiety Rating Scale, The Pittsburgh Sleep Quality Index and agitated behavior Scale
Device · Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 25, 2019 · Synced Sep 22, 2026, 10:06 PM EDT
Recruiting Not applicable Interventional

Cannabis, Linked Emotions, and Adolescent Risk Study

NCT06576076
View directory record Official record
Conditions
Cannabis Use, Depression, Suicidal Ideation, Adolescent Behavior
Interventions
Contingency management for cannabis abstinence
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
12 Years to 18 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Not applicable Interventional

Circuit-Based Approach to Suicide: Biomarkers, Predictors, and Novel Therapeutics

NCT04130958
View directory record Official record
Conditions
Major Depressive Episode, Borderline Personality Disorder, Suicide
Interventions
Intermittent Theta Burst Transcranial Magnetic Stimulation (Active), Intermittent Theta Burst Transcranial Magnetic Stimulation (Sham)
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Not applicable Interventional

Blister Packaging Medication to Increase Treatment Adherence and Clinical Response

NCT01118208
View directory record Official record
Conditions
Medication Adherence, Accidental Overdose, Deliberate Overdose, Suicide, Attempted
Interventions
Blister packaging medications, Dispense as usual
Other
Lead sponsor
VA Eastern Colorado Health Care System
Federal
Eligibility
18 Years and older
Enrollment
303 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 19, 2017 · Synced Sep 22, 2026, 10:06 PM EDT
Completed Not applicable Interventional

Adaptation of Dialectical Behavior Therapy Skills-Groups for Individuals With Suicidal Ideation and Depression

NCT01441258
View directory record Official record
Conditions
Suicidal Ideation, Major Depressive Disorder
Interventions
Dialectical Behavior Therapy Skills (DBT-S) Groups, Wait List-Treatment as Usual, No intervention-treatment as usual
Behavioral
Lead sponsor
Maurizio Fava, MD
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 7, 2015 · Synced Sep 22, 2026, 10:06 PM EDT