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ClinicalTrials.gov public records Last synced Oct 22, 2026, 10:23 PM EDT

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Showing 1–24 of 65 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Sun Damaged Skin Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Procedure Pairing of a Post-Procedure Cream Versus a Comparator in Patients Treated With a Radiofrequency Microneedling for Facial Rejuvenation

NCT06157853
View directory record Official record
Conditions
Photoaging, Wrinkle
Interventions
Radiofrequency Microneedling, Facial Cleanser, Facial Moisturizer, Sunscreen
Procedure · Other
Lead sponsor
Revision Skincare
Industry
Eligibility
35 Years to 65 Years · Female only
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 10, 2024 · Synced Oct 22, 2026, 10:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Singlet Oxygen Quantification After Skin Exposure to Ultraviolet A (UVA) Light

NCT05865431
View directory record Official record
Conditions
Sun Damaged Skin
Interventions
Zinc Oxide and Avobenzone
Drug
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Apr 27, 2025 · Synced Oct 22, 2026, 10:23 PM EDT
Completed Not applicable Interventional Results available

Safety and Effectiveness of the CLEAR + BRILLIANT TOUCH(R) Diode Laser 1440-nm and 1927-nm Combination Wavelength Treatment

NCT05027282
View directory record Official record
Conditions
Photoaging
Interventions
CLEAR + BRILLIANT TOUCH(R) 1440-nm and 1927-nm handpieces.
Device
Lead sponsor
Bausch Health Americas, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 22, 2023 · Synced Oct 22, 2026, 10:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Clinical Study to Evaluate the Efficacy of an Anti-Aging Serum

NCT05271136
View directory record Official record
Conditions
Fine Lines, Wrinkle, Photoaging
Interventions
Anti-aging Serum, Facial Moisturizer, Cleansing Lotion, Sunscreen
Other
Lead sponsor
Revision Skincare
Industry
Eligibility
30 Years to 60 Years · Female only
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Mar 8, 2022 · Synced Oct 22, 2026, 10:23 PM EDT
Completed Phase 2 Interventional Results available

Topical Perillyl Alcohol in Treating Patients With Sun Damaged Skin and Actinic Keratoses

NCT00608634
View directory record Official record
Conditions
Precancerous Condition
Interventions
perillyl alcohol, placebo
Drug · Other
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 1, 2015 · Synced Oct 22, 2026, 10:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Combination Versus Laser Treatment Only

NCT03661697
View directory record Official record
Conditions
Photoaging
Interventions
Laser Therapy, Basic Skin Care Regimen, Lytera
Device · Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 24, 2020 · Synced Oct 22, 2026, 10:23 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Efficacy of Polypodium Leucotomos Extract Decreasing UVA Premutagenic and Photoaging Markers

NCT00520910
View directory record Official record
Conditions
Aging, Skin Abnormalities
Interventions
Polypodium leucotomos
Drug
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 18, 2019 · Synced Oct 22, 2026, 10:23 PM EDT
Not listed Phase 2Phase 3 Interventional

Skin Care Regimen for Improving Photoaging Signs on the Face

NCT06603857
View directory record Official record
Conditions
Improve Photoaging Signs
Interventions
CE Ferulic, Sham Comparator, 1927nm (Clear and Brilliant Perméa®)
Drug · Device
Lead sponsor
Goldman, Butterwick, Fitzpatrick and Groff
Other
Eligibility
30 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 22, 2026, 10:23 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Immunologic Profile of Chronically Photodamaged Skin

NCT02889159
View directory record Official record
Conditions
Photoaged Skin, Normal Skin
Interventions
Candida albicans antigen, histamine phosphate, imiquimod 5% cream, Tape Stripping
Biological · Procedure
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2023
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 13, 2025 · Synced Oct 22, 2026, 10:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Clinical Trial Evaluating the Efficacy of a Skin Cream in Improving Facial Appearance and Skin Elasticity

NCT04769193
View directory record Official record
Conditions
Atrophy, Hemifacial, Elastosis, Photoaging
Interventions
Adipeau face cream
Other
Lead sponsor
Adipeau Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 22, 2026, 10:23 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

SUV PDL1/PD1 in Sun Damaged & Sun Protected Human Skin of Participants

NCT06177106
View directory record Official record
Conditions
Other Skin Changes Due to Chronic Exposure to Nonionizing Radiation
Interventions
Solar Simulated Light
Other
Lead sponsor
University of Arizona
Other
Eligibility
40 Years and older
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Oct 22, 2026, 10:23 PM EDT
Terminated Phase 2 Interventional Results available

Treatment With Dasatinib in Patients With Acral Lentiginous, Mucosal, or Chronic Sun-damaged Melanoma

NCT01092728
View directory record Official record
Conditions
Melanoma
Interventions
Dasatinib, Surgical Resection
Drug · Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 5, 2016 · Synced Oct 22, 2026, 10:23 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

VELOS for the Treatment of Vascular Lesions and Skin Rejuvenation

NCT02468453
View directory record Official record
Conditions
Vascular Lesions, Photoaging
Interventions
velos
Device
Lead sponsor
Syneron Medical
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
4
States / cities
San Diego, California • Wayland, Massachusetts • Edina, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 6, 2018 · Synced Oct 22, 2026, 10:23 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The Effects of Zinc Di-(Dibutyryl Lisinate) on Skin Health and the Skin Microbiome in Photoaged Skin

NCT06096649
View directory record Official record
Conditions
Photoaging
Interventions
Topical Vehicle + Zinc Di-(dibutyryl lisinate), Topical Vehicle
Other
Lead sponsor
Integrative Skin Science and Research
Industry
Eligibility
40 Years to 60 Years · Female only
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Oct 24, 2023 · Synced Oct 22, 2026, 10:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of the Effects of a Biostimulator and Dermal Fillers for Cheek Augmentation and Contour Deficiencies

NCT06351358
View directory record Official record
Conditions
Photoaging, Weight Loss, Skin Laxity, Photodamaged Skin, Volume Deficiency of the Midface
Interventions
Sculptra treatment, Restylane Treatment
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
22 Years to 65 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Washington D.C., District of Columbia • New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Oct 22, 2026, 10:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Twelve Week Clinical Study to Evaluate the Efficacy and Tolerability of a Sunscreen Moisturizer SPF 50+

NCT06148558
View directory record Official record
Conditions
Anti-aging, Photoaging
Interventions
Sunscreen Moisturizer, Gentle Cleansing Lotion, Facial Moisturizer
Other
Lead sponsor
Revision Skincare
Industry
Eligibility
35 Years to 60 Years · Female only
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Newtown Square, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 28, 2023 · Synced Oct 22, 2026, 10:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Single-Center Open-Label Study of 1064 nm for Nonablative Skin Rejuvenation

NCT03421691
View directory record Official record
Conditions
Skin Pigment, Photoaging
Interventions
excel V Laser
Device
Lead sponsor
Cutera Inc.
Industry
Eligibility
35 Years to 55 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 6, 2023 · Synced Oct 22, 2026, 10:23 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Comparison of the Cosmetic Effects of Bakuchiol and Retinol

NCT03112863
View directory record Official record
Conditions
Wrinkle, Photoaging
Interventions
Bakuchiol, Retinol
Drug
Lead sponsor
University of California, Davis
Other
Eligibility
30 Years to 55 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Nov 2, 2021 · Synced Oct 22, 2026, 10:23 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Onabotulinum Toxin Type A and Abobotulinum Toxin Type A Crow's Feet Rhytid Study

NCT01529788
View directory record Official record
Conditions
Intrinsic Aging of Skin, Solar Elastosis
Interventions
Right lateral orbital injection of Botox Cosmetic or Dysport, Left lateral orbital injection of Botox Cosmetic or Dysport
Drug
Lead sponsor
The Maas Clinic
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2014
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 30, 2014 · Synced Oct 22, 2026, 10:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Clinical Study to Evaluate Efficacy and Safety of a Cosmetic Product in the Treatment of Facial Lines

NCT04545970
View directory record Official record
Conditions
Fine Lines, Wrinkles, Photoaging
Interventions
Facial cleanser, Facial moisturizer, Sunscreen
Combination Product
Lead sponsor
Revision Skincare
Industry
Eligibility
35 Years to 60 Years · Female only
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Manhattan Beach, California
Source: ClinicalTrials.gov public record
Updated Sep 16, 2020 · Synced Oct 22, 2026, 10:23 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Clinical Evaluation of Day and Night Skin Care Creams Supplemented With MediCell Technology (MCT)'s Composition of Defensins and Supportive Molecules

NCT02765763
View directory record Official record
Conditions
Skin Aging, Photoaging of Skin
Interventions
2-Minute Reveal Masque, 24/7 Barrier Repair Cream, 8-in-1 BioSerum, Null Formula 2-Minute Reveal Masque, Null Formula 24/7 Barrier Repair Cream, Null Formula 8-in-1 BioSerum
Drug
Lead sponsor
Advanced Dermatology
Other
Eligibility
40 Years to 75 Years · Female only
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Lincolnshire, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 11, 2018 · Synced Oct 22, 2026, 10:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Double-Blind Study Determining the Efficacy of CannaXR in Decreasing UVA Premutagenic and Photoaging Markers

NCT05279495
View directory record Official record
Conditions
Photoaging
Interventions
In a double-blinded fashion, 250 mg CANNAXR cream, Topical VEHICLE cream
Device
Lead sponsor
MINO Labs, LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Aventura, Florida
Source: ClinicalTrials.gov public record
Updated May 8, 2025 · Synced Oct 22, 2026, 10:23 PM EDT
Active, not recruiting Not applicable Interventional

Investigating Age Dependence of Fibroblast and Extracellular Matrix Responses to Cross-linked Hyaluronic Acid Filler in Human Skin

NCT06195605
View directory record Official record
Conditions
Photoaging
Interventions
Restylane-L, Vehicle
Device
Lead sponsor
University of Michigan
Other
Eligibility
30 Years to 50 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 22, 2026, 10:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Hexyresorcinol vs Hydroquinone for Photoaging

NCT04345094
View directory record Official record
Conditions
Photoaging
Interventions
Hexylresourcinol, Hydroquinone
Other
Lead sponsor
Sytheon Ltd.
Industry
Eligibility
35 Years to 65 Years · Female only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jul 10, 2020 · Synced Oct 22, 2026, 10:23 PM EDT