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ClinicalTrials.gov public records Last synced Oct 21, 2026, 4:09 AM EDT

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Showing 25–48 of 65 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Sun-Damaged Skin Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

Immunologic Profile of Chronically Photodamaged Skin

NCT02889159
View directory record Official record
Conditions
Photoaged Skin, Normal Skin
Interventions
Candida albicans antigen, histamine phosphate, imiquimod 5% cream, Tape Stripping
Biological · Procedure
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2023
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 13, 2025 · Synced Oct 21, 2026, 4:09 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Altreno for Chest Rejuvenation

NCT04096742
View directory record Official record
Conditions
Photodamaged Skin, Photoaging
Interventions
tretinoin 0.05% lotion (Altreno), Vehicle
Drug · Other
Lead sponsor
Goldman, Butterwick, Fitzpatrick and Groff
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 2, 2021 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Pomegranate on Aging and Inflammation of the Skin

NCT02258776
View directory record Official record
Conditions
Skin Photoaging, Inflammation and Skin Pathogenic Bacteria
Interventions
Pomegranate Extract, Pomegranate Juice, Placebo
Dietary Supplement
Lead sponsor
University of California, Los Angeles
Other
Eligibility
30 Years to 45 Years · Female only
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 1, 2017 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Not applicable Interventional

Clinical Study To Evaluate Paired Treatment With An Alexandrite Laser And Radiofrequency Microneedling For Facial Aging

NCT05388604
View directory record Official record
Conditions
Wrinkle, Photoaging, Dyschromia
Interventions
RF device, Microneedling device
Device
Lead sponsor
Cynosure, Inc.
Industry
Eligibility
40 Years to 65 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
3
States / cities
Sacramento, California • Montclair, New Jersey • New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 18, 2023 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Procedure Pairing of a Post-Procedure Cream Versus a Comparator in Patients Treated With a Radiofrequency Microneedling for Facial Rejuvenation

NCT06157853
View directory record Official record
Conditions
Photoaging, Wrinkle
Interventions
Radiofrequency Microneedling, Facial Cleanser, Facial Moisturizer, Sunscreen
Procedure · Other
Lead sponsor
Revision Skincare
Industry
Eligibility
35 Years to 65 Years · Female only
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 10, 2024 · Synced Oct 21, 2026, 4:09 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

A Study Evaluating Blended Belotero for the Treatment of Etched-in Fine Facial Lines

NCT02626598
View directory record Official record
Conditions
Rhytidosis Facialis
Interventions
Blended Belotero
Device
Lead sponsor
Skin Care and Laser Physicians of Beverly Hills
Other
Eligibility
25 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 10, 2015 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Twelve Week Clinical Study to Evaluate the Efficacy and Tolerability of a Sunscreen Moisturizer SPF 50+

NCT06148558
View directory record Official record
Conditions
Anti-aging, Photoaging
Interventions
Sunscreen Moisturizer, Gentle Cleansing Lotion, Facial Moisturizer
Other
Lead sponsor
Revision Skincare
Industry
Eligibility
35 Years to 60 Years · Female only
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Newtown Square, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 28, 2023 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Single-Center Open-Label Study of 1064 nm for Nonablative Skin Rejuvenation

NCT03421691
View directory record Official record
Conditions
Skin Pigment, Photoaging
Interventions
excel V Laser
Device
Lead sponsor
Cutera Inc.
Industry
Eligibility
35 Years to 55 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 6, 2023 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Phase 2 Interventional Results available

Eflornithine and/or Diclofenac in Treating Patients With Sun-Damaged Skin

NCT00601640
View directory record Official record
Conditions
Other Benign Neoplasm of Skin, Unspecified
Interventions
Diclofenac Na gel, Eflornithine HCL ointment
Drug
Lead sponsor
University of Arizona
Other
Eligibility
40 Years and older
Enrollment
184 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2014
U.S. locations
3
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 23, 2017 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

An Assessment of TLR4 and TOPK/PRPK Signaling in Sun Damaged Human Skin Acutely Exposed to Solar Simulated Light

NCT05398237
View directory record Official record
Conditions
Sun Damaged Skin
Interventions
Solar Simulated Light (SSL)
Other
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 90 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Sep 24, 2024 · Synced Oct 21, 2026, 4:09 AM EDT
Not listed Phase 2Phase 3 Interventional

Skin Care Regimen for Improving Photoaging Signs on the Face

NCT06603857
View directory record Official record
Conditions
Improve Photoaging Signs
Interventions
CE Ferulic, Sham Comparator, 1927nm (Clear and Brilliant Perméa®)
Drug · Device
Lead sponsor
Goldman, Butterwick, Fitzpatrick and Groff
Other
Eligibility
30 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 21, 2026, 4:09 AM EDT
Active, not recruiting Not applicable Interventional

Investigating Age Dependence of Fibroblast and Extracellular Matrix Responses to Cross-linked Hyaluronic Acid Filler in Human Skin

NCT06195605
View directory record Official record
Conditions
Photoaging
Interventions
Restylane-L, Vehicle
Device
Lead sponsor
University of Michigan
Other
Eligibility
30 Years to 50 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dealcoholized Muscadine Wine and Skin Health in Women

NCT04614753
View directory record Official record
Conditions
Skin Health
Interventions
Dealcoholized Muscadine Wine, Control Beverage
Other
Lead sponsor
University of Florida
Other
Eligibility
40 Years to 67 Years · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 12, 2025 · Synced Oct 21, 2026, 4:09 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Driving Time and Facial Skin Hydration Asymmetry in Florida Drivers

NCT07764809
View directory record Official record
Conditions
Skin Diseases, Photoaging, Skin Hydration
Interventions
BT-Analyze bioimpedance skin hydration measurement
Other
Lead sponsor
IAS Skin Care
Industry
Eligibility
25 Years to 65 Years · Female only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Comparison of the Cosmetic Effects of Bakuchiol and Retinol

NCT03112863
View directory record Official record
Conditions
Wrinkle, Photoaging
Interventions
Bakuchiol, Retinol
Drug
Lead sponsor
University of California, Davis
Other
Eligibility
30 Years to 55 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Nov 2, 2021 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Clinical Trial Evaluating the Efficacy of a Skin Cream in Improving Facial Appearance and Skin Elasticity

NCT04769193
View directory record Official record
Conditions
Atrophy, Hemifacial, Elastosis, Photoaging
Interventions
Adipeau face cream
Other
Lead sponsor
Adipeau Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 21, 2026, 4:09 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Safety and Efficacy Evaluation of the Mosaic Ultra Device

NCT06117293
View directory record Official record
Conditions
Skin Texture Disorder, Photoaging, Wrinkle, Scar, Stretch Mark, Acne Vulgaris, Hair Loss
Interventions
Mosaic
Device
Lead sponsor
CynosureLutronic
Industry
Eligibility
18 Years to 60 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
3
States / cities
Lincolnshire, Illinois • Billerica, Massachusetts • Peabody, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 7, 2023 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

An Exploratory Investigation of a Novel Skincare Regimen

NCT05517720
View directory record Official record
Conditions
Wrinkle, Photoaging, Acne, Skin Inflammation
Interventions
Aria Trio complete Facial System
Other
Lead sponsor
Trophy Skin
Industry
Eligibility
25 Years to 65 Years · Female only
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Aug 26, 2022 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Phase 2 Interventional Results available

Imatinib in Patients With Mucosal or Acral/Lentiginous Melanoma

NCT00424515
View directory record Official record
Conditions
Mucosal Melanoma, Acral/Lentiginous Melanoma, Chronically Sun Damaged Melanomas
Interventions
Imatinib
Drug
Lead sponsor
Dana-Farber Cancer Institute
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
5
States / cities
Denver, Colorado • Tampa, Florida • Chicago, Illinois + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 8, 2016 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Efudex Treatment on Photoaged Skin

NCT00121511
View directory record Official record
Conditions
Photo-aging, Keratosis
Interventions
Efudex (5-fluorouracil)
Drug
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2007
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 27, 2015 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Same-Day Combination of VI Peel and Botox for Correction of Sun Damage, Fine Lines and Wrinkles

NCT05162300
View directory record Official record
Conditions
Photoaging, Wrinkle, Sun Damaged Skin
Interventions
Same Day Intervention of VI Peel (Procedure) and Botulinum Toxin (Drug)
Combination Product
Lead sponsor
Vitality Institute Medical Products
Industry
Eligibility
30 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Rancho Mirage, California
Source: ClinicalTrials.gov public record
Updated Apr 25, 2022 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Trial Evaluating Both Tolerability and Improvement for Signs of Facial Photoaging, Discoloration, and Texture in Adult Females of All Skin Types by Combining a Placebo Moisturizer and Non-ablative Laser.

NCT06090071
View directory record Official record
Conditions
Photoaging
Interventions
LaseMD Laser, Sciton Laser, Phyto A+ Brightening Treatment
Device · Drug
Lead sponsor
Austin Institute for Clinical Research
Network
Eligibility
25 Years to 70 Years · Female only
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Pflugerville, Texas
Source: ClinicalTrials.gov public record
Updated Oct 24, 2024 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Hexyresorcinol vs Hydroquinone for Photoaging

NCT04345094
View directory record Official record
Conditions
Photoaging
Interventions
Hexylresourcinol, Hydroquinone
Other
Lead sponsor
Sytheon Ltd.
Industry
Eligibility
35 Years to 65 Years · Female only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jul 10, 2020 · Synced Oct 21, 2026, 4:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect Of A Controlled Daily Skin Care Regimen On Retinoic Acid Tolerance

NCT00440024
View directory record Official record
Conditions
Sun-Damaged Skin, Retinoid Intolerance
Interventions
Tazorac, Dove Mild Cleanser, Dove Facial Moisturizer
Drug
Lead sponsor
University of Michigan
Other
Eligibility
40 Years to 90 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 13, 2020 · Synced Oct 21, 2026, 4:09 AM EDT