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ClinicalTrials.gov public records Last synced Jul 22, 2026, 12:26 PM EDT

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Showing 1–11 of 11 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Recruiting Not applicable Interventional Accepts healthy volunteers

Role of Novel RADA16 Hydrogel in Endoscopic Skull Base Surgery

NCT05898074
Conditions
Skull Base Neoplasms, Cerebrospinal Fluid Leakage, Nasal; Hypertrophy, Mucous Membrane (Septum)
Interventions
Non-Absorbable Packing (Silastic Splint), PuraGel (RADA16) Hydrogel
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Conditions
Cerebrospinal Fluid Drainage
Interventions
Blind CSF Drain Placement, Fluoroscopy-guided Drain Placement
Procedure
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
302 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Conditions
Drainage
Interventions
Duraprep Surgical Solution
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years to 80 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Conditions
Cerebrospinal Fluid Leak
Interventions
LIQOSEAL, DuraSeal, Adherus
Device
Lead sponsor
Polyganics BV
Industry
Eligibility
18 Years and older
Enrollment
228 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
9
States / cities
Palo Alto, California • Jacksonville, Florida • Rochester, Minnesota + 5 more
Conditions
Cerebrospinal Fluid Leak
Interventions
Acetazolamide
Drug
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Miami, Florida
Conditions
Frequency and Type of Medical Adhesive-Related Skin Injury, NPWT Drape Seal Effectiveness Rate (or Leak Incidence Rate), Clinician Acceptability of New NPWT Drape, Patient Drop-out Rate From Prescribed NPWT Treatment, Pain Assessment During Medical Adhesive Drape Removal
Interventions
Comfort Release® NPWT drape
Device
Lead sponsor
Global Biomedical Technologies, LLC
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
6
States / cities
Los Angeles, California • Torrance, California • Miami, Florida + 2 more
Conditions
Surgical Wound, Recent, Surgical Wound Leak, Dehiscence Wound, Trauma-related Wound
Interventions
Negative Pressure Wound Therapy System
Device
Lead sponsor
ConvaTec Inc.
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
4
States / cities
Miami Lakes, Florida • Chicago, Illinois • Lake Success, New York + 1 more
Conditions
Cataract Surgery Incision Leak
Interventions
ReSure Sealant, Sutures
Device · Procedure
Lead sponsor
Ocular Therapeutix, Inc.
Industry
Eligibility
22 Years and older
Enrollment
488 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Jacksonville, Florida
Terminated Not applicable Interventional Results available

Lumbar Drain After Endoscopic Surgery of the Skull Base

NCT03163134
Conditions
Quality of Life
Interventions
Lumbar Drain
Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Conditions
Cerebrospinal Fluid Leak
Interventions
FS VH S/D 500 s-apr, DuraSeal Dural Sealant
Drug · Device
Lead sponsor
Baxter Healthcare Corporation
Industry
Eligibility
18 Years and older
Enrollment
224 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
10
States / cities
Springfield, Illinois • Springfield, Massachusetts • Detroit, Michigan + 7 more
Recruiting Phase 4 Interventional

CraniSeal Post Approval Study

NCT06406790
Conditions
Leak, Cerebrospinal Fluid
Interventions
CraniSeal, DuraSeal
Device
Lead sponsor
Pramand LLC
Industry
Eligibility
18 Years and older
Enrollment
224 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
8
States / cities
Los Angeles, California • Jacksonville, Florida • Tampa, Florida + 5 more