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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Symptoms of Depression and Anxiety Clear all
Withdrawn No phase listed Observational

A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Depression

NCT04211467
View directory record Official record
Conditions
Depression, Clinical Depression, Depression, Anxiety, Depression, Postpartum, Depression, Endogenous, Depression in Remission, Depression Chronic, Depression Moderate, Depression Severe
Interventions
No Intervention
Other
Lead sponsor
ProgenaBiome
Other
Eligibility
Not listed
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2030
U.S. locations
1
States / cities
Ventura, California
Source: ClinicalTrials.gov public record
Updated Jun 4, 2025 · Synced Jul 23, 2026, 10:05 AM EDT
Completed Not applicable Interventional Results available

Efficacy and Feasibility of a Personalized Treatment for Depression With Co-Occurring Anxiety

NCT00930293
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Interpersonal Psychotherapy for Depression with Panic and Anxiety Symptoms (IPT-PS), Brief Supportive Psychotherapy (BSP), Citalopram hydrobromide
Behavioral · Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 8, 2016 · Synced Jul 23, 2026, 10:05 AM EDT
Completed Not applicable Interventional

Adaptation and Evaluation of the KEEP Model

NCT05816421
View directory record Official record
Conditions
Depression, Anxiety, Post Traumatic Stress Disorder, Suicide and Self-harm, Externalizing Behavior
Interventions
KEEP, Non-Affinity KEEP
Behavioral
Lead sponsor
Oregon Social Learning Center
Other
Eligibility
4 Years to 21 Years
Enrollment
283 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 4, 2025 · Synced Jul 23, 2026, 10:05 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

The Nuestros Días ("Our Days") Study

NCT06475534
View directory record Official record
Conditions
Caregiver Burden, Well-Being, Psychological, Stress, Psychological, Depression, Anxiety
Interventions
Not listed
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 100 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Jul 23, 2026, 10:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Community Resilience Learning Collaborative and Research Network

NCT03977844
View directory record Official record
Conditions
Depression, Social Stress, Anxiety, Quality of Life, Disaster
Interventions
Technical Assistance, Community Engagement and Planning, Community Resources (CR), Community Resources + eBT
Other
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
18 Years and older
Enrollment
258 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated May 23, 2021 · Synced Jul 23, 2026, 10:05 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Using Machine Learning to Optimize User Engagement and Clinical Response to Digital Mental Health Interventions

NCT05567640
View directory record Official record
Conditions
Anxiety Disorders and Symptoms, Depressive Symptoms
Interventions
The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP), Space for depression, Space for resilience
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
1,800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 13, 2023 · Synced Jul 23, 2026, 10:05 AM EDT
Recruiting Phase 2 Interventional

Leveraging mHealth to Promote Opioid Use Recovery and Mental Health Among Residents of a Medium-Sized Midwestern City

NCT07673380
View directory record Official record
Conditions
Opioid Use, Stimulant Use, Depression and Anxiety Symptoms
Interventions
uMAT-R + enhanced community engagement, Original uMAT-R supplementary mHealth recovery intervention
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Jul 23, 2026, 10:05 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Impact of Complimentary and Alternative Practices on Patient Wellbeing During Rehabilitation

NCT05082246
View directory record Official record
Conditions
Anxiety, Depression, Stress, Pain, Heart Rate, Blood Pressure
Interventions
Conscious Breathing, Heartfulness Meditation, Emotional Freedom Technique
Other
Lead sponsor
WellSpan Health
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
York, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 17, 2021 · Synced Jul 23, 2026, 10:05 AM EDT
Terminated Not applicable Interventional

The Impact of Three Distinct Exercise Types on Fatigue, Anxiety, and Depression in Parkinson's Disease

NCT02885285
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Spinning Class, Yoga Class, Dance Class, No Exercise Class
Behavioral · Other
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 25, 2017 · Synced Jul 23, 2026, 10:05 AM EDT
Completed Not applicable Interventional

Family Support Intervention in Intensive Care Units (The Four Supports Study)

NCT01107704
View directory record Official record
Conditions
Physician-Family Communication in Intensive Care Units, Surrogate Decision-making for Critically Ill Patients
Interventions
Family Support Intervention
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
50 Years and older
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 26, 2014 · Synced Jul 23, 2026, 10:05 AM EDT
Completed Phase 2 Interventional

Brief CBT for Anxiety and Advanced Cancer

NCT00706290
View directory record Official record
Conditions
Anxiety, Depression, Unspecified Adult Solid Tumor, Protocol Specific, Cancer, Cognitive Behavioral Therapy
Interventions
Brief Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 5, 2014 · Synced Jul 23, 2026, 10:05 AM EDT
Completed Not applicable Interventional

Impact of the Relaxation Response Resiliency Program on Patients With Atrial Fibrillation

NCT02634697
View directory record Official record
Conditions
Atrial Fibrillation, Stress, Quality of Life, Anxiety, Depression, Hostility
Interventions
Relaxation Response Resiliency Program
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 90 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 27, 2020 · Synced Jul 23, 2026, 10:05 AM EDT
Completed Not applicable Interventional

Yoga-Based Rehabilitation Program in Reducing Physical and Emotional Side Effects in Patients With Cancer

NCT00179348
View directory record Official record
Conditions
Alopecia, Anxiety, Breast Carcinoma, Cognitive Side Effects of Cancer Therapy, Colorectal Carcinoma, Depression, Fatigue, Lung Carcinoma, Nausea and Vomiting, Pain, Psychological Impact of Cancer, Sleep Disorder, Weight Change
Interventions
Quality-of-Life Assessment, Yoga
Procedure
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
18 Years and older
Enrollment
399 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2016
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated May 30, 2023 · Synced Jul 23, 2026, 10:05 AM EDT
Completed Not applicable Interventional

Mental Health First Aid for College Students

NCT02021344
View directory record Official record
Conditions
Depression, Anxiety, Suicidal Ideation, Eating Disorders
Interventions
Mental Health First Aid
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
2,543 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 26, 2013 · Synced Jul 23, 2026, 10:05 AM EDT
Not listed Phase 1Phase 2 Interventional

Recovering Damaged Cells for Sequelae Caused by COVID-19, SARS-CoV-2

NCT04846010
View directory record Official record
Conditions
Sequelae of; Infection, Post Infection Glomerulonephritis, Post-Infectious Peripheral Neuralgia, Post-Infectious Disorder (Disorder), Post-Infectious Arthritis, Post-Infectious Polyneuritis, Post-Infectious Parkinsonism, Post-Infectious Hypothyroidism, Post Infectious Osteoarthritis, Anxiety Disorders, Depression, Depression, Anxiety, Depression, Bipolar, Insomnia, GERD, Gastro Esophageal Reflux, Hepatitis, Glomerulonephritis
Interventions
PurWet, FurFat, PurApo, PurPhl, PurClo, PurInf, Smoliv
Combination Product
Lead sponsor
All Natural Medicine Clinic, LLC
Other
Eligibility
Not listed
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated May 25, 2021 · Synced Jul 23, 2026, 10:05 AM EDT
Completed Not applicable Interventional

A Ten-Week Online Acceptance and Commitment Therapy Intervention for Family Caregivers of People With Dementia

NCT05043441
View directory record Official record
Conditions
Depressive Symptoms
Interventions
Acceptance and commitment therapy (ACT), Psychoeducation
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 8, 2024 · Synced Jul 23, 2026, 10:05 AM EDT
Completed Not applicable Interventional Results available

Brain Stimulation and Enhancing Cognition in Older Adults

NCT03653351
View directory record Official record
Conditions
Cognitive Impairment, Mild, Depressive Symptoms, Anxiety
Interventions
Active Transcranial Direct Current Stimulation (tDCS), Sham Transcranial Direct Current Stimulation (tDCS)
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
60 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
2
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 7, 2021 · Synced Jul 23, 2026, 10:05 AM EDT
Enrolling by invitation Phase 2 Interventional

Ketamine Effects on Learning In Eating Disorders

NCT06736769
View directory record Official record
Conditions
Anorexia Nervosa, Atypical Anorexia Nervosa
Interventions
Ketamine infusion
Drug
Lead sponsor
Amanda Downey, MD
Other
Eligibility
16 Years to 26 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Jul 23, 2026, 10:05 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Moral Injury Symptom Scale/Moral Injury Outcome Scale

NCT04261751
View directory record Official record
Conditions
Moral Injury, Anxiety, Depression, Burn-Out
Interventions
Clinician Questionnaire
Other
Lead sponsor
AdventHealth
Other
Eligibility
18 Years and older
Enrollment
483 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Oct 5, 2023 · Synced Jul 23, 2026, 10:05 AM EDT
Terminated Phase 2 Interventional Results available

Oral Ketamine in the Treatment of Depression and Anxiety in Patients With Cancer

NCT01680172
View directory record Official record
Conditions
Cancer, Depression, Anxiety
Interventions
Ketamine, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
2
States / cities
Scottsdale, Arizona • Yuma, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 28, 2016 · Synced Jul 23, 2026, 10:05 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Improving Social, Emotional, Behavioral, and Academic Functioning

NCT05425381
View directory record Official record
Conditions
Depression, Anxiety, Disruptive Behavior Disorder, Trauma, Psychological
Interventions
Enhanced version of Interconnected Systems Framework, Positive Behavioral Interventions and Supports with Co-located School Mental Health
Behavioral
Lead sponsor
East Carolina University
Other
Eligibility
Not listed
Enrollment
1,208 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
2
States / cities
Greenville, North Carolina • Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 20, 2022 · Synced Jul 23, 2026, 10:05 AM EDT
Withdrawn No phase listed Observational

Study of Dronabinol Treatment for Depression and/or Anxiety in Older Patients

NCT03369639
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Not listed
Lead sponsor
Mclean Hospital
Other
Eligibility
50 Years to 89 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 30, 2019 · Synced Jul 23, 2026, 10:05 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The Network Study: Soldiers Connecting for Work and Health

NCT04463225
View directory record Official record
Conditions
Alcohol Use Disorder, Depression
Interventions
Internet-Delivered Brief Intervention
Other
Lead sponsor
Cornell University
Other
Eligibility
18 Years to 62 Years
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated May 25, 2023 · Synced Jul 23, 2026, 10:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSDM: A Trial to Improve Communication and Shared Decision Making Using a Web-Based Tool

NCT02955563
View directory record Official record
Conditions
Intervention Compliance, Usability, Acceptability
Interventions
CSDM Web-Based Tool Intervention
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 10, 2019 · Synced Jul 23, 2026, 10:05 AM EDT