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ClinicalTrials.gov public records Last synced Nov 11, 2026, 7:38 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 169 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Synaptic Plasticity Clear all

Conditions: Cerebral Palsy
Interventions: Activities-based locomotor training (physical therapy); Other
Lead sponsor: Baylor University; Other
Eligibility: 2 Years to 6 Years
Enrollment: 6 participants
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Waco, Texas

Conditions: Traumatic Brain Injury
Interventions: Constraint-Induced Movement Therapy (CIMT), Lakeshore Enriched Fitness Training (LEFT), standard Transfer Package (sTP), enhanced Transfer Package (eTP); Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years to 90 Years
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Spinal Cord Injuries, Paraplegia, Spinal, Tetraplegia/Tetraparesis, Paraplegia, Spastic
Interventions: Standing transspinal stimulation followed by robotic gait training, Lying transspinal stimulation followed by robotic gait training, Standing sham transspinal stimulation followed by robotic gait training; Combination Product · Other
Lead sponsor: City University of New York; Other
Eligibility: 18 Years to 70 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 2
States / cities: Staten Island, New York • The Bronx, New York

Conditions: Suicidal Ideation, Cognitive Control, Neurocognitive Function
Interventions: DIADEM Low-Intensity Focused Ultrasound Neuromodulation; Device
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 65 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2028
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Olfactory Disorder
Interventions: Smell training; Behavioral
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years to 70 Years
Enrollment: 51 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Anxiety
Interventions: Attention Bias Modification, Attention Control; Behavioral
Lead sponsor: Northern Michigan University; Other
Eligibility: 18 Years to 37 Years
Enrollment: 119 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Marquette, Michigan

Conditions: Cognitive Health, Healthy Aging
Interventions: Cognitive Stimulation, Mindfulness training, Physical Activity, Control Group; Behavioral
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 65 Years and older
Enrollment: 72 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Schizophrenia
Interventions: D-cycloserine, Placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Depression, Major Depressive Disorder, Suicidal Ideation
Interventions: Single-Pulse Transcranial Magnetic Stimulation, EEG-Synchronized Repetitive Transcranial Magnetic Stimulation (rTMS), Cognitive Behavioral Therapy (CBT), Cognitive Flexibility and Emotion Regulation Tasks; Device · Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Mild Cognitive Impairment
Interventions: Working Memory Training; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 60 Years and older
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Stroke, Hemiparesis, Gait Dysfunction
Interventions: PAS at Rest, PAS - Active, PAS - Walking; Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Martinez, California

Conditions: Stroke, Hemiparesis
Interventions: CI therapy; Behavioral
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years and older
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2025
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Alzheimer's Disease
Interventions: Psilocybin, Cognitive Training; Drug · Other
Lead sponsor: National Institute on Aging (NIA); NIH
Eligibility: 65 Years to 120 Years
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Spinal Cord Injuries, Paraplegia, Spinal, Tetraplegia/Tetraparesis
Interventions: Transspinal-transcortical paired-associative stimiulation combined with robotic gait training, Transcortical-transspinal paired-associative stimiulation combined with robotic gait training; Device
Lead sponsor: College of Staten Island, the City University of New York; Other
Eligibility: 18 Years to 70 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Staten Island, New York

Conditions: Pain, Postoperative, Pain, Chronic, Pain, Acute, Surgical Injury, Surgical Wound, Cornea Injury, Cornea, Keratoconus
Interventions: Not listed
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 8 Years to 35 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Cerebral Palsy
Interventions: Robot (Amadeo)-assisted Training; Device
Lead sponsor: Cook Children's Health Care System; Other
Eligibility: 6 Years to 18 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2029
U.S. locations: 1
States / cities: Fort Worth, Texas

Conditions: Cognitive Change
Interventions: Placebo, Origami, Reading; Behavioral
Lead sponsor: University of Kentucky; Other
Eligibility: 65 Years and older
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Cancer Survivors, Chemotherapy-related Cognitive Impairment
Interventions: Neuroplasticity-based Computerized Cognitive Remediation; Behavioral
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 35 Years to 80 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Cognitive Flexibility, Emotional Regulation
Interventions: Healthy Minds Program, Sham Meditation Didactic Material, Sham Stimulation in Lab, Stimulation in Lab, MRI Scanner; Other · Device
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 50 Years
Enrollment: 64 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Spinal Cord Injuries, Neurological Injury, Paralysis, Spasticity, Muscle
Interventions: Spinal Reflex Operant Down Conditioning; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Stroke, Chronic, Aging, Cognitive Decline, Motor Dysfunction, Neuroplasticity
Interventions: High intensity cycling, Low-intensity cycling, Health education session, Moderate Intensity Aerobic Exercise; Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years to 85 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Cerebrovascular Stroke
Interventions: Fast intervention, Active Monitoring; Behavioral
Lead sponsor: University of Southern California; Other
Eligibility: 21 Years and older
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Pomona, California

Conditions: Autism Spectrum Disorder, Intellectual Disability
Interventions: Transcranial Magnetic Stimulation; Device
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 6 Years to 65 Years
Enrollment: 164 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2020
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Non-Arteritic Anterior Ischemic Optic Neuropathy
Interventions: Vision Restoration Therapy (NOVAVISION); Device
Lead sponsor: Emory University; Other
Eligibility: 30 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: Atlanta, Georgia

Search by objective public record fields.

Activities-based Locomotor Training Program Versus Traditional Physical Therapy in Children With Cerebral Palsy

The Brave Initiative: Bringing Rehabilitation to American Veterans in an Enriched Environment

Transspinal Stimulation Plus Locomotor Training for SCI

SERENE Low-Intensity Focused Ultrasound for Cognitive Control

Steroid Nasal Irrigation for Flavor Evaluation and Detection Study

Neuroplasticity in an Extended Amygdala Network as a Target Mechanism for Attention Bias Modification Outcome

Successful Aging and Enrichment (SAGE)

Once Weekly D-cycloserine for Schizophrenia

RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS

Memory Training and Neural Plasticity

Plantarflexor PAS - Stroke

Examining How Motor Rehabilitation Promotes Brain Reorganization Following Stroke, an MRI Study

Neuroplasticity Enhancement From Cognitive Training Reinforced by Psilocybin

Transspinal-Transcortical Paired Stimulation for Neuroplasticity and Recovery After SCI

fMRI and IVCM Cornea Microscopy of CXL in Keratoconus

Robot-assisted Training in Children With CP

Brain Exercises for Synaptic Plasticity

Neuroplasticity-Based Cognitive Remediation for Chemotherapy-Related Cognitive Impairment

The STRENGTHEN Study

Operant Conditioning of Spinal Reflexes Training System--Reflex Operant Down Conditioning

AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions

Fast Arm Motor Skill Training in Chronic Stroke Survivors

TMS for the Investigation of Brain Plasticity in Autism Spectrum Disorders

Vision Restoration Therapy (VRT) to Treat Non-Arteritic Anterior Ischemic Optic Neuropathy