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ClinicalTrials.gov public records Last synced Oct 21, 2026, 4:49 AM EDT

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Showing 289–312 of 1,491 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: TBI Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Soccer Head Gear to Reduce Concussions

NCT02850926
View directory record Official record
Conditions
Brain Concussion
Interventions
Soccer head gear
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
14 Years to 19 Years
Enrollment
3,050 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 10, 2019 · Synced Oct 21, 2026, 4:49 AM EDT
Active, not recruiting Phase 2 Interventional

HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxis

NCT06001385
View directory record Official record
Conditions
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Acute Leukemia, Myelodysplastic Syndromes, Chronic Myeloid Leukemia, Chronic Lymphocytic Leukemia, Myeloproliferative Neoplasm, Lymphoma, Chronic Myelomonocytic Leukemia, Pro-Lymphocytic Leukemia, Myelofibrosis
Interventions
Busulfan, Fludarabine, PBSC Hematopoietic Stem Cell Transplantation (HSCT), Post-Transplant Cyclophosphamide, Mesna, Tacrolimus, Mycophenolate Mofetil, Patient Reported Outcomes, Melphalan, Total-body irradiation, Cyclophosphamide
Drug · Procedure · Other + 1 more
Lead sponsor
Center for International Blood and Marrow Transplant Research
Network
Eligibility
18 Years and older
Enrollment
313 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
32
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Little Rock, Arkansas + 28 more
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 21, 2026, 4:49 AM EDT
Completed No phase listed Observational

Objective Brain Function Assessment of mTBI/Concussion in College Athletes

NCT02477943
View directory record Official record
Conditions
Brain Injuries, Traumatic, Concussion, Mild, Concussion, Brain, Concussion, Intermediate, Concussion, Severe
Interventions
BrainScope Ahead 200iD, Advanced MRI Neuroimaging
Device
Lead sponsor
BrainScope Company, Inc.
Industry
Eligibility
18 Years to 25 Years
Enrollment
520 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
11
States / cities
Fayetteville, Arkansas • Storrs, Connecticut • Tampa, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated May 23, 2019 · Synced Oct 21, 2026, 4:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Aerobic Exercise for Concussion

NCT02959216
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Acute Brain Injury, Brain Concussion
Interventions
Aerobic Exercise, Stretching Exercise
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
13 Years to 18 Years
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
3
States / cities
Boston, Massachusetts • Buffalo, New York • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 24, 2020 · Synced Oct 21, 2026, 4:49 AM EDT
Withdrawn Not applicable Interventional

An Investigation of Return to Play Exertion Protocol in Concussed Adolescents

NCT02389504
View directory record Official record
Conditions
Concussion
Interventions
Dynamic Exertional Physical Therapy, Standard Exertional Physical Therapy
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
14 Years to 17 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 16, 2019 · Synced Oct 21, 2026, 4:49 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies

NCT04195633
View directory record Official record
Conditions
Acute Leukemia, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Adult Diffuse Large Cell Lymphoma, Anaplastic Large Cell Lymphoma, Burkitt Lymphoma, Chronic Myeloid Leukemia, BCR-ABL1 Positive, Chronic Myelomonocytic Leukemia, Hodgkin Lymphoma, Lymphoblastic Lymphoma, Lymphoplasmacytic Lymphoma, Mantle Cell Lymphoma, Mixed Phenotype Acute Leukemia, Myelodysplastic Syndrome, Prolymphocytic Leukemia, Refractory Chronic Lymphocytic Leukemia, Refractory Follicular Lymphoma, Refractory Marginal Zone Lymphoma, Refractory Small Lymphocytic Lymphoma
Interventions
Allogeneic Hematopoietic Stem Cell Transplantation, Cyclophosphamide, Cyclosporine, Filgrastim, Fludarabine, Mycophenolate Mofetil, Mycophenolate Sodium, Total-Body Irradiation, Treosulfan, Bone Marrow Aspiration, Bone Marrow Biopsy, Echocardiography Test, Biospecimen Collection, Computed Tomography, Positron Emission Tomography
Procedure · Drug · Biological + 1 more
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
6 Months and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2029
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 21, 2026, 4:49 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Treatment for Patients With Chronic Post-Concussion Symptoms

NCT03759808
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Concussion Post Syndrome
Interventions
Psychological Intervention
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
13 Years to 25 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 29, 2021 · Synced Oct 21, 2026, 4:49 AM EDT
Terminated Not applicable Interventional Results available

To Study the Effect of Early Cooling in Acute Subdural Hematoma Patients

NCT02064959
View directory record Official record
Conditions
Subdural Hematoma, Traumatic
Interventions
Temperature management Zoll Intravascular Temperature Management device
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
22 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
5
States / cities
Miami, Florida • Atlanta, Georgia • Cincinnati, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Oct 21, 2026, 4:49 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Eye Recovery Automation for Post Injury Dysfunction (iRAPID)

NCT06105892
View directory record Official record
Conditions
Convergence Insufficiency, Traumatic Brain Injury, Concussion, Mild
Interventions
Virtual Eye Rotation Vision Exercise (VERVE), Sham VR Therapy
Device
Lead sponsor
New Jersey Institute of Technology
Other
Eligibility
18 Years to 40 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Oct 21, 2026, 4:49 AM EDT
Recruiting Not applicable Interventional

Measuring Brain Complexity to Detect and Predict Recovery of Consciousness in the ICU

NCT06568536
View directory record Official record
Conditions
Consciousness Disorders
Interventions
Repeated behavioral assessments, functional electroencephalography and brain imagery, TMS-EEG
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
2
States / cities
Boston, Massachusetts • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 15, 2025 · Synced Oct 21, 2026, 4:49 AM EDT
Completed Not applicable Interventional Results available

Myoelectric Upper Limb Orthosis Use by Persons With TBI and Stroke

NCT03215771
View directory record Official record
Conditions
Traumatic Brain Injury, Stroke
Interventions
MyoPro Motion-G, Motor Learning-Based Therapy
Device · Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 15, 2021 · Synced Oct 21, 2026, 4:49 AM EDT
Recruiting No phase listed Observational

Cognitive and Vascular Functioning Following TBI

NCT06034509
View directory record Official record
Conditions
Traumatic Brain Injury, Cognitive Decline, Vascular Dementia
Interventions
No intervention. This is an observational study.
Other
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years to 74 Years
Enrollment
300 participants
Timeline
2023 – 2027
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 26, 2025 · Synced Oct 21, 2026, 4:49 AM EDT
Terminated Not applicable Interventional Results available

TBI MR Study 3 Houston Methodist

NCT02218216
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
MRI Diagnostic
Device
Lead sponsor
GE Healthcare
Industry
Eligibility
15 Years to 50 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 24, 2017 · Synced Oct 21, 2026, 4:49 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Evaluation of VA's Traumatic Brain Injury (TBI) Clinical Reminder and Comprehensive TBI Evaluation (CTBIE)

NCT00852527
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Not listed
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
456 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
3
States / cities
Tucson, Arizona • Hines, Illinois • Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 28, 2015 · Synced Oct 21, 2026, 4:49 AM EDT
Completed Not applicable Interventional

Concussion Treatment in Older Adults

NCT05849064
View directory record Official record
Conditions
Concussion, Mild
Interventions
Behavioral Control, Targeted Intervention
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
50 Years to 99 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Oct 21, 2026, 4:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Blast Exposed Veterans With Auditory Complaints

NCT02122458
View directory record Official record
Conditions
Hearing Impairment, Hearing Aid Fitting
Interventions
mild-gain hearing aids with high-frequency emphasis over 6-months
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
20 Years to 50 Years
Enrollment
363 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
3
States / cities
Portland, Oregon • Pittsburgh, Pennsylvania • Sioux Falls, South Dakota
Source: ClinicalTrials.gov public record
Updated Jun 22, 2023 · Synced Oct 21, 2026, 4:49 AM EDT
Completed No phase listed Observational

COVID-19 Brain Injury

NCT04496076
View directory record Official record
Conditions
Sars-CoV2, Severe Neurologic Injury, Ischemic Stroke, Hemorrhagic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Traumatic Brain Injury, Status Epilepticus
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 16, 2021 · Synced Oct 21, 2026, 4:49 AM EDT
Completed No phase listed Observational

Long-Term Effects of Repetitive, Low-Level Blast Exposure on Special Operations Forces Service Members

NCT05183087
View directory record Official record
Conditions
Traumatic Brain Injury, Blast Injuries
Interventions
3T Connectome MRI, 7 Tesla MRI, TSPO PET, Tau PET, Cognitive and Behavioral Assessments, Blood Biomarkers
Diagnostic Test
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
25 Years to 45 Years · Male only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 4, 2023 · Synced Oct 21, 2026, 4:49 AM EDT
Completed Not applicable Interventional

Early Exercise to Improve Psychosocial Function After Pediatric Mild Traumatic Brain Injury

NCT04199247
View directory record Official record
Conditions
Brain Concussion, Pediatric, Mild Traumatic Brain Injury, Psychological
Interventions
Sub symptom aerobic exercise
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
10 Years to 18 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 4, 2022 · Synced Oct 21, 2026, 4:49 AM EDT
Completed Phase 1 Interventional Results available

DHA For The Treatment of Pediatric Concussion Related to Sports Injury

NCT01903525
View directory record Official record
Conditions
Concussion, Mild Traumatic Brain Injury
Interventions
Docosahexaenoic acid (DHA), Placebo
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
14 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Plano, Texas
Source: ClinicalTrials.gov public record
Updated Jan 11, 2021 · Synced Oct 21, 2026, 4:49 AM EDT
Completed Not applicable Interventional

Speed of Processing Training to Improve Cognition in Traumatic Brain Injury and Mild Cognitive Impairment

NCT02020564
View directory record Official record
Conditions
Traumatic Brain Injury, Mild Cognitive Impairment
Interventions
Speed of Processing Training, Placebo Control
Behavioral
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 59 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2022
U.S. locations
1
States / cities
East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 18, 2023 · Synced Oct 21, 2026, 4:49 AM EDT
Completed Phase 1Phase 2 Interventional

Fludarabine, Total-Body Irradiation, and Donor Stem Cell Transplant Followed By Cyclosporine and Mycophenolate Mofetil in Treating Patients With Chronic Myelogenous Leukemia

NCT00119340
View directory record Official record
Conditions
Leukemia
Interventions
cyclosporine, fludarabine phosphate, mycophenolate mofetil, peripheral blood stem cell transplantation, radiation therapy
Drug · Procedure · Radiation
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
Not listed
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
3
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 21, 2010 · Synced Oct 21, 2026, 4:49 AM EDT
Withdrawn Not applicable Interventional

Non-invasive Intracranial Pressure (ICP) Monitoring in Pediatric Patients

NCT02695264
View directory record Official record
Conditions
Intracranial Hypertension
Interventions
HS-1000 recording
Device
Lead sponsor
HeadSense Medical
Industry
Eligibility
Up to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Akron, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 23, 2016 · Synced Oct 21, 2026, 4:49 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Detection of Hemodynamic Changes in TBI Population With Functional Near Infrared Spectroscopy

NCT01797549
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Not listed
Lead sponsor
Uniformed Services University of the Health Sciences
Federal
Eligibility
18 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 17, 2019 · Synced Oct 21, 2026, 4:49 AM EDT