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ClinicalTrials.gov public records Last synced Nov 14, 2026, 7:49 PM EST

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Showing 1–24 of 1,286 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: TBI (Traumatic Brain Injury) Clear all

Conditions: Concussion, Mild
Interventions: Behavioral Control, Targeted Intervention; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 50 Years to 99 Years
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Concussion, Brain, Concussion Post Syndrome
Interventions: Mindfulness Exercises and Meditations; Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 30 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: TBI, Major Depression, Other Psychiatric Disorders
Interventions: Escitalopram, Placebo; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Brain Injuries, Traumatic
Interventions: Not listed
Lead sponsor: Banyan Biomarkers, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 111 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Traumatic Brain Injury, Subarachnoid Hemorrhage
Interventions: Levetiracetam, Phenytoin; Drug
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years and older
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Brain Concussion
Interventions: Branched Chain Amino Acids, Placebo solution; Drug
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 11 Years to 34 Years
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2023
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Insomnia Disorder, Mild Traumatic Brain Injury
Interventions: Sleep MAPP Care Pathway; Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 900 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2029
U.S. locations: 2
States / cities: Aurora, Colorado • Tampa, Florida

Conditions: TBI (Traumatic Brain Injury), Brain Injuries, Stress, Attention Deficit, Executive Dysfunction
Interventions: State regulation skill training, Treatment-as-usual; Behavioral · Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 21 Years to 55 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Traumatic Brain Injury, Acute Brain Injuries
Interventions: gammaCore active device, gammaCore sham device; Device
Lead sponsor: CentraCare; Other
Eligibility: 18 Years to 60 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Traumatic Brain Injury, Attention Impaired, Emotional Regulation
Interventions: Online group 1, Online group 2; Behavioral
Lead sponsor: Kessler Foundation; Other
Eligibility: 18 Years to 70 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: East Hanover, New Jersey

Conditions: Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness, Coma, Minimally Conscious State, Unresponsive Wakefulness Syndrome, Brain Injury, TBI Traumatic Brain Injury
Interventions: Functional Near-Infrared Spectroscopy Monitoring; Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 55 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Traumatic Brain Injury (Tbi), Traumatic Meningeal Enhancement (Tme)
Interventions: Not listed
Lead sponsor: National Institutes of Health Clinical Center (CC); NIH
Eligibility: 21 Years to 65 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Brain Injuries, Brain Concussion
Interventions: Head Impact Recording Technology (HIRT); Device
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: 18 Years to 24 Years · Male only
Healthy volunteers: Accepts healthy volunteers
U.S. locations: 1
States / cities: State College, Pennsylvania

Conditions: Tinnitus, Traumatic Brain Injury, Post Traumatic Stress Disorder
Interventions: Not listed
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years to 30 Years
Enrollment: 218 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: San Diego, California

Conditions: Pseudobulbar Affect (PBA), Stroke, Dementia, Traumatic Brain Injury (TBI)
Interventions: Nuedexta (DM 20 mg/Q 10 mg); Drug
Lead sponsor: Avanir Pharmaceuticals; Industry
Eligibility: 18 Years and older
Enrollment: 367 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Pensacola, Florida

Conditions: Depression, Traumatic Brain Injury
Interventions: aerobic exercise, stretching and flexibility program; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 14 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Traumas, Brain, Alzheimer Disease, Dementia, Head Injury, Concussion, Brain, TBI
Interventions: Combined Aerobic and Resistance Exercise + Caregiver Skills Training, Stretching Balance and Flexibility + Caregiver Skills Training; Behavioral
Lead sponsor: Palo Alto Veterans Institute for Research; Other
Eligibility: 18 Years to 85 Years
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Fixation, Ocular, Brain Concussion
Interventions: Concussion Pen; Device
Lead sponsor: Children's Mercy Hospital Kansas City; Other
Eligibility: 11 Years to 18 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Kansas City, Missouri

Conditions: Healthy, Minor Traumatic Brain Injury (TBI)
Interventions: Not listed
Lead sponsor: ElMindA Ltd; Industry
Eligibility: 11 Years to 15 Years · Male only
Enrollment: 145 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Minimally Conscious States Due to Traumatic Brain Injury, Persistently Vegetative States Due to Traumatic Brain Injury
Interventions: Vagus nerve stimulation;, No stimulation; Device
Lead sponsor: VA New York Harbor Healthcare System; Federal
Eligibility: 18 Years to 60 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Brain Injuries, Craniocerebral Trauma, Trauma, Nervous System, Traumatic Brain Injury
Interventions: IV Propranolol and Per Tube Clonidine, Placebo; Drug
Lead sponsor: Vanderbilt University; Other
Eligibility: 16 Years to 64 Years
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Mild Traumatic Brain Injury (mTBI)
Interventions: Symptom-Targeted Approach to Rehabilitation for Concussion; Behavioral
Lead sponsor: Henry M. Jackson Foundation for the Advancement of Military Medicine; Other
Eligibility: 18 Years to 64 Years
Enrollment: 222 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 2
States / cities: Wahiawa, Hawaii • San Antonio, Texas

Conditions: Traumatic Brain Injury
Interventions: Group Interactive Structured Treatment, Alternative Intervention; Behavioral
Lead sponsor: Craig Hospital; Other
Eligibility: 18 Years and older
Enrollment: 231 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 6
States / cities: Palo Alto, California • Englewood, Colorado • Indianapolis, Indiana + 3 more

Conditions: Traumatic Brain Injury (TBI) Patients
Interventions: transcranial electrical stimulation, Sham Comparator; Device
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Cincinnati, Ohio

Search by objective public record fields.

Concussion Treatment in Older Adults

Mindfulness Intervention in Young Adults With a Concussion History

Lexapro for the Treatment of Traumatic Brain Injury (TBI) Depression & Other Psychiatric Conditions

Biomarkers of Brain Injury: Magnitude and Outcome of Mild and Moderate TBI

Assess Safety and Efficacy of Levetiracetam(LEV;Keppra)for Seizure Prevention

BCAA Supplementation for Concussion

Sleep MAPP in the Polytrauma/TBI System of Care

Brain Markers of Improvements in Cognitive Functioning

Vagus Nerve Stimulation to Treat Moderate Traumatic Brain Injury

Online Intervention for Traumatic Brain Injury Wellbeing

fNIRS for Disorders of Consciousness

Imaging Characterization of the Biomechanical Coupling of Brain and Skull

Measuring Head Impacts in Sports

Investigating the Neurobiology of Tinnitus

Safety, Tolerability and Effectiveness of Nuedexta in the Treatment of Pseudobulbar Affect (PBA)

Exercise Training in Depressed Traumatic Brain Injury Survivors

The COACH Project: Combined Online Assistance for Caregiver Health

Concussion Pen Screening Tool

An Investigator Initiated Study to Evaluate the Effectiveness of Brain Network Activation (BNA™) Technology in the Management of Sport Related Concussion

Vagus Nerve Stimulation to Augment Recovery From Minimally Conscious or Persistently Vegetative States After Traumatic Brain Injury

DASH After TBI Study: Decreasing Adrenergic or Sympathetic Hyperactivity After Traumatic Brain Injury

Symptom-Targeted Approach to Rehabilitation for Concussion (STAR-C)

Treatment of Social Competence After Traumatic Brain Injury

Early Neuromodulation in Traumatic Brain Injury