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ClinicalTrials.gov public records Last synced Oct 18, 2026, 2:08 AM EDT

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Showing 1–24 of 63 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: TMJ Pain Clear all
Terminated Phase 2 Interventional Results available

Erenumab-aooe for Temporomandibular Disorders Management: TMD Cgrp Antibody RElief (TMD CARE)

NCT05162027
View directory record Official record
Conditions
Temporomandibular Disorders
Interventions
Erenumab-Aooe 70 MG in 1 mL Prefilled Syringe, Placebo
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 2, 2024 · Synced Oct 18, 2026, 2:08 AM EDT
Completed No phase listed Observational

Diagnosis and Evaluation of Patients Needing Third Molar (Wisdom Tooth) Extraction and Patients With Chronic Facial Pain

NCT00001600
View directory record Official record
Conditions
Facial Pain, Temporomandibular Joint Disorder
Interventions
Not listed
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
4,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 18, 2026, 2:08 AM EDT
Completed Phase 2 Interventional Results available

Efficacy of Steroid Supplementation After TMJ Rinsing for Pain Management

NCT01770912
View directory record Official record
Conditions
Pain
Interventions
Lactated Ringers, Triamcinolone hexacetonide
Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 8, 2020 · Synced Oct 18, 2026, 2:08 AM EDT
Completed Phase 2 Interventional Results available

Comparison of Psychological and Pharmacological Treatments for Pain Due to Temporomandibular Joint Disorder (TMD)

NCT00066937
View directory record Official record
Conditions
Temporomandibular Joint Disorders
Interventions
Nortriptyline Oral Capsule, Benztropine Oral Product, CBT, Disease MGT
Drug · Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 65 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 24, 2017 · Synced Oct 18, 2026, 2:08 AM EDT
Recruiting Phase 3 Interventional

Biologic Augmentation of TMJ Arthroscopy Using BMAC

NCT07536399
View directory record Official record
Conditions
TMJ - Oral &Maxillofacial Surgery, Oral and Maxillofacial Conditions, TMJ Pain, TMJ Arthralgia
Interventions
Bone Marrow Aspirate Concentrate, Corticosteroid (CS)
Biological · Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Oct 18, 2026, 2:08 AM EDT
Completed Phase 2 Interventional Results available

Study of Orofacial Pain and PropRANOlol

NCT02437383
View directory record Official record
Conditions
Temporomandibular Disorders
Interventions
Propranolol ER, Placebo
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
3
States / cities
Gainesville, Florida • Buffalo, New York • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 21, 2019 · Synced Oct 18, 2026, 2:08 AM EDT
Completed Not applicable Interventional

Biobehavioral Pain Management in TMD

NCT01794624
View directory record Official record
Conditions
Temporomandibular Joint Disorder
Interventions
Cognitive Therapy for Catastrophizing, Behavioral Therapy for Sleep Continuity Disturbance
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 19, 2018 · Synced Oct 18, 2026, 2:08 AM EDT
Terminated Not applicable Interventional

Nu-V3 Non-Invasive Nerve Stimulation Device Trial for Chronic Pain, Anxiety, Depression, Sleeplessness

NCT05335980
View directory record Official record
Conditions
Chronic Pain, Anxiety, Depression, Sleeplessness
Interventions
Nu-V3
Device
Lead sponsor
Nu-Life Solutions
Industry
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 20, 2022 · Synced Oct 18, 2026, 2:08 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Multimodal Assessment of Sensory Processing and Brain Features in Patients With Chronic Orofacial Pain

NCT02630771
View directory record Official record
Conditions
Toothache, Temporomandibular Joint Disorders
Interventions
Pressure pain threshold
Procedure
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 2, 2019 · Synced Oct 18, 2026, 2:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Duloxetine for Treatment of Painful Temporomandibular Joint Disorder

NCT00981149
View directory record Official record
Conditions
Temporomandibular Joint Disorders
Interventions
duloxetine, Placebo
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 25, 2021 · Synced Oct 18, 2026, 2:08 AM EDT
Terminated Not applicable Interventional Results available

Efficacy of Nalbuphine and Naloxone Administered as Nose Sprays in the Treatment of Orofacial Pain

NCT00716807
View directory record Official record
Conditions
Temporomandibular Joint Dysfunction Syndrome, Burning Mouth Syndrome
Interventions
nalbuphine plus naloxone, nalbuphine plus placebo
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 20, 2016 · Synced Oct 18, 2026, 2:08 AM EDT
Recruiting Not applicable Interventional

An Open Label Study Assessing REN Treatment in Headache Management in Temporomandibular Disorders

NCT07639944
View directory record Official record
Conditions
Temporomandibular Disorder, Orofacial Pain
Interventions
Nerivio treatment
Device
Lead sponsor
Theranica
Industry
Eligibility
12 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
4
States / cities
Newark, Delaware • Ridgeland, Mississippi • Commack, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2026 · Synced Oct 18, 2026, 2:08 AM EDT
Completed Phase 2 Interventional Results available

Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments

NCT03844412
View directory record Official record
Conditions
Vestibulodynia, Temporomandibular Disorder, Fibromyalgia Syndrome, Irritable Bowel Syndrome, Migraines, Tension Headache, Endometriosis, Interstitial Cystitis, Back Pain, Chronic Fatigue Syndrome
Interventions
5% lidocaine/5 mg/ml 0.02% estradiol compound cream, Nortriptyline, Placebo cream, Placebo pill
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
209 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
2
States / cities
Los Angeles, California • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Oct 18, 2026, 2:08 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

CONDOR Temporomandibular Muscle and Joint Disorders (TMJD) Survey

NCT01201512
View directory record Official record
Conditions
Temporomandibular Disorders
Interventions
Not listed
Lead sponsor
Dental Practice-Based Research Network
Network
Eligibility
22 Years and older
Enrollment
503 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 16, 2011 · Synced Oct 18, 2026, 2:08 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

ATI Evidence-based Guide Investigating Clinical Services

NCT02285868
View directory record Official record
Conditions
Primary Body Region (Arranged Most Common to Least), Lumbar/SI, Knee, Shoulder, Cervical/Thoracic, Foot/Ankle, Hip, Elbow, Neurological, Vestibular, Pelvic Floor, TMJ, Fibromyalgia, Headaches, Lymphedema
Interventions
Not listed
Lead sponsor
ATI Holdings, LLC
Industry
Eligibility
Not listed
Enrollment
4,000,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Downers Grove, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Oct 18, 2026, 2:08 AM EDT
Recruiting Not applicable Interventional

Journaling Intervention for Temporomandibular Disorder (TMD) and Chronic Overlapping Pain

NCT06977100
View directory record Official record
Conditions
Temporomandibular Disorders (TMD)
Interventions
Gratitude, General Wellness
Behavioral · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Oct 18, 2026, 2:08 AM EDT
Recruiting Not applicable Interventional

Neural Mechanisms of Immersive Virtual Reality in Chronic Pain (VR TMD EEG)

NCT06214923
View directory record Official record
Conditions
Pain, Virtual Reality, Placebo, Temporomandibular Disorder
Interventions
RelieVRx, Sham-VR, No-VR (natural history control)
Device · Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 88 Years
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Oct 18, 2026, 2:08 AM EDT
Completed Not applicable Interventional

Immediate Effect of Ultrasound Therapy on Bilateral Masseter Myalgia

NCT02892994
View directory record Official record
Conditions
Temporomandibular Joint Dysfunction Syndrome
Interventions
ultrasound
Other
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years and older · Female only
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Sep 8, 2016 · Synced Oct 18, 2026, 2:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

An Implementation and Biobehavioral Study of Temporomandibular Joint and Muscle Disorder (TMJMD)

NCT00952900
View directory record Official record
Conditions
Temporomandibular Joint and Muscle Disorder
Interventions
Biobehavioral, Active Coping/Attention Intervention
Behavioral
Lead sponsor
The University of Texas at Arlington
Other
Eligibility
18 Years and older
Enrollment
456 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2014
U.S. locations
1
States / cities
Arlington, Texas
Source: ClinicalTrials.gov public record
Updated Jun 8, 2015 · Synced Oct 18, 2026, 2:08 AM EDT
Completed Phase 3 Interventional Results available

Botulinum Toxin Versus Placebo Injections to Temporalis and Masseter Muscles

NCT03223298
View directory record Official record
Conditions
Pain, Head, Pain Syndrome, Temporomandibular Disorder, Myofascial Pain Syndrome, Myofascial Pain
Interventions
Botulinum toxin type A, 0.9% Sodium Chloride Injection
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 65 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
2
States / cities
Chicago, Illinois • New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 14, 2023 · Synced Oct 18, 2026, 2:08 AM EDT
Active, not recruiting Not applicable Interventional

EMVITAL + EMFACE Combination Therapy for Temporomandibular Joint (TMJ) Pain Relief

NCT07661121
View directory record Official record
Conditions
Temporomandibular Disorder (TMD), Temporomandibular Joint Pain, Facial Pain, Neck Pain
Interventions
Treatment with BTL-043 and BTL-785F
Device
Lead sponsor
BTL Industries Ltd.
Industry
Eligibility
22 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
4
States / cities
Leesburg, Florida • Ocala, Florida • Covington, Kentucky + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 18, 2026, 2:08 AM EDT
Not yet recruiting Not applicable Interventional

Effects of Core Strengthening Exercises for Treating TMD

NCT07226505
View directory record Official record
Conditions
Temporomandibular Joint Dysfunction, TMD, TMJ Internal Derangement, Myofascial Pain
Interventions
Experimental: Group 1: Core Strengthening, Group 2: Standard TMD PT
Behavioral
Lead sponsor
Loyola University
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 10, 2025 · Synced Oct 18, 2026, 2:08 AM EDT
Withdrawn Phase 1 Interventional

Botox for Treatment of TMJ Disorder With Bruxism

NCT02202070
View directory record Official record
Conditions
Temporomandibular Joint Disorders, Bruxism, Temporomandibular Joint Dysfunction Syndrome, Myofascial Pain Dysfunction Syndrome, Temporomandibular Joint
Interventions
onabotulinumtoxinA
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 23, 2018 · Synced Oct 18, 2026, 2:08 AM EDT
Withdrawn Not applicable Interventional

Evaluation of the Effect of the Erchonia® EVRL on Chronic Jaw Pain Arising From TMJ

NCT07600203
View directory record Official record
Conditions
TMJ, TMJ Pain, TMD
Interventions
Erchonia® EVRL™, Placebo Device
Device
Lead sponsor
Erchonia Corporation
Industry
Eligibility
22 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Acton, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Oct 18, 2026, 2:08 AM EDT