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Showing 1–15 of 15 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Taste Sweet Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Ibuprofen Inhibits Human Sweet Taste

NCT06291337
View directory record Official record
Conditions
Treatment of Sweet Taste Receptors Without or With an Oral Rinse of Ibuprofen Solution in Healthy Participants, Treatment of Sweet Taste Receptors Without or With an Oral Rinse of Naproxen Solution in Healthy Participants
Interventions
Inhibition of Sweet Taste by Ibuprofen Oral Rinses, Inhibition of Sweet Taste by Naproxen Oral Rinses
Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 70 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 3, 2024 · Synced Sep 5, 2026, 12:27 AM EDT
Completed No phase listed Observational

Sensory Study: Taste and Tongue Biology

NCT05985928
View directory record Official record
Conditions
Healthy Adults
Interventions
Not listed
Lead sponsor
University of Massachusetts, Amherst
Other
Eligibility
18 Years to 45 Years
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Amherst, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 4, 2025 · Synced Sep 5, 2026, 12:27 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Sensory Strategy to Cut Sugary Beverages in African/American and Latine Adolescents

NCT07223151
View directory record Official record
Conditions
Obesity, Adolescent, Dietary Sugars, Taste Perception, Insulin Resistance, Feeding Behavior
Interventions
Unsweetened Sparkling Water Replacement, Progressively Reduced Sugar Beverage Replacement, Plain Water Replacement
Behavioral
Lead sponsor
Nana Gletsu Miller
Other
Eligibility
12 Years to 18 Years
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
3
States / cities
Bloomington, Indiana • Indianapolis, Indiana • West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 5, 2026, 12:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sucralose and Lactisole Additions to OGTT in Humans

NCT05900193
View directory record Official record
Conditions
Neat OGTT, OGTT With Added Sucralose, OGTT With Added Lactisole
Interventions
TAS1R2/3 agonist or antagoinst admixture to oral glucose tolerance test
Dietary Supplement
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 70 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 11, 2023 · Synced Sep 5, 2026, 12:27 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Differential Responses to Drugs and Sweet Tastes

NCT03810703
View directory record Official record
Conditions
Bipolar II Disorder
Interventions
Placebo oral capsule, d-amphetamine 10 mg oral capsule, d-amphetamine 20 mg oral capsule
Drug
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 19 Years
Enrollment
93 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
2
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 21, 2023 · Synced Sep 5, 2026, 12:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Taste Acuity and Caloric Intake After Acute Morphine Administration

NCT01763697
View directory record Official record
Conditions
Taste Sweet, Taste Salty, Feeding Behavior
Interventions
taste acuity assessment, Recorded meal
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 28, 2014 · Synced Sep 5, 2026, 12:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Snacks, Smiles and Taste Preferences

NCT03631992
View directory record Official record
Conditions
Development, Child
Interventions
Low Sweet, Regular Sweet
Behavioral
Lead sponsor
Temple University
Other
Eligibility
3 Years to 6 Years
Enrollment
172 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Sep 5, 2026, 12:27 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Does Sweet Taste Potentiate Nicotine Cue Reactivity?

NCT02499757
View directory record Official record
Conditions
Healthy
Interventions
flavor and sweetener, flavor and nicotine, flavor, nicotine and sweetener, flavor
Device
Lead sponsor
Yale University
Other
Eligibility
18 Years to 45 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 8, 2020 · Synced Sep 5, 2026, 12:27 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Added Sugar Intake, Sweet Taste Phenotypes and Biomarkers

NCT05047588
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
Monell Chemical Senses Center
Other
Eligibility
3 Years to 70 Years
Enrollment
277 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 2, 2023 · Synced Sep 5, 2026, 12:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Dietary Sugar Consumption on Sweet Taste Perception

NCT02090478
View directory record Official record
Conditions
Sweet Taste Perception
Interventions
Low sugar diet, Sham diet manipulation
Other
Lead sponsor
Monell Chemical Senses Center
Other
Eligibility
18 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2010
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 17, 2014 · Synced Sep 5, 2026, 12:27 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Impact of Menstrual Phase on Oral Glucose Sensitivity

NCT06800690
View directory record Official record
Conditions
Ovulation, Menstruation
Interventions
Urinary Estrogen Level
Diagnostic Test
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 46 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 29, 2025 · Synced Sep 5, 2026, 12:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intestinal Sweet Taste Receptor Function and Adaptation to Dietary Sugars and Sweeteners

NCT02835859
View directory record Official record
Conditions
Diabetes
Interventions
Dietary: saccharin, Estimate glucose absorptions
Other
Lead sponsor
AdventHealth Translational Research Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Aug 13, 2020 · Synced Sep 5, 2026, 12:27 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Role of Sweetness in Glucose Regulation

NCT03844230
View directory record Official record
Conditions
Obesity
Interventions
Control - Inhibition, Experimental I- Inhibition, Experimental II- Inhibition, Control- Stimulation, Experimental I- Stimulation, Experimental II- Stimulation, Sensory Evaluation
Other
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
21 Years to 40 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Champaign, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 26, 2021 · Synced Sep 5, 2026, 12:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Interactions of Human Gut Microbiota With Intestinal Sweet Taste Receptors

NCT03032640
View directory record Official record
Conditions
Obesity
Interventions
Oral Glucose Tolerance Test (OGTT), Assessment of dietary compliance, Stool sampling, Sodium Saccharin, Placebo, Lactisole
Other
Lead sponsor
AdventHealth Translational Research Institute
Other
Eligibility
18 Years to 45 Years
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Feb 1, 2023 · Synced Sep 5, 2026, 12:27 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Monell USDA Taste Test Study

NCT04079855
View directory record Official record
Conditions
Healthy Diet
Interventions
Diet composition 1, Diet composition 2, Diet composition 3
Other
Lead sponsor
David Baer
Federal
Eligibility
25 Years to 80 Years
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Beltsville, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 13, 2025 · Synced Sep 5, 2026, 12:27 AM EDT