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ClinicalTrials.gov public records Last synced Oct 3, 2026, 8:31 AM EDT

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Showing 49–72 of 77 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Temporomandibular Disorder Clear all
Terminated Not applicable Interventional Results available

Photobiomodulation for the Management of Temporomandibular Disorder Pain

NCT04415281
View directory record Official record
Conditions
Pain Related to TMD
Interventions
THOR® laser system, sham THOR® laser system
Device
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 12, 2023 · Synced Oct 3, 2026, 8:31 AM EDT
Withdrawn No phase listed Observational

Comorbid Painful TMD Among Trigeminal Neuralgia

NCT05914558
View directory record Official record
Conditions
Trigeminal Neuralgia, Temporomandibular Disorder, Myofascial Pain, Trigeminal Neuropathy
Interventions
Clinical appointment
Diagnostic Test
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
2
States / cities
Baltimore, Maryland • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 31, 2025 · Synced Oct 3, 2026, 8:31 AM EDT
Completed Phase 2 Interventional

Nasal Carbon Dioxide (CO2)for the Treatment of Temporomandibular Disorders (TMD)Related Pain

NCT00484029
View directory record Official record
Conditions
Temporomandibular Disorders, Pain, Headaches
Interventions
Nasal Carbon Dioxide, Air
Drug · Other
Lead sponsor
Capnia, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 20, 2010 · Synced Oct 3, 2026, 8:31 AM EDT
Recruiting Not applicable Interventional

Evaluating Noninvasive Brain Stimulation for TMD Pain: A Feasibility Study

NCT07517172
View directory record Official record
Conditions
Temporomandibular Disorder
Interventions
Transcutaneous Auricular Neurostimulation, Sham Stimulation
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 3, 2026, 8:31 AM EDT
Completed Not applicable Interventional Results available

Immediate Effect of Ultrasound Therapy on Bilateral Masseter Myalgia: Randomized Single Blinded Investigational Trial

NCT02295644
View directory record Official record
Conditions
Temporomandibular Joint Dysfunction Syndrome
Interventions
Ultrasound Sonicator 740
Device
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years and older · Female only
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jun 7, 2018 · Synced Oct 3, 2026, 8:31 AM EDT
Active, not recruiting Phase 1Phase 2 Interventional

Neural Mechanisms of Immersive Virtual Reality in Chronic Pain

NCT04851301
View directory record Official record
Conditions
Pain, Virtual Reality, Placebo, Temporomandibular Disorder
Interventions
Active Virtual Reality, sham Virtual Reality, No Intervention, Naloxone, Saline, Natural history
Behavioral · Other · Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 88 Years
Enrollment
259 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 3, 2026, 8:31 AM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

The Use of PET/CT to Evaluate Synovitis in the Temporomandibular Joint (TMJ)

NCT01471418
View directory record Official record
Conditions
Temporomandibular Joint, Conservative Treatment Therapy
Interventions
PET/CT with 18-FDG
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 70 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 8, 2015 · Synced Oct 3, 2026, 8:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Duloxetine for Treatment of Painful Temporomandibular Joint Disorder

NCT00981149
View directory record Official record
Conditions
Temporomandibular Joint Disorders
Interventions
duloxetine, Placebo
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 25, 2021 · Synced Oct 3, 2026, 8:31 AM EDT
Completed No phase listed Observational

An Evaluation of Psychological Parameters That May Influence the Outcome Following Arthroscopy and Arthroplasty for Temporomandibular Joint Surgery

NCT01396694
View directory record Official record
Conditions
Psychological Predictors
Interventions
Questionnaire
Other
Lead sponsor
Emory University
Other
Eligibility
18 Years to 90 Years
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 17, 2016 · Synced Oct 3, 2026, 8:31 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Investigation and Modulation of the Mu-opioid Mechanisms in TMD (in Vivo)

NCT03724032
View directory record Official record
Conditions
Temporomandibular Disorder
Interventions
HD-tDCS*, Sham HD-tDCS*
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 15, 2023 · Synced Oct 3, 2026, 8:31 AM EDT
Active, not recruiting Not applicable Interventional

EMVITAL + EMFACE Combination Therapy for Temporomandibular Joint (TMJ) Pain Relief

NCT07661121
View directory record Official record
Conditions
Temporomandibular Disorder (TMD), Temporomandibular Joint Pain, Facial Pain, Neck Pain
Interventions
Treatment with BTL-043 and BTL-785F
Device
Lead sponsor
BTL Industries Ltd.
Industry
Eligibility
22 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
4
States / cities
Leesburg, Florida • Ocala, Florida • Covington, Kentucky + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 3, 2026, 8:31 AM EDT
Completed Phase 2 Interventional

Alternative Medicine Approaches for Women With Temporomandibular Disorders

NCT00009594
View directory record Official record
Conditions
Temporomandibular Joint Disorders
Interventions
Naturopathic Medicine, Traditional Chinese Medicine
Procedure
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
25 Years to 55 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2004
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 18, 2006 · Synced Oct 3, 2026, 8:31 AM EDT
Completed Phase 2 Interventional

Study of Etanercept and Celecoxib to Treat Temporomandibular Disorders (Painful Joint Conditions)

NCT00001955
View directory record Official record
Conditions
Temporomandibular Joint Disorder
Interventions
Etanercept, Celecoxib
Drug
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2004
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 3, 2026, 8:31 AM EDT
Recruiting Not applicable Interventional

Photobiomodulation for Management of Temporomandibular Disorder Pain

NCT05916235
View directory record Official record
Conditions
Pain Related to TMD
Interventions
THOR® laser system
Device
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 99 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 24, 2025 · Synced Oct 3, 2026, 8:31 AM EDT
Terminated Phase 2 Interventional Results available

Erenumab-aooe for Temporomandibular Disorders Management: TMD Cgrp Antibody RElief (TMD CARE)

NCT05162027
View directory record Official record
Conditions
Temporomandibular Disorders
Interventions
Erenumab-Aooe 70 MG in 1 mL Prefilled Syringe, Placebo
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 2, 2024 · Synced Oct 3, 2026, 8:31 AM EDT
Completed Not applicable Interventional Results available

Managing Temporomandibular Disorder (TMD) Symptoms

NCT00237042
View directory record Official record
Conditions
Temporomandibular Joint Disorders
Interventions
Self Management, Targeted Self Management, 20 mcg ethinyl estradiol and 100 mcg levonorgestrel
Behavioral · Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
252 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 11, 2011 · Synced Oct 3, 2026, 8:31 AM EDT
Completed Not applicable Interventional Results available

Conservative Treatment of Patients With Temporomandibular Disorders

NCT01021306
View directory record Official record
Conditions
Temporomandibular Disorders
Interventions
Chiropractic w/Activator & Self Care, Dental Care & Self Care, Sham AMCT, Self-Care Only Group
Device · Other
Lead sponsor
Palmer College of Chiropractic
Other
Eligibility
21 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
3
States / cities
Coralville, Iowa • Davenport, Iowa • Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated May 22, 2017 · Synced Oct 3, 2026, 8:31 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Safety and Efficacy of Erenumab-aooe in Patients With Temporomandibular Disorder

NCT04884763
View directory record Official record
Conditions
Temporomandibular Disorder
Interventions
Erenumab-aooe (EREN) 140 mg s.c. administered every four weeks for a total of five treatments, Placebo (EREN-P) s.c. administered every four weeks for a total of five treatments
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 59 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 19, 2025 · Synced Oct 3, 2026, 8:31 AM EDT
Withdrawn Phase 1 Interventional Accepts healthy volunteers

Platelet-Rich Plasma vs Corticosteroid Injection as Treatment for Degenerative Pathology of the Temporomandibular Joint

NCT01920373
View directory record Official record
Conditions
Degenerative Joint Disease
Interventions
Group A (corticosteroid injection group), Group B (platelet rich plasma injection group)
Drug · Biological
Lead sponsor
Kaiser Permanente
Other
Eligibility
Not listed
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2013
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 11, 2015 · Synced Oct 3, 2026, 8:31 AM EDT
Completed Phase 2 Interventional

Complementary Medicine Approaches to TMD Pain Management

NCT00010621
View directory record Official record
Conditions
Temporomandibular Joint Disorders
Interventions
Acupuncture, chiropractic therapy, bodywork therapy
Procedure
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2004
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 18, 2006 · Synced Oct 3, 2026, 8:31 AM EDT
Terminated Phase 4 Interventional Results available

Efficacy of PRGF Supplementation After TMJ Arthrocentesis in Patients With TMJ Osteoarthritis

NCT04731233
View directory record Official record
Conditions
TMJ, Osteoarthritis
Interventions
Plasma Rich in Growth Factor (PRGF) Supplementation, Triamcinolone Acetonide
Biological · Drug
Lead sponsor
University of Florida
Other
Eligibility
40 Years to 80 Years · Female only
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 21, 2025 · Synced Oct 3, 2026, 8:31 AM EDT
Completed Not applicable Interventional

Biobehavioral Pain Management in TMD

NCT01794624
View directory record Official record
Conditions
Temporomandibular Joint Disorder
Interventions
Cognitive Therapy for Catastrophizing, Behavioral Therapy for Sleep Continuity Disturbance
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 19, 2018 · Synced Oct 3, 2026, 8:31 AM EDT
Recruiting Not applicable Interventional

Effects of Vagus Nerve Stimulation on Temporomandibular Disorders.

NCT07288411
View directory record Official record
Conditions
TMD, Temporomandibular Disorders (TMDs)
Interventions
nVNS Treatment
Device
Lead sponsor
Arpana Church
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Oct 3, 2026, 8:31 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Testing Educational Modalities for Temporomandibular Disorders Curriculum

NCT07203456
View directory record Official record
Conditions
Confidence, Diagnostic Ability
Interventions
Virtual Patient Based Learning (VPBL), Clinical exposure to patients with TMD, Clinical exposure to TMD + VPBL
Other
Lead sponsor
Midwestern University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Downers Grove, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 2, 2025 · Synced Oct 3, 2026, 8:31 AM EDT