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Showing 1–24 of 138 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Tetraplegia Clear all
Completed Not applicable Interventional Results available

Hand Function for Tetraplegia

NCT00890916
View directory record Official record
Conditions
Spinal Cord Injury, Tetraplegia
Interventions
FIRSTHAND System
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 8, 2021 · Synced Jul 21, 2026, 9:27 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

MyHand-SCI: An Active Hand Orthosis for Spinal Cord Injury

NCT05553457
View directory record Official record
Conditions
Spinal Cord Injuries, Tetraplegia
Interventions
Testing of MyHand-SCI Device
Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Jul 21, 2026, 9:27 AM EDT
Terminated Not applicable Interventional

Activity-Dependent Transspinal Stimulation in SCI

NCT03669302
View directory record Official record
Conditions
Spinal Cord Injuries, Paraplegia, Spinal, Tetraplegia/Tetraparesis, Paraplegia, Spastic
Interventions
Robotic gait training, Robotic gait training and low-frequency transspinal stimulation, Robotic gait training and high-frequency transspinal stimulation
Other · Device
Lead sponsor
City University of New York
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
2
States / cities
Staten Island, New York • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Aug 9, 2022 · Synced Jul 21, 2026, 9:27 AM EDT
Active, not recruiting Not applicable Interventional Results available

Implanted Myoelectric Control for Restoration of Hand Function in Spinal Cord Injury

NCT00583804
View directory record Official record
Conditions
Spinal Cord Injury, Tetraplegia
Interventions
IST-12
Device
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1989 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 2, 2025 · Synced Jul 21, 2026, 9:27 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Body Temperature in Persons With Tetraplegia When Exposed to Heat

NCT01890915
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Heat Exposure
Other
Lead sponsor
James J. Peters Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 2, 2016 · Synced Jul 21, 2026, 9:27 AM EDT
Not yet recruiting Not applicable Interventional

iBCI Optimization for Veterans With Paralysis

NCT05470478
View directory record Official record
Conditions
Spinal Cord Injury, Amyotrophic Lateral Sclerosis, Brain Stem Infarctions, Locked-in Syndrome, Muscular Dystrophy
Interventions
Mobile neural decoding platform (mobile iBCI)
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 80 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Feb 22, 2026 · Synced Jul 21, 2026, 9:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Brain Plus Spinal Stimulation for Cervical SCI

NCT04727866
View directory record Official record
Conditions
Spinal Cord Injuries, Spinal Cord Injury at C5-C7 Level, Tetraplegia/Tetraparesis
Interventions
transcutaneous spinal direct current stimulation (tsDCS) - coronal, transcutaneous spinal direct current stimulation (tsDCS) - caudal, transcutaneous spinal direct current stimulation (tsDCS) - rostral, intermittent theta burst stimulation (iTBS)
Device
Lead sponsor
Bronx VA Medical Center
Federal
Eligibility
18 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jan 16, 2024 · Synced Jul 21, 2026, 9:27 AM EDT
Completed Not applicable Interventional

The Up-LIFT Study of Non-Invasive ARC Therapy for Spinal Cord Injury

NCT04697472
View directory record Official record
Conditions
Chronic Spinal Cord Injury
Interventions
LIFT System
Device
Lead sponsor
ONWARD Medical, Inc.
Industry
Eligibility
22 Years to 75 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
9
States / cities
Englewood, Colorado • Miami, Florida • Atlanta, Georgia + 6 more
Source: ClinicalTrials.gov public record
Updated Sep 15, 2022 · Synced Jul 21, 2026, 9:27 AM EDT
Recruiting Not applicable Interventional

Investigation on the Bidirectional Cortical Neuroprosthetic System

NCT03161067
View directory record Official record
Conditions
Tetraplegia, Quadriplegia
Interventions
BiCNS
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
22 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 8, 2025 · Synced Jul 21, 2026, 9:27 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Body Temperature in Persons With Tetraplegia When Exposed to Cold

NCT01822535
View directory record Official record
Conditions
Tetraplegia, Hypothermia, Mild Cognitive Impairment
Interventions
Midodrine hydrochloride
Drug
Lead sponsor
James J. Peters Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 68 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 3, 2016 · Synced Jul 21, 2026, 9:27 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Spinal Cord Stimulation for Functional Recovery in Humans With Tetraplegia

NCT05157282
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
TESS, Training, Motor Task, sham-TESS
Device · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
2
States / cities
Chicago, Illinois • Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Jul 21, 2026, 9:27 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Self-balancing Personal Exoskeleton for SCI (Site 2)

NCT06814015
View directory record Official record
Conditions
Spinal Cord Injuries (SCI), Paraplegia and Tetraplegia
Interventions
Hands-free exoskeleton
Device
Lead sponsor
Wandercraft
Industry
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 1, 2026 · Synced Jul 21, 2026, 9:27 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

NuroSleeve Powered Brace & Stimulation System to Restore Arm Function

NCT04798378
View directory record Official record
Conditions
Neurologic Diseases, Hemiparesis, Quadriplegia, Muscular Dystrophies, Arthrogryposis, Spinal Cord Injuries, Charcot-Marie-Tooth, Stroke, Weakness of Extremities as Sequela of Stroke, Weakness Due to Upper Motor Neuron Dysfunction, Amyotrophic Lateral Sclerosis, Spinal Muscular Atrophy, Arm Paralysis, Cerebral Palsy
Interventions
Neurosleeve
Device
Lead sponsor
Thomas Jefferson University
Other
Eligibility
4 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
2
States / cities
Wilmington, Delaware • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 8, 2025 · Synced Jul 21, 2026, 9:27 AM EDT
Active, not recruiting No phase listed Observational

Incomplete Cervical SCI Without Instability

NCT05653206
View directory record Official record
Conditions
Cervical Spinal Cord Injury
Interventions
Nonsurgical treatment, Surgical treatment
Procedure
Lead sponsor
AO Foundation, AO Spine
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
3
States / cities
San Francisco, California • Baltimore, Maryland • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Jul 21, 2026, 9:27 AM EDT
Recruiting Not applicable Interventional

Transspinal Stimulation With and Without Blood Flow Restricted Exercise Via Telehealth in Persons With Tetraplegia

NCT05423600
View directory record Official record
Conditions
Tetraplegia/Tetraparesis
Interventions
BES + TS, Experimental: BES+sham TS
Procedure
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 70 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
3
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Jul 21, 2026, 9:27 AM EDT
Completed Not applicable Interventional

Biofeedback Treatment of Anxiety Associated With Chronic Spinal Cord Injury

NCT03975075
View directory record Official record
Conditions
Spinal Cord Injuries, Anxiety, Stress, Tetraplegia
Interventions
Psychophysiological monitoring, Biofeedback training
Behavioral
Lead sponsor
Craig Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Englewood, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 19, 2024 · Synced Jul 21, 2026, 9:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Heat Exposure on Cognition in Persons With Tetraplegia

NCT02488824
View directory record Official record
Conditions
Tetraplegia, Hypothermia, Mild Cognitive Impairment
Interventions
Warm Temperature
Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 68 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Nov 17, 2019 · Synced Jul 21, 2026, 9:27 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia

NCT00507546
View directory record Official record
Conditions
Insomnia, Spinal Cord Injury, Tetraplegia, Sleep Disorders
Interventions
Ramelteon, Placebo
Drug
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated May 21, 2014 · Synced Jul 21, 2026, 9:27 AM EDT
Recruiting Not applicable Interventional

Cortical Recording and Stimulating Array Brain-Machine Interface

NCT01894802
View directory record Official record
Conditions
Tetraplegia, Spinal Cord Injury, Brainstem Stroke, Brachial Plexus Injury, Above Elbow Amputation
Interventions
Implantation of CRS Arrays
Device
Lead sponsor
Michael Boninger
Other
Eligibility
22 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2029
U.S. locations
2
States / cities
Chicago, Illinois • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Jul 21, 2026, 9:27 AM EDT
Recruiting Phase 1 Interventional

A Study to Evaluate the Safety of a Delivery Device for Administering LCTOPC1 in Participants With Spinal Cord Injury

NCT06841770
View directory record Official record
Conditions
Spinal Cord Injury Cervical, Spinal Cord Injury Thoracic, Spinal Cord Injury, Acute, Spinal Cord Injury, Spinal Cord Injury, Chronic
Interventions
OPC1
Biological
Lead sponsor
Lineage Cell Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2037
U.S. locations
2
States / cities
Downey, California • La Jolla, California
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Jul 21, 2026, 9:27 AM EDT
Completed Not applicable Interventional

Upper Extremity Surgery in Spinal Cord Injury

NCT01899664
View directory record Official record
Conditions
Quadriplegia, Spinal Cord Diseases, Spinal Cord Injuries
Interventions
Nerve Transfer Surgery
Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 60 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2021
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 2, 2021 · Synced Jul 21, 2026, 9:27 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Combined Therapeutic Air Mixture and Electrical Stimulation to Improve Breathing and Hand Function in Spinal Cord Injury

NCT06101199
View directory record Official record
Conditions
Cervical Spinal Cord Injury
Interventions
Acute Intermittent Hypercapnic Hypoxia, Transcutaneous spinal cord stimulation, SHAM Acute Intermittent Hypercapnic Hypoxia, SHAM Transcutaneous spinal cord stimulation
Other
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years to 65 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 16, 2025 · Synced Jul 21, 2026, 9:27 AM EDT
Completed Not applicable Interventional Results available

Exoskeletal-assisted Walking to Improve Mobility, Bowel Function and Cardio-Metabolic Profiles in Persons With SCI

NCT02314221
View directory record Official record
Conditions
Spinal Cord Injury, Paraplegia, Tetraplegia
Interventions
Exoskeletal-assisted walking (ReWalk, Ekso)
Device
Lead sponsor
James J. Peters Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 70 Years
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
3
States / cities
Baltimore, Maryland • West Orange, New Jersey • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated May 15, 2025 · Synced Jul 21, 2026, 9:27 AM EDT
Not listed Not applicable Interventional

Telehealth Implementation of Brain-Computer Interface

NCT05951556
View directory record Official record
Conditions
Amyotrophic Lateral Sclerosis, Stroke
Interventions
Use of BCI
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
16 Years to 100 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 18, 2023 · Synced Jul 21, 2026, 9:27 AM EDT