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Showing 1–24 of 38 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Thermoregulation Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Heat Exposure on Cognition in Persons With Tetraplegia

NCT02488824
View directory record Official record
Conditions
Tetraplegia, Hypothermia, Mild Cognitive Impairment
Interventions
Warm Temperature
Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 68 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Nov 17, 2019 · Synced Jun 26, 2026, 5:33 PM EDT
Terminated Not applicable Interventional

Heat Waves and the Elderly With COPD

NCT06295523
View directory record Official record
Conditions
COPD, Aging, Hyperthermia
Interventions
Water Spray, Control
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
65 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Jun 26, 2026, 5:33 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Role of Menopause in Thermoregulation

NCT06798571
View directory record Official record
Conditions
Menopause, Aging
Interventions
Elagolix Oral Tablet, Estradiol patch, cellulose placebo, placebo patch
Drug · Other
Lead sponsor
Penn State University
Other
Eligibility
42 Years to 64 Years · Female only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Jun 26, 2026, 5:33 PM EDT
Completed Not applicable Interventional

Determination of Core Body Temperature in Parturient Warmed With Upper or Underbody Forced Air Cover (Bair Hugger)

NCT05314075
View directory record Official record
Conditions
Cesarean Section
Interventions
Upper Body Forced Air Warming device, Under Body Forced Air Warming device
Procedure
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older · Female only
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 1, 2025 · Synced Jun 26, 2026, 5:33 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Thermoregulation in Individuals With a Leg Amputation

NCT06458426
View directory record Official record
Conditions
Amputation, Diabetes
Interventions
shock-absorbing prosthesis
Device
Lead sponsor
University of Utah
Other
Eligibility
19 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Jun 26, 2026, 5:33 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Physiological Responses to Heat Stress During High-risk Events

NCT06907225
View directory record Official record
Conditions
Thermoregulation
Interventions
None-placebo
Other
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
2
States / cities
Fort Novosel, Alabama • Fort Jackson, South Carolina
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Jun 26, 2026, 5:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Novel Cooling Vest to Protect Persons With SCI From Hyperthermia

NCT05441449
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Cooling Vest
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 68 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Apr 29, 2025 · Synced Jun 26, 2026, 5:33 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Body Temperature in Persons With Tetraplegia When Exposed to Cold

NCT01822535
View directory record Official record
Conditions
Tetraplegia, Hypothermia, Mild Cognitive Impairment
Interventions
Midodrine hydrochloride
Drug
Lead sponsor
James J. Peters Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 68 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 3, 2016 · Synced Jun 26, 2026, 5:33 PM EDT
Not yet recruiting Early Phase 1 Interventional Accepts healthy volunteers

What is the Role of Type III/IV Muscle Afferents in Airway Resistance and Thermoregulatory Responses to Exercise?

NCT07452094
View directory record Official record
Conditions
Placebo - Control, Experimental
Interventions
EXERCISE TRAINING WITH OR WITHOUT MEDICATION
Drug
Lead sponsor
Northern Arizona University
Other
Eligibility
18 Years to 40 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Flagstaff, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Jun 26, 2026, 5:33 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Intermittent Cold and Dry Air Underneath Football Shoulder Pads

NCT00349804
View directory record Official record
Conditions
Body Temperature Regulation
Interventions
cool dry air
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 30 Years · Male only
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 11, 2012 · Synced Jun 26, 2026, 5:33 PM EDT
Completed Phase 1 Interventional Results available

Heat Retention Head Wrap Use for Re-warming of Infants Requiring Cardio-Pulmonary Bypass

NCT01675830
View directory record Official record
Conditions
Impaired Thermoregulation
Interventions
Heat Retention Head Wrap
Device
Lead sponsor
Cardiology Clinical Research & Regulatory Group
Other
Eligibility
1 Day to 1 Year
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 30, 2015 · Synced Jun 26, 2026, 5:33 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Impact of Depression on Thermoregulation

NCT06805851
View directory record Official record
Conditions
Depression, Selective Serotonin Reuptake Inhibitor
Interventions
Not listed
Lead sponsor
Penn State University
Other
Eligibility
18 Years to 40 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Jun 26, 2026, 5:33 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Intranasal Cocaine and Temperature Regulation During Exercise

NCT05809453
View directory record Official record
Conditions
Hyperthermia, Cocaine Use, Exercise
Interventions
Cocaine, Lidocaine
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 50 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 13, 2025 · Synced Jun 26, 2026, 5:33 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Thermoregulation Among Individuals With First-episode Psychosis

NCT04369677
View directory record Official record
Conditions
Psychosis, First Episode Psychosis
Interventions
Not listed
Lead sponsor
Nicholas Breitborde
Other
Eligibility
18 Years to 35 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2025
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Jun 26, 2026, 5:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Exercise in Burn Survivors: Cooling Modalities

NCT04512976
View directory record Official record
Conditions
Burn Injury
Interventions
Control (no cooling modalities), Water Spray Only, Fan Only, Water Spray and Fan
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 27, 2025 · Synced Jun 26, 2026, 5:33 PM EDT
Recruiting Not applicable Interventional

Autonomic Effects of Spinal Cord Stimulation in Spinal Cord Injury

NCT05960448
View directory record Official record
Conditions
Orthostatic Hypotension
Interventions
Transcutaneous Spinal Cord Stimulation (TSCS), Sham Transcutaneous Spinal Cord Stimulation
Other
Lead sponsor
James J. Peters Veterans Affairs Medical Center
Federal
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Sep 30, 2024 · Synced Jun 26, 2026, 5:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Pre-Loaded Betaine Supplementation on Thermoregulation and Exercise Metabolism in the Heat

NCT04585295
View directory record Official record
Conditions
Healthy
Interventions
Betaine, BCAA Big 6, Placebo
Dietary Supplement
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 45 Years · Male only
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Mar 12, 2024 · Synced Jun 26, 2026, 5:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Pre-Exercise Nutrition Strategies on Body Temperature and Thermoregulatory Responses

NCT02814188
View directory record Official record
Conditions
Impaired Thermoregulation
Interventions
Carbohydrate Beverage, Placebo Beverage
Other
Lead sponsor
Old Dominion University
Other
Eligibility
18 Years to 65 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 14, 2017 · Synced Jun 26, 2026, 5:33 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Identification of Critical Thermal Environments for Aged Adults

NCT04284397
View directory record Official record
Conditions
Aging
Interventions
Low dose ASA, Control
Drug · Other
Lead sponsor
Penn State University
Other
Eligibility
18 Years and older
Enrollment
190 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2027
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Jun 26, 2026, 5:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Heated Vest for Persons With Spinal Cord Injury

NCT03662308
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Heated Vest, Non-Heated Vest
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 68 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated May 5, 2024 · Synced Jun 26, 2026, 5:33 PM EDT
Completed Not applicable Interventional Results available

Dietary Nitrate Supplementation and Thermoregulation

NCT03506646
View directory record Official record
Conditions
Peripheral Arterial Disease, Peripheral Artery Disease
Interventions
Placebo, Beet root juice
Dietary Supplement
Lead sponsor
University of Nebraska
Other
Eligibility
50 Years to 85 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Nov 21, 2024 · Synced Jun 26, 2026, 5:33 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Effect of Simulated Burn Injury on Post Exercise Recovery in Hot Environments

NCT07050264
View directory record Official record
Conditions
Burn Injury, Body Temperature Regulation, Cardiovascular Physiology
Interventions
Simulated burn injury via application of absorbent and impermeable material over 60% of the body
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 25, 2026 · Synced Jun 26, 2026, 5:33 PM EDT
Withdrawn Not applicable Interventional

Reports on Sleep Quality and Thermoregulation Among Veterans

NCT04236661
View directory record Official record
Conditions
Sleep Disturbance
Interventions
chilipad
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 6, 2020 · Synced Jun 26, 2026, 5:33 PM EDT
Completed Not applicable Interventional

Metabolism and Thyroid Hormone Changes During Exposure to Cold Temperatures

NCT00521729
View directory record Official record
Conditions
Obesity
Interventions
Exposure to Cold Temperature
Procedure
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 60 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2018
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 15, 2019 · Synced Jun 26, 2026, 5:33 PM EDT