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ClinicalTrials.gov public records Last synced Oct 22, 2026, 6:23 AM EDT

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Showing 1–24 of 53 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Thoracic Fracture Clear all
Not listed Phase 4 Interventional

Liposomal Bupivacaine Intercostal Nerve Block vs Thoracic Epidural for Regional Analgesia in Multiple Rib Fractures

NCT03574376
View directory record Official record
Conditions
Trauma, Trauma Injury, Pain, Acute
Interventions
Bupivacaine Liposome Injection, Bupivacaine
Drug
Lead sponsor
Chadrick Evans
Other
Eligibility
18 Years and older
Enrollment
258 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Peoria, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 9, 2020 · Synced Oct 22, 2026, 6:23 AM EDT
Completed Not applicable Interventional Results available

Early Percutaneous Cryoablation for Pain Control After Rib Fractures Among Elderly Patients

NCT04482582
View directory record Official record
Conditions
Rib Fractures
Interventions
Cryoneurolysis, Standard of Care
Radiation · Other
Lead sponsor
Stanford University
Other
Eligibility
65 Years and older
Enrollment
127 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Mar 27, 2026 · Synced Oct 22, 2026, 6:23 AM EDT
Terminated Early Phase 1 Interventional

PVB vs Ketamine/Lidocaine in Rib Fracture Patients

NCT04413799
View directory record Official record
Conditions
Rib Fractures, Rib Trauma, Rib Fracture Multiple, Pain, Acute
Interventions
lidocaine, ketamine intravenous infusion, paravertebral block with ropivicaine
Combination Product · Drug
Lead sponsor
George Washington University
Other
Eligibility
18 Years to 80 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jun 22, 2025 · Synced Oct 22, 2026, 6:23 AM EDT
Completed Phase 4 Interventional Results available

Dexmedotomidine for Acute Pain Control in Patients With Multiple Rib FracturesRandomized Controlled Trial

NCT05321121
View directory record Official record
Conditions
Rib Fractures, Pain, Acute
Interventions
Dexmedetomidine, Placebo
Drug · Other
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Mar 25, 2026 · Synced Oct 22, 2026, 6:23 AM EDT
Completed Not applicable Interventional Results available

Clinical Study of the U-Plate Fracture Repair System to Treat Rib Fractures

NCT00556543
View directory record Official record
Conditions
Rib Fracture, Flail Chest
Interventions
U-plate fracture repair system
Device
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 1, 2011 · Synced Oct 22, 2026, 6:23 AM EDT
Completed Early Phase 1 Interventional

Ultrasound Guided Serratus Anterior Plane Block in ED Patients With Rib Fractures

NCT06299137
View directory record Official record
Conditions
Rib Fractures, Pain Acute, Regional Anesthesia, Opioid Use
Interventions
Serratus Anterior Plane Block, Ropivacaine injection
Procedure · Drug
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Oct 22, 2026, 6:23 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Study of Effects of Age and Hyperkyphosis on Spine Motion and Loading

NCT03008902
View directory record Official record
Conditions
Kyphosis, Vertebral Fracture
Interventions
Near-infrared passive motion capture recording
Procedure
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 4, 2018 · Synced Oct 22, 2026, 6:23 AM EDT
Terminated Not applicable Interventional Results available

Effects of Using the Duracore Splinting Device on Patient Outcomes Related to Chest Trauma

NCT04909463
View directory record Official record
Conditions
Rib Fractures, Rib Fracture Multiple
Interventions
Chest Splint
Device
Lead sponsor
CommonSpirit Health
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Colorado Springs, Colorado
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Oct 22, 2026, 6:23 AM EDT
Completed Not applicable Interventional Results available

Surgical Stabilization for Rib Fractures

NCT04081233
View directory record Official record
Conditions
Trauma Chest, Rib Fracture Multiple
Interventions
surgical stabilization, Usual care
Procedure
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
16 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 2, 2024 · Synced Oct 22, 2026, 6:23 AM EDT
Terminated No phase listed Observational

Early Aggressive Pain Management is Associated With Improved Outcomes in Blunt Thoracic Trauma

NCT01327287
View directory record Official record
Conditions
Thoracic Injury, Rib Fracture, Sternal Fracture
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 70 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 17, 2015 · Synced Oct 22, 2026, 6:23 AM EDT
Recruiting No phase listed Observational

Zimmer Biomet-RibFix Titan

NCT07485829
View directory record Official record
Conditions
Rib Fracture, Rib Fracture Multiple
Interventions
The RibFix Titan™ device should be used within this arm of the study.
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Oct 22, 2026, 6:23 AM EDT
Completed Not applicable Interventional Results available

Treatment of Adult Traumatic Rib Fractures With Percutaneous Cryoneurolysis

NCT05330611
View directory record Official record
Conditions
Rib Fractures
Interventions
Cryoneurolysis of Intercostal Nerves, Standard of Care
Device · Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 64 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 22, 2026, 6:23 AM EDT
Recruiting Not applicable Interventional

Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU

NCT06538376
View directory record Official record
Conditions
Pulmonary Edema, Pneumonia, Atelectasis, Pleural Effusion, Acute Rejection of Lung Transplant (Disorder), Airway Obstruction, Rib Fractures, Acute Copd Exacerbation, Asthma COPD, Pulmonary Embolism, Hemothorax, Pneumothorax, Mesothelioma, Diaphragmatic Paralysis
Interventions
Portable Dynamic Digital Radiography (DDR)
Diagnostic Test
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
230 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Oct 22, 2026, 6:23 AM EDT
Terminated Phase 1 Interventional

The Erector Spinae Plane Block and Its Effect on Respiratory Status and Pain Management in Rib Fracture Patients

NCT03805360
View directory record Official record
Conditions
Rib Fractures
Interventions
Ropivacaine, Normal Saline Flush, 0.9% Injectable Solution
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 7, 2020 · Synced Oct 22, 2026, 6:23 AM EDT
Completed Phase 4 Interventional

Evaluation of Surgical Treatment on Pain and Disability for Chronic, Non-healing Rib Fracture

NCT00774618
View directory record Official record
Conditions
Rib Fracture
Interventions
Resection with or without plate fixation
Device
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 22, 2013 · Synced Oct 22, 2026, 6:23 AM EDT
Not listed Phase 4 Interventional

US-guided SAPB for Rib Fractures in the ED

NCT03619785
View directory record Official record
Conditions
Rib Fractures, Rib Fracture Multiple
Interventions
Bupivacaine, Fentanyl, morphine, hydromorphone, hydrocodone, acetaminophen, ketorolac, gabapentin, ketamine, ibuprofen
Drug
Lead sponsor
Andrew A Herring
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Dec 19, 2018 · Synced Oct 22, 2026, 6:23 AM EDT
Completed Phase 4 Interventional Results available

Low Dose Ketamine for Blunt Thoracic Trauma

NCT06236113
View directory record Official record
Conditions
Blunt Injury of Thorax, Multiple Rib Fractures, Involving Three Ribs
Interventions
Ketamine 1 Mg/mL-NaCl 0.9% Intravenous Solution
Drug
Lead sponsor
North Memorial Health Care
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Robbinsdale, Minnesota
Source: ClinicalTrials.gov public record
Updated May 21, 2024 · Synced Oct 22, 2026, 6:23 AM EDT
Terminated Not applicable Interventional Results available

Orthosis of Acute Traumatic Rib Fractures Via RibFx Belt for Pain Alleviation and Improved Pulmonary Function

NCT03846024
View directory record Official record
Conditions
Rib Fracture, Rib Fracture Multiple, Trauma, Trauma Chest, Trauma Injury, Trauma, Multiple
Interventions
RibFx Orthosis Belt
Device
Lead sponsor
University of Vermont Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Jan 12, 2023 · Synced Oct 22, 2026, 6:23 AM EDT
Withdrawn No phase listed Observational

Operative Versus Non-Operative Treatment of Clavicle Fracture in PolyTrauma

NCT01133769
View directory record Official record
Conditions
Clavicle Fracture, Chest Injury
Interventions
Not listed
Lead sponsor
Anna Rockich
Other
Eligibility
18 Years to 79 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 20, 2017 · Synced Oct 22, 2026, 6:23 AM EDT
Terminated Phase 4 Interventional

Pain Relief for Ventilated Patients With Multiple Rib Fractures Using the ON-Q Pain Relief System

NCT00880529
View directory record Official record
Conditions
Rib Fractures
Interventions
ON-Q bupivicaine administration, IV opioid administration
Device · Drug
Lead sponsor
The Cooper Health System
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Camden, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 27, 2013 · Synced Oct 22, 2026, 6:23 AM EDT
Recruiting No phase listed Observational

Assessment of Morbidity and Mortality Following Serratus Anterior Plane Block (SAPB) for Unilateral Rib Fractures

NCT07032766
View directory record Official record
Conditions
Pain Management, Rib Fracture Multiple, Serratus Anterior Plane Block
Interventions
Not listed
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
18 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 22, 2026, 6:23 AM EDT
Completed Phase 4 Interventional Results available

Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fractures

NCT03305666
View directory record Official record
Conditions
Drug Effect, Rib Fractures, Rib Trauma, Surgical Procedure, Unspecified, Pain; Catheter (Other), Nerve Pain, Local Infiltration, Anesthesia, Local, Intercostal Rib, Opioid Dependence, Chest Injury Trauma, Pneumonia
Interventions
Liposomal bupivacaine injection, Bupivacaine indwelling catheter
Drug
Lead sponsor
Denver Health and Hospital Authority
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 29, 2021 · Synced Oct 22, 2026, 6:23 AM EDT
Enrolling by invitation Not applicable Interventional

Ultrasound-Guided Percutaneous Cryoneurolysis to Treat Pain Following Thoracic Trauma

NCT06069154
View directory record Official record
Conditions
Rib Fracture, Rib Fracture Multiple
Interventions
Cryoneurolysis, Local anesthetic peripheral nerve block, Sham Cryoneurolysis, Sham peripheral nerve block
Device · Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
5
States / cities
La Jolla, California • Bethesda, Maryland • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Oct 22, 2026, 6:23 AM EDT
Not listed Not applicable Interventional

Rib Fixation for Clinically Severe Rib Fractures From Trauma

NCT02595593
View directory record Official record
Conditions
Rib Fracture, Flail Chest
Interventions
Rib Fixation System
Device
Lead sponsor
Darwin Ang
Other
Eligibility
18 Years to 90 Years
Enrollment
236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
10
States / cities
Fort Walton Beach, Florida • Ft. Pierce, Florida • Kissimmee, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated May 10, 2022 · Synced Oct 22, 2026, 6:23 AM EDT