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ClinicalTrials.gov public records Last synced Oct 2, 2026, 4:26 PM EDT

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Showing 1–24 of 76 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Tinea Unguium, Onychomycosis Clear all
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Evaluating the Efficacy and Compatibility of Efinaconazole 10% Solution (Jublia) for the Treatment of Toenail Onychomycosis in Patients Wearing Toenail Polish Compared to Those Without Polish

NCT03110029
View directory record Official record
Conditions
Onychomycosis of Toenail
Interventions
Efinaconazole 10% Topical Application Solution [JUBLIA], Application of Nail Polish
Drug · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 70 Years · Female only
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 27, 2019 · Synced Oct 2, 2026, 4:26 PM EDT
Withdrawn Phase 3 Interventional

Study to Evaluate the Efficacy and Safety of P-3058 Nail Solution in the Treatment of Onychomycosis

NCT03094468
View directory record Official record
Conditions
Onychomycosis of Toenail
Interventions
P-3058 (terbinafine hydrochloride 10%), Vehicle of P-3058
Drug
Lead sponsor
Polichem S.A.
Industry
Eligibility
12 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
21
States / cities
North Hollywood, California • Oceanside, California • San Diego, California + 15 more
Source: ClinicalTrials.gov public record
Updated Jan 10, 2018 · Synced Oct 2, 2026, 4:26 PM EDT
Not listed Not applicable Interventional

Evaluating the Safety, Tolerability and Preliminary Efficacy of Plasma in Improving the Appearance of Onychomycosis

NCT02724384
View directory record Official record
Conditions
Onychomycosis
Interventions
MOE Plasma Delivery System A, MOE Plasma Delivery System B
Device
Lead sponsor
Moe Medical Devices
Industry
Eligibility
18 Years to 70 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
7
States / cities
Quincy, Massachusetts • Philadelphia, Pennsylvania • Pittsburgh, Pennsylvania + 4 more
Source: ClinicalTrials.gov public record
Updated Sep 14, 2017 · Synced Oct 2, 2026, 4:26 PM EDT
Not listed Phase 3 Interventional

TDT 067 Onychomycosis Study

NCT01145807
View directory record Official record
Conditions
Onychomycosis
Interventions
TDT067, Placebo, Transfersome
Drug
Lead sponsor
Celtic Pharma Development Services
Industry
Eligibility
18 Years to 75 Years
Enrollment
738 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Albequerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Aug 1, 2012 · Synced Oct 2, 2026, 4:26 PM EDT
Completed Phase 1 Interventional

Single-blind Evaluation of Device to Nail Micro-drilling in Onychomycosis

NCT00941317
View directory record Official record
Conditions
Onychomycosis
Interventions
Pathformer (micro-drilling device)
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 17, 2021 · Synced Oct 2, 2026, 4:26 PM EDT
Terminated Phase 3 Interventional

Safety & Efficacy of NAB001 in the Treatment of Mild to Moderate Onychomycosis of the Toenails

NCT01208168
View directory record Official record
Conditions
Onychomycosis
Interventions
NAB001, Vehicle alone
Drug
Lead sponsor
Promius Pharma, LLC
Industry
Eligibility
18 Years to 70 Years
Enrollment
468 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
22
States / cities
Phoenix, Arkansas • Encino, California • San Diego, California + 19 more
Source: ClinicalTrials.gov public record
Updated Jul 11, 2013 · Synced Oct 2, 2026, 4:26 PM EDT
Completed Phase 1 Interventional

Pharmacokinetics and Safety Study of ME1111 in Moderate to Severe Onychomycosis Patients

NCT01841996
View directory record Official record
Conditions
Onychomycosis
Interventions
ME1111 solution, Vehicle Solution
Drug
Lead sponsor
Meiji Seika Pharma Co., Ltd.
Industry
Eligibility
18 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2013
U.S. locations
2
States / cities
Austin, Texas • College Station, Texas
Source: ClinicalTrials.gov public record
Updated Dec 17, 2013 · Synced Oct 2, 2026, 4:26 PM EDT
Suspended Phase 2 Interventional

A Trial to Evaluate the Safety and Efficacy of DBI-001 Gel, DBI-002 Gel, and Aqueous Gel in Subjects With Onychomycosis

NCT05491603
View directory record Official record
Conditions
Onychomycosis
Interventions
DBI-001, DBI-002, Aqueous Gel
Biological
Lead sponsor
DermBiont, Inc.
Industry
Eligibility
18 Years to 50 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
5
States / cities
Encino, California • New Brighton, Minnesota • Portland, Oregon + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 7, 2023 · Synced Oct 2, 2026, 4:26 PM EDT
Completed Phase 2 Interventional

Safety & Efficacy Study of HTU-520 in the Treatment of Distal Subungual Onychomycosis of the Toenail

NCT01400594
View directory record Official record
Conditions
Onychomycosis
Interventions
HTU-520 Patch, Placebo Patch
Drug · Other
Lead sponsor
Hisamitsu Pharmaceutical Co., Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
37
States / cities
Birmingham, Alabama • Glendale, Arizona • Tucson, Arizona + 30 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2015 · Synced Oct 2, 2026, 4:26 PM EDT
Completed Not applicable Interventional

Pulsed Dye Laser Treatment of Onychomycosis

NCT01915355
View directory record Official record
Conditions
Onychomycosis
Interventions
Pulsed Dye Laser for the treatment of nail fungus
Device
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years to 65 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 19, 2016 · Synced Oct 2, 2026, 4:26 PM EDT
Completed Phase 2 Interventional

Deposition of Terbinafine After Iontophoretic Application of ETS Terbinafine Gel in Subjects With Distal Subungual Onychomycosis in the Great Toenail

NCT01484145
View directory record Official record
Conditions
Onychomycosis
Interventions
Terbinafine HCl
Drug
Lead sponsor
Nitric BioTherapeutics, Inc
Industry
Eligibility
18 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Oct 19, 2012 · Synced Oct 2, 2026, 4:26 PM EDT
Completed Phase 2Phase 3 Interventional

Safety and Efficacy of Luliconazole Solution, 10% in Subjects With Mild to Moderate Onychomycosis

NCT01431820
View directory record Official record
Conditions
Distal and Lateral Subungual Onychomycosis
Interventions
Luliconazole Solution, 10%, Vehicle Solution
Drug
Lead sponsor
Topica Pharmaceuticals
Industry
Eligibility
18 Years to 70 Years
Enrollment
334 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
28
States / cities
Phoenix, Arizona • Los Angeles, California • San Diego, California + 23 more
Source: ClinicalTrials.gov public record
Updated Nov 30, 2015 · Synced Oct 2, 2026, 4:26 PM EDT
Not listed Not applicable Interventional

Evaluation of the Effectiveness of Nail Genesis DLSO Product for Onychomycosis

NCT06074315
View directory record Official record
Conditions
Distal Lateral Subungual Onychomycosis, Onychomycosis
Interventions
Nail Genesis DLSO Product, Nail Genesis DLSO Product (vehicle only)
Device
Lead sponsor
Nail Genesis LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
338 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
10
States / cities
Fayetteville, Arkansas • Montclair, California • Sacramento, California + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 8, 2023 · Synced Oct 2, 2026, 4:26 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study of the Effects of Increasing Doses of a Drug for the Treatment of Nail Fungus

NCT01014962
View directory record Official record
Conditions
Onychomycosis
Interventions
Albaconozole, Placebo
Drug
Lead sponsor
Stiefel, a GSK Company
Industry
Eligibility
18 Years to 45 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
West Bend, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 20, 2017 · Synced Oct 2, 2026, 4:26 PM EDT
Completed Not applicable Interventional

Diode Laser Treatment of Onychomycosis

NCT01452490
View directory record Official record
Conditions
Onychomycosis
Interventions
Diode Laser Treatment
Device
Lead sponsor
ConBio, a Cynosure Company
Industry
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
2
States / cities
New London, Connecticut • Westbrook, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 28, 2020 · Synced Oct 2, 2026, 4:26 PM EDT
Completed Phase 1Phase 2 Interventional

Open-Label Pharmacokinetics (PK)/Safety Study of Luliconazole Solution, 10% in Distal Subungual Onychomycosis

NCT01044381
View directory record Official record
Conditions
Onychomycosis
Interventions
Luliconazole Solution, 10%
Drug
Lead sponsor
Topica Pharmaceuticals
Industry
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
College Station, Texas
Source: ClinicalTrials.gov public record
Updated Nov 26, 2014 · Synced Oct 2, 2026, 4:26 PM EDT
Completed Phase 3 Interventional Results available

Efficacy Safety, and Tolerability of Topical Terbinafine in Patients With Mild to Moderate Toenail Fungus of the Big Toenail

NCT00443820
View directory record Official record
Conditions
Onychomycosis
Interventions
terbinafine, Placebo
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
12 Years to 75 Years
Enrollment
526 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
20
States / cities
Novato, California • Northglenn, Colorado • Melbourne, Florida + 17 more
Source: ClinicalTrials.gov public record
Updated Apr 19, 2011 · Synced Oct 2, 2026, 4:26 PM EDT
Completed Not applicable Interventional Results available

Human Factors Testing for OTC Use of the Erchonia® LunulaLaser

NCT05626270
View directory record Official record
Conditions
Onychomycosis
Interventions
LunulaLaser OTC
Device
Lead sponsor
Erchonia Corporation
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Melbourne, Florida
Source: ClinicalTrials.gov public record
Updated May 23, 2024 · Synced Oct 2, 2026, 4:26 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Treatment of Mild to Moderate Distal Subungual Onychomycosis of the Toenail

NCT00453271
View directory record Official record
Conditions
Onychomycosis
Interventions
NB-002, Vehicle control
Drug
Lead sponsor
NanoBio Corporation
Industry
Eligibility
18 Years to 75 Years
Enrollment
443 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
13
States / cities
Miami, Florida • Boise, Idaho • Evansville, Indiana + 9 more
Source: ClinicalTrials.gov public record
Updated May 23, 2013 · Synced Oct 2, 2026, 4:26 PM EDT
Completed Phase 1 Interventional

Safety and Pharmacokinetics of Terbinafine Hydrogen Chloride (HCl) Nail Lacquer in Patients With Onychomycosis

NCT00691184
View directory record Official record
Conditions
Onychomycosis/Onycholysis and Tinea Pedis
Interventions
Placebo, Terbinafine Hydrochloride, Terbinafine
Drug
Lead sponsor
NexMed (U.S.A.), Inc. (subsidiary of Apricus Biosciences, Inc.)
Industry
Eligibility
18 Years to 70 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005
U.S. locations
1
States / cities
Paramus, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 5, 2008 · Synced Oct 2, 2026, 4:26 PM EDT
Not listed Phase 2 Interventional

Systemic Uptake of Diclofenac Sodium in Combination With Miconazole as Antifungal Nail Gel When Applied Daily With Monitoring of Hepatic and Renal Enzymes, and Serum Levels of Diclofenac 12 Hours After Application, and at 3 and 6 Months Study

NCT04341402
View directory record Official record
Conditions
Tinea Unguium, Onychomycosis
Interventions
Antifungal Nail Gel Study
Drug
Lead sponsor
William N Handelman
Other
Eligibility
21 Years to 100 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
St. Petersburg, Florida
Source: ClinicalTrials.gov public record
Updated Apr 10, 2020 · Synced Oct 2, 2026, 4:26 PM EDT
Completed No phase listed Observational

An Open-label Study Evaluating the Effectiveness of CGB-400 Topical Gel for Fungal Infection

NCT05202366
View directory record Official record
Conditions
Fungal Infection, Onychomycosis, Tinea Unguium
Interventions
CGB-400 Topical Gel
Drug
Lead sponsor
CAGE Bio Inc.
Industry
Eligibility
18 Years to 99 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Oct 2, 2026, 4:26 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Cumulative Irritation Test

NCT00680095
View directory record Official record
Conditions
Onychomycosis
Interventions
AN2690, AN2690 Solution, Vehicle, Sodium Lauryl Sulfate, 0.5%
Drug · Other
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007
U.S. locations
1
States / cities
Lynchburg, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 9, 2019 · Synced Oct 2, 2026, 4:26 PM EDT
Completed Phase 3 Interventional Results available

Efficacy and Safety Evaluation of AN2690 Topical Solution to Treat Onychomycosis of the Toenail

NCT01270971
View directory record Official record
Conditions
Onychomycosis of Toenails
Interventions
AN2690 Topical Solution, 5%, Solution Vehicle
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
594 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
27
States / cities
Tucson, Arizona • Hot Springs, Arkansas • Burbank, California + 23 more
Source: ClinicalTrials.gov public record
Updated Feb 22, 2019 · Synced Oct 2, 2026, 4:26 PM EDT