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ClinicalTrials.gov public records Last synced Oct 21, 2026, 4:04 AM EDT

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Showing 145–168 of 1,797 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Tobacco Clear all
Completed Phase 2 Interventional Results available

Meclizine as a Potential Smoking Cessation Treatment

NCT01443858
View directory record Official record
Conditions
Smoking Cessation
Interventions
Meclizine, Nicotine Patch, Placebo
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
4
States / cities
Charlotte, North Carolina • Durham, North Carolina • Raleigh, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 1, 2014 · Synced Oct 21, 2026, 4:04 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Development of a mHealth Intervention for Ambivalent Smokers

NCT04560868
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking Cessation, Motivation, Behavior, Smoking
Interventions
Control mHealth program, Experimental mHealth program, Nicotine patch
Device · Drug
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 23, 2023 · Synced Oct 21, 2026, 4:04 AM EDT
Completed Phase 2 Interventional Results available

Evaluation of Moclobemide, a Reversible MAO-A Inhibitor, as an Adjunct to Nicotine Replacement Therapy in Female Smokers

NCT01926626
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine Patch, Moclobemide
Drug
Lead sponsor
Jed E. Rose
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
3
States / cities
Charlotte, North Carolina • Durham, North Carolina • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 23, 2017 · Synced Oct 21, 2026, 4:04 AM EDT
Completed Not applicable Interventional

Technologically-Augmented Referrals to Mitigate Addiction Consequences

NCT04401215
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Technology Augmented Treatment for Screening, Brief Intervention, Referral, and Treatment (SBIRT)
Behavioral
Lead sponsor
Washington State University
Other
Eligibility
21 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Spokane Valley, Washington
Source: ClinicalTrials.gov public record
Updated Jun 19, 2020 · Synced Oct 21, 2026, 4:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Using Technology to Help Low-income and Latino Smokers Quit

NCT02666482
View directory record Official record
Conditions
Smoking Cessation
Interventions
Stop Smoking SF Web App - baseline
Behavioral
Lead sponsor
i4Health
Other
Eligibility
18 Years to 99 Years
Enrollment
1,107 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Nov 15, 2018 · Synced Oct 21, 2026, 4:04 AM EDT
Recruiting Not applicable Interventional

Adapting and Pilot Testing a Skills-based Smoking Cessation Intervention to Address Developmental and Health-related Stress Among Adults Who Smoke

NCT06654414
View directory record Official record
Conditions
Smoking Cessation, Depression, Anxiety, Nicotine Dependence, Gender Minority Stress
Interventions
PRIDE QUIT, Enhanced Treatment As Usual (ETAU)
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
3
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 21, 2026, 4:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Tobacco Treatment in the Context of Lung Cancer Screening

NCT03927989
View directory record Official record
Conditions
Smoking Cessation
Interventions
Text messaging plus nicotine replacement therapy, Standard Care at Lung Cancer Screening
Behavioral · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
55 Years and older
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 22, 2024 · Synced Oct 21, 2026, 4:04 AM EDT
Completed Phase 1 Interventional

Flexiquit+: Web Program to Promote Smoking Cessation in Sexual and Gender Minority Young Adult Smokers

NCT04194918
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Computer-Assisted Smoking Cessation Intervention, Text Message, Handout, Questionnaire Administration, Quality-of-Life Assessment, Survey Administration
Behavioral · Other
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years to 30 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 5, 2020 · Synced Oct 21, 2026, 4:04 AM EDT
Active, not recruiting Not applicable Interventional

Smoking Cessation Intervention for Cancer Patients

NCT00575718
View directory record Official record
Conditions
Newly Diagnosed Cancer Patients
Interventions
Hospital Counseling + Nicotine Replacement Therapy. questionaires, Hospital Counseling + Nicotine Replacement + Presurgical Scheduled Reduced Smoking, questionaires
Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 5, 2026 · Synced Oct 21, 2026, 4:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A High School Program for Preventing Prescription Drug Misuse

NCT03219190
View directory record Official record
Conditions
Prescription Drug Abuse, Substance Abuse, Substance Use (Drugs, Alcohol)
Interventions
LST High School Hybrid
Behavioral
Lead sponsor
National Health Promotion Associates, Inc.
Industry
Eligibility
14 Years to 18 Years
Enrollment
1,804 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
White Plains, New York
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Oct 21, 2026, 4:04 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Black Raspberry Nectar for the Prevention of Lung Cancer, BE WELL Study

NCT04267874
View directory record Official record
Conditions
Lung Carcinoma, Tobacco-Related Carcinoma
Interventions
Biospecimen Collection, Nutritional Supplementation, Placebo Administration, Questionnaire Administration
Procedure · Dietary Supplement · Drug + 1 more
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
55 Years to 77 Years
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 1, 2023 · Synced Oct 21, 2026, 4:04 AM EDT
Completed Phase 3 Interventional

Smoking Cessation Treatment With Transdermal Nicotine Replacement Therapy - 1

NCT00067158
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
nicotine transdermal system
Drug
Lead sponsor
New York University
Other
Eligibility
18 Years to 99 Years
Enrollment
585 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2004
U.S. locations
13
States / cities
Los Angeles, California • Tarzana, California • Miami, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 21, 2026, 4:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Electronic Cigarette Use on the Lungs

NCT02596685
View directory record Official record
Conditions
Current Smoker, Never Smoker, Tobacco Use Disorder, Former Smoker, E-cig User
Interventions
Bronchoscopy, Electronic Cigarette, Laboratory Biomarker Analysis, Questionnaire Administration
Procedure · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 45 Years
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 30, 2024 · Synced Oct 21, 2026, 4:04 AM EDT
Recruiting Not applicable Interventional

Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+)

NCT07711691
View directory record Official record
Conditions
Lung Cancer Screening, Lung Neoplasms, Smoking ( Cigarette), Early Detection of Cancer
Interventions
Empower LCS, Call+ Telephone Navigation, Usual Care, Education
Behavioral · Other
Lead sponsor
University of California, Irvine
Other
Eligibility
50 Years to 80 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
57
States / cities
Anaheim, California • Costa Mesa, California • Irvine, California + 27 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 21, 2026, 4:04 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Baclofen Effects in Cigarette Smokers

NCT01821560
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Baclofen, placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 60 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 19, 2018 · Synced Oct 21, 2026, 4:04 AM EDT
Completed Not applicable Interventional

An Interprofessional Intervention to Reduce Smoking Rates

NCT03380910
View directory record Official record
Conditions
Smoking, Cigarette
Interventions
Pharmacy and Behavioral Health Team, Motivational Interviewing
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 89 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Henrico, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 15, 2021 · Synced Oct 21, 2026, 4:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study of Hookah Café Customers in the Atlanta Area

NCT05916170
View directory record Official record
Conditions
Waterpipe Tobacco Smoking
Interventions
Health Warnings, No Warnings
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
977 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Oct 21, 2026, 4:04 AM EDT
Completed Phase 4 Interventional

Tobacco Cessation in Postmenopausal Women (Part I) - 1

NCT00061061
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Behavior Therapy
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
40 Years to 79 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2003
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 2, 2015 · Synced Oct 21, 2026, 4:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Attitudes and Smoking Perceptions in the Real Environment

NCT06617520
View directory record Official record
Conditions
Tobacco Use
Interventions
Cigarillo flavor type
Other
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 34 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Aug 27, 2025 · Synced Oct 21, 2026, 4:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Development of a Mindfulness-Based Treatment for the Reduction of Alcohol Use and Smoking Cessation

NCT03734666
View directory record Official record
Conditions
Tobacco Use, Alcohol Use, Unspecified
Interventions
Mindfulness Based Relapse Prevention - Smoking and Alcohol, Cognitive Behavioral Therapy
Behavioral
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Oct 21, 2026, 4:04 AM EDT
Completed Phase 2 Interventional Results available

Sulindac in Preventing Lung Cancer in Current or Former Smokers With Bronchial Dysplasia

NCT00368927
View directory record Official record
Conditions
Precancerous Condition, Stage I Non-small Cell Lung Cancer, Tobacco Use Disorder
Interventions
sulindac, placebo
Drug · Other
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
40 Years to 79 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
5
States / cities
Scottsdale, Arizona • Tampa, Florida • Burlington, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated May 23, 2014 · Synced Oct 21, 2026, 4:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tobacco, Alcohol, Prescription Drug, and Illicit Substance Use- Electronic Spanish Platform

NCT05476588
View directory record Official record
Conditions
Tobacco Use, Alcohol Abuse, Prescription Drug Abuse, Substance Use
Interventions
Screening
Other
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Oct 21, 2026, 4:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

JUUL vs. Mod E-cigarette Study

NCT04237272
View directory record Official record
Conditions
Smoking, Tobacco Use
Interventions
Pod System E-cig, Customizable Tank E-cig, Control
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 21, 2022 · Synced Oct 21, 2026, 4:04 AM EDT
Withdrawn No phase listed Observational

Method Development and Assessment of the Effects of Tobacco Products on Oral Cavity Cells

NCT01484769
View directory record Official record
Conditions
Squamous Cell Carcinoma
Interventions
Not listed
Lead sponsor
University of Louisville
Other
Eligibility
7 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2012
U.S. locations
3
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 10, 2017 · Synced Oct 21, 2026, 4:04 AM EDT